Effects of hesperidin on cyclic strain-induced endothelin-1 release in human umbilical vein endothelial cells

Clinical and Experimental Pharmacology and Physiology

Volumn 35, Issue 8, 2008, Pages 938-943

  Chiou, Chi Sheng ^a   Lin, Jia Wei ^b   Kao, Pai Feng ^b   Liu, Ju Chi ^b   Cheng, Tzu Hurng ^c   Chan, Paul ^b  

^a TAIPEI MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^b TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^c CHINA MEDICAL UNIVERSITY   (Taiwan)

Author keywords

Endothelial cells; Endothelin 1; Extracellular signal regulated kinases; Hesperidin; Nitric oxide; Reactive oxygen species; Strain

Indexed keywords

2 PHENYL 4,4,5,5 TETRAMETHYIMIDAZOLINE 3 OXIDE 1 OXYL; 8 BROMO CYCLIC GMP; CYCLIC GMP DEPENDENT PROTEIN KINASE; ENDOTHELIAL NITRIC OXIDE SYNTHASE; ENDOTHELIN 1; HESPERIDIN; KT 5823; MITOGEN ACTIVATED PROTEIN KINASE; N ACETYL S NITROSOPENICILLAMINE; NITRIC OXIDE; PROTEIN KINASE B; REACTIVE OXYGEN METABOLITE; SCAVENGER;

ARTICLE; CONTROLLED STUDY; DRUG ANTAGONISM; DRUG INHIBITION; DRUG MECHANISM; ENDOTHELIUM CELL; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; PROTEIN EXPRESSION; PROTEIN SECRETION; SIGNAL TRANSDUCTION; UMBILICAL VEIN;

CELLS, CULTURED; CYCLIC GMP-DEPENDENT PROTEIN KINASES; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELIAL CELLS; ENDOTHELIN-1; ENDOTHELIUM, VASCULAR; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; HESPERIDIN; HUMANS; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; STRESS, MECHANICAL; UMBILICAL VEINS;

EID: 46749106386     PISSN: 03051870     EISSN: 14401681     Source Type: Journal    
DOI: 10.1111/j.1440-1681.2008.04939.x     Document Type: Article

References (34)

1. Garg A, Garg S, Zaneveld LJ, Singla AK. Chemistry and pharmacology of the Citrus bioflavonoid hesperidin. Phytother. Res. 2001 15 : 655 69.
2. Vinson JA, Liang X, Proch J, Hontz BA, Dancel J, Sandone N. Polyphenol antioxidants in citrus juices: In vitro and in vivo studies relevant to heart disease. Adv. Exp. Med. Biol. 2002 505 : 113 22.
3. Gielen S, Schuler G, Hambrecht R. Exercise training in coronary artery disease and coronary vasomotion. Circulation 2001 103 : E1 6.
4. Gewaltig MT, Kojda G. Vasoprotection by nitric oxide: Mechanisms and therapeutic potential. Cardiovasc. Res. 2002 55 : 250 60.
5. Schiffrin EL. Role of endothelin-1 in hypertension and vascular disease. Am. J. Hypertens. 2001 14 (Suppl S83 9.
6. Kuntz S, Wenzel U, Daniel H. Comparative analysis of the effects of flavonoids on proliferation, cytotoxicity, and apoptosis in human colon cancer cell lines. Eur. J. Nutr. 1999 38 : 133 42.
7. Mundhenke M, Schwartzkopff B, Kostering M, Deska U, Klein RM, Strauer BE. Endogenous plasma endothelin concentrations and coronary circulation in patients with mild dilated cardiomyopathy. Heart 1999 81 : 278 84.
8. Schiffrin EL, Touyz RM. Vascular biology of endothelin. J. Cardiovasc. Pharmacol. 1998 32 (Suppl. 3 S2 13.
9. Tonnessen T, Giaid A, Saleh D, Naess PA, Yanagisawa M, Christensen G. Increased in vivo expression and production of endothelin-1 by porcine cardiomyocytes subjected to ischemia. Circ. Res. 1995 76 : 767 72.
10. Bollinger A, Herrig I, Fischer M, Hoffmann U, Franzeck UK. Intravital capillaroscopy in patients with chronic venous insufficiency and lymphoedema: Relevance to Daflon 500 mg. Int. J. Microcirc. Clin. Exp. 1995 15 (Suppl. 1 41 4.
11. Pernow J, Wang QD. Endothelin in myocardial ischaemia and reperfusion. Cardiovasc. Res. 1997 33 : 518 26.
12. Webb DJ, Monge JC, Rabelink TJ, Yanagisawa M. Endothelin: New discoveries and rapid progress in the clinic. Trends Pharmacol. Sci. 1998 19 : 5 8.
13. Koller A. Signaling pathways of mechanotransduction in arteriolar endothelium and smooth muscle cells in hypertension. Microcirculation 2002 9 : 277 94.
14. Dimmeler S, Fleming I, Fisslthaler B, Hermann C, Busse R, Zeiher AM. Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation. Nature 1999 399 : 601 5.
15. Fulton D, Gratton JP, McCabe TJ et al. Regulation of endothelium-derived nitric oxide production by the protein kinase Akt. Nature 1999 399 : 597 601.
16. Witztum JL. The oxidation hypothesis of atherosclerosis. Lancet 1994 344 : 793 5.
17. Drexler H. Endothelial dysfunction: Clinical implications. Prog. Cardiovasc. Dis. 1997 39 : 287 324.
18. Zafari AM, Ushio-Fukai M, Minieri CA, Akers M, Lassegue B, Griendling KK. Arachidonic acid metabolites mediate angiotensin II-induced NADH/NADPH oxidase activity and hypertrophy in vascular smooth muscle cells. Antioxid. Redox Signal. 1999 1 : 167 79.
19. Wung BS, Cheng JJ, Hsieh HJ, Shyy YJ, Wang DL. Cyclic strain-induced monocyte chemotactic protein-1 gene expression in endothelial cells involves reactive oxygen species activation of activator protein 1. Circ. Res. 1997 81 : 1 7.
20. Liu JC, Chen JJ, Chan P, Cheng CF, Cheng TH. Inhibition of cyclic strain-induced endothelin-1 gene expression by resveratrol. Hypertension 2003 42 : 1198 205.
21. Fujisaw S, Ishihara M, Kadoma Y. Kinetic evaluation of the reactivity of flavonoids as radical scavengers. SAR QSAR Environ. Res. 2002 13 : 617 27.
22. Ziegler T, Bouzourene K, Harrison VJ, Brunner HR, Hayoz D. Influence of oscillatory and unidirectional flow environments on the expression of endothelin and nitric oxide synthase in cultured endothelial cells. Arterioscler. Thromb. Vasc. Biol. 1998 18 : 686 92.
23. Wang DL, Wung BS, Peng YC, Wang JJ. Mechanical strain increases endothelin-1 gene expression via protein kinase C pathway in human endothelial cells. J. Cell. Physiol. 1995 163 : 400 6.
24. Kimura Y, Matsushita N, Yokoi-Hayashi K, Okuda H. Effects of baicalein isolated from Scutellaria baicalensis Radix on adhesion molecule expression induced by thrombin and thrombin receptor agonist peptide in cultured human umbilical vein endothelial cells. Planta Med. 2001 67 : 331 4.
25. Fraga CG, Martino VS, Ferraro GE, Coussio JD, Boveris A. Flavonoids as antioxidants evaluated by in vitro and in situ liver chemiluminescence. Biochem. Pharmacol. 1987 36 : 717 20.
26. Wilmsen PK, Spada DS, Salvador M. Antioxidant activity of the flavonoid hesperidin in chemical and biological systems. J. Agric. Food Chem. 2005 53 : 4757 61.
27. Tirkey N, Pilkhwal S, Kuhad A, Chopra K. Hesperidin, a citrus bioflavonoid, decreases the oxidative stress produced by carbon tetrachloride in rat liver and kidney. BMC Pharmacol. 2005 5 : 2.
28. Kim JY, Jung KJ, Choi JS, Chung HY. Hesperetin: A potent antioxidant against peroxynitrite. Free Radic. Res. 2004 38 : 761 9.
29. Sano M, Fukuda K, Sato T et al. ERK and p38 MAPK, but not NF-kappaB, are critically involved in reactive oxygen species-mediated induction of IL-6 by angiotensin II in cardiac fibroblasts. Circ. Res. 2001 89 : 661 9.
30. Tanaka K, Honda M, Takabatake T. Redox regulation of MAPK pathways and cardiac hypertrophy in adult rat cardiac myocyte. J. Am. Coll. Cardiol. 2001 37 : 676 85.
31. Cypriani B, Limasset B, Carrie ML et al. Antioxidant activity of micronized diosmin on oxygen species from stimulated human neutrophils. Biochem. Pharmacol. 1993 45 : 1531 5.
32. Ohkita M, Takaoka M, Shiota Y, Nojiri R, Matsumura Y. Nitric oxide inhibits endothelin-1 production through the suppression of nuclear factor kappa B. Clin. Sci. 2002 103 (Suppl. 48 S68 71.
33. Smith AP, Demoncheaux EA, Higenbottam TW. Nitric oxide gas decreases endothelin-1 mRNA in cultured pulmonary artery endothelial cells. Nitric Oxide 2002 6 : 153 9.
34. Mitsutomi N, Akashi C, Odagiri J, Matsumura Y. Effects of endogenous and exogenous nitric oxide on endothelin-1 production in cultured vascular endothelial cells. Eur. J. Pharmacol. 1999 364 : 65 73.