3-Methylcholanthrene and benzo(a)pyrene modulate cardiac cytochrome P450 gene expression and arachidonic acid metabolism in male Sprague Dawley rats

British Journal of Pharmacology

Volumn 158, Issue 7, 2009, Pages 1808-1819

  Aboutabl, Mona E ^a   Zordoky, Beshay N M ^a   El Kadi, Ayman O S ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

Author keywords

3 methylcholanthrene; Aryl hydrocarbon receptor; Benzo(a)pyrene; Cytochrome P450; Epoxyeicosatrienoic acid; Hydroxyeicosatetraenoic acid; Soluble epoxide hydrolase

Indexed keywords

20 HYDROXYICOSATETRAENOIC ACID; 3 METHYLCHOLANTHRENE; ARACHIDONIC ACID; AROMATIC HYDROCARBON RECEPTOR; ATRIAL NATRIURETIC FACTOR; BENZO[A]PYRENE; BRAIN NATRIURETIC PEPTIDE; CYTOCHROME; CYTOCHROME P450; CYTOCHROME P450 1A1; CYTOCHROME P450 1B1; CYTOCHROME P450 2E1; CYTOCHROME P450 4F4; CYTOCHROME P450 4F5; EPOXIDE HYDROLASE; EPOXYICOSATRIENOIC ACID; ICOSATETRAENOIC ACID; OXYGENASE INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARACHIDONIC ACID METABOLISM; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; ELECTROSPRAY MASS SPECTROMETRY; GENE EXPRESSION REGULATION; GENETIC MARKER; HEART; HEART VENTRICLE HYPERTROPHY; LIQUID CHROMATOGRAPHY; MALE; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; ARACHIDONIC ACID; BENZO(A)PYRENE; CARDIOMEGALY; CHROMATOGRAPHY, LIQUID; CYTOCHROME P-450 ENZYME SYSTEM; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HEART; HYDROXYEICOSATETRAENOIC ACIDS; LIGANDS; MALE; METHYLCHOLANTHRENE; ORGAN SIZE; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, ARYL HYDROCARBON; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION;

EID: 71249135631     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.2009.00461.x     Document Type: Article

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