Conformational switches modulate protein interactions in peptide antibiotic synthetases

Science

Volumn 312, Issue 5771, 2006, Pages 273-276

  Koglin, Alexander ^a   Mofid, Mohammad R ^b,d   Löhr, Frank ^a   Schäfer, Birgit ^a   Rogov, Vladimir V ^a,c   Blum, Marc Michael ^a   Mittag, Tanja ^a,e   Marahiel, Mohamed A ^b   Bernhard, Frank ^a   Dötsch, Volker ^a  

^a GOETHE UNIVERSITY   (Germany)

^b PHILIPPS UNIVERSITY MARBURG   (Germany)

^c INSTITUTE OF PROTEIN RESEARCH   (Russian Federation)

^d UNIVERSITY OF MUNICH   (Germany)

^e HOSPITAL FOR SICK CHILDREN   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

AMINES; ANTIBIOTICS; CONFORMATIONS; NUCLEAR MAGNETIC RESONANCE; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; RELAXATION OSCILLATORS;

NONRIBOSOMAL PEPTIDE SYNTHETASES; PEPTIDE ANTIBIOTIC SYNTHETASES; PEPTIDYL CARRIER PROTEIN (PCP); PROTEIN DYNAMICS;

ENZYMES;

CARRIER PROTEIN; PANTETHEINE PHOSPHATE; PEPTIDE; PEPTIDYL CARRIER PROTEIN; POLYPEPTIDE ANTIBIOTIC AGENT; SYNTHETASE; THIOL ESTER HYDROLASE; TRANSFERASE; UNCLASSIFIED DRUG;

ANTIBIOTICS; ENZYME; NUCLEAR MAGNETIC RESONANCE;

ARTICLE; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; PROTEIN TRANSPORT;

APOPROTEINS; BACTERIAL PROTEINS; BINDING SITES; CARRIER PROTEINS; CRYSTALLOGRAPHY, X-RAY; FATTY ACID SYNTHETASE COMPLEX; HOLOENZYMES; MODELS, MOLECULAR; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PANTETHEINE; PEPTIDE SYNTHASES; PROTEIN CONFORMATION; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; THIOLESTER HYDROLASES; TRANSFERASES;

EID: 33645807617     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1122928     Document Type: Article

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