-
1
-
-
1442349808
-
Academia given a helping hand in drug development
-
Verkman A.S. Academia given a helping hand in drug development. Am. J. Physiol. Cell Physiol. 286 (2004) 465-474
-
(2004)
Am. J. Physiol. Cell Physiol.
, vol.286
, pp. 465-474
-
-
Verkman, A.S.1
-
2
-
-
33748286712
-
Why academic drug discovery makes sense
-
Kozikowski A.P., et al. Why academic drug discovery makes sense. Science 313 (2006) 1235-1236
-
(2006)
Science
, vol.313
, pp. 1235-1236
-
-
Kozikowski, A.P.1
-
3
-
-
58149141541
-
Drug discovery: new models for industry -academic partnerships
-
Tralau-Stewart C.J., et al. Drug discovery: new models for industry -academic partnerships. Drug Discovery Today 14 (2009) 95-101
-
(2009)
Drug Discovery Today
, vol.14
, pp. 95-101
-
-
Tralau-Stewart, C.J.1
-
4
-
-
21144440283
-
Chemical genetics to chemical genomics: small molecules offer big insights
-
Spring D.R. Chemical genetics to chemical genomics: small molecules offer big insights. Chem. Soc. Rev. 34 (2005) 472-482
-
(2005)
Chem. Soc. Rev.
, vol.34
, pp. 472-482
-
-
Spring, D.R.1
-
5
-
-
57049118570
-
A robotic platform for quantitative high-throughput screening
-
Michael S., et al. A robotic platform for quantitative high-throughput screening. Assay Drug Dev. Technol. 6 (2008) 637-658
-
(2008)
Assay Drug Dev. Technol.
, vol.6
, pp. 637-658
-
-
Michael, S.1
-
6
-
-
45749087356
-
Chemical biology - identification of small molecule modulators of cellular activity by natural product inspired synthesis
-
Hübel K., et al. Chemical biology - identification of small molecule modulators of cellular activity by natural product inspired synthesis. Chem. Soc. Rev. 37 (2008) 1361-1374
-
(2008)
Chem. Soc. Rev.
, vol.37
, pp. 1361-1374
-
-
Hübel, K.1
-
7
-
-
34447538141
-
High-throughput screening assays for the identification of chemical probes
-
Inglese J., et al. High-throughput screening assays for the identification of chemical probes. Nat. Chem. Biol. 3 (2007) 466-479
-
(2007)
Nat. Chem. Biol.
, vol.3
, pp. 466-479
-
-
Inglese, J.1
-
8
-
-
33846807642
-
Genomics and proteomics: from genes to function: advances in applications of chemical and systems biology
-
Bogyo M., et al. Genomics and proteomics: from genes to function: advances in applications of chemical and systems biology. Curr. Opin. Chem. Biol. 11 (2007) 1-3
-
(2007)
Curr. Opin. Chem. Biol.
, vol.11
, pp. 1-3
-
-
Bogyo, M.1
-
9
-
-
33947280523
-
Lead-like, drug-like or "Pub-like": how different are they?
-
Oprea T.I., et al. Lead-like, drug-like or "Pub-like": how different are they?. J. Comput. Aid. Mol. Des. 21 (2007) 113-119
-
(2007)
J. Comput. Aid. Mol. Des.
, vol.21
, pp. 113-119
-
-
Oprea, T.I.1
-
10
-
-
34347212482
-
Building a pharmacological lexicon: small molecule discovery in Academia
-
Lazo J.S., et al. Building a pharmacological lexicon: small molecule discovery in Academia. Mol. Pharmacol. 72 (2007) 1-7
-
(2007)
Mol. Pharmacol.
, vol.72
, pp. 1-7
-
-
Lazo, J.S.1
-
11
-
-
33845274056
-
Translational research in academia and industry
-
Clackson T. Translational research in academia and industry. Exp. Biol. Med. 231 (2006) 1685-1689
-
(2006)
Exp. Biol. Med.
, vol.231
, pp. 1685-1689
-
-
Clackson, T.1
-
12
-
-
43249128376
-
The structural basis for cap binding by influenza virus polymerase subunit PB2
-
Guilligay D., et al. The structural basis for cap binding by influenza virus polymerase subunit PB2. Nat. Struct. Mol. Biol. 15 (2008) 500-506
-
(2008)
Nat. Struct. Mol. Biol.
, vol.15
, pp. 500-506
-
-
Guilligay, D.1
-
13
-
-
33746047675
-
Discovery of protein phosphatase inhibitor classes by biology-oriented synthesis
-
Nören-Müller A., et al. Discovery of protein phosphatase inhibitor classes by biology-oriented synthesis. Proc. Natl. Acad. Sci. U. S. A. 10 (2006) 10606-10611
-
(2006)
Proc. Natl. Acad. Sci. U. S. A.
, vol.10
, pp. 10606-10611
-
-
Nören-Müller, A.1
-
14
-
-
33646538811
-
Gold in the ivory tower: equity rewards of outlicensing
-
Edwards M., et al. Gold in the ivory tower: equity rewards of outlicensing. Nat. Biotechnol. 24 (2006) 509-515
-
(2006)
Nat. Biotechnol.
, vol.24
, pp. 509-515
-
-
Edwards, M.1
-
15
-
-
12344250982
-
Small-molecule screening and profiling by using automated microscopy
-
Mitchison T.J. Small-molecule screening and profiling by using automated microscopy. Chembiochem 6 (2005) 33-39
-
(2005)
Chembiochem
, vol.6
, pp. 33-39
-
-
Mitchison, T.J.1
-
16
-
-
37749050446
-
Comparison of miniaturized time-resolved fluorescence resonance energy transfer and enzyme-coupled Luciferase high-throughput screening assays to discover inhibitors of Rho-Kinase II (ROCK-II)
-
Schröter T., et al. Comparison of miniaturized time-resolved fluorescence resonance energy transfer and enzyme-coupled Luciferase high-throughput screening assays to discover inhibitors of Rho-Kinase II (ROCK-II). J. Biomol. Screen. 13 (2008) 17-28
-
(2008)
J. Biomol. Screen.
, vol.13
, pp. 17-28
-
-
Schröter, T.1
-
17
-
-
33645887230
-
Critical review of the role of HTS in drug discovery
-
Macarron R. Critical review of the role of HTS in drug discovery. Drug Discov. Today 11 (2006) 277-279
-
(2006)
Drug Discov. Today
, vol.11
, pp. 277-279
-
-
Macarron, R.1
-
18
-
-
12844283957
-
High-throughput drug discovery: what can we expect from HTS?
-
Gribbon P., et al. High-throughput drug discovery: what can we expect from HTS?. Drug Discov. Today 10 (2005) 17-22
-
(2005)
Drug Discov. Today
, vol.10
, pp. 17-22
-
-
Gribbon, P.1
-
19
-
-
37749002867
-
Case study: impact of technology investment on lead discovery at Bristol-Myers Squibb, 1998-2006
-
Houston J.G., et al. Case study: impact of technology investment on lead discovery at Bristol-Myers Squibb, 1998-2006. Drug Discovery Today 13 (2008) 44-51
-
(2008)
Drug Discovery Today
, vol.13
, pp. 44-51
-
-
Houston, J.G.1
-
20
-
-
34250752914
-
The interdependence between screening methods and screening libraries
-
Shelat A.A., et al. The interdependence between screening methods and screening libraries. Curr. Opin. Chem. Biol. 11 (2007) 244-251
-
(2007)
Curr. Opin. Chem. Biol.
, vol.11
, pp. 244-251
-
-
Shelat, A.A.1
-
21
-
-
57549104046
-
Comprehensive survey of chemical libraries for drug discovery and chemical biology
-
Dolle R.E., et al. Comprehensive survey of chemical libraries for drug discovery and chemical biology. J. Comb. Chem. 10 (2007) 753-802
-
(2007)
J. Comb. Chem.
, vol.10
, pp. 753-802
-
-
Dolle, R.E.1
-
22
-
-
37749014576
-
Lab automation: tales along the road to automation
-
Blow N. Lab automation: tales along the road to automation. Nat. Methods 5 (2008) 109-112
-
(2008)
Nat. Methods
, vol.5
, pp. 109-112
-
-
Blow, N.1
-
23
-
-
33645464806
-
Cellular imaging in drug discovery
-
Lang P., et al. Cellular imaging in drug discovery. Nat. Rev. Drug Discov. 5 (2006) 343-356
-
(2006)
Nat. Rev. Drug Discov.
, vol.5
, pp. 343-356
-
-
Lang, P.1
-
24
-
-
46749105500
-
The impact of diversity-based, high-throughput screening on drug discovery: "Chance favours the prepared mind"
-
Snowden M., et al. The impact of diversity-based, high-throughput screening on drug discovery: "Chance favours the prepared mind". Curr. Opin. Drug Discov. Dev. 11 (2008) 553-558
-
(2008)
Curr. Opin. Drug Discov. Dev.
, vol.11
, pp. 553-558
-
-
Snowden, M.1
-
25
-
-
5044250975
-
High-throughput screening at McMaster University: automation in academe
-
Cechetto J.D., et al. High-throughput screening at McMaster University: automation in academe. J. Assoc. Lab. Autom. 9 (2004) 307-311
-
(2004)
J. Assoc. Lab. Autom.
, vol.9
, pp. 307-311
-
-
Cechetto, J.D.1
-
26
-
-
33744550519
-
Small molecule screening by imaging
-
Eggert U.S., et al. Small molecule screening by imaging. Curr. Opin. Chem. Biol. 10 (2006) 232-237
-
(2006)
Curr. Opin. Chem. Biol.
, vol.10
, pp. 232-237
-
-
Eggert, U.S.1
-
27
-
-
33947395259
-
High-content siRNA screening
-
Krausz E. High-content siRNA screening. Mol. BioSyst. 3 (2007) 232-240
-
(2007)
Mol. BioSyst.
, vol.3
, pp. 232-240
-
-
Krausz, E.1
-
28
-
-
34548317025
-
The potential of high-content high-throughput microscopy in drug discovery
-
Starkuviene V., et al. The potential of high-content high-throughput microscopy in drug discovery. Br. J. Pharmacol. 152 (2007) 62-71
-
(2007)
Br. J. Pharmacol.
, vol.152
, pp. 62-71
-
-
Starkuviene, V.1
-
29
-
-
85032752151
-
Test informatics challenges of high-throughput microscopy
-
Xiaobo Z., et al. Test informatics challenges of high-throughput microscopy. Signal Process. Mag. 23 (2006) 63-72
-
(2006)
Signal Process. Mag.
, vol.23
, pp. 63-72
-
-
Xiaobo, Z.1
-
30
-
-
40849141939
-
Helping science to succeed: improving processes in R&D
-
Sewing A., et al. Helping science to succeed: improving processes in R&D. Drug Discov. Today 13 (2008) 227-233
-
(2008)
Drug Discov. Today
, vol.13
, pp. 227-233
-
-
Sewing, A.1
-
31
-
-
42949133852
-
Academic institutions and industry: bridging the gap
-
Hofbauer K.G. Academic institutions and industry: bridging the gap. Expert Opin. Drug Discov. 3 (2008) 369-373
-
(2008)
Expert Opin. Drug Discov.
, vol.3
, pp. 369-373
-
-
Hofbauer, K.G.1
-
32
-
-
48149083026
-
Pharmaceutical strategy and innovation: an academic's perspective
-
Baxendale I.R., et al. Pharmaceutical strategy and innovation: an academic's perspective. ChemMedChem 2 (1997) 768-788
-
(1997)
ChemMedChem
, vol.2
, pp. 768-788
-
-
Baxendale, I.R.1
-
33
-
-
33750311712
-
DNA-encoded chemical libraries
-
Scheuermann J., et al. DNA-encoded chemical libraries. J. Biotechnol. 126 (2006) 568-581
-
(2006)
J. Biotechnol.
, vol.126
, pp. 568-581
-
-
Scheuermann, J.1
-
34
-
-
68049137094
-
-
Morgan, B. et al. [Praecis Pharmaceuticals Incorporated] (2007) Methods for identifying compounds of interest using encoded libraries. USP Application 20070224607
-
Morgan, B. et al. [Praecis Pharmaceuticals Incorporated] (2007) Methods for identifying compounds of interest using encoded libraries. USP Application 20070224607
-
-
-
-
35
-
-
34249013394
-
Lead discovery by DNA-encoded chemical libraries
-
Melkko S., et al. Lead discovery by DNA-encoded chemical libraries. Drug Discov. Today 12 (2007) 465-471
-
(2007)
Drug Discov. Today
, vol.12
, pp. 465-471
-
-
Melkko, S.1
-
36
-
-
54049117207
-
Compound discovery tools still evolving
-
Lipp E. Compound discovery tools still evolving. Genet. Eng. Biotech. News 28 (2008) 5
-
(2008)
Genet. Eng. Biotech. News
, vol.28
, pp. 5
-
-
Lipp, E.1
-
37
-
-
29144453813
-
Characterisation of kinase-selective inhibitors by chemical proteomics
-
Daub H. Characterisation of kinase-selective inhibitors by chemical proteomics. Biochim. Biophys. Acta 1754 (2005) 183-190
-
(2005)
Biochim. Biophys. Acta
, vol.1754
, pp. 183-190
-
-
Daub, H.1
-
38
-
-
19944432043
-
Cellular targets of gefitinib
-
Brehmer D., et al. Cellular targets of gefitinib. Cancer Res. 65 (2005) 379-382
-
(2005)
Cancer Res.
, vol.65
, pp. 379-382
-
-
Brehmer, D.1
-
39
-
-
55049140325
-
Chemical and pathway proteomics: powerful tools for oncology drug discovery and personalized health care
-
Kruse U., et al. Chemical and pathway proteomics: powerful tools for oncology drug discovery and personalized health care. Mol. Cell. Proteom. 7 (2008) 1887-1901
-
(2008)
Mol. Cell. Proteom.
, vol.7
, pp. 1887-1901
-
-
Kruse, U.1
-
40
-
-
0026647914
-
Encoded combinatorial chemistry
-
Brenner S., et al. Encoded combinatorial chemistry. Proc. Natl. Acad. Sci. U. S. A. 89 (1992) 5381-5383
-
(1992)
Proc. Natl. Acad. Sci. U. S. A.
, vol.89
, pp. 5381-5383
-
-
Brenner, S.1
|