A Hammett correlation for CC-1065 and duocarmycin analogs: Magnitude of substituent electronic effects on functional reactivity

Bioorganic and Medicinal Chemistry Letters

Volumn 6, Issue 6, 1996, Pages 659-664

  Boger, Dale L ^b   McKie, Jeffrey A ^b   Han, Nianhe ^b   Tarby, Christine M ^b   Riggs, Haiqiong W ^b   Kitos, Paul A ^b  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC ANTIBIOTIC; DUOCARMYCIN A; RACHELMYCIN;

ARTICLE; DNA ALKYLATION; QUANTITATIVE STRUCTURE ACTIVITY RELATION;

EID: 0029872086     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/0960-894X(96)00093-5     Document Type: Article

References (29)

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22. Full details of the preparation of 14 and 15 and their extension to more advanced analogs of 1-3 will be disclosed elsewhere. Boger, D. L.; McKie, J. A.; Cai, H.; Cacciari, B.; Baraldi, P. G. J. Org. Chem. 1996, 61, in press. Boger, D. L.; Tarby, C. M.; Han, N.; Kitos, P. A. unpublished studies.
23. Full details of the preparation of 14 and 15 and their extension to more advanced analogs of 1-3 will be disclosed elsewhere. Boger, D. L.; McKie, J. A.; Cai, H.; Cacciari, B.; Baraldi, P. G. J. Org. Chem. 1996, 61, in press. Boger, D. L.; Tarby, C. M.; Han, N.; Kitos, P. A. unpublished studies.
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29. Identical trends have been observed with the advanced analogs of 1-3 incorporating the MCBI and CCBI alkylation subunits.