Downregulation of Fzd6 and Cthrc1 and upregulation of olfactory receptors and protocadherins by dietary beta-carotene in lungs of Bcmo1-/- mice

Carcinogenesis

Volumn 31, Issue 8, 2010, Pages 1329-1337

  van Helden, Yvonne G J ^a,b   Godschalk, Roger W ^b   Heil, Sandra G ^a   Bunschoten, Annelies ^a   Hessel, Susanne ^c   Amengual, Jaume ^d,e   Luisa Bonet, M ^d   von Lintig, Johannes ^e   van Schooten, Frederik J ^b   Keijer, Jaap ^a  

^a WAGENINGEN UNIVERSITY   (Netherlands)

^b MAASTRICHT UNIVERSITY   (Netherlands)

^c UNIVERSITY OF FREIBURG   (Germany)

^d UNIVERSITAT DE LES ILLES BALEARS   (Spain)

^e CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA CAROTENE; BETA CAROTENE 15,15' MONOOXYGENASE; CADHERIN; TOBACCO SMOKE; TRANSCRIPTOME;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CTHRC1 GENE; DIET SUPPLEMENTATION; DIETARY INTAKE; DOWN REGULATION; FZD6 GENE; GENE; GENE CONTROL; GENE EXPRESSION; KNOCKOUT MOUSE; MALE; MOUSE; NEUROSECRETORY CELL; NONHUMAN; NUCLEOTIDE SEQUENCE; OLFACTORY RECEPTOR; PRIORITY JOURNAL; SENSORY NERVE; UPREGULATION;

ANIMALS; BETA CAROTENE; BETA-CAROTENE 15,15'-MONOOXYGENASE; CADHERINS; CAROTENOIDS; DIET; DNA PRIMERS; EXTRACELLULAR MATRIX PROTEINS; FRIZZLED RECEPTORS; GENE AMPLIFICATION; GENOME; LUNG; MALE; MICE; MICE, KNOCKOUT; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; RECEPTORS, G-PROTEIN-COUPLED; RECEPTORS, ODORANT; RETINOIDS; RNA; UP-REGULATION;

EID: 77955412180     PISSN: 01433334     EISSN: 14602180     Source Type: Journal    
DOI: 10.1093/carcin/bgq083     Document Type: Article

References (51)

1. van Poppel,G. (1996) Epidemiological evidence for beta-carotene in prevention of cancer and cardiovascular disease. Eur. J. Clin. Nutr., 50 (suppl. 3), S57-S61.
2. Ziegler,R.G. (1989) A review of epidemiologic evidence that carotenoids reduce the risk of cancer. J. Nutr., 119, 116-122.
3. Albanes,D. et al. (1996) Alpha-Tocopherol and beta-carotene supplements and lung cancer incidence in the alpha-tocopherol, beta-carotene cancer prevention study: effects of base-line characteristics and study compliance. J. Natl Cancer Inst., 88, 1560-1570.
4. Omenn,G.S. et al. (1996) Risk factors for lung cancer and for intervention effects in CARET, the Beta-Carotene and Retinol Efficacy Trial. J. Natl Cancer Inst., 88, 1550-1559.
5. Hennekens,C.H. et al. (1996) Lack of effect of long-term supplementation with beta carotene on the incidence of malignant neoplasms and cardiovascular disease. N. Engl. J. Med., 334, 1145-1149.
6. Palozza,P. (1998) Prooxidant actions of carotenoids in biologic systems. Nutr. Rev., 56, 257-265.
7. van Helden,Y.G. et al. (2009) Beta-carotene metabolites enhance inflammation-induced oxidative DNA damage in lung epithelial cells. Free Radic. Biol. Med., 46, 299-304.
8. Russell,R.M. (2004) The enigma of beta-carotene in carcinogenesis: what can be learned from animal studies. J. Nutr., 134, 262S-268S.
9. von Lintig,J. et al. (2000) Filling the gap in vitamin A research. Molecular identification of an enzyme cleaving beta-carotene to retinal. J. Biol. Chem., 275, 11915-11920.
10. von Lintig,J. et al. (2001) Molecular analysis of vitamin A formation: cloning and characterization of beta-carotene 15,15′-dioxygenases. Arch. Biochem. Biophys., 385, 47-52.
11. Hessel,S. et al. (2007) CMO1 deficiency abolishes vitamin A production from beta-carotene and alters lipid metabolism in mice. J. Biol. Chem., 282, 33553-33561.
12. Rodenburg,W. et al. (2008) A framework to identify physiological responses in microarray-based gene expression studies: selection and interpretation of biologically relevant genes. Physiol. Genomics, 33, 78-90.
13. van Schothorst,E.M. et al. (2007) Assessment of reducing RNA input for Agilent oligo microarrays. Anal. Biochem., 363, 315-317.
14. Wettenhall,J.M. et al. (2004) limmaGUI: a graphical user interface for linear modeling of microarray data. Bioinformatics, 20, 3705-3706.
15. Pellis,L. et al. (2003) The intraclass correlation coefficient applied for evaluation of data correction, labeling methods, and rectal biopsy sampling in DNA microarray experiments. Physiol. Genomics, 16, 99-106.
16. Lee,H.K. et al. (2005) ErmineJ: tool for functional analysis of gene expression data sets. BMC Bioinformatics, 6, 269.
17. Keijer,J. et al. (2009) Transcriptome analysis in benefit-risk assessment of micronutrients and bioactive food components. Mol. Nutr. Food Res., 54, 240-248.
18. Tamayo,P. et al. (1999) Interpreting patterns of gene expression with selforganizing maps: methods and application to hematopoietic differentiation. Proc. Natl Acad. Sci. USA, 96, 2907-2912.
19. Bhanot,P. et al. (1996) A new member of the frizzled family from Drosophila functions as a Wingless receptor. Nature, 382, 225-230.
20. Pyagay,P. et al. (2005) Collagen triple helix repeat containing 1, a novel secreted protein in injured and diseased arteries, inhibits collagen expression and promotes cell migration. Circ. Res., 96, 261-268.
21. Yamamoto,S. et al. (2008) Cthrc1 selectively activates the planar cell polarity pathway of Wnt signaling by stabilizing the Wnt-receptor complex. Dev. Cell, 15, 23-36.
22. Guo,N. et al. (2004) Frizzled6 controls hair patterning in mice. Proc. Natl Acad. Sci. USA, 101, 9277-9281.
23. Tokuhara,M. et al. (1998) Molecular cloning of human Frizzled-6. Biochem. Biophys. Res. Commun., 243, 622-627.
24. Morishita,H. et al. (2007) Protocadherin family: diversity, structure, and function. Curr. Opin. Cell Biol., 19, 584-592.
25. Weber,M. et al. (2002) Olfactory receptor expressed in ganglia of the autonomic nervous system. J. Neurosci. Res., 68, 176-184.
26. Yagi,T. (2008) Clustered protocadherin family. Dev. Growth Differ., 50 (suppl. 1), S131-S40.
27. Adriaensen,D. et al. (2003) Functional morphology of pulmonary neuroepithelial bodies: extremely complex airway receptors. Anat. Rec. A Discov. Mol. Cell Evol. Biol., 270, 25-40.
28. Linnoila,R.I. (2006) Functional facets of the pulmonary neuroendocrine system. Lab. Invest., 86, 425-444.
29. Hu,J. et al. (2007) Detection of near-atmospheric concentrations of CO2 by an olfactory subsystem in the mouse. Science, 317, 953-957.
30. Lahiri,S. et al. (2003) CO2/H(+) sensing: peripheral and central chemoreception. Int. J. Biochem. Cell Biol., 35, 1413-1435.
31. Pan,J. et al. (2004) Innervation of pulmonary neuroendocrine cells and neuroepithelial bodies in developing rabbit lung. J. Histochem. Cytochem., 52, 379-389.
32. Weichselbaum,M. et al. (2005) A confocal microscopic study of solitary pulmonary neuroendocrine cells in human airway epithelium. Respir. Res., 6, 115.
33. Van Lommel,A. et al. (1999) The pulmonary neuroendocrine system: the past decade. Arch. Histol. Cytol., 62, 1-16.
34. De Proost,I. et al. (2009) Purinergic signaling in the pulmonary neuroepithelial body microenvironment unraveled by live cell imaging. FASEB J., 23, 1153-1160.
35. Peake,J.L. et al. (2000) Alteration of pulmonary neuroendocrine cells during epithelial repair of naphthalene-induced airway injury. Am. J. Pathol., 156, 279-286.
36. Reynolds,S.D. et al. (2000) Neuroepithelial bodies of pulmonary airways serve as a reservoir of progenitor cells capable of epithelial regeneration. Am. J. Pathol., 156, 269-278.
37. Michaelidis,T.M. et al. (2008) Wnt signaling and neural stem cells: caught in the Wnt web. Cell Tissue Res., 331, 193-210.
38. Beites,C.L. et al. (2005) Identification and molecular regulation of neural stem cells in the olfactory epithelium. Exp. Cell Res., 306, 309-316.
39. Katoh,M. et al. (2007) WNT signaling pathway and stem cell signaling network. Clin. Cancer Res., 13, 4042-4045.
40. Golan,T. et al. (2004) The human Frizzled 6 (HFz6) acts as a negative regulator of the canonical Wnt. beta-catenin signaling cascade. J. Biol. Chem., 279, 14879-14888.
41. Devenport,D. et al. (2008) Planar polarization in embryonic epidermis orchestrates global asymmetric morphogenesis of hair follicles. Nat. Cell Biol., 10, 1257-1268.
42. Steel,M.D. et al. (2005) Beta-catenin/T-cell factor-mediated transcription is modulated by cell density in human bronchial epithelial cells. Int. J. Biochem. Cell Biol., 37, 1281-1295.
43. Fernandez,F.G. et al. (2006) Large-cell neuroendocrine carcinoma of the lung. Cancer Control, 13, 270-275.
44. Travis,W.D. et al. (1995) Lung cancer. Cancer, 75, 191-202.
45. Gosney,J.R. et al. (1988) Neuroendocrine cell populations in normal human lungs: a quantitative study. Thorax, 43, 878-882.
46. Gustafsson,B.I. et al. (2008) Bronchopulmonary neuroendocrine tumors. Cancer, 113, 5-21.
47. Reya,T. et al. (2005) Wnt signalling in stem cells and cancer. Nature, 434, 843-850.
48. Kim,J. et al. (2007) Wnt inhibitory factor inhibits lung cancer cell growth. J. Thorac. Cardiovasc. Surg., 133, 733-737.
49. You,L. et al. (2004) Inhibition of Wnt-2-mediated signaling induces programmed cell death in non-small-cell lung cancer cells. Oncogene, 23, 6170-6174.
50. Dickman,E.D. et al. (1997) Temporally-regulated retinoic acid depletion produces specific neural crest, ocular and nervous system defects. Development, 124, 3111-3121.
51. Dupe,V. et al. (2003) A newborn lethal defect due to inactivation of retinaldehyde dehydrogenase type 3 is prevented by maternal retinoic acid treatment. Proc. Natl Acad. Sci. USA, 100, 14036-14041.