메뉴 건너뛰기




Volumn 7, Issue 4, 2010, Pages 1125-1132

Positive feedback system provides efficient and persistent transgene expression

Author keywords

artificial transcription factor; Long term transgene expression; positive feedback system

Indexed keywords

ALBUMIN; HYBRID PROTEIN; LUCIFERASE; PLASMID DNA; PROTEIN VP16; TRANSCRIPTION FACTOR GAL4;

EID: 77955265560     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp1000108     Document Type: Article
Times cited : (10)

References (36)
  • 1
    • 0344120637 scopus 로고    scopus 로고
    • Pharmacokinetic and pharmacodynamic considerations in gene therapy
    • Kamiya, H.; Akita, H.; Harashima, H. Pharmacokinetic and pharmacodynamic considerations in gene therapy Drug Discovery Today 2003, 8, 990-996
    • (2003) Drug Discovery Today , vol.8 , pp. 990-996
    • Kamiya, H.1    Akita, H.2    Harashima, H.3
  • 2
    • 31444439735 scopus 로고    scopus 로고
    • Intranuclear dispositions of exogenous DNA in vivo: Silencing, methylation and fragmentation
    • Ochiai, H.; Harashima, H.; Kamiya, H. Intranuclear dispositions of exogenous DNA in vivo: silencing, methylation and fragmentation FEBS Lett. 2006, 580, 918-922
    • (2006) FEBS Lett. , vol.580 , pp. 918-922
    • Ochiai, H.1    Harashima, H.2    Kamiya, H.3
  • 3
    • 34447633952 scopus 로고    scopus 로고
    • Transient activation of transgene expression by hydrodynamics-based injection may cause rapid decrease in plasmid DNA expression
    • Ochiai, H.; Fujimuro, M.; Yokosawa, H.; Harashima, H.; Kamiya, H. Transient activation of transgene expression by hydrodynamics-based injection may cause rapid decrease in plasmid DNA expression Gene Ther. 2007, 14, 1152-1159
    • (2007) Gene Ther. , vol.14 , pp. 1152-1159
    • Ochiai, H.1    Fujimuro, M.2    Yokosawa, H.3    Harashima, H.4    Kamiya, H.5
  • 5
    • 0035989006 scopus 로고    scopus 로고
    • CpG-depleted plasmid DNA vectors with enhanced safety and long-term gene expression in vivo
    • Yew, N. S.; Zhao, H.; Przybylska, M.; Wu, I. H.; Tousignant, J. D.; Scheule, R. K.; Cheng, S. H. CpG-depleted plasmid DNA vectors with enhanced safety and long-term gene expression in vivo Mol. Ther. 2002, 5, 731-738
    • (2002) Mol. Ther. , vol.5 , pp. 731-738
    • Yew, N.S.1    Zhao, H.2    Przybylska, M.3    Wu, I.H.4    Tousignant, J.D.5    Scheule, R.K.6    Cheng, S.H.7
  • 6
    • 4344700911 scopus 로고    scopus 로고
    • Long-term transgene expression from plasmid DNA gene therapy vectors is negatively affected by CpG dinucleotides
    • Hodges, B. L.; Taylor, K. M.; Joseph, M. F.; Bourgeois, S. A.; Scheule, R. K. Long-term transgene expression from plasmid DNA gene therapy vectors is negatively affected by CpG dinucleotides Mol. Ther. 2004, 10, 269-278
    • (2004) Mol. Ther. , vol.10 , pp. 269-278
    • Hodges, B.L.1    Taylor, K.M.2    Joseph, M.F.3    Bourgeois, S.A.4    Scheule, R.K.5
  • 7
    • 0041315884 scopus 로고    scopus 로고
    • Minicircle DNA vectors devoid of bacterial DNA result in persistent and high-level transgene expression in vivo
    • Chen, Z. Y.; He, C. Y.; Ehrhardt, A.; Kay, M. A. Minicircle DNA vectors devoid of bacterial DNA result in persistent and high-level transgene expression in vivo Mol. Ther. 2003, 8, 495-500
    • (2003) Mol. Ther. , vol.8 , pp. 495-500
    • Chen, Z.Y.1    He, C.Y.2    Ehrhardt, A.3    Kay, M.A.4
  • 8
    • 2642519089 scopus 로고    scopus 로고
    • Silencing of episomal transgene expression by plasmid bacterial DNA elements in vivo
    • Chen, Z. Y.; He, C. Y.; Meuse, L.; Kay, M. A. Silencing of episomal transgene expression by plasmid bacterial DNA elements in vivo Gene Ther. 2004, 11, 856-864
    • (2004) Gene Ther. , vol.11 , pp. 856-864
    • Chen, Z.Y.1    He, C.Y.2    Meuse, L.3    Kay, M.A.4
  • 9
    • 0041911490 scopus 로고    scopus 로고
    • Long-term therapeutic levels of human alpha-1 antitrypsin in plasma after hydrodynamic injection of nonviral DNA
    • AlinÌo, S. F.; Crespo, A.; Dasié, F. Long-term therapeutic levels of human alpha-1 antitrypsin in plasma after hydrodynamic injection of nonviral DNA Gene Ther. 2003, 10, 1672-1679
    • (2003) Gene Ther. , vol.10 , pp. 1672-1679
    • Alinìo, S.F.1    Crespo, A.2    Dasié, F.3
  • 10
    • 33645528583 scopus 로고    scopus 로고
    • Quantitative comparison of intracellular trafficking and nuclear transcription between adenoviral and lipoplex systems
    • Hama, S.; Akita, H.; Ito, R.; Mizuguchi, H.; Harashima, H. Quantitative comparison of intracellular trafficking and nuclear transcription between adenoviral and lipoplex systems Mol. Ther. 2006, 13, 786-794
    • (2006) Mol. Ther. , vol.13 , pp. 786-794
    • Hama, S.1    Akita, H.2    Ito, R.3    Mizuguchi, H.4    Harashima, H.5
  • 11
    • 0023697252 scopus 로고
    • GAL4-VP16 is an unusually potent transcriptional activator
    • Sadowski, I.; Ma, J.; Triezenberg, S.; Ptashne, M. GAL4-VP16 is an unusually potent transcriptional activator Nature 1988, 335, 563-564
    • (1988) Nature , vol.335 , pp. 563-564
    • Sadowski, I.1    Ma, J.2    Triezenberg, S.3    Ptashne, M.4
  • 12
    • 0032570662 scopus 로고    scopus 로고
    • Evaluation of GAL4/TATA in vivo. Induction of transgene expression by adenovirally mediated gene codelivery
    • Fang, B.; Ji, L.; Bouvet, M.; Roth, J. A. Evaluation of GAL4/TATA in vivo. Induction of transgene expression by adenovirally mediated gene codelivery J. Biol. Chem. 1998, 273, 4972-4975
    • (1998) J. Biol. Chem. , vol.273 , pp. 4972-4975
    • Fang, B.1    Ji, L.2    Bouvet, M.3    Roth, J.A.4
  • 13
    • 0035807838 scopus 로고    scopus 로고
    • Two-step transcriptional amplification as a method for imaging reporter gene expression using weak promoters
    • Iyer, M.; Wu, L.; Carey, M.; Wang, Y.; Smallwood, A.; Gambhir, S. S. Two-step transcriptional amplification as a method for imaging reporter gene expression using weak promoters Proc. Natl. Acad. Sci. U.S.A. 2001, 98, 14595-14600
    • (2001) Proc. Natl. Acad. Sci. U.S.A. , vol.98 , pp. 14595-14600
    • Iyer, M.1    Wu, L.2    Carey, M.3    Wang, Y.4    Smallwood, A.5    Gambhir, S.S.6
  • 14
    • 0348133605 scopus 로고    scopus 로고
    • Optimization of adenoviral vectors to direct highly amplified prostate-specific expression for imaging and gene therapy
    • Sato, M.; Johnson, M.; Zhang, L.; Zhang, B.; Le, K.; Gambhir, S. S.; Carey, M.; Wu, L. Optimization of adenoviral vectors to direct highly amplified prostate-specific expression for imaging and gene therapy Mol. Ther. 2003, 8, 726-737
    • (2003) Mol. Ther. , vol.8 , pp. 726-737
    • Sato, M.1    Johnson, M.2    Zhang, L.3    Zhang, B.4    Le, K.5    Gambhir, S.S.6    Carey, M.7    Wu, L.8
  • 15
    • 33745336510 scopus 로고    scopus 로고
    • Plasmid engineering for controlled and sustained gene expression for nonviral gene therapy
    • van Gaal, E. V.; Hennink, W. E.; Crommelin, D. J.; Mastrobattista, E. Plasmid engineering for controlled and sustained gene expression for nonviral gene therapy Pharm. Res. 2006, 23, 1053-1074
    • (2006) Pharm. Res. , vol.23 , pp. 1053-1074
    • Van Gaal, E.V.1    Hennink, W.E.2    Crommelin, D.J.3    Mastrobattista, E.4
  • 16
    • 0032445097 scopus 로고    scopus 로고
    • A strategy for enhancing the transcriptional activity of weak cell type-specific promoters
    • Nettelbeck, D. M.; Jéroìme, V.; Müller, R. A strategy for enhancing the transcriptional activity of weak cell type-specific promoters Gene Ther. 1998, 5, 1656-1664
    • (1998) Gene Ther. , vol.5 , pp. 1656-1664
    • Nettelbeck, D.M.1    Jéroìme, V.2    Müller, R.3
  • 17
    • 4644262107 scopus 로고    scopus 로고
    • Highly specific transgene expression mediated by a complex adenovirus vector incorporating a prostate-specific amplification feedback loop
    • Woraratanadharm, J.; Rubinchik, S.; Yu, H.; Fan, F.; Morrow, S. M.; Dong, J. Y. Highly specific transgene expression mediated by a complex adenovirus vector incorporating a prostate-specific amplification feedback loop Gene Ther. 2004, 11, 1399-1407
    • (2004) Gene Ther. , vol.11 , pp. 1399-1407
    • Woraratanadharm, J.1    Rubinchik, S.2    Yu, H.3    Fan, F.4    Morrow, S.M.5    Dong, J.Y.6
  • 18
    • 0022893665 scopus 로고
    • Tissue-specific in vitro transcription from the mouse albumin promoter
    • Gorski, K.; Carneiro, M.; Schibler, U. Tissue-specific in vitro transcription from the mouse albumin promoter Cell 1986, 47, 767-776
    • (1986) Cell , vol.47 , pp. 767-776
    • Gorski, K.1    Carneiro, M.2    Schibler, U.3
  • 20
    • 44449145951 scopus 로고    scopus 로고
    • Sustained liver-specific transgene expression from the albumin promoter in mice following hydrodynamic plasmid DNA delivery
    • Wooddell, C. I.; Reppen, T.; Wolff, J. A.; Herweijer, H. Sustained liver-specific transgene expression from the albumin promoter in mice following hydrodynamic plasmid DNA delivery J. Gene Med. 2008, 10, 551-563
    • (2008) J. Gene Med. , vol.10 , pp. 551-563
    • Wooddell, C.I.1    Reppen, T.2    Wolff, J.A.3    Herweijer, H.4
  • 21
    • 0032805251 scopus 로고    scopus 로고
    • Hydrodynamics-based transfection in animals by systemic administration of plasmid DNA
    • Liu, F.; Song, Y.; Liu, D. Hydrodynamics-based transfection in animals by systemic administration of plasmid DNA Gene Ther. 1999, 6, 1258-1266
    • (1999) Gene Ther. , vol.6 , pp. 1258-1266
    • Liu, F.1    Song, Y.2    Liu, D.3
  • 22
    • 0033166561 scopus 로고    scopus 로고
    • High levels of foreign gene expression in hepatocytes after tail vein injections of naked plasmid DNA
    • Zhang, G.; Budker, V.; Wolff, J. A. High levels of foreign gene expression in hepatocytes after tail vein injections of naked plasmid DNA Hum. Gene Ther. 1999, 10, 1735-1737
    • (1999) Hum. Gene Ther. , vol.10 , pp. 1735-1737
    • Zhang, G.1    Budker, V.2    Wolff, J.A.3
  • 23
    • 0027078473 scopus 로고
    • A synergistic increase in potency of a multimerized VP16 transcriptional activation domain
    • Emami, K. H.; Carey, M. A synergistic increase in potency of a multimerized VP16 transcriptional activation domain EMBO J. 1992, 11, 5005-5012
    • (1992) EMBO J. , vol.11 , pp. 5005-5012
    • Emami, K.H.1    Carey, M.2
  • 24
    • 0025098809 scopus 로고
    • A potent GAL4 derivative activates transcription at a distance in vitro
    • Carey, M.; Leatherwood, J.; Ptashne, M. A potent GAL4 derivative activates transcription at a distance in vitro Science 1990, 247, 710-712
    • (1990) Science , vol.247 , pp. 710-712
    • Carey, M.1    Leatherwood, J.2    Ptashne, M.3
  • 25
    • 0029828735 scopus 로고    scopus 로고
    • Biochemical mechanism of transcriptional activation by GAL4-VP16
    • Tantin, D.; Chi, T.; Hori, R.; Pyo, S.; Carey, M. Biochemical mechanism of transcriptional activation by GAL4-VP16 Methods Enzymol. 1996, 274, 133-149
    • (1996) Methods Enzymol. , vol.274 , pp. 133-149
    • Tantin, D.1    Chi, T.2    Hori, R.3    Pyo, S.4    Carey, M.5
  • 27
    • 1442354965 scopus 로고    scopus 로고
    • The activator-recruited cofactor/Mediator coactivator subunit ARC92 is a functionally important target of the VP16 transcriptional activator
    • Yang, F.; DeBeaumont, R.; Zhou, S.; Näär, A. M. The activator-recruited cofactor/Mediator coactivator subunit ARC92 is a functionally important target of the VP16 transcriptional activator Proc. Natl. Acad. Sci. U.S.A. 2004, 101, 2339-2344
    • (2004) Proc. Natl. Acad. Sci. U.S.A. , vol.101 , pp. 2339-2344
    • Yang, F.1    Debeaumont, R.2    Zhou, S.3    Näär, A.M.4
  • 28
    • 0033612538 scopus 로고    scopus 로고
    • Large-scale chromatin unfolding and remodeling induced by VP16 acidic activation domain
    • Tumbar, T.; Sudlow, G.; Belmont, A. S. Large-scale chromatin unfolding and remodeling induced by VP16 acidic activation domain J. Cell Biol. 1999, 145, 1341-1354
    • (1999) J. Cell Biol. , vol.145 , pp. 1341-1354
    • Tumbar, T.1    Sudlow, G.2    Belmont, A.S.3
  • 29
    • 33748415010 scopus 로고    scopus 로고
    • A mechanism for coordinating chromatin modification and preinitiation complex assembly
    • Black, J. C.; Choi, J. E.; Lombardo, S. R.; Carey, M. A mechanism for coordinating chromatin modification and preinitiation complex assembly Mol. Cell 2006, 23, 809-818
    • (2006) Mol. Cell , vol.23 , pp. 809-818
    • Black, J.C.1    Choi, J.E.2    Lombardo, S.R.3    Carey, M.4
  • 30
    • 0025336731 scopus 로고
    • Conversion of the lac repressor into an allosterically regulated transcriptional activator for mammalian cells
    • Labow, M. A.; Baim, S. B.; Shenk, T.; Levine, A. J. Conversion of the lac repressor into an allosterically regulated transcriptional activator for mammalian cells Mol. Cell. Biol. 1990, 10, 3343-3356
    • (1990) Mol. Cell. Biol. , vol.10 , pp. 3343-3356
    • Labow, M.A.1    Baim, S.B.2    Shenk, T.3    Levine, A.J.4
  • 31
    • 0026043945 scopus 로고
    • A chimeric mammalian transactivator based on the lac repressor that is regulated by temperature and isopropyl Β-D-thiogalactopyranoside
    • Baim, S. B.; Labow, M. A.; Levine, A. J.; Shenk, T. A chimeric mammalian transactivator based on the lac repressor that is regulated by temperature and isopropyl Β-D-thiogalactopyranoside Proc. Natl. Acad. Sci. U.S.A. 1991, 88, 5072-5076
    • (1991) Proc. Natl. Acad. Sci. U.S.A. , vol.88 , pp. 5072-5076
    • Baim, S.B.1    Labow, M.A.2    Levine, A.J.3    Shenk, T.4
  • 33
    • 0026720075 scopus 로고
    • Tight control of gene expression in mammalian cells by tetracycline responsive promoters
    • Gossen, M.; Bujard, H. Tight control of gene expression in mammalian cells by tetracycline responsive promoters Proc. Natl. Acad. Sci. U.S.A. 1992, 89, 5547-5551
    • (1992) Proc. Natl. Acad. Sci. U.S.A. , vol.89 , pp. 5547-5551
    • Gossen, M.1    Bujard, H.2
  • 35
    • 64049084841 scopus 로고    scopus 로고
    • Effect of tissue-specific promoters and microRNA recognition elements on stability of transgene expression after hydrodynamic naked plasmid DNA delivery
    • Wolff, L. J.; Wolff, J. A.; Sebestyén, M. G. Effect of tissue-specific promoters and microRNA recognition elements on stability of transgene expression after hydrodynamic naked plasmid DNA delivery Hum. Gene Ther. 2009, 20, 374-388
    • (2009) Hum. Gene Ther. , vol.20 , pp. 374-388
    • Wolff, L.J.1    Wolff, J.A.2    Sebestyén, M.G.3
  • 36
    • 0034202522 scopus 로고    scopus 로고
    • Inclusion of the hepatic locus control region, an intron, and untranslated region increases and stabilizes hepatic factor IX gene expression in vivo but not in vitro
    • Miao, C. H.; Ohashi, K.; Patijn, G. A.; Meuse, L.; Ye, X.; Thompson, A. R.; Kay, M. A. Inclusion of the hepatic locus control region, an intron, and untranslated region increases and stabilizes hepatic factor IX gene expression in vivo but not in vitro Mol. Ther. 2000, 1, 522-532
    • (2000) Mol. Ther. , vol.1 , pp. 522-532
    • Miao, C.H.1    Ohashi, K.2    Patijn, G.A.3    Meuse, L.4    Ye, X.5    Thompson, A.R.6    Kay, M.A.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.