메뉴 건너뛰기




Volumn 5, Issue 8, 2007, Pages 1774-1781

Apigenin-induced nitric oxide production involves calcium-activated potassium channels and is responsible for antiangiogenic effects

Author keywords

Apigenin; Endothelial cells; K+ channel

Indexed keywords

APAMIN; APIGENIN; BASIC FIBROBLAST GROWTH FACTOR; CALCIUM; CALCIUM ACTIVATED POTASSIUM CHANNEL; CYCLIC GMP; FLUORESCENT DYE; IBERIOTOXIN; NITRIC OXIDE; PROTEIN KINASE B;

EID: 34447643757     PISSN: 15387933     EISSN: 15387836     Source Type: Journal    
DOI: 10.1111/j.1538-7836.2007.02615.x     Document Type: Article
Times cited : (24)

References (31)
  • 4
    • 0038022616 scopus 로고    scopus 로고
    • Flavonoids inhibit VEGF/bFGF-induced angiogenesis in vitro by inhibiting the matrix-degrading proteases
    • Kim MH. Flavonoids inhibit VEGF/bFGF-induced angiogenesis in vitro by inhibiting the matrix-degrading proteases. J Cell Biochem 2003; 89: 529-38.
    • (2003) J Cell Biochem , vol.89 , pp. 529-538
    • Kim, M.H.1
  • 5
    • 4544325479 scopus 로고    scopus 로고
    • Apigenin suppresses the expression of VEGF, an important factor for angiogenesis, in endothelial cells via degradation of HIF-1alpha protein
    • Osada M, Imaoka S, Funae Y. Apigenin suppresses the expression of VEGF, an important factor for angiogenesis, in endothelial cells via degradation of HIF-1alpha protein. FEBS Lett 2004; 575: 59-63.
    • (2004) FEBS Lett , vol.575 , pp. 59-63
    • Osada, M.1    Imaoka, S.2    Funae, Y.3
  • 6
    • 14644432362 scopus 로고    scopus 로고
    • Apigenin inhibits VEGF and HIF-1 expression via PI3K/AKT/p70S6K1 and HDM2/p53 pathways
    • Fang J, Xia C, Cao Z, Zheng JZ, Reed E, Jiang BH. Apigenin inhibits VEGF and HIF-1 expression via PI3K/AKT/p70S6K1 and HDM2/p53 pathways. FASEB J 2005; 19: 342-53.
    • (2005) FASEB J , vol.19 , pp. 342-353
    • Fang, J.1    Xia, C.2    Cao, Z.3    Zheng, J.Z.4    Reed, E.5    Jiang, B.H.6
  • 7
    • 0347987010 scopus 로고    scopus 로고
    • Inhibitory effects of several flavonoids on E-selectin expression on human umbilical vein endothelial cells stimulated by tumor necrosis factor-alpha
    • Takano-Ishikawa Y, Goto M, Yamaki K. Inhibitory effects of several flavonoids on E-selectin expression on human umbilical vein endothelial cells stimulated by tumor necrosis factor-alpha. Phytother Res 2003; 17: 1224-7.
    • (2003) Phytother Res , vol.17 , pp. 1224-1227
    • Takano-Ishikawa, Y.1    Goto, M.2    Yamaki, K.3
  • 8
    • 2442530445 scopus 로고    scopus 로고
    • Flavones mitigate tumor necrosis factor-alpha-induced adhesion molecule upregulation in cultured human endothelial cells: Role of nuclear factor-kappa B
    • Choi JS, Choi YJ, Park SH, Kang JS, Kang YH. Flavones mitigate tumor necrosis factor-alpha-induced adhesion molecule upregulation in cultured human endothelial cells: Role of nuclear factor-kappa B. J Nutr 2004; 134: 1013-9.
    • (2004) J Nutr , vol.134 , pp. 1013-1019
    • Choi, J.S.1    Choi, Y.J.2    Park, S.H.3    Kang, J.S.4    Kang, Y.H.5
  • 10
    • 30544440831 scopus 로고    scopus 로고
    • Wild artichoke prevents the age-associated loss of vasomotor function
    • Rossoni G, Grande S, Galli C, Visioli F. Wild artichoke prevents the age-associated loss of vasomotor function. J Agric Food Chem 2005; 53: 10291-6.
    • (2005) J Agric Food Chem , vol.53 , pp. 10291-10296
    • Rossoni, G.1    Grande, S.2    Galli, C.3    Visioli, F.4
  • 15
    • 33747854541 scopus 로고    scopus 로고
    • Fluvastatin stabilizes the blood brain barrier in vitro by nitric oxide dependent dephosphorylation of myosin light chains
    • Kuhlmann CR, Lessmann V, Luhmann HJ. Fluvastatin stabilizes the blood brain barrier in vitro by nitric oxide dependent dephosphorylation of myosin light chains. Neuropharmacology 2006; 51: 907-13.
    • (2006) Neuropharmacology , vol.51 , pp. 907-913
    • Kuhlmann, C.R.1    Lessmann, V.2    Luhmann, H.J.3
  • 20
    • 0034789020 scopus 로고    scopus 로고
    • Ion channels and their functional role in vascular endothelium
    • Nilius B, Droogmans G. Ion channels and their functional role in vascular endothelium. Physiol Rev 2001; 81: 1415-59.
    • (2001) Physiol Rev , vol.81 , pp. 1415-1459
    • Nilius, B.1    Droogmans, G.2
  • 21
    • 0142179148 scopus 로고    scopus 로고
    • Up-regulation of endothelial nitric-oxide synthase by endothelium-derived hyperpolarizing factor involves mitogen-activated protein kinase and protein kinase C signaling pathways
    • Wang H, Lin L, Jiang J, Wang Y, Lu ZY, Bradbury JA, Lih FB, Wang DW, Zeldin DC. Up-regulation of endothelial nitric-oxide synthase by endothelium-derived hyperpolarizing factor involves mitogen-activated protein kinase and protein kinase C signaling pathways. J Pharmacol Exp Ther 2003; 307: 753-64.
    • (2003) J Pharmacol Exp Ther , vol.307 , pp. 753-764
    • Wang, H.1    Lin, L.2    Jiang, J.3    Wang, Y.4    Lu, Z.Y.5    Bradbury, J.A.6    Lih, F.B.7    Wang, D.W.8    Zeldin, D.C.9
  • 22
    • 0024423885 scopus 로고
    • Ion channels and regulation of intracellular calcium in vascular endothelial cells
    • Adams DJ, Barakeh J, Laskey R, Van Breemen C. Ion channels and regulation of intracellular calcium in vascular endothelial cells. FASEB J 1989; 3: 2389-400.
    • (1989) FASEB J , vol.3 , pp. 2389-2400
    • Adams, D.J.1    Barakeh, J.2    Laskey, R.3    Van Breemen, C.4
  • 23
    • 0025301338 scopus 로고
    • Calcium influx into endothelial cells and formation of endothelium-derived relaxing factor is controlled by the membrane potential
    • Lückhoff A, Busse R. Calcium influx into endothelial cells and formation of endothelium-derived relaxing factor is controlled by the membrane potential. Pflügers Arch 1990; 416: 305-11.
    • (1990) Pflügers Arch , vol.416 , pp. 305-311
    • Lückhoff, A.1    Busse, R.2
  • 25
    • 0033960338 scopus 로고    scopus 로고
    • Apigenin inhibits endothelial-cell proliferation in G(2)/M phase whereas it stimulates smooth-muscle cells by inhibiting P21 and P27 expression
    • Trochon V, Blot E, Cymbalista F, Engelmann C, Tang RP, Thomaidis A, Vasse M, Soria J, Lu H, Soria C. Apigenin inhibits endothelial-cell proliferation in G(2)/M phase whereas it stimulates smooth-muscle cells by inhibiting P21 and P27 expression. Int J Cancer 2000; 85: 691-6.
    • (2000) Int J Cancer , vol.85 , pp. 691-696
    • Trochon, V.1    Blot, E.2    Cymbalista, F.3    Engelmann, C.4    Tang, R.P.5    Thomaidis, A.6    Vasse, M.7    Soria, J.8    Lu, H.9    Soria, C.10
  • 27
    • 1642389510 scopus 로고    scopus 로고
    • Cerivastatin activates endothelial calcium-activated potassium channels and thereby modulates endothelial nitric oxide production and cell proliferation
    • Kuhlmann CR, Gast C, Li F, Schafer M, Tillmanns H, Waldecker B, Wiecha J. Cerivastatin activates endothelial calcium-activated potassium channels and thereby modulates endothelial nitric oxide production and cell proliferation. J Am Soc Nephrol 2004; 15: 868-75.
    • (2004) J Am Soc Nephrol , vol.15 , pp. 868-875
    • Kuhlmann, C.R.1    Gast, C.2    Li, F.3    Schafer, M.4    Tillmanns, H.5    Waldecker, B.6    Wiecha, J.7
  • 28
    • 0032973685 scopus 로고    scopus 로고
    • Nitric oxide inhibits proliferation of human endothelial cells via a mechanism independent of cGMP
    • Heller R, Polack T, Grabner R, Till U. Nitric oxide inhibits proliferation of human endothelial cells via a mechanism independent of cGMP. Atherosclerosis 1999; 144: 49-57.
    • (1999) Atherosclerosis , vol.144 , pp. 49-57
    • Heller, R.1    Polack, T.2    Grabner, R.3    Till, U.4
  • 29
    • 0033542476 scopus 로고    scopus 로고
    • Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation
    • Dimmeler S, Flemming I, Fisslthaler B, Hermann C, Busse R, Zeiher AM. Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation. Nature 1999; 399: 601-5.
    • (1999) Nature , vol.399 , pp. 601-605
    • Dimmeler, S.1    Flemming, I.2    Fisslthaler, B.3    Hermann, C.4    Busse, R.5    Zeiher, A.M.6
  • 31
    • 0346059592 scopus 로고    scopus 로고
    • MKP-1-induced dephosphorylation of extracellular signal-regulated kinase is essential for triggering nitric oxide-induced apoptosis in human breast cancer cell lines: Implications in breast cancer
    • Pervin S, Singh R, Freije WA, Chaudhuri G. MKP-1-induced dephosphorylation of extracellular signal-regulated kinase is essential for triggering nitric oxide-induced apoptosis in human breast cancer cell lines: Implications in breast cancer. Cancer Res 2003; 63: 8853-60.
    • (2003) Cancer Res , vol.63 , pp. 8853-8860
    • Pervin, S.1    Singh, R.2    Freije, W.A.3    Chaudhuri, G.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.