Enzymatic therapeutic index of acyclovir: Viral versus human polymerase γ specificity

Journal of Biological Chemistry

Volumn 282, Issue 34, 2007, Pages 25159-25167

  Hanes, Jeremiah W ^a   Zhu, Yali ^b   Parris, Deborah S ^b   Johnson, Kenneth A ^a  

^a UNIVERSITY OF TEXAS AT AUSTIN   (United States)

^b OHIO STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACYCLOVIR TRIPHOSPHATE; DISSOCIATION CONSTANT; POLYMERASE HOLOENZYME; TOXICITY INDEX;

CELL MEMBRANES; DISEASES; DISSOCIATION; DNA; GROUND STATE; TOXICITY;

ENZYME KINETICS;

ACICLOVIR TRIPHOSPHATE; DNA DIRECTED DNA POLYMERASE GAMMA; TENOFOVIR; THYMIDINE KINASE; UNCLASSIFIED DRUG; VIRUS 1 DNA POLYMERASE; VIRUS ENZYME;

ARTICLE; COMPARATIVE STUDY; DRUG EFFICACY; DRUG MECHANISM; ENZYME METABOLISM; ENZYME SPECIFICITY; MITOCHONDRIAL TOXICITY; PRIORITY JOURNAL;

ACYCLOVIR; ANIMALS; ANTIVIRAL AGENTS; DNA, MITOCHONDRIAL; DNA-DIRECTED DNA POLYMERASE; DOSE-RESPONSE RELATIONSHIP, DRUG; EXONUCLEASES; HERPESVIRUS 1, HUMAN; HUMANS; INSECTS; KINETICS; MODELS, BIOLOGICAL; SUBSTRATE SPECIFICITY; TIME FACTORS; VIRUS REPLICATION;

HUMAN HERPESVIRUS 1;

EID: 34548337282     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M703972200     Document Type: Article

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