Combination of rapamycin and IL-2 do not affect antigen presentation ability of rat B cell and could promote Tregs proliferation and inhibitory activity

Cellular Immunology

Volumn 264, Issue 2, 2010, Pages 180-185

  Zhang, Chuntao ^a   Shan, Juan ^a   Lu, Jun ^a   Huang, Yuchuan ^a   Feng, Li ^a   Long, Dan ^a   Li, Shengfu ^a   Li, Quansheng ^a   Li, Youping ^a,b  

^a SICHUAN UNIVERSITY   (China)

^b Chinese Evidence Based Medicine Centre   (China)

Author keywords

Immune tolerance; Rapamycin; Rat; Tregs

Indexed keywords

CD4 ANTIGEN; INTERLEUKIN 2; INTERLEUKIN 2 RECEPTOR ALPHA; MESSENGER RNA; PROTEIN PIM 2; RAPAMYCIN; TRANSCRIPTION FACTOR FOXP3; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG; FORKHEAD TRANSCRIPTION FACTOR; FOXP3 PROTEIN, RAT;

ANIMAL CELL; ANTIGEN PRESENTATION; ANTIGEN PRESENTING CELL; ARTICLE; B LYMPHOCYTE; CD4+ CD25+ T LYMPHOCYTE; CONTROLLED STUDY; DRUG EFFECT; EFFECTOR CELL; GENE EXPRESSION; IMMUNOLOGICAL TOLERANCE; IN VITRO STUDY; LYMPHOCYTE PROLIFERATION; NONHUMAN; PRIORITY JOURNAL; RAT; REGULATORY T LYMPHOCYTE; ANIMAL; BIOSYNTHESIS; CELL CULTURE; CELL PROLIFERATION; DRUG COMBINATION; DRUG EFFECTS; GENETICS; IMMUNOLOGY; IMMUNOSUPPRESSIVE TREATMENT; LEWIS RAT; METABOLISM; PATHOLOGY;

ANIMALS; ANTIGEN PRESENTATION; ANTIGENS, CD4; B-LYMPHOCYTES; CELL PROLIFERATION; CELLS, CULTURED; DRUG THERAPY, COMBINATION; FORKHEAD TRANSCRIPTION FACTORS; IMMUNOSUPPRESSION; INTERLEUKIN-2; INTERLEUKIN-2 RECEPTOR ALPHA SUBUNIT; RATS; RATS, INBRED LEW; SIROLIMUS; T-LYMPHOCYTES, REGULATORY; TRANSFORMING GROWTH FACTOR BETA1;

RATTUS;

EID: 77955095308     PISSN: 00088749     EISSN: 10902163     Source Type: Journal    
DOI: 10.1016/j.cellimm.2010.06.008     Document Type: Article

References (23)

1. + regulatory T cells. Transl Res. 2009, 153:60-70.
2. + regulatory T lymphocytes. Nat. Med. 2008, 14:88-92.
3. Stephan S., Datta K., Wang E., et al. Effect of rapamycin alone and in combination with antiangiogenesis therapy in an orthotopic model of human pancreatic cancer. Clin Cancer Res. 2004, 10:6993-7000.
4. Majewski M., Korecka M., Kossev P., et al. The immunosuppressive macrolide RAD inhibits growth of human Epstein-Barr virus-trans-formed B lymphocytes in vitro and in vivo: a potential approach to prevention and teatment of posttransplant lymphoproliferative disorders. Proc Natl Acad Med Sci USA 2000, 97:4285-4290.
5. + T cells. J. Autoimmun. 2008, 30:293-302.
6. + regulatory T cells cultured with rapamycin. J. Immunol. 2007, 178:320-329.
7. Groth C.G., Backman L., Morales J.M., et al. Sirolimus (rapamycin)-based therapy in human renal transplantation: similar efficacy and different toxicity compared with cyclosporine. Sirolimus European Renal Transplant Study Group. Transplantation 1999, 67:1036.
8. MacDonald A.S. A worldwide, phase III, randomized, controlled, safety and efficacy study of a sirolimus/cyclosporine regimen for prevention of acute rejection in recipients of primary mismatched renal allografts. Transplantation 2001, 71:271-280. The Rapamune Global Study Group.
9. + regulatory T cells. Blood 2005, 105:4743-4748.
10. L.C. Chen, J.C. Delgado, P.E. Jensen, et al. Direct expansion of human allospecific FoxP3+CD4+ regulatory T cells with allogeneic B cells for therapeutic application. J Immunol. (2009)15; 183(6):4094-4102.
11. + naturally anergic and suppressive T cells as a key function of the thymus in maintaining immunologic self-tolerance. Immunology 1999, 162:5317-5326.
12. + regulatory T cells ameliorates rejection of DA-to-lewis rat liver transplantation. Surgery 2007, 142:67-73.
13. + T cells. J. Immunol. 2006, 177:944-949.
14. +regulatory T cells by antigen-processing dendritic cells. J. Exp. Med. 2003, 198:235-247.
15. +T regulatory cells in human neonatal T cell responses to environmental antigens/allergens. J. Immunol. 2004, 173:3084-3092.
16. + regulatory T cell function. J. Exp. Med. 2002, 196:851-857.
17. Hori S., Nomura T., Sakaguchi S. Control of regulatory T cell development by the transcription factor Foxp3. Science 2003, 299:1057-1061.
18. + regulatory T cells. Nat. Immunol. 2003, 4:330-336.
19. + T regulatory cells. Nat. Immunol. 2003, 4:337-342.
20. + regulatory T cells is mediated by cell surface-bound transforming growth factor beta. J. Exp. Med. 2001, 194:629-644.
21. Mikkers H., Nawijn M., Allen J., et al. Mice deficient for all PIM kinases display reduced body size and impaired responses to hematopoietic growth factors. Mol. Cell. Biol. 2004, 24:6104-6115.
22. Fox C.J., Hammerman P.S., Cinalli R.M., et al. The serine/threonine kinase Pim-2 is a transcriptionally regulated apopototic inhibitor. Genes Dev. 2003, 17:1841-1854.
23. Mizuki M., Schwable J., Steur C. Et al.Suppression of myeloid transcription factors and induction of STAT response genes by AML-specific Flt3 mutations. Blood 2003, 101:3164-3173.