Immunoreactivity of corticotropin-releasing hormone, adrenocorticotropic hormone and α-melanocyte-stimulating hormone in alopecia areata

Experimental Dermatology

Volumn 15, Issue 7, 2006, Pages 515-522

  Kim, Hei Sung ^a   Cho, Dae Ho ^b   Kim, Hee Jung ^a   Lee, Jun Young ^a   Cho, Baik Kee ^a   Park, Hyun Jeong ^a  

^a The Catholic University of Korea   (South Korea)

^b Sookmyung Women's University   (South Korea)

Author keywords

Adrenocorticotropic hormone; Alopecia areata; Corticotropin releasing Hormone; Stress; melanocyte stimulating hormone

Indexed keywords

ALPHA INTERMEDIN; CORTICOTROPIN; CORTICOTROPIN RELEASING FACTOR; MESSENGER RNA; PROOPIOMELANOCORTIN;

ADULT; ALOPECIA AREATA; ARTICLE; BASEMENT MEMBRANE; CHI SQUARE TEST; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE SEVERITY; EPIDERMIS; FEMALE; HORMONE SYNTHESIS; HUMAN; HUMAN TISSUE; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; MALE; MELANOCYTE; MENTAL STRESS; PATHOGENESIS; PROTEIN EXPRESSION; SCALP; SKIN FIBROBLAST; STATISTICAL SIGNIFICANCE; STUDENT T TEST;

EID: 33744829783     PISSN: 09066705     EISSN: 16000625     Source Type: Journal    
DOI: 10.1111/j.1600-0625.2006.00003.x     Document Type: Article

References (37)

1. Slominski A T, Botchkarev V, Choudhry M et al. Cutaneous expression of CRH and CRH-R. Is there a "skin stress response system?". Ann N Y Acad Sci 1999: 885: 287-311.
2. Slominski A, Wortsman J, Luger T, Paus R, Solomon S. Corticotropin releasing hormone and proopiomelanocortin involvement in the cutaneous response to stress. Physiol Rev 2000: 80: 979-1020.
3. Kono M, Nagata H, Umemura S, Kawana S, Osamura R Y. In situ expression of corticotrophin-releasing hormone (CRH) and proopiomelanocortin (POMC) genes in human skin. FASEB J 2001: 15: 2297-2299.
4. Slominski A, Mihm M C. Potential mechanism of skin response to stress. Int J Dermatol 1996: 35: 849-851.
5. Slominski A, Wortsman J. Neuroendocrinology of the skin. Endocr Rev 2000: 21: 457-487.
6. Gupta M A, Gupta A K, Watteel G N. Stress and alopecia areata: A psychodermatologic study. Acta Derm Venereol 1997: 77: 296-298.
7. Katsarou-Katsari A, Filippou A, Theoharides T C. Effect of stress and other psychological factors on the pathophysiology and treatment of dermatoses. Int J Immunopathol Pharmacol 1999: 12: 7-11.
8. Katsarou-Katsari A, Singh L K, Theoharides T C. Alopecia areata and affected skin CRH receptor upregulation induced by acute emotional stress. Dermatology 2001: 203: 157-161.
9. Ito N, Ito T, Betterman A, Paus R. The human hair bulb is a source and target of CRH. J Invest Dermatol 2004: 122: 235-237.
10. Slominski A, Pisarchik A, Tobin D J, Mazurkiewicz J E, Wortsman J. Differential expression of a cutaneous corticotropin-releasing hormone system. Endocrinology 2004: 145: 941-950.
11. Pisarchik A, Slominski A T. Alternative splicing of CRH-R1 receptors in human and mouse skin: Identification of new variants and their differential expression. FASEB J 2001: 15: 2754-2756.
12. Slominski A, Wortsman J, Marukiewicz J E et al. Detection of proopiomelanocortin-derived antigens in normal and pathologic human skin. J Lab Clin Med 1993: 122: 658-666.
13. Norris D. Alopecia arata: Current stated of knowledge. J Am Acad Dermatol 2004: 51: S16-S17.
14. De Weert J, Temmerman L, Kint A. Alopecia areata: A clinical study. Dermatologica 1984: 168: 224-229.
15. Muller S A, Winkelmann R K. Alopecia areata. An evaluation of 736 patients. Arch Dermatol 1963: 88: 290-297.
16. Griesemer R D. Emotionally triggered disease in a dermatologic practice. Psychiatr Ann 1978: 8: 407-412.
17. Van Der Steen P, Boezeman J, Duller P, Happle R. Can alopecia areata be triggered by emotional stress? An uncontrolled evaluation of 178 patients with extensive hair loss. Acta Derm Venereol 1992: 72: 279-280.
18. De Waard-van der Spek F B, Oranje A P, De Raeymaecker D M, Peerboom-Wynia J D. Juvenile versus maturity-onset-alopecia arata -a comparative retrospective clinical study. Clin Exp Dermatol 1989: 14: 429-433.
19. Macalpin I. Is alopecia areata psychosomatic? A psychiatric study. Br J Dermatol 1958: 70: 117-131.
20. Gupta M A, Gupta A K. Psychodermatology: An update. J Am Acad Dermatol 1996: 34: 1030-1046.
21. Perini G I, Veller Fornasa C, Cipriani Bettin A, Zecchino F, Peserico A. Life events and alopecia areata. Psychother Psychosom 1984: 41: 48-52.
22. Toyoda M, Makino T, Kagoura M, Morohashi M. Expression of neuropeptide-degrading enzymes in alopecia areata: An immunohistochemical study. Br J Dermatol 2001: 144: 46-54.
23. Peters E M J, Arck P C, Paus R. Hair growth inhibition by psychoemotional stress: A mouse model for neural mechanisms in hair growth control. Exp Dermatol 2006: 15: 1-13.
24. Pincelli C, Fantini F, Giannetti A. Neuropeptides and skin inflammation. Dermatology 1993: 187: 153-158.
25. Singh L K, Pang X, Alexacos N, Letourneau R, Theoharides T C. Acute immobilization stress triggers skin mast cell degranulation via corticotrophin releasing hormone, neurotensin and substance P: A link to neurogenic skin disorders. Brain Behav Immun 1999: 13: 225-239.
26. Paus R, Theoharides T C, Arck P C. Neuroimmunoendocrine circuitry of the 'brain-skin connection'. Trends Immunol 2006: 27: 32-39.
27. Tanii T, Okada T, Fukai K, Nakagawa K, Hamada T. Increase of mast cells in the alopecia lesions of mice. Acta Derm Venereol 1985: 65: 64-66.
28. Gjerede E A, Woie K, Wei E T, Reed R K. Corticotropin-releasing hormone inhibits lowering of interstitial pressure in rat trachea after neurogenic inflammation. Eur J Pharmacol 1998: 352: 99-102.
29. McLoon L K, Wirtschafter J. Local injections of corticotrophin releasing factor reduce doxorubicin-induced acute inflammation in the eyelid. Invest Opthalmol Vis Sci 1997: 38: 834-841.
30. Wei E T, Gao G C, Thomas H A. Peripheral anti-inflammatory actions of corticotrophin-releasing factor. Ciba Found Symp 1993: 172: 258-268.
31. Paus R, Botchkarev V A, Botchkareva N V et al. The skin POMC system. Leads and lessons from the hair follicle. Ann N Y Acad Sci 1999: 885: 350-363.
32. Slominski A, Zybtek B, Szczesniewski A et al. CRH stimulation of corticosteroids production in melanocytes is mediated by ACTH. Am J Physiol Endocrinol Metab 2005: 288: E701-E706.
33. Slominski A, Zbytek B, Semak I, Sweatman T, Wortsman J. CRH stimulates POMC activity and corticosterone production in dermal fibroblasts. J Neuroimmunol 2005: 162: 97-102.
34. Slominski A, Wortsman J, Pisarchik A et al. Cutaneous expression of corticotropin-releasing hormone (CRH), urocortin, and CRH receptors. FASEB J 2001: 15: 1678-1693.
35. Zbytek B, Pfeffer L M, Slominski A T. Corticotropin-releasing hormone stimulates NF-kB in human epidermal keratinocytes. J Endocrinol 2004: 181: R1-R7.
36. Zbytek B, Pfeffer L M, Slominski A T. Corticotropin-releasing hormone inhibits nuclear factor-kappaB pathway in HaCaT kerainocytes. J Invest Dermatol 2003: 121: 1496-1499.
37. Richards H L, Ray D W, Mason D et al. Response of the hypothalamic-pituitary-adrenal axis to psychological stress in patients with psoriasis. Br J Dermatol 2005: 183: 1114-1120.