Antihypertensive activity of Salvia elegans Vahl. (Lamiaceae): ACE inhibition and angiotensin II antagonism

Journal of Ethnopharmacology

Volumn 130, Issue 2, 2010, Pages 340-346

  Jiménez Ferrer, Enrique ^a   Hernández Badillo, Fidel ^a   González Cortazar, Manases ^a   Tortoriello, Jaime ^a   Herrera Ruiz, Maribel ^a  

^a INSTITUTO MEXICANO DEL SEGURO SOCIAL   (Mexico)

Author keywords

Angiotensin converting enzyme; Angiotensin II; Salvia elegans

Indexed keywords

ANGIOTENSIN II ANTAGONIST; DIPEPTIDYL CARBOXYPEPTIDASE; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; LISINOPRIL; LOSARTAN; PLANT EXTRACT; SALVIA ELEGANS EXTRACT; UNCLASSIFIED DRUG; ANGIOTENSIN 1 RECEPTOR ANTAGONIST; ANGIOTENSIN II; ANTIHYPERTENSIVE AGENT;

ANGIOSPERM; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIHYPERTENSIVE ACTIVITY; ARTICLE; BLOOD PRESSURE; CONTROLLED STUDY; DIASTOLIC BLOOD PRESSURE; ENZYME ACTIVE SITE; ENZYME ACTIVITY; MOUSE; NONHUMAN; SALVIA ELEGANS; SYSTOLIC BLOOD PRESSURE; ULTRAVIOLET SPECTROSCOPY; ANIMAL; ANTAGONISTS AND INHIBITORS; CHEMICALLY INDUCED; CHEMISTRY; DISEASE MODEL; DOSE RESPONSE; DRUG EFFECTS; HYPERTENSION; INSTITUTE FOR CANCER RESEARCH MOUSE; INTRAVENOUS DRUG ADMINISTRATION; KINETICS; METABOLISM; PATHOPHYSIOLOGY; PLANT; SALVIA; THIN LAYER CHROMATOGRAPHY; ULTRAVIOLET SPECTROPHOTOMETRY;

ANGIOTENSIN II; ANGIOTENSIN II TYPE 1 RECEPTOR BLOCKERS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; ANIMALS; ANTIHYPERTENSIVE AGENTS; BLOOD PRESSURE; CHROMATOGRAPHY, THIN LAYER; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; HYPERTENSION; INJECTIONS, INTRAVENOUS; KINETICS; LISINOPRIL; LOSARTAN; MICE; MICE, INBRED ICR; PEPTIDYL-DIPEPTIDASE A; PLANT COMPONENTS, AERIAL; PLANT EXTRACTS; SALVIA; SPECTROPHOTOMETRY, ULTRAVIOLET;

LAMIACEAE; MUS; SALVIA ELEGANS;

EID: 77954955574     PISSN: 03788741     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jep.2010.05.013     Document Type: Article

References (28)

1. Aguilar A., Camacho J.R., Chino S., Jacquez-López M.E. Herbario Medicinal de Instituto Mexicano del Seguro Social 1994, México, 107 pp.
2. Aguirre-Crespo F., Vergara-Galicia J., Villalobos-Molina R., López-Guerrero J., Navarrete-Vázquez G., Estrada-Soto S. Ursolic acid mediates the vasorelaxant activity of Lepechinia caulescens via NO release in isolated rat thoracic aorta. Life Science 2006, 791062-791068.
3. Atlas S.A. The renin-angiotensin aldosterone system: pathophysiological role and pharmacologic inhibition. Journal Managed Care Pharmacy 2007, 13:9-20.
4. Biblioteca Digital de la Medicina Tradicional Mexicana. Available at: (accessed 04.17.10). http://www.medicinatradicionalmexicana.unam.mx/index.php.
5. Bormann H., Melzig M.F. Inhibition of metallopeptidases by flavonoids and related compounds. Pharmazie 2000, 55:29-132.
6. Chen C.H., Lin J.Y., Lin C.N., Hsu S.Y. Inhibition of angiotensin-I-converting enzyme by tetrahydroxyxanthones isolated from Tripterospermum lanceolatum. Journal of Natural Products 1992, 55:691-695.
7. Chen Y., Ruan Y., Li L., Chu Y., Xu X., Wang Q., Zhou X. Effects of Salvia miltiorrhiza extracts on rat hypoxic pulmonary hypertension, heme oxygenase-1 and nitric oxide synthase. Chinese Medical Journal 2003, 116:757-760.
8. Chiou C.S., Lin J.W., Kao P.F., Liu J.C., Cheng T.H., Chan P. Effects of hesperidin on cyclic strain-induced endothelin-1 release in human umbilical vein endothelial cells. Clinical and Experimental Pharmacology and Physiology 2008, 35:938-943.
9. Dickinson C.J., Lawrence J.R. A slowly developing pressor response to small concentrations of angiotensin. Its bearing on the pathogenesis of chronic renal hypertension. Lancet 1963, 1:1354-1356.
10. Erdogan A., Most A.K., Wienecke B., Fehsecke A., Leckband C., Voss R., Grebe M.T., Tillmanns H., Schaefer C.A., Kuhlman R. Apigenin-induced nitric oxide production involves calcium-activated potassium channels and is responsible for antiangiogenic effects. Journal of Thrombosis and Haemostasis 2007, 5:1774-1781.
11. Fabiani M.E., Dinh D.T., Nassis L., Casley D.J., Johnston C.I. Comparative in vivo effects of irbesartan and losartan on angiotensin II receptor binding in the rat kidney following oral administration. Clinical Science 2000, 99:331-341.
12. Han S., Zheng Z., Ren D. Effect of Salvia miltiorrhiza on left ventricular hypertrophy and cardiac aldosterone in spontaneously hypertensive rats. Journal of Huazhong University of Science and Technology. Medical Sciences 2002, 22:302-304.
13. Herrera-Ruiz M., García-Beltrán Y., Mora S., Díaz-Véliz G., Viana G.S.B., Tortoriello J., Ramírez G. Antidepressant and anxiolytic effects of hydroalcoholic extract from Salvia elegans. Journal of Ethnopharmacology 2006, 107:53-58.
14. Johnston C.I. Angiotensin receptor antagonists: focus on losartan. Lancet 1995, 346:403-1407.
15. Kang D.G., Yun Y.G., Rvoo J.H., Lee H.S. Anti-hypertensive effect of water extract of dancen on renovascular hypertension through inhibition of the renin angiotensin system. American Journal of Chinese Medicine 2002, 30:87-93.
16. Lin L.Z., Harnly J.M. A screening methods for the identification of glycosylated flavonoids and other phenolic compounds using standard analytical approach for all plants materials. Journal of Agricultural and Food Chemistry 2007, 55:1084-1096.
17. Lo M.W., Goldberg M.R., McCrea J.B., Lu H., Furtek C.I., Bjornsson T.D. Pharmacokinetics of losartan, an angiotensin II receptor antagonist, and its active metabolite EXP3174 in humans. Clinical Pharmacology and Therapeutics 1995, 58:641-649.
18. a edición.
19. Marquina S., García Y., Álvarez L., Tortoriello J. 3-Acetoxy-7-methoxyflavona, a novel flavonoid from the anxiolytic extract of Salvia elegans (Lamiaceae). Natural Products Communication 2008, 3:185-188.
20. Martínez-Maldonado M. Pathophysiology of renovascular hypertension. Hypertension 1991, 17:707-719.
21. Mora S., Millán R., Lungenstrass H., Díaz-Véliz G., Morán J.A., Herrera-Ruiz M., Tortoriello J. The hydroalcoholic extract of Salvia elegans induces anxiolytic- and antidepressant-like effects in rats. Journal of Ethnopharmacology 2006, 106:76-81.
22. Ramírez J., Palacios M., Gutiérrez O. Estudio del efecto antihipertensivo de Salvia scutellarioides en un modelo de ratas hipertensas. Colombia Medica 2006, 37:53-60.
23. Reagan-Shaw S., Nihal M., Ahmad N. Dose translation from animal to human studies revisited. The FASEB Journal 2008, 22:659-661.
24. Rodríguez-Rodríguez R., Herrera M.D., Perona J.S., Ruiz-Gutiérrez V. Potential vasorelaxant effects of oleanolic acid and erythrodiol, two triterpenoids contained in 'orujo' olive oil, on rat aorta. The British Journal of Nutrition 2004, 92:635-642.
25. Rodríguez-Rodriíguez R., Perona J.S., Herrera M.D., Ruiz-Gutiérrez V. Triterpenic compounds from " orujo" olive oil elicit vasorelaxation in aorta from spontaneously hypertensive rats. Journal of Agricultural and Food Chemistry 2006, 54:2096-2102.
26. Rodríguez-Rodríguez R., Stankevicius E., Herrera M.D., Ostergaard L., Andersen M.R., Ruiz-Gutiérrez V., Simonsen U. Oleanolic acid induces relaxation and calcium-independent release of endothelium-derived nitric oxide. The British Journal of Pharmacology 2008, 155:535-546.
27. Segel I.H. Enzyme kinetics. Behavior and analysis of rapid equilibrium and steady-state enzyme systems 1975, John Wiley & Sons, New York/Chichester/Brisbane/Toronto, pp. 100-111.
28. Wienen W., Hauel N., Van Meel J.C.A., Narr B., Ries U., Entzeroth M. Pharmacological characterization of the novel nonpeptide angiotensin II receptor antagonist, BIBR 277. The British Journal of Pharmacology 1993, 110:245-252.