Novel Protease Inhibitors (PIs) containing macrocyclic components and 3(R),3a(S),6a(R)-bis-tetrahydrofuranylurethane that are potent against multi-PI-resistant HIV-1 variants in vitro

Antimicrobial Agents and Chemotherapy

Volumn 54, Issue 8, 2010, Pages 3460-3470

  Tojo, Yasushi ^a   Koh, Yasuhiro ^a   Amano, Masayuki ^a   Aoki, Manabu ^a   Das, Debananda ^b   Kulkarni, Sarang ^c   Anderson, David D ^c   Ghosh, Arun K ^c   Mitsuya, Hiroaki ^a,b  

^a KUMAMOTO UNIVERSITY   (Japan)

^b NATIONAL CANCER INSTITUTE   (United States)

^c PURDUE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMPRENAVIR; ATAZANAVIR; DARUNAVIR; GRL 216; GRL 246; GRL 286; GRL 396; INDINAVIR; LOPINAVIR; MACROCYCLIC COMPOUND; NELFINAVIR; PROTEINASE INHIBITOR; RITONAVIR; SAQUINAVIR; TIPRANAVIR; UNCLASSIFIED DRUG;

ANTIVIRAL ACTIVITY; ANTIVIRAL RESISTANCE; ARTICLE; CYTOTOXICITY; DIMERIZATION; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG SENSITIVITY; DRUG STRUCTURE; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; IN VITRO STUDY; NONHUMAN; PRIORITY JOURNAL; VIRUS REPLICATION;

CELL LINE; DIMERIZATION; DRUG RESISTANCE, MULTIPLE, VIRAL; FURANS; GENETIC VARIATION; HIV PROTEASE; HIV PROTEASE INHIBITORS; HIV-1; HUMANS; MACROCYCLIC COMPOUNDS; MICROBIAL SENSITIVITY TESTS; MODELS, MOLECULAR; STRUCTURE-ACTIVITY RELATIONSHIP; VIRUS REPLICATION;

EID: 77955348909     PISSN: 00664804     EISSN: 10986596     Source Type: Journal    
DOI: 10.1128/AAC.01766-09     Document Type: Article

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