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Volumn 9, Issue 11, 2003, Pages 1077-1084

New patterns of HIV-1 resistance during HAART

Author keywords

Antiretrovirals; HIV resistance; Mutational patterns

Indexed keywords

ABACAVIR; AMPRENAVIR; ANTIRETROVIRUS AGENT; ATAZANAVIR; DIDANOSINE; EFAVIRENZ; ENFUVIRTIDE; ETRAVIRINE; LAMIVUDINE; LOPINAVIR; LOPINAVIR PLUS RITONAVIR; NEVIRAPINE; NUCLEOSIDE DERIVATIVE; NUCLEOTIDE; PROTEINASE INHIBITOR; RITONAVIR; RNA DIRECTED DNA POLYMERASE; RNA DIRECTED DNA POLYMERASE INHIBITOR; SAQUINAVIR; STAVUDINE; TENOFOVIR; TIPRANAVIR; UNCLASSIFIED DRUG;

EID: 0242539778     PISSN: 1198743X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1469-0691.2003.00730.x     Document Type: Article
Times cited : (31)

References (59)
  • 1
    • 0033942065 scopus 로고    scopus 로고
    • Importance of protease inhibitor plasma levels in HIV-infected patients treated with genotypic-guided therapy: Pharmacological data from the VIRADAPT study
    • Durant J, Clevenbergh P, Garraffo R et al. Importance of protease inhibitor plasma levels in HIV-infected patients treated with genotypic-guided therapy: pharmacological data from the VIRADAPT study. AIDS 2000; 14: 1333-9.
    • (2000) AIDS , vol.14 , pp. 1333-1339
    • Durant, J.1    Clevenbergh, P.2    Garraffo, R.3
  • 2
    • 0037006651 scopus 로고    scopus 로고
    • Individualising HIV treatment - Pharmacogenetics and immunogenetics
    • Telenti A, Aubert V, Spertini F. Individualising HIV treatment - pharmacogenetics and immunogenetics. Lancet 2002; 359: 722-3.
    • (2002) Lancet , vol.359 , pp. 722-723
    • Telenti, A.1    Aubert, V.2    Spertini, F.3
  • 3
    • 0035743513 scopus 로고    scopus 로고
    • In vivo emergence of drug-resistant mutations at less than 50 HIV-1RNA copies/mL that are maintained at viral rebound in longitudinal plasma samples from HIV-1 infected patients on HAART
    • Elbeik T, Hoo BS, Campodonico ME et al. In vivo emergence of drug-resistant mutations at less than 50 HIV-1RNA copies/mL that are maintained at viral rebound in longitudinal plasma samples from HIV-1 infected patients on HAART. J Hum Virol 2001; 4: 317-28.
    • (2001) J. Hum. Virol. , vol.4 , pp. 317-328
    • Elbeik, T.1    Hoo, B.S.2    Campodonico, M.E.3
  • 4
    • 0033606540 scopus 로고    scopus 로고
    • Drug-resistance genotyping in HIV-1 therapy: The VIRADAPT randomised controlled trial
    • Durant J, Clevenbergh P, Halfon P et al. Drug-resistance genotyping in HIV-1 therapy: the VIRADAPT randomised controlled trial. Lancet 1999; 353: 2195-9.
    • (1999) Lancet , vol.353 , pp. 2195-2199
    • Durant, J.1    Clevenbergh, P.2    Halfon, P.3
  • 5
    • 0033920318 scopus 로고    scopus 로고
    • A randomised study of antiretroviral management based on plasma genotypic antiretroviral resistance testing in patients failing therapy
    • Baxter JD, Mayers DL, Wentworth DN et al. A randomised study of antiretroviral management based on plasma genotypic antiretroviral resistance testing in patients failing therapy. AIDS 2000; 14: F83-92.
    • (2000) AIDS , vol.14
    • Baxter, J.D.1    Mayers, D.L.2    Wentworth, D.N.3
  • 6
    • 0001813472 scopus 로고    scopus 로고
    • Phenotypic resistance testing significantly improves response to therapy: Final analysis of a randomised trial (VIRA3001)
    • Cohen C, Keisser H, Hunt S et al. Phenotypic resistance testing significantly improves response to therapy: final analysis of a randomised trial (VIRA3001). Antiviral Ther 2000; 5: 67.
    • (2000) Antiviral Ther. , vol.5 , pp. 67
    • Cohen, C.1    Keisser, H.2    Hunt, S.3
  • 7
    • 0002940884 scopus 로고    scopus 로고
    • Impact of treatment guided by phenotypic or genotypic resistance tests on the response to antiretroviral therapy: A randomised trial (NARVAL, ANRS 088)
    • Meynard JL, Vray M, Morand-Joubert L et al. Impact of treatment guided by phenotypic or genotypic resistance tests on the response to antiretroviral therapy: a randomised trial (NARVAL, ANRS 088). Antiviral Ther 2000; 5: 67-8.
    • (2000) Antiviral Ther. , vol.5 , pp. 67-68
    • Meynard, J.L.1    Vray, M.2    Morand-Joubert, L.3
  • 8
    • 0001847243 scopus 로고    scopus 로고
    • Zidovudine genotypic and phenotypic resistance arising in patients never exposed to zidovudine
    • Pozniak AL, Gilleece Y, Nelson M et al. Zidovudine genotypic and phenotypic resistance arising in patients never exposed to zidovudine. Antiviral Ther 2000; 5: 42.
    • (2000) Antiviral Ther. , vol.5 , pp. 42
    • Pozniak, A.L.1    Gilleece, Y.2    Nelson, M.3
  • 9
    • 0003081037 scopus 로고    scopus 로고
    • Patients failing on d4T-based therapies that have developed thymidine analogue mutations; multidrug resistance or V75T mutations have reduced phenotypic susceptibiity to stavudine
    • Ross LL, Fisher R, Scarsella A et al. Patients failing on d4T-based therapies that have developed thymidine analogue mutations; multidrug resistance or V75T mutations have reduced phenotypic susceptibiity to stavudine. Antiviral Ther 2000; 5: 38-9.
    • (2000) Antiviral Ther. , vol.5 , pp. 38-39
    • Ross, L.L.1    Fisher, R.2    Scarsella, A.3
  • 10
    • 0001934201 scopus 로고    scopus 로고
    • Presence of thymidine analogue mutations and virologic response to non-nucleoside reverse transcriptase inhibitors
    • Costagliola D, Descamps D, Calvez V et al. Presence of thymidine analogue mutations and virologic response to non-nucleoside reverse transcriptase inhibitors. Antiviral Ther 2001; 6: S8.
    • (2001) Antiviral Ther. , vol.6
    • Costagliola, D.1    Descamps, D.2    Calvez, V.3
  • 11
    • 0028828540 scopus 로고
    • Development of zidovudine resistance mutations in patients receiving prolonged didanosine monotherapy
    • Demeter LM, Nawatz T, Murse G et al. Development of zidovudine resistance mutations in patients receiving prolonged didanosine monotherapy. J Infect Dis 1995; 172: 1480-5.
    • (1995) J. Infect. Dis. , vol.172 , pp. 1480-1485
    • Demeter, L.M.1    Nawatz, T.2    Murse, G.3
  • 12
    • 85030946009 scopus 로고    scopus 로고
    • Mechanisms of nucleoside analogue resistance
    • [abstract 27]
    • Boyer PL, Srafianos SG, Arnold E et al. Mechanisms of nucleoside analogue resistance [abstract 27]. Antiviral Ther 2002; 7: S25.
    • (2002) Antiviral Ther. , vol.7
    • Boyer, P.L.1    Srafianos, S.G.2    Arnold, E.3
  • 13
    • 0033165851 scopus 로고    scopus 로고
    • A mechanism of ZDV resistance: An increase in nucleotide-dependent primer unblocking by mutant HIV-1 reverse transcriptase
    • Meyer PR, Matsuura SE, So AG et al. A mechanism of ZDV resistance: an increase in nucleotide-dependent primer unblocking by mutant HIV-1 reverse transcriptase. Mol Cell 1999; 4: 35-43.
    • (1999) Mol. Cell , vol.4 , pp. 35-43
    • Meyer, P.R.1    Matsuura, S.E.2    So, A.G.3
  • 14
    • 0000770125 scopus 로고    scopus 로고
    • Effects of M41L and T215Y mutations in HIV-1 reverse transcriptase on removal of chain terminators from blocked primer/templates
    • Meyer PR, Pfeifer P, Matsuura S et al. Effects of M41L and T215Y mutations in HIV-1 reverse transcriptase on removal of chain terminators from blocked primer/templates. Antiviral Ther 2000; 5: 14.
    • (2000) Antiviral Ther. , vol.5 , pp. 14
    • Meyer, P.R.1    Pfeifer, P.2    Matsuura, S.3
  • 15
    • 0347981391 scopus 로고    scopus 로고
    • Choice of conucleoside analogue in d4T-treated subjects may influence the pattern of thymidine analogue mutations (TAMs) and multi-nucleoside resistant mutations (MRM)
    • [abstract 568-T] Seattle. Alexandria, VIA: Foundation for Retrovirology and Human Health
    • Ross L, Liao Q, Henry K et al. Choice of conucleoside analogue in d4T-treated subjects may influence the pattern of thymidine analogue mutations (TAMs) and multi-nucleoside resistant mutations (MRM) [abstract 568-T]. In: 9th Conference on Retroviruses and Opportunistic Infections, Seattle. Alexandria, VIA: Foundation for Retrovirology and Human Health, 2002: 263.
    • (2002) 9th Conference on Retroviruses and Opportunistic Infections , pp. 263
    • Ross, L.1    Liao, Q.2    Henry, K.3
  • 16
    • 0012612571 scopus 로고    scopus 로고
    • Rate of emergence of thymidine-resistant analogue mutations in HIV-1 selected by stavudine or zidovudine based regimens in treatment naive patients
    • [abstract 36]
    • Kuritzkes D, Bassett RL, Young RK et al. Rate of emergence of thymidine-resistant analogue mutations in HIV-1 selected by stavudine or zidovudine based regimens in treatment naive patients [abstract 36]. Antiviral Ther 2002; 7: S31.
    • (2002) Antiviral Ther. , vol.7
    • Kuritzkes, D.1    Bassett, R.L.2    Young, R.K.3
  • 17
    • 0001894543 scopus 로고    scopus 로고
    • Epidemiology and conditions of selection of 44D/A and/or 118I reverse transcriptase mutations in 344 patients
    • Deluguerre C, Mouroux M, Yvon-Groussin A et al. Epidemiology and conditions of selection of 44D/A and/or 118I reverse transcriptase mutations in 344 patients. Antiviral Ther 2000; 5: 18-19.
    • (2000) Antiviral Ther. , vol.5 , pp. 18-19
    • Deluguerre, C.1    Mouroux, M.2    Yvon-Groussin, A.3
  • 18
    • 0242539514 scopus 로고    scopus 로고
    • The V118I mutation in the reverse transcriptase of HIV-1 diminishes the incorporation of multiple nucleoside analogue inhibitors
    • [abstract 26]
    • Girouard M, Diallo K, Marchand M et al. The V118I mutation in the reverse transcriptase of HIV-1 diminishes the incorporation of multiple nucleoside analogue inhibitors [abstract 26]. Antiviral Ther 2002; 7: S24.
    • (2002) Antiviral Ther. , vol.7
    • Girouard, M.1    Diallo, K.2    Marchand, M.3
  • 19
    • 0036523770 scopus 로고    scopus 로고
    • Mutations in HIV-1 reverse transcriptase during therapy with abacavir, lamivudine and zidovudine in HIV-1 infected adults with no prior antiretroviral therapy
    • Ait-Khaled M, Rakik A, Griffin P et al. Mutations in HIV-1 reverse transcriptase during therapy with abacavir, lamivudine and zidovudine in HIV-1 infected adults with no prior antiretroviral therapy. Antiviral Ther 2002; 7: 43-51.
    • (2002) Antiviral Ther. , vol.7 , pp. 43-51
    • Ait-Khaled, M.1    Rakik, A.2    Griffin, P.3
  • 20
    • 0002813266 scopus 로고    scopus 로고
    • Prior treatment with mono or dual NRTIs before HAART as predictor of virologic failure in simplified abacavir-based triple NRTI regimen: Results from the Simplified Maintenance Trial (SMT) and 30017
    • Opravil M, Yerly S, Stazewsky S et al. Prior treatment with mono or dual NRTIs before HAART as predictor of virologic failure in simplified abacavir-based triple NRTI regimen: results from the Simplified Maintenance Trial (SMT) and 30017. Antiviral Ther 2000; 5: 95-6.
    • (2000) Antiviral Ther. , vol.5 , pp. 95-96
    • Opravil, M.1    Yerly, S.2    Stazewsky, S.3
  • 21
    • 85030944272 scopus 로고    scopus 로고
    • NEFA simplification trial: Patterns of resistance mutations among patients with virological failure
    • Dalmau D, Ochoa de Echaguen A, Martinez E et al. NEFA simplification trial: patterns of resistance mutations among patients with virological failure. Antiviral Ther 2002; 7: S113.
    • (2002) Antiviral Ther. , vol.7
    • Dalmau, D.1    Ochoa de Echaguen, A.2    Martinez, E.3
  • 22
    • 0003054560 scopus 로고    scopus 로고
    • Zidovudine/lamivudine resistance is preceded by a transient period of zidovudine hypersensitivity
    • Tian H, Whitcomb JM, Limli K et al. Zidovudine/ lamivudine resistance is preceded by a transient period of zidovudine hypersensitivity. Antiviral Ther 1998; 3: 22-3.
    • (1998) Antiviral Ther. , vol.3 , pp. 22-23
    • Tian, H.1    Whitcomb, J.M.2    Limli, K.3
  • 23
    • 0030048748 scopus 로고    scopus 로고
    • Multidrug-resistant HIV-1 strains resulting from combination antiretroviral therapy
    • Iversen AK, Shaffer RW, Wehrly K et al. Multidrug-resistant HIV-1 strains resulting from combination antiretroviral therapy. J Virol 1996; 70: 1086-90.
    • (1996) J. Virol. , vol.70 , pp. 1086-1090
    • Iversen, A.K.1    Shaffer, R.W.2    Wehrly, K.3
  • 24
    • 0028273314 scopus 로고
    • Combination therapy with zidovudine and didanosine selects for drug-resistant HIV-1 strains with unique patterns of pol gene mutations
    • Shafer RW, Kozal MJ, Winters M et al. Combination therapy with zidovudine and didanosine selects for drug-resistant HIV-1 strains with unique patterns of pol gene mutations. J Infect Dis 1994; 169: 722-9.
    • (1994) J. Infect. Dis. , vol.169 , pp. 722-729
    • Shafer, R.W.1    Kozal, M.J.2    Winters, M.3
  • 25
    • 0003214033 scopus 로고    scopus 로고
    • Antiviral activity of tenofovir against nucleoside-resistant HIV samples
    • [abstract 2115] Toronto. Washington DC: American Society for Microbiology
    • Miller MD, Margot NA, Hertgs K et al. Antiviral activity of tenofovir against nucleoside-resistant HIV samples [abstract 2115]. In: 40th Interscience Conference on Antimicrobial Agents and Chemotherapy, Toronto. Washington DC: American Society for Microbiology, 2000: 350.
    • (2000) 40th Interscience Conference on Antimicrobial Agents and Chemotherapy , pp. 350
    • Miller, M.D.1    Margot, N.A.2    Hertgs, K.3
  • 26
    • 0001937508 scopus 로고    scopus 로고
    • A unique molecular mechanism of resistance to multiple dideoxynucleosides provided by MDR mutations and insertions/deletions in HIV-1 reverse transcriptase gene
    • Tamalet C, Yahi N, Tourres C et al. A unique molecular mechanism of resistance to multiple dideoxynucleosides provided by MDR mutations and insertions/deletions in HIV-1 reverse transcriptase gene. Antiviral Ther 2000; 5: 20.
    • (2000) Antiviral Ther. , vol.5 , pp. 20
    • Tamalet, C.1    Yahi, N.2    Tourres, C.3
  • 27
    • 0012415383 scopus 로고    scopus 로고
    • Crystal structure of HIV-1 RT with template-primer terminated with the acyclic nucleotide RT inhibitor tenofovir suggests mechanisms of evading resistance
    • [abstract 44] Seattle. Alexandria, VA: Foundation for Retrovirology and Human Health
    • Tuske S, Sarafianos S, Clark AD et al. Crystal structure of HIV-1 RT with template-primer terminated with the acyclic nucleotide RT inhibitor tenofovir suggests mechanisms of evading resistance [abstract 44]. In: 9th Conference on Retroviruses and Opportunistic Infections, Seattle. Alexandria, VA: Foundation for Retrovirology and Human Health, 2002: 68.
    • (2002) 9th Conference on Retroviruses and Opportunistic Infections , pp. 68
    • Tuske, S.1    Sarafianos, S.2    Clark, A.D.3
  • 28
    • 0003077314 scopus 로고    scopus 로고
    • Effect of baseline nucleoside-associated resistance on response to tenofovir DF therapy. Integrated analyses of studies 902 and 907
    • [abstract 43] Seattle
    • Miller MD, Margot NA, Lu B et al. Effect of baseline nucleoside-associated resistance on response to tenofovir DF therapy. Integrated analyses of studies 902 and 907 [abstract 43]. In: 9th Conference on Retroviruses and Opportunistic Infections, Seattle. 2002.
    • (2002) 9th Conference on Retroviruses and Opportunistic Infections
    • Miller, M.D.1    Margot, N.A.2    Lu, B.3
  • 30
    • 0242624333 scopus 로고    scopus 로고
    • Reverse transcriptase mutations that confer non-nucleoside reverse transcriptase inhibitor resistance may also impair replication capacity
    • [abstract 72]
    • Huang W, Wrin T, Gamarink A et al. Reverse transcriptase mutations that confer non-nucleoside reverse transcriptase inhibitor resistance may also impair replication capacity [abstract 72]. Antiviral Ther 2002; 7: S60.
    • (2002) Antiviral Ther. , vol.7
    • Huang, W.1    Wrin, T.2    Gamarink, A.3
  • 31
    • 0036349478 scopus 로고    scopus 로고
    • Early switch from nevirapine to efavirenz suggested for HIV salvage therapy
    • Casado JL, Moreno A, Hertogs K et al. Early switch from nevirapine to efavirenz suggested for HIV salvage therapy. AIDS Res Hum Retroviruses 2002; 18: 771-5.
    • (2002) AIDS Res. Hum. Retroviruses , vol.18 , pp. 771-775
    • Casado, J.L.1    Moreno, A.2    Hertogs, K.3
  • 32
    • 0033183721 scopus 로고    scopus 로고
    • Therapy for the treatment-experienced patient
    • Gallant J. Therapy for the treatment-experienced patient. Hopkins HIV Rev 1999; 11: 14-15.
    • (1999) Hopkins HIV Rev. , vol.11 , pp. 14-15
    • Gallant, J.1
  • 33
    • 0035984019 scopus 로고    scopus 로고
    • A mutation in the 3′ region of the HIV-1 RT (Y318F) associated with nonnucleoside reverse transcriptase inhibitor resistance
    • Harrigan PR, Salim M, Stammers DK et al. A mutation in the 3′ region of the HIV-1 RT (Y318F) associated with nonnucleoside reverse transcriptase inhibitor resistance. J Virol 2002; 76: 6836-40.
    • (2002) J. Virol. , vol.76 , pp. 6836-6840
    • Harrigan, P.R.1    Salim, M.2    Stammers, D.K.3
  • 34
    • 85030944399 scopus 로고    scopus 로고
    • The clinical relevance of non-nucleoside reverse transcriptase inhibitor hypersusceptibility: A prospective cohort analysis
    • [abstract ThOrB1388] Barcelona. Barcelona: Prous Science, S.A
    • Haubrich R, Hellmann N, Keiser P et al. The clinical relevance of non-nucleoside reverse transcriptase inhibitor hypersusceptibility: a prospective cohort analysis [abstract ThOrB1388]. In: XIV International AIDS Conference, Barcelona. Barcelona: Prous Science, S.A., 2002: 377.
    • (2002) XIV International AIDS Conference , pp. 377
    • Haubrich, R.1    Hellmann, N.2    Keiser, P.3
  • 35
    • 0003272719 scopus 로고    scopus 로고
    • Antiretroviral strategies in naive HIV subjects: Comparison of sequential 3-drug regimens (ACTG 384)
    • [abstract LbOr20A] Barcelona. Barcelona: Prous Science, S.A. Program Supplement, 26
    • Robbins G, Shafer R, Smeaton L et al. Antiretroviral strategies in naive HIV subjects: comparison of sequential 3-drug regimens (ACTG 384) [abstract LbOr20A]. In: XIV International AIDS Conference, Barcelona. Barcelona: Prous Science, S.A., 2002: 377. Program Supplement, 26.
    • (2002) XIV International AIDS Conference , pp. 377
    • Robbins, G.1    Shafer, R.2    Smeaton, L.3
  • 36
    • 0035876456 scopus 로고    scopus 로고
    • Phenotypic hypersusceptibility in non-nucleoside reverse transcriptase inhibitors in treatment-experienced HIV-infected patients: Impact on virological response to efavirenz-based therapy
    • Shulman N, Zolopa A, Passaro D et al. Phenotypic hypersusceptibility in non-nucleoside reverse transcriptase inhibitors in treatment-experienced HIV-infected patients: impact on virological response to efavirenz-based therapy. AIDS 2001; 115: 1125-32.
    • (2001) AIDS , vol.115 , pp. 1125-1132
    • Shulman, N.1    Zolopa, A.2    Passaro, D.3
  • 37
    • 0037640883 scopus 로고    scopus 로고
    • Efavirenz hypersusceptibility improves virologic response to multidrug salvage regimens in ACTG 398
    • [abstract 45] Seattle. Alexandria, VA: Foundation for Retrovirology and Human Health
    • Mellors J, Vaida F, Bennet K et al. Efavirenz hypersusceptibility improves virologic response to multidrug salvage regimens in ACTG 398 [abstract 45]. In: 9th Conference on Retroviruses and Opportunistic Infections, Seattle. Alexandria, VA: Foundation for Retrovirology and Human Health, 2002: 69.
    • (2002) 9th Conference on Retroviruses and Opportunistic Infections , pp. 69
    • Mellors, J.1    Vaida, F.2    Bennet, K.3
  • 38
    • 0037692641 scopus 로고    scopus 로고
    • TMC125 monotherapy for 1 week results in a similar initial rate of decline of HIV-1 RNA as therapy with a 5-drug regimen
    • [abstract 5] Seattle. Alexandria, VA: Foundation for Retrovirology and Human Health
    • Sankatsing S, Weverling G, van't Klooster G et al. TMC125 monotherapy for 1 week results in a similar initial rate of decline of HIV-1 RNA as therapy with a 5-drug regimen [abstract 5]. In: 9th Conference on Retroviruses and Opportunistic Infections, Seattle. Alexandria, VA: Foundation for Retrovirology and Human Health, 2002: 54.
    • (2002) 9th Conference on Retroviruses and Opportunistic Infections , pp. 54
    • Sankatsing, S.1    Weverling, G.2    van't Klooster, G.3
  • 39
    • 0242539520 scopus 로고    scopus 로고
    • TMC 125 can suppress the selection of resistant HIV from a virus population carrying the K103N or Y181C mutation
    • Vingerhoets J, Azjin H, Fransen E et al. TMC 125 can suppress the selection of resistant HIV from a virus population carrying the K103N or Y181C mutation. Antiviral Ther 2002; 7: S8.
    • (2002) Antiviral Ther. , vol.7
    • Vingerhoets, J.1    Azjin, H.2    Fransen, E.3
  • 40
    • 0035986086 scopus 로고    scopus 로고
    • Prevalence of HIV protease mutations on failure of nelfinavir-containing HAART: A retrospective analysis of four clinical studies and two observational cohorts
    • Clotet B, Ruiz L, Martinez-Picado J et al. Prevalence of HIV protease mutations on failure of nelfinavir-containing HAART: a retrospective analysis of four clinical studies and two observational cohorts. HIV Clin Trials 2002; 3: 316-23.
    • (2002) HIV Clin. Trials , vol.3 , pp. 316-323
    • Clotet, B.1    Ruiz, L.2    Martinez-Picado, J.3
  • 41
    • 0032928065 scopus 로고    scopus 로고
    • Replicative fitness of protease inhibitor-resistant mutants of HIV-1
    • Martinez-Picado J, Savara AV, Sutton L et al. Replicative fitness of protease inhibitor-resistant mutants of HIV-1. J Virol 1999; 73: 3744-52.
    • (1999) J. Virol. , vol.73 , pp. 3744-3752
    • Martinez-Picado, J.1    Savara, A.V.2    Sutton, L.3
  • 42
    • 1842464762 scopus 로고    scopus 로고
    • Molecular mechanisms of I50V HIV-1 protease resistance and cross-resistance to protease inhibitors
    • [abstract 563-T] Seattle. Alexandria, VA: Foundation for Retrovirology and Human Health
    • Xu R, Andrew W, Spalstestein A et al. Molecular mechanisms of I50V HIV-1 protease resistance and cross-resistance to protease inhibitors [abstract 563-T]. In: 9th Conference on Retroviruses and Opportunistic Infections, Seattle. Alexandria, VA: Foundation for Retrovirology and Human Health, 2002: 62.
    • (2002) 9th Conference on Retroviruses and Opportunistic Infections , pp. 62
    • Xu, R.1    Andrew, W.2    Spalstestein, A.3
  • 43
    • 0036310578 scopus 로고    scopus 로고
    • Changes in HIV type 1 Gag at positions L449 and P453 are linked to 150V protease mutant in vivo and cause reduction of sensitivity to amprenavir and improved viral fitness in vitro
    • Maguire M, Guinea R, Griffin P et al. Changes in HIV type 1 Gag at positions L449 and P453 are linked to 150V protease mutant in vivo and cause reduction of sensitivity to amprenavir and improved viral fitness in vitro. J Virol 2002; 76: 7398-406.
    • (2002) J. Virol. , vol.76 , pp. 7398-7406
    • Maguire, M.1    Guinea, R.2    Griffin, P.3
  • 44
    • 0036174439 scopus 로고    scopus 로고
    • Emergence of resistance to protease inhibitor amprenavir in HIV1: Selection of four alternative viral protease genotypes ad influence of viral susceptibility to coadministered reverse transcriptase nucleoside inhibitors
    • Maguire M, Shortino D, Klein A et al. Emergence of resistance to protease inhibitor amprenavir in HIV1: selection of four alternative viral protease genotypes ad influence of viral susceptibility to coadministered reverse transcriptase nucleoside inhibitors. Antimicrob Agents Chemother 2002; 46: 731-8.
    • (2002) Antimicrob. Agents Chemother. , vol.46 , pp. 731-738
    • Maguire, M.1    Shortino, D.2    Klein, A.3
  • 45
    • 0037012979 scopus 로고    scopus 로고
    • Amprenavir-resistant-HIV-1 exhibits lopinavir cross-resistance and reduced replication capacity
    • Prado JG, Wrin T, Beauchaine J et al. Amprenavir-resistant-HIV-1 exhibits lopinavir cross-resistance and reduced replication capacity. AIDS 2002; 16: 1009-17.
    • (2002) AIDS , vol.16 , pp. 1009-1017
    • Prado, J.G.1    Wrin, T.2    Beauchaine, J.3
  • 46
    • 0242455882 scopus 로고    scopus 로고
    • Exploring theorical mechanisms for lack of resistance to lopinavir/ritonavir in antiretroviral naive subjects
    • [abstract 436-W] Seattle. Alexandria, VA: Foundation for Retrovirology and Human Health
    • Hsu A, Kempf D, Granneman R et al. Exploring theorical mechanisms for lack of resistance to lopinavir/ritonavir in antiretroviral naive subjects [abstract 436-W]. In: 9th Conference on Retroviruses and Opportunistic Infections, Seattle. Alexandria, VA: Foundation for Retrovirology and Human Health, 2002: 217.
    • (2002) 9th Conference on Retroviruses and Opportunistic Infections , pp. 217
    • Hsu, A.1    Kempf, D.2    Granneman, R.3
  • 47
    • 0034909925 scopus 로고    scopus 로고
    • Identification of genotypic changes in human immunodeficiency virus protease that correlate with reduce susceptibility to the protease inhibitor lopinavir among viral isolates from protease inhibitor-experienced patients
    • Kempf D, Isaacson J, King MS et al. Identification of genotypic changes in human immunodeficiency virus protease that correlate with reduce susceptibility to the protease inhibitor lopinavir among viral isolates from protease inhibitor-experienced patients. J Virol 2001; 75: 7462-9.
    • (2001) J. Virol. , vol.75 , pp. 7462-7469
    • Kempf, D.1    Isaacson, J.2    King, M.S.3
  • 48
    • 0003321265 scopus 로고    scopus 로고
    • Quantitative estimate of the effect of individual baseline mutations in HIV protease on the virologic response to lopinavir/ritonavir therapy in heavily experienced patients
    • [abstract 559-T] Seattle. Alexandria, VA: Foundation for Retrovirology and Human Health
    • Isaacson J, Kempf D, Calvez V et al. Quantitative estimate of the effect of individual baseline mutations in HIV protease on the virologic response to lopinavir/ritonavir therapy in heavily experienced patients [abstract 559-T]. In: 9th Conference on Retroviruses and Opportunistic Infections, Seattle. Alexandria, VA: Foundation for Retrovirology and Human Health, 2002: 260.
    • (2002) 9th Conference on Retroviruses and Opportunistic Infections , pp. 260
    • Isaacson, J.1    Kempf, D.2    Calvez, V.3
  • 49
    • 0036720761 scopus 로고    scopus 로고
    • Human immunodeficiency virus type-1 genotypic and pharmacokinetics determinants of the virological response to lopinavir-ritonavir-containing therapy in protease inhibitor-experienced patients
    • Masquelier B, Breihl D, Neau D et al. Human immunodeficiency virus type-1 genotypic and pharmacokinetics determinants of the virological response to lopinavir-ritonavir-containing therapy in protease inhibitor-experienced patients. Antimicrob Agents Chemother 2002; 46: 2926-32.
    • (2002) Antimicrob. Agents Chemother. , vol.46 , pp. 2926-2932
    • Masquelier, B.1    Breihl, D.2    Neau, D.3
  • 50
    • 0036736496 scopus 로고    scopus 로고
    • Atazanavir: A novel HIV-1 protease inhibitor
    • Piliero PJ. Atazanavir: a novel HIV-1 protease inhibitor. Expert Opin Invest Drugs 2002; 11: 1295-301.
    • (2002) Expert Opin. Invest. Drugs , vol.11 , pp. 1295-1301
    • Piliero, P.J.1
  • 51
    • 0037651412 scopus 로고    scopus 로고
    • Identification of amino acid substitutions correlated with reduced atazanavir susceptibility in patients treated with atazanavir-containing regimens
    • [abstract 4]
    • Colonno RJ, Friborg J, Rose RE et al. Identification of amino acid substitutions correlated with reduced atazanavir susceptibility in patients treated with atazanavir-containing regimens [abstract 4]. Antiviral Ther 2002; 7: S4.
    • (2002) Antiviral Ther. , vol.7
    • Colonno, R.J.1    Friborg, J.2    Rose, R.E.3
  • 52
    • 0012194415 scopus 로고    scopus 로고
    • Safety and efficacy of tipranavir, a non-peptidic protease inhibitor, in multiple PI-failure patients
    • [abstract 3] Buenos Aires. Buenos Aires: International Aids Society
    • Curry R, Markowitz M, Slater L, Mayers D et al. Safety and efficacy of tipranavir, a non-peptidic protease inhibitor, in multiple PI-failure patients [abstract 3]. In: 1st IAS Conference on HIV Pathogenesis and Treatment, Buenos Aires. Buenos Aires: International Aids Society, 2001: 79.
    • (2001) 1st IAS Conference on HIV Pathogenesis and Treatment , pp. 79
    • Curry, R.1    Markowitz, M.2    Slater, L.3    Mayers, D.4
  • 53
    • 0038746305 scopus 로고    scopus 로고
    • Resistance to tipranavir is uncommon in a randomized trial of tipranavir/ritonavir in multiple PI-failure patients
    • [abstract 562-T] Seattle. Alexandria, VA: Foundation for Retrovirology and Human Health
    • Schwartz R, Kazanjian P, Slater L et al. Resistance to tipranavir is uncommon in a randomized trial of tipranavir/ritonavir in multiple PI-failure patients [abstract 562-T]. In: 9th Conference on Retroviruses and Opportunistic Infections, Seattle. Alexandria, VA: Foundation for Retrovirology and Human Health, 2002: 261.
    • (2002) 9th Conference on Retroviruses and Opportunistic Infections , pp. 261
    • Schwartz, R.1    Kazanjian, P.2    Slater, L.3
  • 54
    • 85030941611 scopus 로고    scopus 로고
    • Susceptibility profile of tipranavir at baseline and subsequent virologic response in a cohort of patients with multiple-PI failure
    • McCallister S, Neubacher D, Verbiest W et al. Susceptibility profile of tipranavir at baseline and subsequent virologic response in a cohort of patients with multiple-PI failure. Anitviral Therapy 2002, 7: S105.
    • (2002) Anitviral Therapy , vol.7
    • McCallister, S.1    Neubacher, D.2    Verbiest, W.3
  • 56
    • 85030943525 scopus 로고    scopus 로고
    • New mutations at residue positions critical to T-20 resistance in T-20 naive patients infected with clade B HIV-1 isolates
    • [abstract 18]
    • Roman F, Gonzalez D, Boulme R et al. New mutations at residue positions critical to T-20 resistance in T-20 naive patients infected with clade B HIV-1 isolates [abstract 18]. Antiviral Ther 2002; 7: S14.
    • (2002) Antiviral Ther. , vol.7
    • Roman, F.1    Gonzalez, D.2    Boulme, R.3
  • 57
    • 0038069784 scopus 로고    scopus 로고
    • Impact of HIV-1 gp41 amino acid substitutions (positions 36-45) on susceptibility to T-20 (enfuvirtide) in vitro: Analysis of primary virus isolates recovered from patients during chronic enfuvirtide treatment and site-directed mutants in NL4-3
    • [abstract 22]
    • Mink M, Greenberg M, Mosier S et al. Impact of HIV-1 gp41 amino acid substitutions (positions 36-45) on susceptibility to T-20 (enfuvirtide) in vitro: analysis of primary virus isolates recovered from patients during chronic enfuvirtide treatment and site-directed mutants in NL4-3 [abstract 22]. Antiviral Ther 2002; 7: S17.
    • (2002) Antiviral Ther. , vol.7
    • Mink, M.1    Greenberg, M.2    Mosier, S.3
  • 58
    • 0242708495 scopus 로고    scopus 로고
    • Novel mutations in a highly conserved region of HIV-1 gp41 are associated with T-20 treatment
    • [abstract 13]
    • Kemp SD, Ruiz L, Lucas AM et al. Novel mutations in a highly conserved region of HIV-1 gp41 are associated with T-20 treatment [abstract 13]. Antiviral Ther 2002; 7: S11.
    • (2002) Antiviral Ther. , vol.7
    • Kemp, S.D.1    Ruiz, L.2    Lucas, A.M.3
  • 59
    • 0037119035 scopus 로고    scopus 로고
    • Resistance mutation in HIV entry inhibitors
    • Hanna S, Yang C, Owen S et al. Resistance mutation in HIV entry inhibitors. AIDS 2002; 16: 1603-8.
    • (2002) AIDS , vol.16 , pp. 1603-1608
    • Hanna, S.1    Yang, C.2    Owen, S.3


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