Synthesis of a phosphonate-linked aminoglycoside-coenzyme a bisubstrate and use in mechanistic studies of an enzyme involved in aminoglycoside resistance

Chemistry - A European Journal

Volumn 15, Issue 9, 2009, Pages 2064-2070

  Gao, Feng ^a,b   Yan, Xuxu ^a   Auclair, Karine ^a  

^a MCGILL UNIVERSITY   (Canada)

^b ALBANY MOLECULAR RESEARCH INC   (United States)

Author keywords

Coenzyme A; Enzyme; Inhibitors; Medicinal chemistry; Michael addition; Neamine

Indexed keywords

AMIDES; CATALYSIS; FUNCTIONAL GROUPS; FUNCTIONAL MATERIALS; HUMAN REHABILITATION ENGINEERING; SULFUR COMPOUNDS;

COENZYME A; INHIBITORS; MEDICINAL CHEMISTRY; MICHAEL ADDITION; NEAMINE;

ENZYMES;

ACYLTRANSFERASE; AMINOGLYCOSIDE; AMINOGLYCOSIDE N(6') ACETYLTRANSFERASE; AMINOGLYCOSIDE N(6')-ACETYLTRANSFERASE; COENZYME A; FRAMYCETIN; NEAMINE; PHOSPHONIC ACID DERIVATIVE;

ANTIBIOTIC RESISTANCE; ARTICLE; CATALYSIS; CHEMISTRY; ENTEROCOCCUS FAECIUM; ENZYMOLOGY; METABOLISM; SYNTHESIS;

ACETYLTRANSFERASES; AMINOGLYCOSIDES; CATALYSIS; COENZYME A; DRUG RESISTANCE, BACTERIAL; ENTEROCOCCUS FAECIUM; FRAMYCETIN; PHOSPHONIC ACIDS;

EID: 60749102929     PISSN: 09476539     EISSN: 15213765     Source Type: Journal    
DOI: 10.1002/chem.200802172     Document Type: Article

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