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Volumn 10, Issue 9, 2002, Pages 2941-2952

Novel furano analogues of duocarmycin C1 and C2: Design, synthesis, and biological evaluation of seco-iso-cyclopropylfurano[2,3-e]indoline (seco-iso-CFI) and seco-cyclopropyltetrahydrofurano[2,3-f]quinoline (seco-CFQ) analogues

(14) Howard, Tiffany T a Lingerfelt, Brian M a Purnell, Bethany L a Scott, Adrienne E a Price, Carly A a Townes, Heather M a McNulty, LuAnne a Handl, Heather L a Summerville, Kaitlin a Hudson, Stephen J a Bowen, J Phillip b Kiakos, Konstantinos c Hartley, John A c Lee, Moses a

a FURMAN UNIVERSITY (United States)

b UNIVERSITY OF GEORGIA (United States)

c UNIVERSITY COLLEGE LONDON (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

1 (CHLOROMETHYL) 5 HYDROXY 1,2 DIHYDRO 3 [(5,6,7 TRIMETHOXY 1H INDOL 2 YL)CARBONYL] 3H 5 METHYLFURANO[2,3 E]INDOLINE; 1 (CHLOROMETHYL) 5 HYDROXY 1,2 DIHYDRO 3 [(5,6,7 TRIMETHOXY 1H INDOL 2 YL)CARBONYL] 3H FURANO[2,3 E]INDOLINE; 2 CHLORO 6 HYDROXY 4 [(5,6,7 TRIMETHOXY 1H INDOL 2 YL)CARBONYL] 1,2,3,4 TETRAHYDRO 4H 5 METHYLFURANO[2,3 F]QUINOLINE; 2 CHLORO 6 HYDROXY 4 [(5,6,7 TRIMETHOXY 1H INDOL 2 YL)CARBONYL] 1,2,3,4 TETRAHYDRO 4H FURANO[2,3 F]QUINOLINE; ADOZELESIN; DUOCARMYCIN DERIVATIVE; HYDROCHLORIC ACID; OXYGEN; RACHELMYCIN; TAQ POLYMERASE; UNCLASSIFIED DRUG; VINYL CHLORIDE; ALKYLATING AGENT; DNA; FURAN DERIVATIVE; INDOLE DERIVATIVE; INDOLINE; PYRINDAMYCIN A; PYRINDAMYCIN B; PYRROLE DERIVATIVE; QUINOLINE DERIVATIVE;

ALKYLATION; ANIMAL CELL; APOPTOSIS; ARTICLE; ATOM; BONE MARROW CELL; COLONY FORMING UNIT; CONTROLLED STUDY; CYCLIZATION; CYTOTOXICITY; DRUG CONJUGATION; DRUG DESIGN; DRUG SCREENING; DRUG SYNTHESIS; ELECTRON; ENERGY; FLOW CYTOMETRY; HEMATOPOIETIC CELL; HUMAN; HUMAN CELL; IC 50; LEUKEMIA CELL; MASTOCYTOMA; MELANOMA; MOLECULAR MODEL; MOUSE; NONHUMAN; PHARMACOPHORE; TUMOR CELL CULTURE; TUMOR GROWTH; ANIMAL; BINDING SITE; CELL CYCLE; CELL DIVISION; CHEMICAL STRUCTURE; CHEMISTRY; DNA ADDUCT; DRUG EFFECT; HEMATOPOIETIC STEM CELL; METABOLISM; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

MURINAE;

ANIMALS; ANTINEOPLASTIC AGENTS, ALKYLATING; BINDING SITES; BONE MARROW CELLS; CELL CYCLE; CELL DIVISION; DNA; DNA ADDUCTS; DRUG DESIGN; DRUG SCREENING ASSAYS, ANTITUMOR; FURANS; HEMATOPOIETIC STEM CELLS; INDOLES; MICE; MODELS, MOLECULAR; PYRROLES; QUINOLINES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0036310887 PISSN: 09680896 EISSN: None Source Type: Journal
DOI: 10.1016/S0968-0896(02)00157-8 Document Type: Article

Times cited : (35)

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