Structural characterization of OxyD, a cytochrome P450 involved in β-hydroxytyrosine formation in vancomycin biosynthesis

Journal of Biological Chemistry

Volumn 285, Issue 32, 2010, Pages 24562-24574

  Cryle, Max J ^a   Meinhart, Anton ^a   Schlichting, Ilme ^a  

^a MAX PLANCK INSTITUTE FOR MEDICAL RESEARCH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; ANTIBIOTICS; BINDING ENERGY; BIOCHEMISTRY; BIOSYNTHESIS; CRYSTAL ORIENTATION; ORGANIC ACIDS; PHOSPHATASES;

ACTIVE SITE; ACYL CARRIER PROTEINS; AGLYCONES; AMINOACYL; AMYCOLATOPSIS MEDITERRANEI; BINDING AFFINITIES; CARRIER PROTEINS; CYTOCHROME P450; GLYCOPEPTIDE ANTIBIOTICS; MODIFIED AMINO ACIDS; NATURAL PRODUCTS; POTENTIAL BINDING SITES; RIBOSOMAL PEPTIDES; SEQUENCE DATA; STRUCTURAL CHARACTERIZATION; SYNTHASES; VANCOMYCIN;

PROTEINS;

AMINO ACID DERIVATIVE; BETA HYDROXYTYROSINE; CARRIER PROTEIN; CYTOCHROME P450; PEPTIDE SYNTHASE; PROTEIN BPSD; PROTEIN OXYD; UNCLASSIFIED DRUG; VANCOMYCIN; ANTIINFECTIVE AGENT; DOPA; HYBRID PROTEIN; MIXED FUNCTION OXIDASE;

ACTINOMYCETALES; AMINO TERMINAL SEQUENCE; ARTICLE; BINDING AFFINITY; BINDING SITE; CRYSTAL STRUCTURE; DRUG SYNTHESIS; MOLECULAR CLONING; NOCARDIA MEDITERRANEA; NONHUMAN; OPERON; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN MODIFICATION; PROTEIN PURIFICATION; CATALYSIS; CHEMICAL MODEL; CHEMICAL STRUCTURE; CHEMISTRY; CONFORMATION; METABOLISM; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; PROCEDURES; PROTEIN CONFORMATION; ULTRAVIOLET SPECTROPHOTOMETRY;

ACTINOMYCETALES; ANTI-BACTERIAL AGENTS; BASE SEQUENCE; CATALYSIS; CLONING, MOLECULAR; CYTOCHROME P-450 ENZYME SYSTEM; DIHYDROXYPHENYLALANINE; MIXED FUNCTION OXYGENASES; MODELS, CHEMICAL; MODELS, MOLECULAR; MOLECULAR CONFORMATION; MOLECULAR SEQUENCE DATA; PROTEIN CONFORMATION; PROTEIN INTERACTION MAPPING; RECOMBINANT FUSION PROTEINS; SPECTROPHOTOMETRY, ULTRAVIOLET; VANCOMYCIN;

EID: 77955284586     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.131904     Document Type: Article

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