Ursolic acid mediates the vasorelaxant activity of Lepechinia caulescens via NO release in isolated rat thoracic aorta

Life Sciences

Volumn 79, Issue 11, 2006, Pages 1062-1068

  Aguirre Crespo, Francisco ^a   Vergara Galicia, Jorge ^a   Villalobos Molina, Rafael ^b,c   Javier López Guerrero, Juan ^b   Navarrete Vázquez, Gabriel ^a   Estrada Soto, Samuel ^a  

^a UNIVERSIDAD AUTÓNOMA DEL ESTADO DE MORELOS   (Mexico)

^b DEPARTAMENTO DE FÍSICA   (Mexico)

^c UNIVERSIDAD NACIONAL AUTÓNOMA DE MÉXICO   (Mexico)

Author keywords

Aortic smooth muscle; cGMP; Lepechinia caulescens; Nitric oxide; Oleanolic acid; Relaxation; Ursolic acid

Indexed keywords

1H 1,2,4 OXADIAZOLO[4,3 A]QUINOXALIN 1 ONE; ATROPINE; CARBACHOL; HERBACEOUS AGENT; INDOMETACIN; LEPECHINIA CAULESCENS EXTRACT; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITROPRUSSIDE SODIUM; NORADRENALIN; OLEANOLIC ACID; PLANT EXTRACT; POTASSIUM CHLORIDE; UNCLASSIFIED DRUG; URSOLIC ACID;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG EFFECT; DRUG MECHANISM; DRUG SCREENING; ENZYME ACTIVATION; IC 50; LEPECHINIA CAULESCENS; MALE; MEDICINAL PLANT; NONHUMAN; RAT; THORACIC AORTA; VASOCONSTRICTION; VASODILATATION;

ANIMALS; AORTA, THORACIC; ATROPINE; ENDOTHELIUM, VASCULAR; ENZYME ACTIVATION; ENZYME INHIBITORS; LAMIACEAE; MALE; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; OXADIAZOLES; PLANT EXTRACTS; QUINOXALINES; RATS; RATS, WISTAR; TRITERPENES; VASODILATION; VASODILATOR AGENTS;

LEPECHINIA CAULESCENS;

EID: 33746300491     PISSN: 00243205     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.lfs.2006.03.006     Document Type: Article

References (23)

1. Aguilar A., Camacho J.R., Chino S., Jácquez P., and López M.E. Herbario medicinal del Instituto Mexicano del Seguro Social (1994), Instituto Mexicano del Seguro Social, México 98-99
2. Aguirre-Crespo F., Castillo-España P., Villalobos-Molina R., López-Guerrero J.J., and Estrada-Soto S. Vasorelaxant effect of Mexican medicinal plants on isolated rat aorta. Pharmaceutical Biology 43 6 (2005) 540-546
3. Aktan F. iNOS-mediated nitric oxide production and its regulation. Life Sciences 75 6 (2004) 639-653
4. Bailey N.T.J. Statistical Methods in Biology (1995), Cambridge University Press, Cambridge 234-236
5. a Edición (2002), Limusa, México 295-399
6. Delgado G., Hernández J., Chávez M.I., Álvarez L., Gonzaga V., and Martínez E. Di- and triterpenoid acids from Lepechinia caulescens. Phytochemistry 37 (1994) 1119-1121
7. Delgado G., Sánchez E., Hernández J., Chávez M.I., Álvarez L., and Martínez E. Abietanoid acids from Lepechinia caulescens. Phytochemistry 31 (1992) 3159-3161
8. Hoffman B.B. Therapy of hypertension. Goodman and Gilman's. The Pharmacological Basis of Therapeutics. 11th ed. (2005) 845-897
9. INEGI/Secretaría de Salud. Dirección general de información en salud. CONAPO, Proyecciones de la población de México 2000-2050 (2002)
10. Oleanolic acid and ursolic acid: research perspectives. Journal of Ethnopharmacology 100 (2002) 92-94
11. Liu J. Oleanolic acid and ursolic acid: research perspectives. Journal of Ethnopharmacology 22 100 (2005) 92-94
12. Moncada S., Higgs A., and Furchgott R. XIV International union of pharmacology nomenclature in nitric oxide research. Pharmacology Reviews 49 (1997) 137-142
13. Monroy-Ortíz, C., Castillo, E., 2000. Plantas Medicinales Utilizadas en el Estado de Morelos. Centro de Investigaciones Biológicas, Universidad Autónoma del Estado de Morelos, Cuernavaca, Morelos, México.
14. Rodríguez-López V., Salazar L., and Estrada S. Spasmolytic activity of several extracts obtained from some Mexican medicinal plants. Fitoterapia 74 (2003) 725-728
15. Rodríguez-Rodríguez R., Herrera M.D., Perona J.S., and Ruiz-Gutiérrez V. Potential vasorelaxant effects of oleanolic acid and erythrodiol, two triterpenoids container in 'orujo' olive oil, on rat aorta. British Journal of Nutrition 92 (2004) 635-642
16. Román-Ramos R., Contreras-Weber C.C., Nohpal-Grajeda G., Flores-Saenz J.L., and Alarcón-Aguilar F.J. Blood glucose level decrease caused by extracts and fractions from Lepechinia caulescens in healthy and alloxan-diabetic mice. Pharmaceutical Biology 39 (2001) 317-321
17. Sardana S., and Madan A.K. Topological models for prediction of antihypertensive activity of substituted benzylimidazoles. Journal of Molecular Structure 638 (2003) 41-49
18. Schlossmann J., and Hofmann F. cGMP-dependent protein kinases in drug discovery. Drug Discovery Today 10 9 (2005) 627-634
19. Secretaria de Salud, Dirección de Medicina Tradicional y Desarrollo Intercultural, 2004. Fortalecimiento y desarrollo de la medicina tradicional mexicana y su relación intercultural con la medicina institucional. [Acceded: February 10th 2004].
20. 13CNMR signals in urs-12-enes. Journal of the Chemical Society, Chemical Communications 1 (1975) 954-955
21. Somova L.I., Shode F.O., and Mipando M. Cardiotonic and antidysrhythmic effects of oleanolic and ursolic acids, methyl maslinate and uvaol. Phytomedicine 11 (2004) 121-129
22. Vanhoutte P.M. Endothelial adrenoceptors. Journal of Cardiovascular Pharmacology 38 5 (2001) 796-808
23. Yi-Ching L., Huei-Hsia T., Rong-Jyh L., Deng-Chyang W., Bin-Nan W., Young-Tso L., and Ing-Jun C. Endothelium-dependent and -independent vasorelaxation by a theophylline derivative MCPT: roles of cyclic nucleotides, potassium channel opening and phosphodiesterase inhibition. Life Sciences 76 (2005) 931-944