The unusual nucleotide recognition properties of the resistance enzyme ANT(4′): Inorganic Tri/polyphosphate as a substrate for aminoglycoside inactivation

Chemistry - A European Journal

Volumn 16, Issue 29, 2010, Pages 8635-8640

  Revuelta, Julia ^a   Corzana, Francisco ^b   Bastida, Agatha ^a   Asensio, Juan Luis ^a  

^a INSTITUTO DE QUÍMICA ORGÁNICA GENERAL   (Spain)

^b UNIVERSITY OF LA RIOJA   (Spain)

Author keywords

Aminoglycoside inactivation; Antibiotics; Enzymes; Isothermal titration calorimetry (ITC); Nucleotide binding; Nucleotides

Indexed keywords

AMINOGLYCOSIDE INACTIVATION; AMINOGLYCOSIDES; BINDING EPITOPES; COSUBSTRATES; ISOTHERMAL TITRATION CALORIMETRY; MOLECULAR DETERMINANTS; NUCLEOTIDE BINDING; POLYPHOSPHATES; RECOGNITION PROPERTIES; TRIPHOSPHATE;

ANTIBIOTICS; CALORIMETRY; CATALYSTS; ENZYME ACTIVITY; ENZYMES; OLIGOMERS; TITRATION;

NUCLEOTIDES;

AMINOGLYCOSIDE; ANTIINFECTIVE AGENT; PHOSPHATE;

ANTIBIOTIC RESISTANCE; ARTICLE; CHEMICAL STRUCTURE; CHEMISTRY; DRUG ANTAGONISM; ENZYME SPECIFICITY; ENZYMOLOGY; STAPHYLOCOCCUS AUREUS; THERMODYNAMICS;

AMINOGLYCOSIDES; ANTI-BACTERIAL AGENTS; DRUG RESISTANCE, BACTERIAL; MODELS, MOLECULAR; PHOSPHATES; STAPHYLOCOCCUS AUREUS; SUBSTRATE SPECIFICITY; THERMODYNAMICS;

EID: 77955144385     PISSN: 09476539     EISSN: 15213765     Source Type: Journal    
DOI: 10.1002/chem.201000641     Document Type: Article

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