Alzheimer caregiver stress: Basal natural killer cell activity, pituitary-adrenal cortical function, and sympathetic tone

Annals of Behavioral Medicine

Volumn 19, Issue 2, 1997, Pages 83-90

  Irwin, Michael ^a   Hauger, Richard ^b   Patterson, Thomas L ^b   Semple, Shirley ^b   Ziegler, Michael ^b   Grant, Igor ^b  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AGED; ALZHEIMER DISEASE; ARTICLE; CAREGIVER; CORTICOTROPIN BLOOD LEVEL; CORTICOTROPIN RELEASE; DEPRESSION; FEMALE; HOST RESISTANCE; HUMAN; HYPOPHYSIS ADRENAL SYSTEM; MAJOR CLINICAL STUDY; MALE; NATURAL KILLER CELL; STRESS; SYMPATHETIC TONE;

EID: 0030866187     PISSN: 08836612     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02883324     Document Type: Article

References (53)

1. Irwin M, Patterson T, Smith TL, et al: Reduction of immune function in life stress and depression. Biological Psychiatry. 1990, 27:22-30.
2. Kiecolt-Glaser JK, Glaser R: Stress and immune function in humans. In Ader R, Felten D, Cohen N (eds), Psychoneuroimmunology. San Diego, CA: Academic Press, 1991, 849-867.
3. Irwin M, Daniels M, Bloom ET, Smith TL, Weiner H: Life events, depressive symptoms, and immune function. American Journal of Psychiatry. 1987, 144(4):437-441.
4. Trinchieri G: Biology of natural killer cells. Advances in Immunology. 1989, 47:187-376.
5. Levy SM, Fernstrom J, Herberman RB, et al: Persistently low natural killer cell activity and circulating levels of plasma beta endorphin: Risk factors for infectious disease. Life Sciences. 1991, 48:107-116.
6. Irwin M, Brown M, Patterson T, et al: Neuropeptide Y and natural killer cell activity: Findings in depression and Alzheimer caregiver stress. FASEB Journal. 1991, 5:3100-3107.
7. Esterling BA, Kiecolt-Glaser JK, Bodnar JC, Glaser R: Chronic stress, social support, and persistent alterations in the natural killer cell response to cytokines in older adults. Health Psychology. 1994, 13:291-298.
8. Herbert TB, Cohen S: Stress and immunity in humans: A meta-analytic review. Psychosomatic Medicine. 1993, 55:364-379.
9. Schleifer SJ, Keller SE, Bond RN, Cohen J, Stein M: Major depressive disorder and immunity: Role of age, sex, severity, and hospitalisation. Archives of General Psychiatry. 1989, 46:81-87.
10. Evans DL, Folds JD, Petitto JM, et al: Circulating natural killer cell phenotypes in men and women with major depression. Archives of General Psychiatry. 1992, 49:388-395.
11. Miller AH, Asnis GM, Lackner C, Halbreich U, Norin AJ: Depression, natural killer cell activity, and cortisol secretion. Biological Psychiatry. 1991,29:878-886.
12. Friedman SB, Mason JW, Hamburg DA: Urinary 17-hydroxycorticosteroid levels in parents of children with neoplastic disease: A study of chronic psychological stress. Psychosomatic Medicine. 1963, 25:364-376.
13. Wolff CT, Friedman SB, Hofer MA, Mason JW, Hamburg DA: Relationship between psychological defenses and mean urinary 17-OHCS excretion rates: I. A predictive study of parents of fatally ill children. Psychosomatic Medicine. 1964, 26:576-585.
14. Rose RM: Endocrine responses to stressful psychological events. Psychiatric Clinics of North America 1980, 3:251-276.
15. Hamburg DA: Plasma and urinary corticosteroid levels in naturally occurring psychologic stresses. Research Publications - Association for Research in Nervous and Mental Disease. 1962, 40:406-413.
16. Brantley PJ, Dictz LS, McKnight GT, Jones GN, Tulley R: Convergence between the daily stress inventory and endocrine measures of stress. Journal of Consulting and Clinical Psychology. 1988, 56:549-551.
17. Rose RM: Normality and stress: Response and adaptation from an endocrine perspective. In Offer D, Sabshin M (eds), The Diversity of Normal Behavior. New York: Basic Books, 1991, 60-87.
18. Irwin M, Daniels M, Risch SC, Bloom E, Weiner H: Plasma cortisol and natural killer cell activity during bereavement. Biological Psychiatry. 1988, 24:173-178.
19. Jacobs SC, Mason JW, Kosten TR, et al: Bereavement and catecholamines. Journal of Psychosomatic Research. 1986, 30:489-496.
20. Rose RM, Fogg LF: Definition of a responder: Analysis of behavioral, cardiovascular, and endocrine responses to varied workload in air traffic controllers. Psychosomatic Medicine. 1993, 55:325-338.
21. Johnson EO, Kamilaris TC, Chrousos GP, Gold PW: Mechanisms of stress: A dynamic overview of hormonal and behavioral homeostasis. Neuroscience and Biobehavioral Reviews. 1992, 16:115-140.
22. Rose RM, Jenkins CD, Hurst M, Herds JA, Hall RD: Endocrine activity in air traffic controllers at work: II. Biological, psychological and work correlates. Psychoneuroendocrinology. 1982, 7:113-123.
23. Yehuda R, Giller EL, Southwick SM, Lowy MT, Mason JW: Hypothalamic-pituitary-adrenal dysfunction in posttraumatic stress disorder. Biological Psychiatry. 1991, 30:1031-1048.
24. Chrousos GP: The hypothalamic-pituitary-adrenal axis and immunemediated inflammation. New England Journal of Medicine. 1995, 332:1351-1362.
25. Yehuda R, Kahana B, Binder-Brynes K, et al: Low urinary cortisol excretion in holocaust survivors with posttraumatic stress disorder. American Journal of Psychiatry. 1995, 152:982-986.
26. Kronfol Z, House JD: Depression, hypothalamic-pituitary adrenocortical activity, and lymphocyte function. Psychopharmacology Bulletin. 1985, 21:476-478.
27. Darko D, Irwin M, Risch SC, Gillin JC: Plasma beta-endorphin and natural killer cell activity in patients with major depression. Psychiatry Research. 1992, 43: 11-119.
28. Hartmann DP, Holaday JW, Bernton EW: Inhibition of lymphocyte proliferation by antibodies to prolactin. FASEB Journal. 1989, 3:2194-2202.
29. Darko DF, Gillin JC, Risch SC, et al: Mitogen-stimulated lymphocyte proliferation and pituitary hormones in major depression. Biological Psychiatry. 1989, 26:145-155.
30. Clodi M, Svoboda T, Kotzmann H, et al: Effect of elevated scrum prolactin concentrations on cytokine production and natural killer cell activity. Neuroendocrinology. 1992, 56:775-779.
31. Hollingshead AB: Two Factors Index of Social Position. New Haven. CT: AB Hollingshead, 1957.
32. Hughes CP, Berg L, Danziger WL, Coben LA, Martin RL: A new clinical scale for the staging of dementia. British Journal of Psychiatry. 1982, 140:566-572.
33. Grant I, Brown G, Harris T, McDonald W: Severely threatening events and marked life difficulties preceeding onset or exacerbation of multiple sclerosis. J Neurol Neurosurg. 1989, 52:8-13.
34. Brown GW, Harris TO, Hepworth C: Life events and endogenous depression. Archives of General Psychiatry. 1994, 51:525-534.
35. Beck AT: Depression: Clinical, Experimental, and Theoretical Aspects. New York: Harper and Row. 1967.
36. Hamilton M: A rating scale for depression. Journal of Neurology, Neurosurgery and Psychiatry 1960, 23:56-62.
37. Grant I, Patterson TL, Yager J: Social supports in relation to physical health and symptoms of depression in the elderly. American Journal of Psychiatry. 1988, 145(10):1254-1258.
38. Plotsky PM, Thrivikraman KV, Watts AG, Hauger RL: Hypothalamic-pituitary-adrenal axis function in the Zucker obese rat. Endocrinology. 1992, 130:1931-1941.
39. Zahradntk R, Brennan G, Hutchison JS, Odell WD: Immunoradiometric assay of corticotropin with use of avidin-biotin separation. Clinical Chemistry. 1989, 35:804-807.
40. Lisansky J, Hauger R, Strassman R, et al: β-endorphin response to a low dosage of human corticotropin releasing hormone during metyrapone administration in depression. Endocrine Research. 1992, 18:241-260.
41. Hiemke C, Brunner R, Hammes E, et al: Circadian variations in antigen-specific proliferation of human T lymphocytes and correlation to cortisol production. Psychoneuroendocrinology. 1995, 20:335-342.
42. Kiecolt-Glaser JK, Glaser R, Gravenstein S, Malarkey WB: Chronic stress alters the immune response to influenza virus vaccine in older adults. Proceedings of the National Academy of Science. 1996, 93:3043-3047.
43. Irwin M, Daniels M, Smith TL, Bloom E, Weiner H: Impaired natural killer cell activity during bereavement. Brain, Behavior, and Immunity 1987, 1:98-104.
44. Zisook S, Shuchter SR, Irwin M, et al: Bereavement, depression, and immune function. Psychiatry Research. 1995, 52:1-10.
45. Kiecolt-Glaser JK, Glaser R, Dyer C, et al: Chronic stress and immunity in family caregivers of Alzheimer's disease victims. Psychosomatic Medicine. 1987, 49:523-535.
46. Kiecolt-Glaser JK, Glaser R, Shuttleworth EC, et al: Chronic stress and immunity in family caregivers of Alzheimer's disease victims. Psychosomatic Medicine. 1991, 49(5):523-535.
47. Kiecolt-Glaser JK, Dura JR, Speicher CE, Trask OJ, Glaser R: Spousal caregivers of dementia victims: Longitudinal changes in immunity and health. Psychosomatic Medicine. 1991, 53:343-362.
48. Hauger RL, Thrivikraman KV, Plotsky PM: Age-related alterations of hypothalamic-pituitary-adrenal axis function in male Fischer 344 rats. Endocrinology. 1994, 134:1528-1536.
49. Irwin M, Hauger R, Brown M: Central corticotropin releasing hormone activates the sympathetic nervous system and reduces immune function: Increased responsivity of the aged rat. Endocrinology. 1992, 131:1047-1053.
50. Kutza J, Kaye D, Murasko DM: Basal natural killer cell activity of young versus elderly humans. Journal of Gerontology. 1995, 50A:B110-B116.
51. Hauger RL, Lorang M, Irwin M, Aguilera G: CRF receptor regulation and sensitization of ACTH responses to acute ether stress during chronic intermittent immobilization stress. Brain Research. 1990, 532:34-40.
52. Pike JL, Smith TL, Hauger RL, et al: Chronic life stress alters sympathetic, neuroendocrine, and immune responsivity to an acute psychological stressor in humans. Psychosomatic Medicine. 1997, 59:447-457.
53. Fawzy FI, Fawzy NW, Hyun CS, et al: Malignant melanoma: Effects of an early structured psychiatric intervention, coping, and affective state on recurrence and survival six years later. Archives of General Psychiatry. 1993, 5(9):681-689.