Stress and immunity

Clinical and Basic Immunodermatology

Volumn , Issue , 2008, Pages 45-65

  Tausk, Francisco A ^a   Elenkov, Ilia ^b   Paus, Ralph ^c,d   Richardson, Steven ^e   Label, Marcelo ^f  

^a UNIVERSITY OF ROCHESTER   (United States)

^b Institute of Neurobiology and Molecular Medicine   (Italy)

^c UNIVERSITY HOSPITAL SCHLESWIG HOLSTEIN   (Germany)

^d UNIVERSITY OF MANCHESTER   (United Kingdom)

^e OAKWOOD HOSPITAL AND MEDICAL CENTER   (United States)

^f HOSPITAL RAMOS MEJÍA   (Argentina)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 77955321605     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1007/978-1-84800-165-7_4     Document Type: Chapter

References (235)

1. Chrousos GP. The hypothalamic-pituitary-Adrenal axis and immune-mediated inflammation. N Engl J Med 1995;332(20):1351-62
2. Besedovsky HO, del Rey A, Sorkin E. What do the immune system and the brain know about each other. Immunology Today 1983;4(12):342-6
3. Elenkov IJ WR, Chrousos GP, Vizi ES. The sympathetic nerve-An integrative interface between two supersystems: The brain and the immune system. Pharmacol Rev 2000;52(4):595-638
4. Besedovsky H, del Rey A, Sorkin E, Dinarello CA. Immunoregulatory feedback between interleukin-1 and glucocorticoid hormones. Science 1986;233(4764):652-4
5. Boumpas DT, Chrousos GP, Wilder RL, Cupps TR, Balow JE. Glucocorticoid therapy for immune-mediated diseases: Basic and clinical correlates. Ann Intern Med 1993;119(12):1198-208
6. Girndt M, Sester U, Kaul H, Hunger F, Kohler H. Glucocorticoids inhibit activation-dependent expression of costimulatory molecule B7-1 in human monocytes. Transplantation 1998;66(3):370-5
7. Pan J, Ju D, Wang Q, et al. Dexamethasone inhibits the antigen presentation of dendritic cells in MHC class II pathway. Immunol Lett 2001;76(3):153-61
8. Galon J, Franchimont D, Hiroi N, et al. Gene profiling reveals unknown enhancing and suppressive actions of glucocorticoids on immune cells. FASEB J 2002;16(1):61-71
9. Benschop RJ, Rodriguez-Feuerhahn M, Schedlowski M. Catecholamine-induced leukocytosis: Early observations, current research, and future directions. Brain Behav Immun 1996;10(2):77-91
10. Maisel AS, Michel MC. Beta-Adrenoceptor control of immune function in congestive heart failure. Br J Clin Pharmacol 1990;30(suppl 1):49S-53S.
11. CarlsonSL, BrooksWH, RoszmanTL. Neurotransmitterlymphocyte interactions: Dual receptor modulation of lymphocyte proliferation and cAMP production. J Neuroimmunol 1989;24(1-2):155-62
12. Chambers DA, Cohen RL, Perlman RL. Neuroimmune modulation: Signal transduction and catecholamines. Neurochem Int 1993;22(2):95-110
13. Elliott L, Brooks W, Roszman T. Inhibition of anti-CD3 monoclonal antibody-induced T-cell proliferation by dexamethasone, isoproterenol, or prostaglandin E2 either alone or in combination. Cell Mol Neurobiol 1992;12(5):411-27
14. Hadden JW, Hadden EM, Middleton E Jr. Lymphocyte blast transformation. I. Demonstration of adrenergic receptors in human peripheral lymphocytes. Cell Immunol 1970;1(6):583-95
15. Bartik MM, Bauman GP, Brooks WH, Roszman TL. Costimulatory signals modulate the antiproliferative effects of agents that elevate cAMP in T cells. Cell Immunol 1994;158(1):116-30
16. Fearon DT, Locksley RM. The instructive role of innate immunity in the acquired immune response. Science 1996;272(5258):50-3
17. Mosmann TR, Sad S. The expanding universe of T-cell subsets: Th1, Th2 and more. Immunol Today 1996;17(3):138-46
18. Trinchieri G. Interleukin-12 and the regulation of innate resistance and adaptive immunity. Nature Rev 2003;3(2):133-46
19. Elenkov IJ, Chrousos GP. Stress hormones, Th1/Th2 patterns, pro/anti-inflammatory cytokines and susceptibility to disease. Trends Endocrinol Metab 1999;10(9):359-68
20. Elenkov IJ, Papanicolaou DA, Wilder RL, Chrousos GP. Modulatory effects of glucocorticoids and catecholamines on human interleukin-12 and interleukin-10 production: Clinical implications. Proc Assoc Am Physicians 1996;108:374-81
21. Blotta MH, DeKruyff RH, Umetsu DT. Corticosteroids inhibit IL-12 production in human monocytes and enhance their capacity to induce IL-4 synthesis in CD4+ lymphocytes. J Immunol 1997;158(12):5589-95
22. Hasko G, Szabo C, Nemeth ZH, Salzman AL, Vizi ES. Stimulation of beta-Adrenoceptors inhibits endotoxin-induced IL-12 production in normal and IL-10 deficient mice. J Neuroimmunol 1998;88(1-2):57-61
23. Panina-Bordignon P, Mazzeo D, Lucia PD, et al. Beta2-Agonists prevent Th1 development by selective inhibition of interleukin 12. J Clin Invest 1997;100(6):1513-9
24. DeKruyff RH, Fang Y, Umetsu DT. Corticosteroids enhance the capacity of macrophages to induce Th2 cytokine synthesis in CD4+ lymphocytes by inhibiting IL-12 production. J Immunol 1998;160(5):2231-7
25. Wu CY, Wang K, McDyer JF, Seder RA. Prostaglandin E2 and dexamethasone inhibit IL-12 receptor expression and IL-12 responsiveness. J Immunol 1998;161(6):2723-30
26. Ramirez F, Fowell DJ, Puklavec M, Simmonds S, Mason D. Glucocorticoids promote a TH2 cytokine response by CD4+ T cells in vitro. J Immunol 1996;156(7):2406-12
27. van Der Poll T, Barber AE, Coyle SM, Lowry SF. Hypercortisolemia increases plasma interleukin-10 concentrations during human endotoxemia-A clinical research center study. J Clin Endocrinol Metab 1996;81(10):3604-6
28. Hetier E, Ayala J, Bousseau A, Prochiantz A. Modulation of interleukin-1 and tumor necrosis factor expression by beta-Adrenergic agonists in mouse ameboid microglial cells. Experimental brain research. Exp Hirnforschung 1991;86(2):407-13
29. Koff WC, Fann AV, Dunegan MA, Lachman LB. Catecholamine-induced suppression of interleukin-1 production. Lymphokine Res 1986;5(4):239-47
30. Nakamura A, Johns EJ, Imaizumi A, Abe T, Kohsaka T. Regulation of tumour necrosis factor and interleukin-6 gene transcription by beta2-Adrenoceptor in the rat astrocytes. J Neuroimmunol 1998;88(1-2): 144-53
31. Severn A, Rapson NT, Hunter CA, Liew FY. Regulation of tumor necrosis factor production by adrenaline and beta-Adrenergic agonists. J Immunol 1992;148(11):3441-5
32. Van Der Poll T, Lowry SF. Epinephrine inhibits endotoxin-induced IL-1 beta production: Roles of tumor necrosis factor-Alpha and IL-10. Am J Physiol 1997;273(6 pt 2):R1885-90
33. Sanders VM, Baker RA, Ramer-Quinn DS, Kasprowicz DJ, Fuchs BA, Street NE. Differential expression of the beta2-Adrenergic receptor by Th1 and Th2 clones: Implications for cytokine production and B cell help. J Immunol 1997;158(9):4200-10
34. Borger P, Hoekstra Y, Esselink MT, et al. Betaadrenoceptor-mediated inhibition of IFN-gamma, IL-3, and GM-CSF mRNA accumulation in activated human T lymphocytes is solely mediated by the beta2-Adrenoceptor subtype. Am J Respir Cell Mol Biol 1998;19(3):400-7
35. Maimone D, Cioni C, Rosa S, Macchia G, Aloisi F, Annunziata P. Norepinephrine and vasoactive intestinal peptide induce IL-6 secretion by astrocytes: Synergism with IL-1 beta and TNF alpha. J Neuroimmunol 1993;47(1):73-81
36. Norris JG, Benveniste EN. Interleukin-6 production by astrocytes: Induction by the neurotransmitter norepinephrine. J Neuroimmunol 1993;45(1-2):137-45
37. van Der Poll T, Coyle SM, Barbosa K, Braxton CC, Lowry SF. Epinephrine inhibits tumor necrosis factoralpha and potentiates interleukin 10 production during human endotoxemia. J Clin Invest 1996;97(3):713-9
38. Felten DL, Felten SY, Carlson SL, Olschowka JA, Livnat S. Noradrenergic and peptidergic innervation of lymphoid tissue. J Immunol 1985;135(2 suppl):755s-65s.
39. Felten SY, Felten DL, Bellinger DL, et al. Noradrenergic sympathetic innervation of lymphoid organs. Prog Allergy 1988;43:14-36
40. Lundberg JM, Rudehill A, Sollevi A, Fried G, Wallin G. Co-release of neuropeptide Y and noradrenaline from pig spleen in vivo: Importance of subcellular storage, nerve impulse frequency and pattern, feedback regulation and resupply by axonal transport. Neuroscience 1989;28(2):475-86
41. Straub RH, Herrmann M, Frauenholz T, et al. Neuroimmune control of interleukin-6 secretion in the murine spleen. Differential beta-Adrenergic effects of electrically released endogenous norepinephrine under various endotoxin conditions. J Neuroimmunol 1996;71(1-2):37-43
42. Bedoui S, Kawamura N, Straub RH, Pabst R, Yamamura T, von Horsten S. Relevance of neuropeptide Y for the neuroimmune crosstalk. J Neuroimmunol 2003;134(1-2):1-11
43. Naseer T, Minshall EM, Leung DY, et al. Expression of IL-12 and IL-13 mRNA in asthma and their modulation in response to steroid therapy. Am J Respir Crit Care Med 1997;155(3):845-51
44. Bentley AM, Hamid Q, Robinson DS, et al. Prednisolone treatment in asthma. Reduction in the numbers of eosinophils, T cells, tryptase-only positive mast cells, and modulation of IL-4, IL-5, and interferon-gamma cytokine gene expression within the bronchial mucosa. Am J Respir Crit Care Med 1996;153(2):551-6
45. Bradding P, Feather IH, Wilson S, Holgate ST, Howarth PH. Cytokine immunoreactivity in seasonal rhinitis: Regulation by a topical corticosteroid. Am J Respir Crit Care Med 1995;151(6):1900-6
46. Batuman OA, Ferrero A, Cupp C, Jimenez SA, Khalili K. Differential regulation of transforming growth factor beta-1 gene expression by glucocorticoids in human T and glial cells. J Immunol 1995;155(9):4397-405
47. Broug-Holub E, Kraal G. Dose-And time-dependent activation of rat alveolar macrophages by glucocorticoids. Clin Exp Immunol 1996;104(2):332-6
48. Spengler RN, Allen RM, Remick DG, Strieter RM, Kunkel SL. Stimulation of alpha-Adrenergic receptor augments the production of macrophage-derived tumor necrosis factor. J Immunol 1990;145(5):1430-4
49. Le Tulzo Y, Shenkar R, Kaneko D, et al. Hemorrhage increases cytokine expression in lung mononuclear cells in mice: Involvement of catecholamines in nuclear factor-kappaB regulation and cytokine expression. J Clin Invest 1997;99(7):1516-24
50. Broug-Holub E, Persoons JH, Schornagel K, Mastbergen SC, Kraal G. Effects of stress on alveolar macrophages: A role for the sympathetic nervous system. Am J Respir Cell Mol Biol 1998;19(5):842-8
51. Engstad CS, Lund T, Osterud B. Epinephrine promotes IL-8 production in human leukocytes via an effect on platelets. Thromb Haemost 1999;81(1): 139-45
52. Kaplanski G, Porat R, Aiura K, Erban JK, Gelfand JA, Dinarello CA. Activated platelets induce endothelial secretion of interleukin-8 in vitro via an interleukin-1-mediated event. Blood 1993;81(10):2492-5
53. Kavelaars A, van De Pol M, Zijlstra J, Heijnen CJ. Beta 2-Adrenergic activation enhances interleukin-8 production by human monocytes. J Neuroimmunol 1997;77(2):211-6
54. Mohamed-Ali V, Flower L, Sethi J, et al. beta-Adrenergic regulation of IL-6 release from adipose tissue: In vivo and in vitro studies. J Clin Endocrinol Metab 2001;86(12):5864-9
55. Vicennati V, Vottero A, Friedman C, Papanicolaou DA. Hormonal regulation of interleukin-6 production in human adipocytes. Int J Obes Relat Metab Disord 2002;26(7):905-11
56. Baumann H, Gauldie J. The acute phase response. Immunol Today 1994;15(2):74-80
57. Li Y, Chi L, Stechschulte DJ, Dileepan KN. Histamineinduced production of interleukin-6 and interleukin-8 by human coronary artery endothelial cells is enhanced by endotoxin and tumor necrosis factoralpha. Microvasc Res 2001;61(3):253-62
58. Murray DR, Prabhu SD, Chandrasekar B. Chronic beta-Adrenergic stimulation induces myocardial proinflammatory cytokine expression. Circulation 2000;101(20):2338-41
59. Karalis K, Sano H, Redwine J, Listwak S, Wilder RL, Chrousos GP. Autocrine or paracrine inflammatory actions of corticotropin-releasing hormone in vivo. Science 1991;254(5030):421-3
60. Elenkov IJ, Webster EL, Torpy DJ, Chrousos GP. Stress, corticotropin-releasing hormone, glucocorticoids, and the immune/inflammatory response: Acute and chronic effects. Ann N Y Acad Sci 1999;876: 1-11; discussion 13
61. Theoharides TC, Singh LK, Boucher W, et al. Corticotropin-releasing hormone induces skin mast cell degranulation and increased vascular permeability, a possible explanation for its proinflammatory effects. Endocrinology 1998;139(1):403-13
62. Foreman JC. Neuropeptides and the pathogenesis of allergy. Allergy 1987;42(1):1-11
63. Church MK, Lowman MA, Robinson C, Holgate ST, Benyon RC. Interaction of neuropeptides with human mast cells. Int Arch Allergy Appl Immunol 1989;88(1-2):70-8
64. Theoharides TC, Spanos C, Pang X, et al. Stressinduced intracranial mast cell degranulation: A corticotropin-releasing hormone-mediated effect. Endocrinology 1995;136(12):5745-50
65. Sanders VM, Munson AE. Norepinephrine and the antibody response. Pharmacol Rev 1985;37(3): 229-48
66. Coqueret O, Dugas B, Mencia-Huerta JM, Braquet P. Regulation of IgE production from human mononuclear cells by beta 2-Adrenoceptor agonists. Clin Exp Allergy 1995;25(4):304-11
67. Coqueret O, Lagente V, Frere CP, Braquet P, Mencia-Huerta JM. Regulation of IgE production by beta 2-Adrenoceptor agonists. Ann N Y Acad Sci 1994;725:44-9
68. Wu CY, Sarfati M, Heusser C, et al. Glucocorticoids increase the synthesis of immunoglobulin E by interleukin 4-stimulated human lymphocytes. J Clin Invest 1991;87(3):870-7
69. Zieg G, Lack G, Harbeck RJ, Gelfand EW, Leung DY. In vivo effects of glucocorticoids on IgE production. J Allergy Clin Immunol 1994;94(2 pt 1) :222-30
70. Selye H. A syndrome produced by diverse nocuous agents. Nature 1936;138:32
71. Selye H. The general adaptation syndrome and the disease of adaptation. J Clin Endocrinol 1946;6: 117-230
72. Visintainer MA, Volpicelli JR, Seligman ME. Tumor rejection in rats after inescapable or escapable shock. Science 1982;216(4544):437-9
73. Flint MS, Valosen JM, Johnson EA, Miller DB, Tinkle SS. Restraint stress applied prior to chemical sensitization modulates the development of allergic contact dermatitis differently than restraint prior to challenge. J Neuroimmunol 2001;113(1):72-80
74. Schedlowski M, Jacobs R, Stratmann G, et al. Changes of natural killer cells during acute psychological stress. J Clin Immunol 1993;13(2):119-26
75. Kiecolt-Glaser JK, McGuire L, Robles TF, Glaser R. Psychoneuroimmunology and psychosomatic medicine: Back to the future. Psychosom Med 2002;64(1):15-28
76. Stone R. Social science. Stress: The invisible hand in Eastern Europe's death rates [news]. Science 2000;288(5472):1732-3
77. Schulz R, Beach SR. Caregiving as a risk factor for mortality: The Caregiver Health Effects Study [see comments]. JAMA 1999;282(23):2215-9
78. Kiecolt-Glaser JK, Glaser R. Chronic stress and mortality among older adults [editorial; comment]. JAMA 1999;282(23):2259-60
79. Kamarck TW, Everson SA, Kaplan GA, et al. Exaggerated blood pressure responses during mental stress are associated with enhanced carotid atherosclerosis in middle-Aged Finnish men: Findings from the Kuopio Ischemic Heart Disease Study. Circulation 1997;96(11):3842-8
80. Dhabhar FS, McEwen BS. Acute stress enhances while chronic stress suppresses immune function in vivo: A potential role for leukocyte trafficking. Brain Behav Immun 1997;11:286-306
81. Dhabhar FS, McEwen BS. Enhancing versus suppressive effects of stress hormones on skin immune function. Proc Natl Acad Sci U S A 1999;96(3):1059-64
82. Biondi M, Zannino LG. Psychological stress, neuroimmunomodulation, and susceptibility to infectious diseases in animals and man: A review. Psychother Psychosom 1997;66(1):3-26
83. Konstantinos AP SJ. Stress and influenza viral infection: Modulation of proinflammatory cytokine responses in the lung. Respir Physiol 2001;128(1):71-7
84. Cohen S, Tyrrell DA, Smith AP. Psychological stress and susceptibility to the common cold [see comments]. N Engl J Med 1991;325(9):606-12
85. Cohen S, Line S, Manuck SB, Rabin BS, Heise ER, Kaplan JR. Chronic social stress, social status, and susceptibility to upper respiratory infections in nonhuman primates [see comments]. Psychosom Med 1997;59(3):213-21
86. Bailey MT, Engler H, Sheridan JF. Stress induces the translocation of cutaneous and gastrointestinal microflora to secondary lymphoid organs of C57BL/6 mice. J Neuroimmunol 2006;171(1-2):29-37
87. Rojas IG, Padgett DA, Sheridan JF, Marucha PT. Stress-induced susceptibility to bacterial infection during cutaneous wound healing. Brain Behav Immun 2002;16(1):74-84
88. Buske-Kirschbaum A GA, Wermke C, Pirke KM, Hellhammer D. Preliminary evidence for Herpes labialis recurrence following experimentally induced disgust. Psychother Psychosom 2001;70(2):86-91
89. Cohen F, Kemeny ME, Kearney KA, Zegans LS, Neuhaus JM, Conant MA. Persistent stress as a predictor of genital herpes recurrence. Arch Intern Med 1999;159(20):2430-6
90. Yang EV, Glaser R. Stress-induced immunomodulation: Implications for tumorigenesis. Brain Behav Immun 2003;17(suppl 1):S37-40
91. Reiche EM, Nunes SO, Morimoto HK. Stress, depression, the immune system, and cancer. Lancet Oncol 2004;5(10):617-25
92. Reiche EM, Morimoto HK, Nunes SM. Stress and depression-induced immune dysfunction: Implications for the development and progression of cancer. Int Rev Psychiatry (Abingdon, England) 2005;17(6):515-27
93. Lillberg K, Verkasalo PK, Kaprio J, Teppo L, Helenius H, Koskenvuo M. Stressful life events and risk of breast cancer in 10,808 women: A cohort study. Am J Epidemiol 2003;157(5):415-23
94. Riley V. Psychoneuroendocrine influences on immunocompetence and neoplasia. Science 1981;212(4499): 1100-9
95. Wu W, Yamaura T, Murakami K, et al. Social isolation stress enhanced liver metastasis of murine colon 26-L5 carcinoma cells by suppressing immune responses in mice. Life Sci 2000;66(19):1827-38
96. Laudenslager ML, Ryan SM, Drugan RC, Hyson RL, Maier SF. Coping and immunosuppression: Inescapable but not escapable shock suppresses lymphocyte proliferation. Science 1983;221(4610):568-70
97. Ben-Eliyahu S, Page GG, Yirmiya R, Shakhar G. Evidence that stress and surgical interventions promote tumor development by suppressing natural killer cell activity. Int J Cancer 1999;80(6):880-8
98. Ben-Eliyahu S. The promotion of tumor metastasis by surgery and stress: Immunological basis and implications for psychoneuroimmunology. Brain Behav Immun 2003;17(suppl 1):S27-36
99. Bachen EA, Manuck SB, Cohen S, et al. Adrenergic blockade ameliorates cellular immune responses to mental stress in humans. Psychosom Med 1995;57(4):366-72
100. Benschop RJ, Nieuwenhuis EE, Tromp EA, Godaert GL, Ballieux RE, van Doornen LJ. Effects of beta-Adrenergic blockade on immunologic and cardiovascular changes induced by mental stress. Circulation 1994;89(2):762-9
101. Glaser R, Thorn BE, Tarr KL, Kiecolt-Glaser JK, D'Ambrosio SM. Effects of stress on methyltransferase synthesis: An important DNA repair enzyme. Health Psychol 1985;4(5):403-12
102. Kiecolt-Glaser JK, Stephens RE, Lipetz PD, Speicher CE, Glaser R. Distress and DNA repair in human lymphocytes. J Behav Med 1985;8(4):311-20
103. Parker J, Klein SL, McClintock MK, et al. Chronic stress accelerates ultraviolet-induced cutaneous carcinogenesis. J Am Acad Dermatol 2004;51(6):919-22
104. Ramirez AJ, Craig TK, Watson JP, Fentiman IS, North WR, Rubens RD. Stress and relapse of breast cancer [see comments]. BMJ 1989;298(6669):291-3
105. Havlik RJ, Vukasin AP, Ariyan S. The impact of stress on the clinical presentation of melanoma. Plast Reconstr Surg 1992;90(1):57-61; discussion 62-64
106. Reynolds P, Kaplan GA. Social connections and risk for cancer: Prospective evidence from the Alameda County Study. Behav Med 1990;16(3):101-10
107. Jacobs JR, Bovasso GB. Early and chronic stress and their relation to breast cancer [In Process Citation]. Psychol Med 2000;30(3):669-78
108. Grossarth-Maticek R, Eysenck HJ, Boyle GJ, Heeb J, Costa SD, Diel IJ. Interaction of psychosocial and physical risk factors in the causation of mammary cancer, and its prevention through psychological methods of treatment. J Clin Psychol 2000;56(1):33-50
109. Kiecolt-Glaser JK, Glaser R. Psychoneuroimmunology and cancer: Fact or fiction? Eur J Cancer 1999;35(11):1603-7
110. Spiegel D, Bloom JR, Kraemer HC, Gottheil E. Effect of psychosocial treatment on survival of patients with metastatic breast cancer [see comments]. Lancet 1989;2(8668):888-91
111. Fawzy FI, Fawzy NW, Hyun CS, et al. Malignant melanoma. Effects of an early structured psychiatric intervention, coping, and affective state on recurrence and survival 6 years later. Arch Gen Psychiatry 1993;50(9):681-9
112. Herberman RB, Ortaldo JR. Natural killer cells: Their roles in defenses against disease. Science 1981;214:24-30
113. Irwin M, Daniels M, Smith TL, Bloom E, Weiner H. Impaired natural killer cell activity during bereavement. Brain Behav Immun 1987;1(1):98-104
114. Irwin M, Daniels M, Risch SC, Bloom E, Weiner H. Plasma cortisol and natural killer cell activity during bereavement. Biol Psychiatry 1988;24(2): 173-8
115. Kiecolt-Glaser JK, Garner W, Speicher C, Penn GM, Holliday J, Glaser R. Psychosocial modifiers of immunocompetence in medical students. Psychosom Med 1984;46(1):7-14
116. Kiecolt-Glaser JK, Speicher CE, Holliday JE, Glaser R. Stress and the transformation of lymphocytes by Epstein-Barr virus. J Behav Med 1984;7(1):1-12
117. Kiecolt-Glaser JK, Fisher LD, Ogrocki P, Stout JC, Speicher CE, Glaser R. Marital quality, marital disruption, and immune function. Psychosom Med 1987;49(1):13-34
118. Kiecolt-Glaser JK, Malarkey WB, Chee M, et al. Negative behavior during marital conflict is associated with immunological down-regulation [see comments]. Psychosom Med 1993;55(5):395-409
119. Baron RS, Cutrona CE, Hicklin D, Russell DW, Lubaroff DM. Social support and immune function among spouses of cancer patients. J Pers Soc Psychol 1990;59(2):344-52
120. Kiecolt-Glaser JK, Dyer CS, Shuttleworth EC. Upsetting social interactions and distress among Alzheimer's disease family care-givers: A replication and extension. Am J Community Psychol 1988;16(6):825-37
121. Irwin M, Hauger R, Patterson TL, Semple S, Ziegler M, Grant I. Alzheimer caregiver stress: Basal natural killer cell activity, pituitary-Adrenal cortical function, and sympathetic tone. Ann Behav Med 1997;19(2):83-90
122. Irwin M, Brown M, Patterson T, Hauger R, Mascovich A, Grant I. Neuropeptide Y and natural killer cell activity: Findings in depression and Alzheimer caregiver stress. FASEB J 1991;5(15):3100-7
123. Glaser R, Rice J, Speicher CE, Stout JC, Kiecolt-Glaser JK. Stress depresses interferon production by leukocytes concomitant with a decrease in natural killer cell activity. Behav Neurosci 1986;100(5):675-8
124. Schedlowski M, Jacobs R, Alker J, et al. Psychophysiological, neuroendocrine and cellular immune reactions under psychological stress. Neuropsychobiology 1993;28(1-2):87-90
125. Schedlowski M, Falk A, Rohne A, et al. Catecholamines induce alterations of distribution and activity of human natural killer (NK) cells. J Clin Immunol 1993;13(5):344-51
126. Schedlowski M, Fluge T, Richter S, Tewes U, Schmidt RE, Wagner TO. Beta-endorphin, but not substance-P, is increased by acute stress in humans. Psychoneuroendocrinology 1995;20(1):103-10
127. Esterling BA, Kiecolt-Glaser JK, Glaser R. Psychosocial modulation of cytokine-induced natural killer cell activity in older adults. Psychosom Med 1996;58(3):264-72
128. Borella P, Bargellini A, Rovesti S, et al. Emotional stability, anxiety, and natural killer activity under examination stress. Psychoneuroendocrinology 1999;24(6):613-27
129. King JA, Edwards E. Early stress and genetic influences on hypothalamic-pituitary-Adrenal axis functioning in adulthood. Horm Behav 1999;36(2):79-85
130. Heim C, Newport DJ, Heit S, et al. Pituitary-Adrenal and autonomic responses to stress in women after sexual and physical abuse in childhood. JAMA 2000;284(5):592-7
131. Aksentijevich S, Whitfield HJ Jr, Young WSd, et al. Arthritis-susceptible Lewis rats fail to emerge from the stress hyporesponsive period. Brain Res Dev Brain Res 1992;65(1):115-8
132. Sternberg EM, Hill JM, Chrousos GP, et al. Inflammatory mediator-induced hypothalamic-pituitary-Adrenal axis activation is defective in streptococcal cell wall arthritis-susceptible Lewis rats. Proc Natl Acad Sci U S A 1989;86(7):2374-8
133. Sternberg EM, Young WSd, Bernardini R, et al. A central nervous system defect in biosynthesis of corticotropin-releasing hormone is associated with susceptibility to streptococcal cell wall-induced arthritis in Lewis rats. Proc Natl Acad Sci U S A 1989;86(12):4771-5
134. Rupprecht M, Salzer B, Raum B, et al. Physical stress-induced secretion of adrenal and pituitary hormones in patients with atopic eczema compared with normal controls. Exp Clin Endocrinol Diabetes 1997;105(1):39-45
135. Rupprecht M HO, Schluter D, Schafers HJ, Koch HU, Beck G, Rupprecht R. Cortisol, corticotrophin, and beta-endorphin responses to corticotrophinreleasing hormone in patients with atopic eczema. Psychoneuroendocrinology 1995;20:543-51
136. Buske-Kirschbaum A, Jobst S, Hellhammer DH. Altered reactivity of the hypothalamus-pituitaryadrenal axis in patients with atopic dermatitis: Pathologic factor or symptom? Ann N Y Acad Sci 1998;840:747-54
137. Buske-Kirschbaum A, Jobst S, Psych D, et al. Attenuated free cortisol response to psychosocial stress in children with atopic dermatitis. Psychosom Med 1997;59(4):419-26
138. Masi AT, Chrousos GP. Hypothalamic-pituitaryadrenal-glucocorticoid axis function in rheumatoid arthritis [editorial; comment]. J Rheumatol 1996;23(4):577-81
139. Gudbjornsson B, Skogseid B, Oberg K, Wide L, Hallgren R. Intact adrenocorticotropic hormone secretion but impaired cortisol response in patients with active rheumatoid arthritis. Effect of glucocorticoids [see comments]. J Rheumatol 1996;23(4):596-602
140. Richards HL, Ray DW, Kirby B, et al. Response of the hypothalamic- pituitary-Adrenal axis to psychological stress in patients with psoriasis. Br J Dermatol 2005;153(6):1114-20
141. Chiu A, Chon SY, Kimball AB. The response of skin disease to stress: Changes in the severity of acne vulgaris as affected by examination stress. Arch Dermatol 2003;139(7):897-900
142. Papadopoulos L, Bor R, Legg C, Hawk JL. Impact of life events on the onset of vitiligo in adults: Preliminary evidence for a psychological dimension in aetiology. Clin Exp Dermatol 1998;23(6):243-8
143. Barisic-Drusko V, Rucevic I. Trigger factors in childhood psoriasis and vitiligo. Collegium Antropologicum 2004;28(1):277-85
144. Gulec AT, Tanriverdi N, Duru C, Saray Y, Akcali C. The role of psychological factors in alopecia areata and the impact of the disease on the quality of life. Int J Dermatol 2004;43(5):352-6
145. Chaudhary S. Psychosocial stressors in oral lichen planus. Australian dental journal 2004;49(4):192-5
146. Goldberg I IA, Brenner S. Pemphigus vulgaris triggered by rifampin and emotional stress. Skin Med 2004;3(5):294
147. Berrino AM, Voltolini S, Fiaschi D, et al. Chronic urticaria: Importance of a medical-psychological approach. Allerg Immunologie 2006;38(5):149-52
148. Kimball AB JC, Weiss S, Vreeland MG, Wu Y. The psychosocial burden of psoriasis. Am J Clin Dermatol 2005;6(6):383-92
149. Fortune DG RH, Griffiths CEM, Main CJ. Psychological stress, distress and disability in patients with psoriasis: Consensus and variation in the contribution of illness perceptions, coping and alexithymia. Br J Dermatol 2002;41:157-74
150. Fortune DG RH, Griffiths CEM, Main CJ. Psychologic factors in psoriasis: Consequences, mechanisms, and interventions. Dermatol Clin 2005;4:681-94
151. Schmid-Ott G, Jacobs R, Jager B, et al. Stress induced endocrine and immunological changes in psoriasis patients and healthy controls. Psychother Psychosom 1998;67:37-42
152. Raychaudhuri SP, Farber EM, Raychaudhuri SK. Role of nerve growth factor in RANTES expression by keratinocytes. Acta Derm Venereol 2000;80(4):247-50
153. Nickoloff BJ, Schroder JM, von Den Driesch P, et al. Is psoriasis a T-cell disease? Exp Dermatol 2000;9:357-75
154. Farber EM, Nall L. Psoriasis: A stress-related disease. Cutis 1993;51(5):322-6
155. Farber EM, Nickoloff BJ, Recht B, Fraki JE. Stress, symmetry, and psoriasis: Possible role of neuropeptides. J Am Acad Dermatol 1986;14 (2 pt 1):305-11
156. Farber EM, Lanigan SW, Boer J. The role of cutaneous sensory nerves in the maintenance of psoriasis. Int J Dermatol 1990;29(6):418-20
157. Raychaudhuri SP, Farber EM. Are sensory nerves essential for the development of psoriatic lesions? J Am Acad Dermatol 1993;28(3):488-9
158. Aloe L, Alleva E, Fiore M. Stress and nerve growth factor: Findings in animal models and humans. Pharmacol Biochemi Behav 2002;73(1):159-66
159. Raychaudhuri SP JW, Farber EM. Psoriatic keratinocytes express high levels of nerve growth factor. Acta Derm Venereol 1998;78(2):84-6
160. Raychaudhuri SP, Jiang WY, Smoller BR, Farber EM. Nerve growth factor and its receptor system in psoriasis. Br J Dermatol 2000;143(1):198-200
161. Ginsburg IH. Coping with psoriasis: A guide for counseling patients. Cutis 1996;57(5):323-5
162. Tausk F, Whitmore SE. A pilot study of hypnosis in the treatment of patients with psoriasis. Psychother Psychosom 1999;68(4):221-5
163. Benhard JD, Kristeller J, Kabat-Zinn J. Effectiveness of relaxation and visualization techniques as an adjunct to phototherapy and photochemotherapy of psoriasis. J Am Acad Dermatol 1988;19(3):572-4
164. Kabat-Zinn J, Wheeler E, Light T, et al. Influence of a mindfulness meditation-based stress reduction intervention on rates of skin clearing in patients with moderate to severe psoriasis undergoing phototherapy (UVB) and photochemotherapy (PUVA). Psychosom Med 1998;60(5):625-32
165. Langan SM, Bourke JF, Silcocks P, Williams HC. An exploratory prospective observational study of environmental factors exacerbating atopic eczema in children. Br J Dermatol 2006;154(5):979-80
166. Faulstich ME, Williamson DA, Duchmann EG, Conerly SL, Brantley PJ. Psychophysiological analysis of atopic dermatitis. J Psychosom Res 1985;29(4):415-7
167. King RM, Wilson GV. Use of a diary technique to investigate psychosomatic relations in atopic dermatitis. J Psychosom Res 1991;35(6):697-706
168. Schmid-Ott G, Jaeger B, Adamek C, et al. Levels of circulating CD8(+) T lymphocytes, natural killer cells, and eosinophils increase upon acute psychosocial stress in patients with atopic dermatitis. J Allergy Clin Immunol 2001;107(1):171-7
169. Schmid-Ott G, Jaeger B, Meyer S, Stephan E, Kapp A, Werfel T. Different expression of cytokine and membrane molecules by circulating lymphocytes on acute mental stress in patients with atopic dermatitis in comparison with healthy controls. J Allergy Clin Immunol 2001;108(3):455-62
170. Kagi MK, Wutrich B, Montano E, Barandun J, Blaser K, Walker C. Differential cytokine profiles in peripheral blood lymphocyte supernatants and skin biopsies from patients with different forms of atopic dermatitis, psoriasis and normal individuals. Int Arch Allergy Immunol 1994;103(4):332-40
171. Mori A, Yamamoto K, Dohi M, Suko M, Okudaira H. Interleukin-4 gene expression in human peripheral blood mononuclear cells. Int Arch Allergy Appl Immunol 1991;95(2-3):282-4
172. Tamir A, Ophir J, Brenner S. Pemphigus vulgaris triggered by emotional stress [letter]. Dermatology 1994;189(2):210
173. Braun CM HS, Bashian GG, Kagey-Sobotka A, Lichtenstein LM, Essayan DM. Corticosteroid modulation of human, antigen-specific Th1 and Th2 responses. J Allergy Clin Immunol 1997;100(3):400-7
174. Byron KA, Varigos G, Wootton A. Hydrocortisone inhibition of human interleukin-4. Immunology 1992;77(4):624-6
175. Cupps TR, Gerrard TL, Falkoff RJ, Whalen G, Fauci AS. Effects of in vitro corticosteroids on B cell activation, proliferation, and differentiation. J Clin Invest 1985;75(2):754-61
176. Schwiebert LM, Beck LA, Stellato C, et al. Glucocorticosteroid inhibition of cytokine production: Relevance to antiallergic actions [published erratum appears in J Allergy Clin Immunol 1996;98(3):718]. J Allergy Clin Immunol 1996;97 (1 pt 2):143-52
177. Buske-Kirschbaum A GA, Hollig H, Morschhauser E, Hellhammer D. Altered responsiveness of the hypothalamus-pituitary-Adrenal axis and the sympathetic adrenomedullary system to stress in patients with atopic dermatitis. J Clin Endocrinol Metab 2002;87(9):4245-51
178. Rupprecht M RR, Kornhuber J, Wodarz N, Koch HU, Riederer P, Hornstein OP. Elevated glucocorticoid receptor concentrations before and after glucocorticoid therapy in peripheral mononuclear leukocytes of patients with atopic dermatitis. Dermatologica 1991;183:100-5
179. Altemus M, Rao B, Dhabhar FS, Ding W, Granstein RD. Stress-induced changes in skin barrier function in healthy women. J Invest Dermatol 2001;117(2):309-17
180. Zane L. Psychoneuroendocrinimmunodermatology: Pathophysiological mechanisms of stress in cutaneous disease. In: Koo JYM, CS Lee, eds. Psychocutaneous Medicine. New York: Marcel Dekker, 2003:65-95
181. Schallreuter KU PM, Swanson NN, Beazley WD, Korner C, Ehrke C, Buttner G.
182. Delgado M F-AM, Fuentes A. Effect of adrenaline and glucocorticoids on monocyte cAMP-specific phosphodiesterase (PDE4) in a monocyte cell line. Arch Dermatol Res 2002:190-7
183. Chan SC BM, Willcox TM, Li SH, Stevens SR, Tara D, Hanifin JM. Abnormal IL-4 gene expression by atopic dermatitis T lymphocytes is reflected in altered nuclear protein interactions with IL-4 transcription regulatory element. J Invest Dermatol 1996;106:1131-6
184. Cole WC, Roth HL, Sachs LB. Group psychotherapy as an aid in the medical treatment of eczema. J Am Acad Dermatol 1988;18(2 pt 1):286-91
185. Ehlers A, Stangier U, Gieler U. Treatment of atopic dermatitis: A comparison of psychological and dermatological approaches to relapse prevention. J Consult Clin Psychol 1995;63(4):624-35
186. Horne DJ, White AE, Varigos GA. A preliminary study of psychological therapy in the management of atopic eczema. Br J Med Psychol 1989;62(pt 3):241-8
187. Howlett S. Emotional dysfunction, child-family relationships and childhood atopic dermatitis. Br J Dermatol 1999;140(3):381-4
188. Stewart AC, Thomas SE. Hypnotherapy as a treatment for atopic dermatitis in adults and children. Br J Dermatol 1995;132(5):778-83
189. Gupta MA, Gupta AK. Psychodermatology: An update. J Am Acad Dermatol 1996;34(6):1030-46
190. Slominski A, Wortsman J, Plonka PM, Schallreuter KU, Paus R, Tobin DJ. Hair follicle pigmentation. J Invest Dermatol 2005;124(1):13-21
191. Slominski A, Wortsman J, Luger T, Paus R, Solomon S. Corticotropin releasing hormone and proopiomelanocortin involvement in the cutaneous response to stress. Physiol Rev 2000;80(3): 979-1020
192. Peters EM, Ericson ME, Hosoi J, et al. Neuropeptide control mechanisms in cutaneous biology: Physiological and clinical significance. J Invest Dermatol 2006;126(9):1937-47
193. Paus R, Theoharides TC, Arck PC. Neuroimmunoendocrine circuitry of the 'brain-skin connection.' Trends Immunol 2006;27(1):32-9
194. Maurer M, Metz M. The status quo and quo vadis of mast cells. Exp Dermatol 2005;14(12):923-9
195. Maurer M, Theoharides T, Granstein RD, et al. What is the physiological function of mast cells? Exp Dermatol 2003;12(6):886-910
196. Botchkarev VA, Yaar M, Peters EM, et al. Neurotrophins in skin biology and pathology. J Invest Dermatol 2006;126(8):1719-27
197. Siebenhaar F, Sharov AA, Peters EM, et al. Substance P as an immunomodulatory neuropeptide in a mouse model for autoimmune hair loss (alopecia areata). J Invest Dermatol 2007
198. Zouboulis CC, Bohm M. Neuroendocrine regulation of sebocytes-A pathogenetic link between stress and acne. Exp Dermatol 2004;13(suppl 4):31-5
199. Luger TA, Scholzen T, Brzoska T, Becher E, Slominski A, Paus R. Cutaneous immunomodulation and coordination of skin stress responses by alpha-melanocyte-stimulating hormone. Ann N Y Acad Sci 1998;840:381-94
200. Arck PC, Slominski A, Theoharides TC, Peters EM, Paus R. Neuroimmunology of stress: Skin takes center stage. J Invest Dermatol 2006;126(8):1697-704
201. Biro T, Ko MC, Bromm B, et al. How best to fight that nasty itch -from new insights into the neuroimmunological, neuroendocrine, and neurophysiological bases of pruritus to novel therapeutic approaches. Exp Dermatol 2005;14(3):225-40
202. Paus R, Schmelz M, Biro T, Steinhoff M. Frontiers in pruritus research: Scratching the brain for more effective itch therapy. J Clin Invest 2006;116(5):1174-86
203. Zouboulis CC, Seltmann H, Hiroi N, et al. Corticotropin-releasing hormone: An autocrine hormone that promotes lipogenesis in human sebocytes. Proc Natl Acad Sci U S A 2002;99(10):7148-53
204. Ito N, Ito T, Kromminga A, et al. Human hair follicles display a functional equivalent of the hypothalamic-pituitary-Adrenal axis and synthesize cortisol. FASEB J 2005;19(10):1332-4
205. Park HJ, Kim HJ, Lee JY, Cho BK, Gallo RL, Cho DH. Adrenocorticotropin hormone stimulates interleukin-18 expression in human HaCaT keratinocytes. J Invest Dermatol 2007
206. Zbytek B, Paus R. CRH mediates inflammation induced by lipopolysaccharide in human adult epidermal keratinocytes. J Invest Dermatol 2007;127(3):730-2
207. Paus R, Maurer M, Slominski A, Czarnetzki BM. Mast cell involvement in murine hair growth. Developmental biology 1994;163(1):230-40
208. Maurer M, Fischer E, Handjiski B, et al. Activated skin mast cells are involved in murine hair follicle regression (catagen). Lab Invest 1997;77(4):319-32
209. Slominski A, Botchkareva NV, Botchkarev VA, et al. Hair cycle-dependent production of ACTH in mouse skin. Biochim Biophys Acta 1998;1448(1):147-52
210. Paus R, Heinzelmann T, Robicsek S, Czarnetzki BM, Maurer M. Substance P stimulates murine epidermal keratinocyte proliferation and dermal mast cell degranulation in situ. Arch Dermatol Res 1995;287(5):500-2
211. Ansel JC, Brown JR, Payan DG, Brown MA. Substance P selectively activates TNF-Alpha gene expression in murine mast cells. J Immunol 1993;150(10):4478-85
212. Paus R, Heinzelmann T, Schultz KD, Furkert J, Fechner K, Czarnetzki BM. Hair growth induction by substance P. Lab Invest 1994;71(1):134-40
213. Paus R, Luftl M, Czarnetzki BM. Nerve growth factor modulates keratinocyte proliferation in murine skin organ culture. Br J Dermatol 1994;130(2): 174-80
214. Botchkarev VA, Botchkareva NV, Albers KM, Chen LH, Welker P, Paus R. A role for p75 neurotrophin receptor in the control of apoptosis-driven hair follicle regression. FASEB J 2000;14(13):1931-42
215. Botchkarev VA, Botchkareva NV, Peters EM, Paus R. Epithelial growth control by neurotrophins: Leads and lessons from the hair follicle. Prog Brain Res 2004;146:493-513
216. Peters EM, Stieglitz MG, Liezman C, et al. p75 Neurotrophin receptor-mediated signaling promotes human hair follicle regression (Catagen). Am J Pathol 2006;168(1):221-34
217. Arck PC, Handjiski B, Hagen E, Joachim R, Klapp BF, Paus R. Indications for a 'brain-hair follicle axis (BHA)': Inhibition of keratinocyte proliferation and up-regulation of keratinocyte apoptosis in telogen hair follicles by stress and substance P. FASEB J 2001;15(13):2536-8
218. Peters EM, Handjiski B, Kuhlmei A, et al. Neurogenic inflammation in stress-induced termination of murine hair growth is promoted by nerve growth factor. Am J Pathol 2004;165(1):259-71
219. Arck PC, Handjiski B, Kuhlmei A, et al. Mast cell deficient and neurokinin-1 receptor knockout mice are protected from stress-induced hair growth inhibition. J Mol Med (Berlin, Germany) 2005;83(5):386-96
220. Craven AJ, Ormandy CJ, Robertson FG, et al. Prolactin signaling influences the timing mechanism of the hair follicle: Analysis of hair growth cycles in prolactin receptor knockout mice. Endocrinology 2001;142(6):2533-9
221. Craven AJ, Nixon AJ, Ashby MG, et al. Prolactin delays hair regrowth in mice. J Endocrinol 2006;191(2):415-25
222. Foitzik K, Krause K, Conrad F, Nakamura M, Funk W, Paus R. Human scalp hair follicles are both a target and a source of prolactin, which serves as an autocrine and/or paracrine promoter of apoptosis-driven hair follicle regression. Am J Pathol 2006;168(3):748-56
223. Foitzik K, Krause K, Nixon AJ, et al. Prolactin and its receptor are expressed in murine hair follicle epithelium, show hair cycle-dependent expression, and induce catagen. Am J Pathol 2003;162(5):1611-21
224. Slominski A, Wortsman J, Mazurkiewicz JE, et al. Detection of proopiomelanocortin-derived antigens in normal and pathologic human skin. J Lab Clin Med 1993;122(6):658-66
225. Roloff B, Fechner K, Slominski A, et al. Hair cycledependent expression of corticotropin-releasing factor (CRF) and CRF receptors in murine skin. FASEB J 1998;12(3):287-97
226. Ito N, Ito T, Betterman A, Paus R. The human hair bulb is a source and target of CRH. J Invest Dermatol 2004;122(1):235-7
227. Kauser S, Thody AJ, Schallreuter KU, Gummer CL, Tobin DJ. beta-Endorphin as a regulator of human hair follicle melanocyte biology. J Invest Dermatol 2004;123(1):184-95
228. Kauser S, Thody AJ, Schallreuter KU, Gummer CL, Tobin DJ. A fully functional proopiomelanocortin/ melanocortin-1 receptor system regulates the differentiation of human scalp hair follicle melanocytes. Endocrinology 2005;146(2):532-43
229. Krause K, Schnitger A, Fimmel S, Glass E, Zouboulis CC. Corticotropin-releasing hormone skin signaling is receptor-mediated and is predominant in the sebaceous glands. Horm Metab Res 2007;39(2):166-70
230. Rousseau K, Kauser S, Pritchard LE, et al. Proopiomelanocortin (POMC), the ACTH/ melanocortin precursor, is secreted by human epidermal keratinocytes and melanocytes and stimulates melanogenesis. FASEB J 2007;21(8):1844-56
231. Ziegler CG, Krug AW, Zouboulis CC, Bornstein SR. Corticotropin releasing hormone and its function in the skin. Horm Metab Res 2007;39(2):106-9
232. Slominski A, Wortsman J, Tuckey RC, Paus R. Differential expression of HPA axis homolog in the skin. Mol Cell Endocrinol 2007;265-266:143-9
233. Slominski A, Paus R, Wortsman J. On the potential role of proopiomelanocortin in skin physiology and pathology. Mol Cell Endocrinol 1993;93 (1):C1-6
234. Kim HS, Cho DH, Kim HJ, Lee JY, Cho BK, Park HJ. Immunoreactivity of corticotropin-releasing hormone, adrenocorticotropic hormone and alphamelanocyte-stimulating hormone in alopecia areata. Exp Dermatol 2006;15(7):515-22
235. Aoki E, Shibasaki T, Kawana S. Intermittent foot shock stress prolongs the telogen stage in the hair cycle of mice. Exp Dermatol 2003;12(4):371-7