Examining the cardiac NK-2 genes in early heart development

Pediatric Cardiology

Volumn 31, Issue 3, 2010, Pages 335-341

  Bartlett, Heather ^a   Veenstra, Gert Jan C ^b   Weeks, Daniel L ^c  

^a UNIVERSITY OF IOWA   (United States)

^b RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^c NONE

Author keywords

Abnormal heart formation; Cardiac NK 2 genes; Cardiac NK 2 transcription factors; Congenital heart disease; Early heart development

Indexed keywords

HOMEODOMAIN PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR GATA 4; TRANSCRIPTION FACTOR NKX2.10; TRANSCRIPTION FACTOR NKX2.3; TRANSCRIPTION FACTOR NKX2.5; TRANSCRIPTION FACTOR NKX2.6; TRANSCRIPTION FACTOR NKX2.7; TRANSCRIPTION FACTOR NKX2.8; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; CARBOXY TERMINAL SEQUENCE; CHICKEN; CONFERENCE PAPER; CONGENITAL HEART DISEASE; DROSOPHILA; EMBRYO DEVELOPMENT; GENE EXPRESSION; GENE MUTATION; HEART DEVELOPMENT; HUMAN; NONHUMAN; PROTEIN FUNCTION; XENOPUS LAEVIS; ZEBRA FISH;

ANIMALS; DROSOPHILA; GENES, REGULATOR; HEART; HEART DEFECTS, CONGENITAL; HOMEODOMAIN PROTEINS; HUMANS; TRANSCRIPTION FACTORS; XENOPUS LAEVIS;

EID: 77954763028     PISSN: 01720643     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00246-009-9605-0     Document Type: Conference Paper

References (41)

1. Akazawa H, Komuro I (2005) Cardiac transcription factor Csx/Nkx2-5: its role in cardiac development and diseases. Pharmacol Ther 107:252-268.
2. Akkers RC, van Heeringen SJ, Jacobi UG, Janssen-Megens EM, Francoijs KJ, Stunnenberg HG, Veenstra GJ (2009) A hierarchy of H3K4me3 and H3K27me3 acquisition in spatial gene regulation in Xenopus embryos. Dev Cell 17:425-434.
3. Allen BG, Allen-Brady K, Weeks DL (2006) Reduction of XNkx2-10 expression leads to anterior defects and malformation of the embryonic heart. Mech Dev 123:719-729.
4. Alsan BH, Schultheiss TM (2002) Regulation of avian cardiogenesis by Fgf8 signaling. Development 129:1935-1943.
5. Backs J, Olson EN (2006) Control of cardiac growth by histone acetylation/deacetylation. Circ Res 98:15-24.
6. Benson DW, Silberbach GM, Kavanaugh-McHugh A, Cottrill C, Zhang Y, Riggs S, Smalls O, Johnson MC, Watson MS, Seidman JG, Seidman CE, Plowden J, Kugler JD (1999) Mutations in the cardiac transcription factor NKX2.5 affect diverse cardiac developmental pathways. J Clin Invest 104:1567-1573.
7. Biben C, Harvey RP (1997) Homeodomain factor Nkx-2.5 controls left/right asymmetric expression of bHLH gene eHand during murine heart development. Genes Dev 11:1357-1369.
8. Brown CO III, Chi X, Garcia-Gras E, Shirai M, Feng XH, Schwartz RJ (2004) The cardiac determination factor, Nkx2-5, is activated by mutual cofactors GATA-4 and Smad1/4 via a novel upstream enhancer. J Biol Chem 279:10659-10669.
9. Chen CY, Schwartz RJ (1995) Identification of novel DNA binding targets and regulatory domains of a murine tinman homeodomain factor, nkx-2.5. J Biol Chem 270:15628-15633.
10. Chen JN, Fishman MC (1996) Zebra fish tinman homolog demarcates the heart field and initiates myocardial differentiation. Development 122:3809-3816.
11. Chen Y, Yuen WH, Fu J, Huang G, Melendez AJ, Ibrahim FB, Lu H, Cao X (2007) The mitochondrial respiratory chain controls intracellular calcium signaling and NFAT activity essential for heart formation in Xenopus laevis. Mol Cell Biol 27:6420-6432.
12. Cleaver OB, Patterson KD, Krieg PA (1996) Overexpression of the tinman-related genes XNkx-2.5 and XNkx-2.3 in Xenopus embryos results in myocardial hyperplasia. Development 122:3549-3556.
13. Cripps RM, Olson EN (2002) Control of cardiac development by an evolutionarily conserved transcriptional network. Dev Biol 246:14-28.
14. Durocher D, Chen CY, Ardati A, Schwartz RJ, Nemer M (1996) The atrial natriuretic factor promoter is a downstream target for Nkx-2.5 in the myocardium. Mol Cell Biol 16:4648-4655.
15. Durocher D, Charron F, Warren R, Schwartz RJ, Nemer M (1997) The cardiac transcription factors Nkx2-5 and GATA-4 are mutual cofactors. Embo J 16:5687-5696.
16. Foley A, Mercola M (2004) Heart induction: embryology to cardiomyocyte regeneration. Trends Cardiovasc Med 14:121-125.
17. Fu Y, Yan W, Mohun TJ, Evans SM (1998) Vertebrate tinman homologues XNkx2-3 and XNkx2-5 are required for heart formation in a functionally redundant manner. Development 125:4439-4449.
18. Grow MW, Krieg PA (1998) Tinman function is essential for vertebrate heart development: elimination of cardiac differentiation by dominant inhibitory mutants of the tinman-related genes, XNkx2-3 and XNkx2-5. Dev Biol 204:187-196.
19. Habets PE, Moorman AF, Clout DE, van Roon MA, Lingbeek M, van Lohuizen M, Campione M, Christoffels VM (2002) Cooperative action of Tbx2 and Nkx2.5 inhibits ANF expression in the atrioventricular canal: implications for cardiac chamber formation. Genes Dev 16:1234-1246.
20. Harvey RP (1996) NK-2 homeobox genes and heart development. Dev Biol 178:203-216.
21. Heathcote K, Braybrook C, Abushaban L, Guy M, Khetyar ME, Patton MA, Carter ND, Scambler PJ, Syrris P (2005) Common arterial trunk associated with a homeodomain mutation of NKX2.6. Hum Mol Genet 14:585-593.
22. Hiroi Y, Kudoh S, Monzen K, Ikeda Y, Yazaki Y, Nagai R, Komuro I (2001) Tbx5 associates with Nkx2-5 and synergistically promotes cardiomyocyte differentiation. Nat Genet 28:276-280.
23. Inga A, Reamon-Buettner SM, Borlak J, Resnick MA (2005) Functional dissection of sequence-specific NKX2-5 DNA binding domain mutations associated with human heart septation defects using a yeast-based system. Hum Mol Genet 14:1965-1975.
24. Kasahara H, Lee B, Schott JJ, Benson DW, Seidman JG, Seidman CE, Izumo S (2000) Loss of function and inhibitory effects of human CSX/NKX2.5 homeoprotein mutations associated with congenital heart disease. J Clin Invest 106:299-308.
25. Kasahara H, Usheva A, Ueyama T, Aoki H, Horikoshi N, Izumo S (2001) Characterization of homo- and heterodimerization of cardiac Csx/Nkx2.5 homeoprotein. J Biol Chem 276:4570-4580.
26. Kim Y, Nirenberg M (1989) Drosophila NK-homeobox genes. Proc Natl Acad Sci USA 86:7716-7720.
27. Lien CL, McAnally J, Richardson JA, Olson EN (2002) Cardiacspecific activity of an Nkx2-5 enhancer requires an evolutionarily conserved Smad binding site. Dev Biol 244:257-266.
28. Lints TJ, Parsons LM, Hartley L, Lyons I, Harvey RP (1993) Nkx-2.5: a novel murine homeobox gene expressed in early heart progenitor cells and their myogenic descendants. Development 119:969.
29. Lyons I, Parsons LM, Hartley L, Li R, Andrews JE, Robb L, Harvey RP (1995) Myogenic and morphogenetic defects in the heart tubes of murine embryos lacking the homeobox gene Nkx2- 5. Genes Dev 9:1654-1666.
30. Newman CS, Krieg PA (1998) Tinman-related genes expressed during heart development in Xenopus. Dev Genet 22:230-238.
31. Newman CS, Reecy J, Grow MW, Ni K, Boettger T, Kessel M, Schwartz RJ, Krieg PA (2000) Transient cardiac expression of the tinman-family homeobox gene, XNkx2-10. Mech Dev 91:369-373.
32. Pabst O, Zweigerdt R, Arnold HH (1999) Targeted disruption of the homeobox transcription factor Nkx2-3 in mice results in postnatal lethality and abnormal development of small intestine and spleen. Development 126:2215-2225.
33. Patterson KD, Cleaver O, Gerber WV, Grow MW, Newman CS, Krieg PA (1998) Homeobox genes in cardiovascular development. Curr Top Dev Biol 40:1-44.
34. Peterkin T, Gibson A, Patient R (2003) GATA-6 maintains BMP- 4 and Nkx2 expression during cardiomyocyte precursor maturation. Embo J 22:4260-4273.
35. Riazi AM, Takeuchi JK, Hornberger LK, Zaidi SH, Amini F, Coles J, Bruneau BG, Van Arsdell GS (2009) NKX2-5 regulates the expression of beta-catenin and GATA4 in ventricular myocytes. PLoS One 4:e5698.
36. Sepulveda JL, Belaguli N, Nigam V, Chen CY, Nemer M, Schwartz RJ (1998) GATA-4 and Nkx-2.5 coactivate Nkx-2 DNA binding targets: role for regulating early cardiac gene expression. Mol Cell Biol 18:3405-3415.
37. Sparrow DB, Cai C, Kotecha S, Latinkic B, Cooper B, Towers N, Evans SM, Mohun TJ (2000) Regulation of the tinman homologues in Xenopus embryos. Dev Biol 227:65-79.
38. Tanaka M, Schinke M, Liao HS, Yamasaki N, Izumo S (2001) Nkx2.5 and Nkx2.6, homologs of Drosophila tinman, are required for development of the pharynx. Mol Cell Biol 21:4391- 4398.
39. Tu CT, Yang TC, Tsai HJ (2009) Nkx2.7 and Nkx2.5 function redundantly and are required for cardiac morphogenesis of zebra fish embryos. PLoS One 4:e4249.
40. Yamazaki K, Takahashi A, Takazoe M, Kubo M, Onouchi Y, Fujino A, Kamatani N, Nakamura Y, Hata A (2009) Positive association of genetic variants in the upstream region of NKX2-3 with Crohn's disease in Japanese patients. Gut 58:228-232.
41. Zeitlinger J, Stark A, Kellis M, Hong JW, Nechaev S, Adelman K, Levine M, Young RA (2007) RNA polymerase stalling at developmental control genes in the Drosophila melanogaster embryo. Nat Genet 39:1512-1516.