A novel achiral seco-cyclopropylpyrido[e]indolone (CPyI) analog of CC-1065 and the duocarmycins: Synthesis, DNA interactions, in vivo anticancer and anti-parasitic evaluation

Bioorganic and Medicinal Chemistry

Volumn 18, Issue 14, 2010, Pages 5016-5024

  Chavda, Sameer ^a   Babu, Balaji ^a   Yanow, Stephanie K ^b,c   Jardim, Armando ^c   Spithill, Terry W ^c,d   Kiakos, Konstantinos ^e   Kluza, Jerome ^e   Hartley, John A ^e   Lee, Moses ^a,f  

^a HOPE COLLEGE   (United States)

^b UNIVERSITY OF ALBERTA   (Canada)

^c Institute of Parasitology   (Canada)

^d CHARLES STURT UNIVERSITY   (Australia)

^e UNIVERSITY COLLEGE LONDON   (United Kingdom)

^f FURMAN UNIVERSITY   (United States)

Author keywords

Achiral; Adenine N3; Alkylation; Anti parasite; Anticancer; Antileishmania; Antimalaria; Antitrypanosoma; Centanamycin; DNA; Duocarmycins; Minor groove

Indexed keywords

DUOCARMYCIN DERIVATIVE; RACHELMYCIN; SECO CYCLOPROPYLPYRIDO[E]INDOLONE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ANTIPROTOZOAL ACTIVITY; ARTICLE; CONTROLLED STUDY; COVALENT BOND; CYTOTOXICITY; DRUG DNA INTERACTION; DRUG STRUCTURE; DRUG SYNTHESIS; FEMALE; HUMAN; LEISHMANIA DONOVANI; LEISHMANIA MEXICANA; MOUSE; NONHUMAN; PLASMODIUM FALCIPARUM; TRYPANOSOMA BRUCEI;

ANIMALS; ANTIBIOTICS, ANTINEOPLASTIC; ANTIPROTOZOAL AGENTS; CELL LINE, TUMOR; DNA; DRUG SCREENING ASSAYS, ANTITUMOR; FEMALE; HUMANS; INDOLES; MELANOMA; MICE; MICE, INBRED C57BL; PARASITIC SENSITIVITY TESTS; PYRROLIDINONES;

LEISHMANIA DONOVANI; LEISHMANIA MEXICANA; MURINAE; MUS; PLASMODIUM FALCIPARUM; PROTOZOA; TRYPANOSOMA BRUCEI;

EID: 77955329653     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2010.05.078     Document Type: Article

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