O2 reactivity of flavoproteins: Dynamic access of dioxygen to the active site and role of a H+ relay system in D-amino acid oxidase

Journal of Biological Chemistry

Volumn 285, Issue 32, 2010, Pages 24439-24446

  Saam, Jan ^a   Rosini, Elena ^b,c   Molla, Gianluca ^b,c   Schulten, Klaus ^a   Pollegioni, Loredano ^b,c   Ghisla, Sandro ^b  

^a UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

^b UNIVERSITY OF INSUBRIA   (Italy)

^c POLITECNICO DI MILANO   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE SITE; D-AMINO ACID OXIDASE; DIOXYGENS; GROUP BOUND; HIGH AFFINITY; HIGH-AFFINITY SITES; MOLECULAR DYNAMICS SIMULATIONS; PROTEIN FRAMEWORKS; RELAY SYSTEM; SAMPLING METHOD; SIDE CHAINS; STERIC CONSTRAINT; TURNOVER NUMBER; WATER MOLECULE; WILD TYPES;

CARBOXYLIC ACIDS; GLUCOSE; GLUCOSE OXIDASE; GLUCOSE SENSORS; MOLECULAR DYNAMICS; ORGANIC ACIDS; PHOSPHATASES;

AMINO ACIDS;

AMINO ACID; DEXTRO AMINO ACID OXIDASE; FLAVOPROTEIN; GLUCOSE OXIDASE; GLYCINE; HISTIDINE; HYDROGEN; IMINO ACID; NITROGEN DERIVATIVE; NITROGEN DIOXIDE; OXYGEN; QUERCETIN; VALINE; WATER; OXIDOREDUCTASE; PROTON;

ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; ENZYME ACTIVE SITE; ENZYME ACTIVITY; MOLECULAR DYNAMICS; NONHUMAN; OXYGEN TRANSPORT; PRIORITY JOURNAL; PROTEIN FOLDING; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN METABOLISM; PROTEIN VARIANT; WILD TYPE; BIOCHEMISTRY; CHEMICAL STRUCTURE; CHEMISTRY; ENZYMOLOGY; METHODOLOGY; RHODOTORULA; SIGNAL TRANSDUCTION;

BIOCHEMISTRY; CATALYTIC DOMAIN; D-AMINO-ACID OXIDASE; FLAVOPROTEINS; GLUCOSE OXIDASE; HISTIDINE; IMINO ACIDS; MODELS, MOLECULAR; OXIDOREDUCTASES; OXYGEN; PROTONS; RHODOTORULA; SIGNAL TRANSDUCTION; VALINE; WATER;

EID: 77955288875     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.131193     Document Type: Article

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