Preferential Th2 polarization by OCH is supported by incompetent NKT cell induction of CD40L and following production of inflammatory cytokines by bystander cells in vivo

International Immunology

Volumn 17, Issue 12, 2005, Pages 1619-1629

  Oki, Shinji ^a   Tomi, Chiharu ^a   Yamamura, Takashi ^a   Miyake, Sachiko ^a  

^a NATIONAL INSTITUTE OF NEUROSCIENCE   (Japan)

Author keywords

Cell activation; Cytokines; Inflammation; Natural killer; Rodent; T cells

Indexed keywords

ALPHA GALACTOSYLCERAMIDE; CD40 LIGAND; CD40 LIGAND MONOCLONAL ANTIBODY; CYTOKINE; GAMMA INTERFERON; GLYCOLIPID; INTERLEUKIN 12; INTERLEUKIN 4; OLIGODEOXYNUCLEOTIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BYSTANDER EFFECT; CONTROLLED STUDY; CYTOKINE PRODUCTION; DOSE RESPONSE; DRUG EFFICACY; DRUG MECHANISM; DRUG POTENTIATION; IN VIVO STUDY; MOUSE; NATURAL KILLER CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INDUCTION; TH2 CELL;

ANIMALS; AUTOIMMUNE DISEASES; BYSTANDER EFFECT; CD40 LIGAND; CELLS, CULTURED; CYTOKINES; GLYCOLIPIDS; KILLER CELLS, NATURAL; MICE; TH2 CELLS;

EID: 28744453420     PISSN: 09538178     EISSN: 14602377     Source Type: Journal    
DOI: 10.1093/intimm/dxh342     Document Type: Article

References (40)

1. Kronenberg, M. and Gapin, L. 2002. The unconventional lifestyle of NKT cells. Nat. Rev. Immunol. 2:557.
2. Taniguchi, M., Harada, M., Kojo, S., Nakayama, T. and Wakao, H. 2003. The regulatory role of Valpha14 NKT cells in innate and acquired immune response. Annu. Rev. Immunol. 21:483.
3. Smyth, M. J., Crowe, N. Y., Pellicci, D. G. et al. 2002. Sequential production of interferon-gamma by NK1.1(+) T cells and natural killer cells is essential for the antimetastatic effect of alpha-galactosylceramide. Blood 99:1259.
4. Singh, N., Hong, S., Scherer, D. C. et al. 1999. Cutting edge: activation of NK T cells by CD1d and alpha-galactosylceramide directs conventional T cells to the acquisition of a Th2 phenotype. J. Immunol. 163:2373.
5. Hayakawa, Y., Takeda, K., Yagita, H., Van Kaer, L., Saiki, I. and Okumura, K. 2001. Differential regulation of Th1 and Th2 functions of NKT cells by CD28 and CD40 costimulatory pathways. J. Immunol. 166:6012.
6. Mizuno, M., Masumura, M., Tomi, C. et al. 2004. Synthetic glycolipid OCH prevents insulitis and diabetes in NOD mice. J. Autoimmun. 23:293.
7. Chiba, A., Oki, S., Miyamoto, K., Hashimoto, H., Yamamura, T. and Miyake, S. 2004. Suppression of collagen-induced arthritis by natural killer T cell activation with OCH, a sphingosine-truncated analog of alpha-galactosylceramide. Arthritis Rheum. 50:305.
8. Miyamoto, K., Miyake, S. and Yamamura, T. 2001. A synthetic glycolipid prevents autoimmune encephalomyelitis by inducing TH2 bias of natural killer T cells. Nature 413:531.
9. Oki, S., Chiba, A., Yamamura, T. and Miyake, S. 2004. The clinical implication and molecular mechanism of preferential IL-4 production by modified glycolipid-stimulated NKT cells. J. Clin. Investig. 113:1631.
10. Carnaud, C., Lee, D., Donnars, O. et al. 1999. Cross-talk between cells of the innate immune system: NKT cells rapidly activate NK cells. J. Immunol. 163:4647.
11. Fujii, S. I., Shimizu, K., Smith, C., Bonifaz, L. and Steinman, R. M. 2003. Activation of natural killer T cells by {alpha}-galactosylceramide rapidly induces the full maturation of dendritic cells in vivo and thereby acts as an adjuvant for combined CD4 and CD8 T cell immunity to a coadministered protein. J. Exp. Med. 198:267.
12. Hermans, I. F., Silk, J. D., Gileadi, U. et al. 2003. NKT cells enhance CD4+ and CD8+ T cell responses to soluble antigen in vivo through direct interaction with dendritic cells. J. Immunol. 171:5140.
13. Kitamura, H., Ohta, A., Sekimoto, M. et al. 2000. Alpha-galactosylceramide induces early B-cell activation through IL-4 production by NKT cells. Cell Immunol. 199:37.
14. Schmieg, J., Yang, G., Franck, R. W. and Tsuji, M. 2003. Superior protection against malaria and melanoma metastases by a C-glycoside analogue of the natural killer T cell ligand alpha-galactosylceramide. J. Exp. Med. 198:1631.
15. Vincent, M. S., Leslie, D. S., Gumperz, J. E., Xiong, X., Grant, E. P. and Brenner, M. B. 2002. CD1-dependent dendritic cell instruction. Nat. Immunol. 3:1163.
16. Tomura, M., Yu, W. G., Ahn, H. J. et al. 1999. A novel function of Valpha14+CD4+NKT cells: Stimulation of IL-12 production by antigen-presenting cells in the innate immune system. J. Immunol. 163:93.
17. Brigl, M., Bry, L., Kent, S. C., Gumperz, J. E. and Brenner, M. B. 2003. Mechanism of CD1d-restricted natural killer T cell activation during microbial infection. Nat. Immunol. 4:1230.
18. Gilliet, M., Boonstra, A., Paturel, C. et al. 2002. The development of murine plasmacytoid dendritic cell precursors is differentially regulated by FLT3-ligand and granulocyte/macrophage colony-stimulating factor. J. Exp. Med. 195:953.
19. Chiba, A., Kaieda, S., Oki, S., Yamamura, T. and Miyake, S. 2005. The involvement of V(alpha)14 natural killer T cells in the pathogenesis of arthritis in murine models. Arthritis Rheum. 52:1941.
20. Pal, E., Tabira, T., Kawano, T., Taniguchi, M., Miyake, S. and Yamamura, T. 2001. Costimulation-dependent modulation of experimental autoimmune encephalomyelitis by ligand stimulation of V alpha 14 NK T cells. J. Immunol. 166:662.
21. Kitamura, H., Iwakabe, K., Yahata, T. et al. 1999. The natural killer T (NKT) cell ligand alpha-galactosylceramide demonstrates its immunopotentiating effect by inducing interleukin (IL)-12 production by dendritic cells and IL-12 receptor expression on NKT cells. J. Exp. Med. 189:1121.
22. Trinchieri, G. 2003. Interleukin-12 and the regulation of innate resistance and adaptive immunity. Nat. Rev. Immunol. 3:133.
23. Schulz, O., Edwards, A. D., Schito, M. et al. 2000. CD40 triggering of heterodimeric IL-12 p70 production by dendritic cells in vivo requires a microbial priming signal. Immunity 13:453.
24. Hilkens, C. M., Kalinski, P., de Boer, M. and Kapsenberg, M. L. 1997. Human dendritic cells require exogenous interleukin-12-inducing factors to direct the development of naive T-helper cells toward the Th1 phenotype. Blood 90:1920.
25. Vieira, P. L., de Jong, E. C., Wierenga, E. A., Kapsenberg, M. L. and Kalinski, P. 2000. Development of Th1-inducing capacity in myeloid dendritic cells requires environmental instruction. J. Immunol. 164:4507.
26. Snijders, A., Kalinski, P., Hilkens, C. M. and Kapsenberg, M. L. 1998. High-level IL-12 production by human dendritic cells requires two signals. Int. Immunol. 10:1593.
27. Klinman, D. M. 2004. Immunotherapeutic uses of CpG oligodeoxynucleotides. Nat. Rev. Immunol. 4:249.
28. Krug, A., Towarowski, A., Britsch, S. et al. 2001. Toll-like receptor expression reveals CpG DNA as a unique microbial stimulus for plasmacytoid dendritic cells which synergizes with CD40 ligand to induce high amounts of IL-12. Eur. J. Immunol. 31:3026.
29. Parekh, V. V., Singh, A. K., Wilson, M. T. et al. 2004. Quantitative and qualitative differences in the in vivo response of NKT cells to distinct alpha- and beta-anomeric glycolipids. J. Immunol. 173:3693.
30. Goff, R. D., Gao, Y., Mattner, J. et al. 2004. Effects of lipid chain lengths in alpha-galactosylceramides on cytokine release by natural killer T cells. J. Am. Chem. Soc. 126:13602.
31. Smyth, M. J., Thia, K. Y., Street, S. E. et al. 2000. Differential tumor surveillance by natural killer (NK) and NKT cells. J. Exp. Med. 191:661.
32. Whiteside, T. L. and Herberman, R. B. 1995. The role of natural killer cells in immune surveillance of cancer. Curr. Opin. Immunol. 7:704.
33. Ortaldo, J. R., Young, H. A., Winkler-Pickett, R. T., Bere, E. W., Jr, Murphy, W. J. and Wiltrout, R. H. 2004. Dissociation of NKT stimulation, cytokine induction, and NK activation in vivo by the use of distinct TCR-binding ceramides. J. Immunol. 172:943.
34. Ueno, Y., Tanaka, S., Sumii, M. et al. 2005. Single dose of OCH improves mucosal T helper type 1/T helper type 2 cytokine balance and prevents experimental colitis in the presence of valpha14 natural killer T cells in mice. Inflamm. Bowel Dis. 11:35.
35. Cella, M., Scheidegger, D., Palmer-Lehmann, K., Lane, P., Lanzavecchia, A. and Alber, G. 1996. Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity: T-T help via APC activation. J. Exp. Med. 184:747.
36. Quezada, S. A., Jarvinen, L. Z., Lind, E. F. and Noelle, R. J. 2004. CD40/CD154 interactions at the interface of tolerance and immunity. Annu. Rev. Immunol. 22:307.
37. Hayes, M. P., Murphy, F. J. and Burd, P. R. 1998. Interferon-gamma-dependent inducible expression of the human interleukin-12 p35 gene in monocytes initiates from a TATA-containing promoter distinct from the CpG-rich promoter active in Epstein-Barr virus-transformed lymphoblastoid cells. Blood 91:4645.
38. Ma, X., Chow, J. M., Gri, G. et al. 1996. The interleukin 12 p40 gene promoter is primed by interferon gamma in monocytic cells. J. Exp. Med. 183:147.
39. Grohmann, U., Belladonna, M. L., Bianchi, R. et al. 1998. IL-12 acts directly on DC to promote nuclear localization of NF-kappaB and primes DC for IL-12 production. Immunity 9:315.
40. Gumperz, J. E. 2004. CD1d-restricted NKT cells and myeloid IL-12 production: An immunological crossroads leading to promotion or suppression of effective anti-tumor immune responses? J. Leukoc. Biol. 76:307.