CpG island methylator phenotype in colorectal cancer: A current perspective

Current Colorectal Cancer Reports

Volumn 4, Issue 2, 2008, Pages 77-83

  Goel, Ajay ^a   Shin, Sung Kwan ^b  

^a BAYLOR UNIVERSITY MEDICAL CENTER   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

EID: 77955070735     PISSN: 15563790     EISSN: 15563804     Source Type: Journal    
DOI: 10.1007/s11888-008-0014-1     Document Type: Review

References (52)

1. Vogelstein B, Kinzler KW: Cancer genes and the pathways they control. Nat Med 2004, 10:789-799.
2. Herman JG, Baylin SB: Gene silencing in cancer in association with promoter hypermethylation. N Engl J Med 2003, 349:2042-2054.
3. Liu B, Farrington SM, Petersen GM, et al.: Genetic instability occurs in the majority of young patients with colorectal cancer. Nat Med 1995, 1:348-352.
4. Kane MF, Loda M, Gaida GM, et al.: Methylation of the hMLH1 promoter correlates with lack of expression of hMLH1 in sporadic colon tumors and mismatch repair-defective human tumor cell lines. Cancer Res 1997, 57:808-811.
5. Hanahan D, Weinberg RA: The hallmarks of cancer. Cell 2000, 100:57-70.
6. Greger V, Passarge E, Hopping W, et al.: Epigenetic changes may contribute to the formation and spontaneous regression of retinoblastoma. Hum Genet 1989, 83:155-158.
7. Toyota M, Ahuja N, Ohe-Toyota M, et al.: CpG island methylator phenotype in colorectal cancer. Proc Natl Acad Sci U S A 1999, 96:8681-8686.
8. Jones PA, Laird PW: Cancer epigenetics comes of age. Nat Genet 1999, 21:163-167.
9. Goel A, Nagasaka T, Arnold CN, et al.: The CpG island methylator phenotype and chromosomal instability are inversely correlated in sporadic colorectal cancer. Gastroen-terology 2007, 132:127-138.
10. Samowitz WS, Albertsen H, Herrick J, et al.: Evaluation of a large, population-based sample supports a CpG island methylator phenotype in colon cancer. Gastroenterology 2005, 129:837-845.
11. Ahuja N, Mohan AL, Li Q, et al.: Association between CpG island methylation and microsatellite instability in colorectal cancer. Cancer Res 1997, 57:3370-3374.
12. Toyota M, Ohe-Toyota M, Ahuja N, Issa JP: Distinct genetic profles in colorectal tumors with or without the CpG island methylator phenotype. Proc Natl Acad Sci U S A 2000, 97:710-715.
13. Eads CA, Danenberg KD, Kawakami K, et al.: CpG island hypermethylation in human colorectal tumors is not associated with DNA methyltransferase overexpression. Cancer Res 1999, 59:2302-2306.
14. Yamashita K, Dai T, Dai Y, et al.: Genetics supersedes epigenetics in colon cancer phenotype. Cancer Cell 2003, 4:121-131.
15. Whitehall VL, Wynter CV, Walsh MD, et al.: Morphological and molecular heterogeneity within nonmicrosatellite instability-high colorectal cancer. Cancer Res 2002, 62:6011-6014.
16. Hawkins N, Norrie M, Cheong K, et al.: CpG island methylation in sporadic colorectal cancers and its relationship to microsatellite instability. Gastroenterology 2002, 122:1376-1387.
17. Van RM, Grieu F, Elsaleh H, et al.: Characterisation of colorectal cancers showing hypermethylation at multiple CpG islands. Gut 2002, 51:797-802.
18. Kim H, Kim YH, Kim SE, et al.: Concerted promoter hypermethylation of hMLH1, p16INK4A, and E-cadherin in gastric carcinomas with microsatellite instability. J Pathol 2003, 200:23-31.
19. Shen L, Ahuja N, Shen Y, et al.: DNA methylation and environmental exposures in human hepatocellular carcinoma. J Natl Cancer Inst 2002, 94:755-761.
20. Garcia-Manero G, Daniel J, Smith TL, et al.: DNA methylation of multiple promoter-associated CpG islands in adult acute lymphocytic leukemia. Clin Cancer Res 2002, 8:2217-2224.
21. Frazier ML, Xi L, Zong J, et al.: Association of the CpG island methylator phenotype with family history of cancer in patients with colorectal cancer. Cancer Res 2003, 63:4805-4808.
22. Rashid A, Issa JP: CpG island methylation in gastroentero-logic neoplasia: a maturing feld. Gastroenterology 2004, 127:1578-1588.
23. Weisenberger DJ, Siegmund KD, Campan M, et al.: CpG island methylator phenotype underlies sporadic microsatellite instability and is tightly associated with BRAF mutation in colorectal cancer. Nat Genet 2006, 38:787-793.
24. Ogino S, Cantor M, Kawasaki T, et al.: CpG island methylator phenotype (CIMP) of colorectal cancer is best characterised by quantitative DNA methylation analysis and prospective cohort studies. Gut 2006, 55:1000-1006.
25. Goel A, Arnold CN, Niedzwiecki D, et al.: Characterization of sporadic colon cancer by patterns of genomic instability. Cancer Res 2003, 63:1608-1614.
26. Samowitz WS: The CpG island methylator phenotype in colorectal cancer. J Mol Diagn 2007, 9:281-283.
27. Watanabe T, Wu TT, Catalano PJ, et al.: Molecular predictors of survival after adjuvant chemotherapy for colon cancer. N Engl J Med 2001, 344:1196-1206.
28. Ward RL, Cheong K, Ku SL, et al.: Adverse prognostic effect of methylation in colorectal cancer is reversed by microsatellite instability. J Clin Oncol 2003, 21:3729-3736.
29. Davies H, Bignell GR, Cox C, et al.: Mutations of the BRAF gene in human cancer. Nature 2002, 417:949-954.
30. Yuen ST, Davies H, Chan TL, et al.: Similarity of the phenotypic patterns associated with BRAF and KRAS mutations in colorectal neoplasia. Cancer Res 2002, 62:6451-6455.
31. Kambara T, Simms LA, Whitehall VL, et al.: BRAF mutation is associated with DNA methylation in serrated polyps and cancers of the colorectum. Gut 2004, 53:1137-1144.
32. Minoo P, Moyer MP, Jass JR: Role of BRAF-V600E in the serrated pathway of colorectal tumourigenesis. J Pathol 2007, 212:124-133.
33. Peli J, Schroter M, Rudaz C, et al.: Oncogenic Ras inhibits Fas ligand-mediated apoptosis by downregulating the expression of Fas. EMBO J 1999, 18:1824-1831.
34. Gazin C, Wajapeyee N, Gobeil S, et al.: An elaborate pathway required for Ras-mediated epigenetic silencing. Nature 2007, 449:1073-1077.
35. Ogino S, Kawasaki T, Kirkner GJ, et al.: CpG island methylator phenotype-low (CIMP-low) in colorectal cancer: possible associations with male sex and KRAS mutations. J Mol Diagn 2006, 8:582-588.
36. Shen L, Toyota M, Kondo Y, et al.: Integrated genetic and epigenetic analysis identifes three different subclasses of colon cancer. Proc Natl Acad Sci U S A 2007, 104:18654-18659.
37. Nagasaka T, Koi M, Kloor M, et al.: Mutations in both KRAS and BRAF contribute to the methylator phenotype in colon cancer. Gastroenterology 2008, In press.
38. Robertson KD, Wolffe AP: DNA methylation in health and disease. Nat Rev Genet 2000, 1:11-19.
39. Li E: Chromatin modifcation and epigenetic reprogramming in mammalian development. Nat Rev Genet 2002, 3:662-673.
40. Samowitz WS, Albertsen H, Sweeney C, et al.: Association of smoking, CpG island methylator phenotype, and V600E BRAF mutations in colon cancer. J Natl Cancer Inst 2006, 98:1731-1738.
41. Slattery ML, Curtin K, Sweeney C, et al.: Diet and lifestyle factor associations with CpG island methylator phenotype and BRAF mutations in colon cancer. Int J Cancer 2007, 120:656-663.
42. Kaneko Y, Sakurai S, Hironaka M, et al.: Distinct methylated profles in Helicobacter pylori dependent and independent gastric MALT lymphomas. Gut 2003, 52:641-646.
43. Maekita T, Nakazawa K, Mihara M, et al.: High levels of aberrant DNA methylation in Helicobacter pylori-infected gastric mucosae and its possible association with gastric cancer risk. Clin Cancer Res 2006, 12:989-995.
44. Chan AO, Peng JZ, Lam SK, et al.: Eradication of Heli-cobacter pylori infection reverses E-cadherin promoter hypermethylation. Gut 2006, 55:463-468.
45. Perri F, Cotugno R, Piepoli A, et al.: Aberrant DNA methylation in non-neoplastic gastric mucosa of H. Pylori infected patients and effect of eradication. Am J Gastroen-terol 2007, 102:1361-1371.
46. Goel A, Li MS, Nagasaka T, et al.: Association of JC virus T-antigen expression with the methylator phenotype in sporadic colorectal cancers. Gastroenterology 2006, 130:1950-1961.
47. Herath NI, Leggett BA, Macdonald GA: Review of genetic and epigenetic alterations in hepatocarcinogenesis. J Gastroenterol Hepatol 2006, 21:15-21.
48. Kang GH, Lee S, Kim WH, et al.: Epstein-Barr virus-positive gastric carcinoma demonstrates frequent aberrant methylation of multiple genes and constitutes CpG island methylator phenotype-positive gastric carcinoma. Am J Pathol 2002, 160:787-794.
49. Ohm JE, McGarvey KM, Yu X, et al.: A stem cell-like chromatin pattern may predispose tumor suppressor genes to DNA hypermethylation and heritable silencing. Nat Genet 2007, 39:237-242.
50. Ohm JE, Baylin SB: Stem cell chromatin patterns: an instructive mechanism for DNA hypermethylation? Cell Cycle 2007, 6:1040-1043.
51. Rashid A, Shen L, Morris JS, et al.: CpG island methylation in colorectal adenomas. Am J Pathol 2001, 159:1129-1135.
52. Ogino S, Odze RD, Kawasaki T, et al.: Correlation of pathologic features with CpG island methylator phenotype (CIMP) by quantitative DNA methylation analysis in colorectal carcinoma. Am J Surg Pathol 2006, 30:1175-1183.