Structural and dynamical effects induced by the anticancer drug topotecan on the human topoisomerase I - DNA Complex

PLoS ONE

Volumn 5, Issue 6, 2010, Pages

  Mancini, Giordano ^a   D'Annessa, Ilda ^a,b   Coletta, Andrea ^b   Sanna, Nico ^a   Chillemi, Giovanni ^a   Desideri, Alessandro ^b  

^a CASPUR   (Italy)

^b UNIVERSITY OF ROME TOR VERGATA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

DNA TOPOISOMERASE; TOPOTECAN;

ARTICLE; CHEMICAL ANALYSIS; CHEMICAL REACTION; CHEMICAL STRUCTURE; COMPUTER SIMULATION; DOUBLE STRANDED DNA BREAK; GENE CLUSTER; HYDROGEN BOND; MOLECULAR DYNAMICS; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN INTERACTION; PROTEIN STRUCTURE;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; CATALYTIC DOMAIN; DNA; DNA TOPOISOMERASES, TYPE I; HUMANS; MODELS, MOLECULAR; MOLECULAR DYNAMICS SIMULATION; PROTEIN STRUCTURE, SECONDARY; TOPOISOMERASE I INHIBITORS; TOPOTECAN;

EID: 77955180152     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0010934     Document Type: Article

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