Synthesis and antitumor activity of duocarmycin derivatives: Modification at C-8 position of A-ring pyrrole compounds bearing the simplified DNA-binding groups

Bioorganic and Medicinal Chemistry

Volumn 8, Issue 2, 2000, Pages 381-391

  Amishiro, Nobuyoshi ^a   Nagamura, Satoru ^a   Murakata, Chikara ^a   Okamoto, Akihiko ^a   Kobayashi, Eiji ^a   Asada, Masao ^a   Gomi, Katsushige ^a   Tamaoki, Tatsuya ^a   Okabe, Masami ^a   Yamaguchi, Naoko ^a   Yamaguchi, Kazuo ^a   Saito, Hiromitsu ^a  

^a KYOWA HAKKO KOGYO CO LTD   (Japan)

Author keywords

Antibiotics; Antitumor compounds; DNA; Natural products; Prodrug

Indexed keywords

DUOCARMYCIN A; DUOCARMYCIN DERIVATIVE; PIBROZELESIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; DRUG STABILITY; DRUG STRUCTURE; DRUG SYNTHESIS; HELA CELL; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; SARCOMA; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTIBIOTICS, ANTINEOPLASTIC; BLOOD CELL COUNT; DNA; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MICE; PYRROLES; PYRROLIDINONES; SPECTROMETRY, MASS, FAST ATOM BOMBARDMENT; TUMOR CELLS, CULTURED;

ANIMALIA; MURINAE;

EID: 0033997822     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(99)00293-X     Document Type: Article

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