Cytokine dependent and independent iNKT cell activation

Cytokine

Volumn 51, Issue 3, 2010, Pages 227-231

  Reilly, Emma C ^a   Wands, Jack R ^a,b   Brossay, Laurent ^a  

^a BROWN UNIVERSITY   (United States)

^b BROWN UNIVERSITY   (United States)

Author keywords

CD1d; Cytokines; Natural killer T cells

Indexed keywords

ALPHA INTERFERON; CD1D ANTIGEN; CD4 ANTIGEN; CERAMIDE TRIHEXOSIDE; CYTOKINE; GAMMA INTERFERON; GLYCOLIPID; INTERLEUKIN 12; INTERLEUKIN 13; INTERLEUKIN 17; INTERLEUKIN 18; INTERLEUKIN 2; INTERLEUKIN 33; INTERLEUKIN 5; LYSOPHOSPHATIDYLCHOLINE; NATURAL KILLER CELL RECEPTOR NKG2D; PHOSPHATIDYLCHOLINE; T LYMPHOCYTE RECEPTOR; TOLL LIKE RECEPTOR; LYMPHOCYTE ANTIGEN RECEPTOR; NATURAL KILLER CELL RECEPTOR;

ALPHAPROTEOBACTERIA; ANTIGEN RECOGNITION; BORRELIA; CELL ACTIVATION; CYTOKINE PRODUCTION; CYTOKINE RELEASE; CYTOKINE RESPONSE; CYTOMEGALOVIRUS; EHRLICHIA; HEPATITIS B VIRUS; HERPES SIMPLEX VIRUS 2; HUMAN; IMMUNE RESPONSE; IMMUNOCOMPETENT CELL; INNATE IMMUNITY; MYCOBACTERIUM TUBERCULOSIS; NATURAL KILLER CELL; NONHUMAN; PRIORITY JOURNAL; REVIEW; RICKETTSIA; SALMONELLA TYPHIMURIUM; SPHINGOMONAS; STAPHYLOCOCCUS AUREUS; T LYMPHOCYTE ACTIVATION; T LYMPHOCYTE SUBPOPULATION; TH1 CELL; TH2 CELL; ANIMAL; CYTOLOGY; IMMUNOLOGY; LYMPHOCYTE ACTIVATION; METABOLISM; NATURAL KILLER T CELL;

ANIMALS; CYTOKINES; HUMANS; LYMPHOCYTE ACTIVATION; NATURAL KILLER T-CELLS; RECEPTORS, ANTIGEN, T-CELL; RECEPTORS, NATURAL KILLER CELL; TOLL-LIKE RECEPTORS;

EID: 77955267859     PISSN: 10434666     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cyto.2010.04.016     Document Type: Review

References (71)

1. Kronenberg M., Gapin L. The unconventional lifestyle of NKT cells. Nat Rev Immunol 2002, 2:557-568.
2. Brigl M., Brenner M.B. CD1: antigen presentation and T cell function. Annu Rev Immunol 2004, 22:817-890.
3. Kronenberg M. Towards an understanding of NKT cell biology: progress and paradoxes. Annu Rev Immunol 2004, 23:877-900.
4. Godfrey D.I., MacDonald H.R., Kronenberg M., Smyth M.J., Van Kaer L. NKT cells: what's in a name?. Nat Rev Immunol 2004, 4:231-237.
5. Bendelac A., Savage P.B., Teyton L. The biology of NKT cells. Annu Rev Immunol 2006, 25:297-336.
6. Kawano T., Cui J., Koezuka Y., Toura I., Kaneko Y., Motoki K., et al. CD1d-restricted and TCR-mediated activation of Vα14 NKT cells by glycosylceramides. Science 1997, 278:1626-1629.
7. + NKT lymphocytes. J Immunol 1998, 161:3271-3281.
8. Benlagha K., Weiss A., Beavis A., Teyton L., Bendelac A. In vivo identification of glycolipid antigen-specific T cells using fluorescent CD1d tetramers. J Exp Med 2000, 191:1895-1903.
9. Matsuda J.L., Naidenko O.V., Gapin L., Nakayama T., Taniguchi M., Wang C.R., et al. Tracking the response of natural killer T cells to a glycolipid antigen using CD1d tetramers. J Exp Med 2000, 192:741-754.
10. Smiley S.T., Kaplan M.H., Grusby M.J. Immunoglobulin E production in the absence of interleukin-4-secreting CD1-dependent cells. Science 1997, 275:977-979.
11. Chen Y.H., Chiu N.M., Mandal M., Wang N., Wang C.R. Impaired NK1+ T cell development and early IL-4 production in CD1-deficient mice. Immunity 1997, 6:459-467.
12. Mendiratta S.K., Martin W.D., Hong S., Boesteanu A., Joyce S., Van Kaer L. CD1d1 mutant mice are deficient in natural T cells that promptly produce IL-4. Immunity 1997, 6:469-477.
13. Kinjo Y., Wu D., Kim G., Xing G.W., Poles M.A., Ho D.D., et al. Recognition of bacterial glycosphingolipids by natural killer T cells. Nature 2005, 434:520-525.
14. Mattner J., Debord K.L., Ismail N., Goff R.D., Cantu C., Zhou D., et al. Exogenous and endogenous glycolipid antigens activate NKT cells during microbial infections. Nature 2005, 434:525-529.
15. Sriram V., Du W., Gervay-Hague J., Brutkiewicz R.R. Cell wall glycosphingolipids of Sphingomonas paucimobilis are CD1d-specific ligands for NKT cells. Eur J Immunol 2005, 35:1692-1701.
16. Kinjo Y., Tupin E., Wu D., Fujio M., Garcia-Navarro R., Benhnia M.R., et al. Natural killer T cells recognize diacylglycerol antigens from pathogenic bacteria. Nat Immunol 2006, 7:978-986.
17. Matsuda J.L., Gapin L., Baron J.L., Sidobre S., Stetson D.B., Mohrs M., et al. Mouse Vα14i natural killer T cells are resistant to cytokine polarization in vivo. Proc Natl Acad Sci USA 2003, 100:8395-8400.
18. Wesley J.D., Robbins S.H., Sidobre S., Kronenberg M., Terrizzi S., Brossay L. Cutting edge: IFN-γ signaling to macrophages is required for optimal Vα14i NK T/NK cell cross-talk. J Immunol 2005, 174:3864-3868.
19. Fujii S., Shimizu K., Kronenberg M., Steinman R.M. Prolonged IFN-γ-producing NKT response induced with a-galactosylceramide-loaded DCs. Nat Immunol 2002, 3:867-874.
20. Miyamoto K., Miyake S., Yamamura T. A synthetic glycolipid prevents autoimmune encephalomyelitis by inducing TH2 bias of natural killer T cells. Nature 2001, 413:531-534.
21. Oki S., Chiba A., Yamamura T., Miyake S. The clinical implication and molecular mechanism of preferential IL-4 production by modified glycolipid-stimulated NKT cells. J Clin Invest 2004, 113:1631-1640.
22. Yu K.O., Im J.S., Molano A., Dutronc Y., Illarionov P.A., Forestier C., et al. Modulation of CD1d-restricted NKT cell responses by using N-acyl variants of α-galactosylceramides. Proc Natl Acad Sci USA 2005, 102:3383-3388.
23. Schmieg J., Yang G., Franck R.W., Tsuji M. Superior protection against malaria and melanoma metastases by a C-glycoside analogue of the natural killer T cell ligand α-galactosylceramide. J Exp Med 2003, 198:1631-1641.
24. Stanic A.K., Shashidharamurthy R., Bezbradica J.S., Matsuki N., Yoshimura Y., Miyake S., et al. Another view of T cell antigen recognition: cooperative engagement of glycolipid antigens by Vα14-Jα18 natural T(iNKT) cell receptor [corrected]. J Immunol 2003, 171:4539-4551.
25. Oki S., Tomi C., Yamamura T., Miyake S. Preferential T(h)2 polarization by OCH is supported by incompetent NKT cell induction of CD40L and following production of inflammatory cytokines by bystander cells in vivo. Int Immunol 2005, 17:1619-1629.
26. Im J.S., Arora P., Bricard G., Molano A., Venkataswamy M.M., Baine I., et al. Kinetics and cellular site of glycolipid loading control the outcome of natural killer T cell activation. Immunity 2009, 30:888-898.
27. Sullivan B.A., Nagarajan N.A., Wingender G., Wang J., Scott I., Tsuji M., et al. Mechanisms for glycolipid antigen-driven cytokine polarization by Vα14i NKT cells. J Immunol 2010, 184:141-153.
28. Parekh V.V., Wilson M.T., Olivares-Villagomez D., Singh A.K., Wu L., Wang C.R., et al. Glycolipid antigen induces long-term natural killer T cell anergy in mice. J Clin Invest 2005, 115:2572-2583.
29. Kim S., Lalani S., Parekh V.V., Vincent T.L., Wu L., Van Kaer L. Impact of bacteria on the phenotype, functions, and therapeutic activities of invariant NKT cells in mice. J Clin Invest 2008, 118:2301-2315.
30. Gumperz J.E., Miyake S., Yamamura T., Brenner M.B. Functionally distinct subsets of CD1d-restricted natural killer T cells revealed by CD1d tetramer staining. J Exp Med 2002, 195:625-636.
31. Lee P.T., Benlagha K., Teyton L., Bendelac A. Distinct functional lineages of human V(α)24 natural killer T cells. J Exp Med 2002, 195:637-641.
32. Michel M.L., Mendes-da-Cruz D., Keller A.C., Lochner M., Schneider E., Dy M., et al. Critical role of ROR-γt in a new thymic pathway leading to IL-17-producing invariant NKT cell differentiation. Proc Natl Acad Sci USA 2008, 105:19845-19850.
33. Michel M.L., Keller A.C., Paget C., Fujio M., Trottein F., Savage P.B., et al. Identification of an IL-17-producing NK1.1(neg) iNKT cell population involved in airway neutrophilia. J Exp Med 2007, 204:995-1001.
34. Terashima A., Watarai H., Inoue S., Sekine E., Nakagawa R., Hase K., et al. A novel subset of mouse NKT cells bearing the IL-17 receptor B responds to IL-25 and contributes to airway hyperreactivity. J Exp Med 2008, 205:2727-2733.
35. Doisne J.M., Becourt C., Amniai L., Duarte N., Le Luduec J.B., Eberl G., et al. Skin and peripheral lymph node invariant NKT cells are mainly retinoic acid receptor-related orphan receptor (γ)t+ and respond preferentially under inflammatory conditions. J Immunol 2009, 183:2142-2149.
36. Coquet J.M., Chakravarti S., Kyparissoudis K., McNab F.W., Pitt L.A., McKenzie B.S., et al. Diverse cytokine production by NKT cell subsets and identification of an IL-17-producing CD4-NK1.1-NKT cell population. Proc Natl Acad Sci USA 2008, 105:11287-11292.
37. Brigl M., Bry L., Kent S.C., Gumperz J.E., Brenner M.B. Mechanism of CD1d-restricted natural killer T cell activation during microbial infection. Nat Immunol 2003, 4:1230-1237.
38. Salio M., Speak A.O., Shepherd D., Polzella P., Illarionov P.A., Veerapen N., et al. Modulation of human natural killer T cell ligands on TLR-mediated antigen-presenting cell activation. Proc Natl Acad Sci USA 2007, 104:20490-20495.
39. Paget C., Mallevaey T., Speak A.O., Torres D., Fontaine J., Sheehan K.C., et al. Activation of invariant NKT cells by toll-like receptor 9-stimulated dendritic cells requires type I interferon and charged glycosphingolipids. Immunity 2007, 27:597-609.
40. Brutkiewicz R.R. CD1d ligands: the good, the bad, and the ugly. J Immunol 2006, 177:769-775.
41. Zhou D., Mattner J., Cantu C., Schrantz N., Yin N., Gao Y., et al. Lysosomal glycosphingolipid recognition by NKT cells. Science 2004, 306:1786-1789.
42. Fox L.M., Cox D.G., Lockridge J.L., Wang X., Chen X., Scharf L., et al. Recognition of lyso-phospholipids by human natural killer T lymphocytes. PLoS Biol 2009, 7:e1000228.
43. Yuan W., Kang S.-J., Evans J.E., Cresswell P. Natural lipid ligands associated with human CD1d targeted to different subcellular compartments. J Immunol 2009, 182:4784-4791.
44. Speak A.O., Salio M., Neville D.C., Fontaine J., Priestman D.A., Platt N., et al. From the cover: implications for invariant natural killer T cell ligands due to the restricted presence of isoglobotrihexosylceramide in mammals. Proc Natl Acad Sci USA 2007, 104:5971-5976.
45. Porubsky S., Speak A.O., Luckow B., Cerundolo V., Platt F.M., Grone H.J. From the cover: normal development and function of invariant natural killer T cells in mice with isoglobotrihexosylceramide (iGb3) deficiency. Proc Natl Acad Sci USA 2007, 104:5977-5982.
46. Christiansen D., Milland J., Mouhtouris E., Vaughan H., Pellicci D.G., McConville M.J., et al. Humans lack iGb3 due to the absence of functional iGb3-synthase: implications for NKT cell development and transplantation. PLoS Biol 2008, 6:e172.
47. Duthie M.S., Kahn M., White M., Kapur R.P., Kahn S.J. Both CD1d antigen presentation and interleukin-12 are required to activate natural killer T cells during Trypanosoma cruzi infection. Infect Immunol 2005, 73:1890-1894.
48. Sada-Ovalle I., Chiba A., Gonzales A., Brenner M.B., Behar S.M. Innate invariant NKT cells recognize Mycobacterium tuberculosis-infected macrophages, produce interferon-gamma, and kill intracellular bacteria. PLoS Pathog 2008, 4:e1000239.
49. Sakuishi K., Oki S., Araki M., Porcelli S.A., Miyake S., Yamamura T. Invariant NKT cells biased for IL-5 production act as crucial regulators of inflammation. J Immunol 2007, 179:3452-3462.
50. Stetson D.B., Mohrs M., Reinhardt R.L., Baron J.L., Wang Z.E., Gapin L., et al. Constitutive cytokine mRNAs mark natural killer (NK) and NK T cells poised for rapid effector function. J Exp Med 2003, 198:1069-1076.
51. Leite-De-Moraes M.C., Hameg A., Arnould A., Machavoine F., Koezuka Y., Schneider E., et al. A distinct IL-18-induced pathway to fully activate NK T lymphocytes independently from TCR engagement. J Immunol 1999, 163:5871-5876.
52. Eberl G., MacDonald H.R. Rapid death and regeneration of NKT cells in anti-CD3e{open}- or IL-12-treated mice. A major role for bone marrow in NKT cell homeostasis. Immunity 1998, 9:345-353.
53. Park S.H., Kyin T., Bendelac A., Carnaud C. The contribution of NKT cells, NK cells, and other gamma-chain-dependent non-T non-B cells to IL-12-mediated rejection of tumors. J Immunol 2003, 170:1197-1201.
54. Wesley J.D., Tessmer M.S., Chaukos D., Brossay L. NK cell-like behavior of Vα14i NK T cells during MCMV infection. PLoS Pathog 2008, 4:e1000106.
55. Tyznik A.J., Tupin E., Nagarajan N.A., Her M.J., Benedict C.A., Kronenberg M. Cutting edge: the mechanism of invariant NKT cell responses to viral danger signals. J Immunol 2008, 181:4452-4456.
56. Paget C., Bialecki E., Fontaine J., Vendeville C., Mallevaey T., Faveeuw C., et al. Role of invariant NK T lymphocytes in immune responses to CpG oligodeoxynucleotides. J Immunol 2009, 182:1846-1853.
57. Nagarajan N.A., Kronenberg M. Invariant NKT cells amplify the innate immune response to lipopolysaccharide. J Immunol 2007, 178:2706-2713.
58. Bourgeois E., Van L.P., Samson M., Diem S., Barra A., Roga S., et al. The pro-Th2 cytokine IL-33 directly interacts with invariant NKT and NK cells to induce IFN-γ production. Eur J Immunol 2009, 39:1046-1055.
59. Stout-Delgado H.W., Du W., Shirali A.C., Booth C.J., Goldstein D.R. Aging promotes neutrophil-induced mortality by augmenting IL-17 production during viral infection. Cell Host Microbe 2009, 6:446-456.
60. Rachitskaya A.V., Hansen A.M., Horai R., Li Z., Villasmil R., Luger D., et al. Cutting edge: NKT cells constitutively express IL-23 receptor and ROR{γ}t and rapidly produce IL-17 upon receptor ligation in an IL-6-independent fashion. J Immunol 2008, 180:5167-5171.
61. Stock P., Lombardi V., Kohlrautz V., Akbari O. Induction of airway hyperreactivity by IL-25 Is dependent on a subset of invariant NKT cells expressing IL-17RB. J Immunol 2009, 182:5116-5122.
62. Shimizu H., Matsuguchi T., Fukuda Y., Nakano I., Hayakawa T., Takeuchi O., et al. Toll-like receptor 2 contributes to liver injury by Salmonella infection through Fas ligand expression on NKT cells in mice. Gastroenterology 2002, 123:1265-1277.
63. Takashi H., Tetsuya M., Hideyuki S., Toshiki Y., Hitoshi N., Toshiyuki A., et al. NKT cells stimulated with a ligand for TLR2 at least partly contribute to liver injury caused by Escherichia coli infection in mice. Eur J Immunol 2003, 33:2511-2519.
64. Askenase P.W., Itakura A., Leite-de-Moraes M.C., Lisbonne M., Roongapinun S., Goldstein D.R., et al. TLR-dependent IL-4 production by invariant Vα14+Jα18+ NKT cells to initiate contact sensitivity in vivo. J Immunol 2005, 175:6390-6401.
65. Gardner T.R., Chen Q., Jin Y., Ajuebor M.N. Toll-like receptor 3 ligand dampens liver inflammation by stimulating Vα14 invariant natural killer T cells to negatively regulate γδT cells. Am J Pathol 2010, 176:1779-1789.
66. Arase H., Arase N., Saito T. Interferon gamma production by natural killer (NK) cells and NK1.1+ T cells upon NKR-P1 cross-linking. J Exp Med 1996, 183:2391-2396.
67. Exley M., Porcelli S., Furman M., Garcia J., Balk S. CD161 (NKR-P1A) co-stimulation of CD1d-dependent activation of human T cells expressing invariant Vα24JαQ T cell receptor α chains. J. Exp. Med. 1998, 188:867-876.
68. McNab F.W., Pellicci D.G., Field K., Besra G., Smyth M.J., Godfrey D.I., et al. Peripheral NK1.1 NKT cells are mature and functionally distinct from their thymic counterparts. J Immunol 2007, 179:6630-6637.
69. Baron J.L., Gardiner L., Nishimura S., Shinkai K., Locksley R., Ganem D. Activation of a nonclassical NKT cell subset in a transgenic mouse model of hepatitis B virus infection. Immunity 2002, 16:583-594.
70. Guillonneau C., Mintern J.D., Hubert Fo.-X., Hurt A.C., Besra G.S., Porcelli S., et al. Combined NKT cell activation and influenza virus vaccination boosts memory CTL generation and protective immunity. Proc Natl Acad Sci 2009, 106:3330-3335.
71. Sullivan B.A., Kronenberg M. Activation or anergy: NKT cells are stunned by α-galactosylceramide. J Clin Invest 2005, 115:2328-2329.