Potential vasorelaxant effects of oleanolic acid and erythrodiol, two triterpenoids contained in 'orujo' olive oil, on rat aorta

British Journal of Nutrition

Volumn 92, Issue 4, 2004, Pages 635-642

  Rodríguez Rodríguez, Rosalía ^a   Herrera, María Dolores ^b   Perona, Javier S ^a   Ruiz Gutiérrez, Valentina ^a  

^a INSTITUTO DE LA GRASA   (Spain)

^b UNIVERSITY OF SEVILLE   (Spain)

Author keywords

'Orujo' olive oil; Endothelium; Erythrodiol; Oleanolic acid; Rat aorta; Vasorelaxation

Indexed keywords

ADENOSINE TRIPHOSPHATASE (CALCIUM); ERYTHRODIOL; INDOMETACIN; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; OLEANOLIC ACID; OLIVE OIL; PHENYLEPHRINE; POTASSIUM CHLORIDE; TRITERPENOID; UNCLASSIFIED DRUG;

ANIMAL TISSUE; AORTA CONSTRICTION; ARTICLE; CONCENTRATION (PARAMETERS); CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG MECHANISM; DRUG STRUCTURE; ENZYME INHIBITION; MALE; NONHUMAN; RAT; STATISTICAL ANALYSIS; STATISTICAL SIGNIFICANCE; VASODILATATION;

ANIMALS; AORTA, THORACIC; CALCIUM-TRANSPORTING ATPASES; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELIUM, VASCULAR; MALE; NITRIC OXIDE; OLEANOLIC ACID; PHENYLEPHRINE; PLANT OILS; POTASSIUM CHLORIDE; RATS; TISSUE CULTURE TECHNIQUES; VASODILATION; VASODILATOR AGENTS;

EID: 6944226303     PISSN: 00071145     EISSN: None     Source Type: Journal    
DOI: 10.1079/BJN20041231     Document Type: Article

References (42)

1. Álvarez de Sotomayor M, Pérez-Guerrero C, Herrera MD & Marhuenda E (2001) Effect of simvastatin on vascular smooth muscle responsiveness: involvement of Ca(2 + ) homeostasis. Eur J Pharmacol 415, 217-224.
2. American Dietetic Association (1999) Position of the American Dietetic Association: functional foods. J Am Diet Assoc 99, 1278-1285.
3. Boulanger CM (1999) Secondary endothelial dysfunction: hypertension and heart failure. J Mol Cell Cardiol 31, 39-49.
4. Choi CY, You HJ & Jeong HG (2001) Nitric oxide and tumor necrosis factor-alpha production by oleanolic acid via nuclear factor-kappaB activation in macrophages. Biochem Biophys Res Commun 288, 49-55.
5. De la Puerta R, Martínez-Domínguez E & Ruíz-Gutiérrez V (2000) Effect of minor components of virgin olive oil on topical antiinflammatory assays. Z Naturforsch 55C, 814-819.
6. De la Puerta R, Ruíz-Gutiérrez V & Hoult JRS (1999) Inhibition of leukocyte 5-lipooxygenase by phenolics from virgin olive oil. Biochem Pharmacol 57, 445-449.
7. Furchgott RF & Vanhoutte PM (1989) Endothelium-derived relaxing and contracting factors. FASEB J 3, 2007-2018.
8. Furchgott RF & Zawadzki JV (1980) The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. Nature 299, 373-376.
9. Godfraind T, Miller R & Wibo M (1986) Calcium antagonism and calcium entry blockade. Pharmacol Rev 38, 321-416.
10. Honda T, Rounds BV, Bore L, Finlay HJ, Favaloro FG Jr, Suh N, Wang Y, Sporn MB & Gribble GW (2000) Synthetic oleanane and ursane triterpenoids with modified rings A and C: a series of highly active inhibitors of nitric oxide production in mouse macrophages. J Med Chem 43, 4233-4246.
11. Hsu HY, Yang JJ & Lin CC (1997) Effects of oleanolic acid and ursolic acid on inhibiting tumor growth and enhancing the recovery of hematopoietic system postirradiation in mice. Cancer Lett 111 7-13.
12. Kashiwada Y, Wang HK, Nagao T, et al. (1998) Anti-AIDS agents. 30. Anti-HIV activity of oleanolic acid, pomolic acid, and structurally related triterpenoids. J Nat Prod 61, 1090-1095.
13. Keys A (1995) Mediterranean diet and public health: personal reflections. Am J Clin Nutr 61, 1321S-1323S.
14. Kim ND, Kang SY & Schini VB (1994) Gingenosides evoke endothelium-dependent vascular relaxation in rat aorta. Gen Pharmacol 25, 1071-1077.
15. Laight DW, Kaw AV, Carrier MJ & Anggard EE (1998) Interaction between superoxide anion and nitric oxide in the regulation of vascular endothelial function. Br J Pharmacol 124, 238-244.
16. Libby P (2002) Inflammation and atherosclerosis. Nature 420, 868-874.
17. Liu J (1995) Pharmacology of oleanolic acid and ursolic acid. J Ethnopharmacol 49, 57-68.
18. Liu Y, Hartley DP & Liu J (1998) Protection against carbon tetrachloride hepatotoxicity by oleanolic acid is not mediated through metallothionein. Toxicol Lett 95, 77-85.
19. Lückhoff A, Pohl U, Mulsch A & Busse R (1988) Differential role of extra- and intracellular calcium in the release of EDRF and prostacyclin from cultured endothelial cells. Br J Pharmacol 95 189-196.
20. Lüscher TF & Barton M (1997) Biology of the endothelium. Clin Cardiol 20, Suppl. 2, II-3-II-10.
21. Mañez S, Recio MC, Giner RM & Ríos JL (1997) Effect of selected triterpenoids on chronic dermal inflammation. Eur J Pharmacol 334, 103-105.
22. Matsuda H, Li Y, Murakami T, Matsumura N, Yamahara J & Yoshikawa M (1998) Antidiabetic principles of natural medicines. III. Structure-related inhibitory activity and action mode of oleanolic acid glycosides on hypoglycemic activity. Chem Pharm Bull (Tokyo) 46 1399-1403.
23. Mengoni F, Lichtner M, Battinelli L, Marzi M, Mastroianni CM, Vullo V & Mazzanti G (2002) In vitro anti-HIV activity of oleanolic acid on infected human mononuclear cells. Planta Med 68, 111-114.
24. Mombouli JV & Vanhoutte PM (1999) Endothelial dysfunction: from physiology to therapy. J Mol Cell Cardiol 31, 61-74.
25. Moncada S, Palmer RM & Higgs EA (1991) Nitric oxide: physiology, pathophysiology, and pharmacology. Pharmacol Rev 43 109-142.
26. Pérez-Camino MC & Cert A (1999) Quantitative determination of hydroxy pentacyclic triterpene acids in vegetable oils. J Agric Food Chem 47, 1558-1562.
27. Perona JS & Ruíz-Gutiérrez V (2000) Effect of two high-oleic oils on the liver lipid composition of spontaneously hypertensive rats. Life Sci 66, 521-531.
28. Recio MC, Giner RM, Mañez S & Rios JL (1995) Structural requirements for the anti-inflammatory activity of natural triterpenoids. Planta Med 61, 182-185.
29. Ringbom T, Segura L, Noreen Y, Perera P & Bohlin L (1998) Ursolic acid from Plantago major, a selective inhibitor of cyclooxygenase-2 catalyzed prostaglandin biosynthesis. J Nat Prod 61, 1212-1215.
30. Somova LI, Nadar A, Rammanan P & Shode FO (2003a) Cardiovascular, antihyperlipidemic and antioxidant effects of oleanolic and ursolic acids in experimental hypertension. Phytomedicine 10 115-121.
31. Somova LI, Shode FO, Ramnanan P & Nadar A (2003b) Antihypertensive, antiatherosclerotic and antioxidant activity of triterpenoids isolated from Olea europaea, subspecies africana leaves. J Ethnopharmacol 84, 299-305.
32. Tanner MA, Bu X, Steimle JA & Myers PR (1999) The direct release of nitric oxide by gypenosides derived from the herb Gynostemma pentaphyllum. Nitric Oxide 3, 359-365.
33. Vanhoutte PM (2001) Endothelium-derived free radicals: for worse and for better. J Clin Invest 107, 23-25.
34. Vázquez-Roncero A & Janer ML (1969) Ácidos triterpénicos del olivo (Triterpenoid acids of the olive tree). Grasas y Aceites 20, 133-138.
35. Vioque E & Maza MP (1963) Sobre los ácidos triterpénicos del aceite de orujo y oliva (About orujo and olive oil triterpenic acids). Grasas y Aceites 14, 9-11.
36. Vioque E & Morris LJ (1961) Minor components of olive oils. I. Triterpenoid acids in an acetone-extracted orujo oil. J Am Oil Chem Soc 38, 485-488.
37. Visioli F & Galli C (1998) The effect of minor constituents of olive oil on cardiovascular disease: new findings. Nutr Rev 56, 142-147.
38. Yang D, Feletou M, Boulanger CM, Wu HF, Levens N, Zhang JN & Vanhoutte PM (2002) Oxygen-derived free radicals mediate endothelium-dependent contractions to acetylcholine in aortas from spontaneously hypertensive rats. Br J Pharmacol 136, 104-110.
39. Yim TK, Wu WK, Pak WF & Ko KM (2001) Hepatoprotective action of an oleanolic acid-enriched extract of Ligustrum lucidum fruits is mediated through an enhancement on hepatic glutathione regeneration capacity in mice. Phytother Res 15, 589-592.
40. Yoshikawa M & Matsuda H (2000) Antidiabetogenic activity of oleanolic acid glycosides from medicinal foodstuffs. Biofactors 13, 231-237.
41. 2+ in EDRF release in rat aorta. J Vasc Res 31, 18-24.
42. Zhu YM, Shen JK, Wang HK, Cosentino LM & Lee KH (2001) Synthesis and anti-HIV activity of oleanolic acid derivatives. Bioorg Med Chem Lett 11, 3115-3118.