Substrate specificity of feline and canine herpesvirus thymidine kinase

Antiviral Research

Volumn 79, Issue 2, 2008, Pages 128-132

  Solaroli, N ^a   Johansson, M ^a   Persoons, L ^b   Balzarini, J ^b   Karlsson, A ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

Author keywords

Gene therapy; Herpesviruses; Nucleoside kinases; Suicide gene; Thymidine kinase

Indexed keywords

1 DEXTRO ARABINOFURANOSYLTHYMINE; 2',2' DIFLUORODEOXYGUANOSINE; 5 (2 BROMOVINYL) 2' DEOXYURIDINE; AMINO ACID; GEMCITABINE; NUCLEOSIDE ANALOG; PYRIMIDINE DERIVATIVE; THYMIDINE DERIVATIVE; THYMIDINE KINASE; THYMIDINE KINASE 1; THYMIDINE KINASE 2; ZIDOVUDINE;

AMINO ACID SEQUENCE; ANIMAL CELL; ANTIVIRAL ACTIVITY; ARTICLE; CANINE HERPESVIRUS; CONTROLLED STUDY; CYTOPATHOGENIC EFFECT; ENZYME ACTIVITY; ENZYME SPECIFICITY; FELINE HERPETOVIRUS; HERPES SIMPLEX VIRUS 1; HERPES VIRUS; HUMAN; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION;

AMINO ACID SEQUENCE; ANIMALS; CATS; CELL LINE; CLONING, MOLECULAR; DOGS; HERPESVIRIDAE; KINETICS; MICROBIAL SENSITIVITY TESTS; MOLECULAR SEQUENCE DATA; PYRIMIDINES; SEQUENCE HOMOLOGY, AMINO ACID; SUBSTRATE SPECIFICITY; THYMIDINE; THYMIDINE KINASE; VIRAL PROTEINS;

CANID HERPESVIRUS 1; FELID HERPESVIRUS 1; FELIDAE; HUMAN HERPESVIRUS 1; MAMMALIA;

EID: 43649087276     PISSN: 01663542     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.antiviral.2008.03.003     Document Type: Article

References (14)

1. Balzarini J., De Clercq E., Verbruggen A., Ayusawa D., Shimizu K., and Seno T. Thymidylate synthase is the principal target enzyme for the cytostatic activity of (E)-5-(2-bromovinyl)-2′-deoxyuridine against murine mammary carcinoma (FM3A) cells transformed with the herpes simplex virus type 1 or type 2 thymidine kinase gene. Mol. Pharmacol. 32 (1987) 410-416
2. Balzarini J., Liekens S., Solaroli N., El Omari K., Stammers D.K., and Karlsson A. Engineering of a single conserved amino acid residue of herpes simplex virus type 1 thymidine kinase allows a predominant shift from pyrimidine to purine nucleoside phosphorylation. J. Biol. Chem. 281 (2006) 19273-19279
3. Beltinger C., Fulda S., Kammertoens T., Uckert W., and Debatin K.M. Mitochondrial amplification of death signals determines thymidine kinase/ganciclovir-triggered activation of apoptosis. Cancer Res. 60 (2000) 3212-3217
4. Fillat C., Carrio M., Cascante A., and Sangro B. Suicide gene therapy mediated by the herpes simplex virus thymidine kinase gene/ganciclovir system: fifteen years of application. Curr. Gene Ther. 3 (2003) 13-26
5. Floeth F.W., Shand N., Bojar H., Prisack H.B., Felsberg J., Neuen-Jacob E., Aulich A., Burger K.J., Bock W.J., and Weber F. Local inflammation and devascularization-in vivo mechanisms of the "bystander effect" in VPC-mediated HSV-Tk/GCV gene therapy for human malignant glioma. Cancer Gene Ther. 8 (2001) 843-851
6. Hussein I.T., Miguel R.N., Tiley L.S., and Field H.J. Substrate specificity and molecular modelling of the feline herpesvirus-1 thymidine kinase. Arch Virol. 153 (2008) 495-505
7. Johansson M., van Rompay A.R., Degrève B., Balzarini J., and Karlsson A. Cloning and characterization of the multisubstrate deoxyribonucleoside kinase of Drosophila melanogaster. J. Biol. Chem. 274 (1999) 23814-23819
8. Maggs D.J., and Clarke H.E. In vitro efficacy of ganciclovir, cidofovir, penciclovir, foscarnet, idoxuridine, and acyclovir against feline herpesvirus type-1. Am. J. Vet. Res. 65 (2004) 399-403
9. Munir K.M., French D.C., Dube D.K., and Loeb L.A. Permissible amino acid substitutions within the putative nucleoside binding site of herpes simplex virus type 1 encoded thymidine kinase established by random sequence mutagenesis. J. Biol. Chem. 267 (1992) 6584-6589
10. Nunberg J.H., Wright D.K., Cole G.E., Petrovskis E.A., Post L.E., Compton T., and Gilbert J.H. Identification of the thymidine kinase gene of feline herpesvirus: use of degenerate oligonucleotides in the polymerase chain reaction to isolate herpesvirus gene homologs. J. Virol. 63 (1989) 3240-3249
11. Rémond M., Sheldrick P., Lebreton F., and Foulon T. Sequence of the canine herpesvirus thymidine kinase gene: taxon-preferred amino acid residues in the alphaherpesviral thymidine kinases. Virus Res. 39 (1995) 341-354
12. Solaroli N., Bjerke M., Amiri M.H., Johansson M., and Karlsson A. Active site mutants of Drosophila melanogaster multisubstrate deoxyribonucleoside kinase. Eur. J. Biochem. 270 (2003) 2879-2884
13. Voges J., Reszka R., Gossmann A., Dittmar C., Richter R., Garlip G., Kracht L., Coenen H.H., Sturm V., Wienhard K., Heiss W.D., and Jacobs A.H. Imaging-guided convection-enhanced delivery and gene therapy of glioblastoma. Ann. Neurol. 54 (2003) 479-487
14. Wei S.J., Chao Y., Hung Y.M., Lin W.C., Yang D.M., Shih Y.L., Ch'ang L.Y., Whang-Peng J., and Yang W.K. S- and G2-phase cell cycle arrests and apoptosis induced by ganciclovir in murine melanoma cells transduced with herpes simplex virus thymidine kinase. Exp. Cell Res. 241 (1998) 66-75