Plumbagin-induced apoptosis in lymphocytes is mediated through increased reactive oxygen species production, upregulation of Fas, and activation of the caspase cascade

Toxicology and Applied Pharmacology

Volumn 247, Issue 1, 2010, Pages 41-52

  McKallip, Robert J ^a   Lombard, Catherine ^b   Sun, Jingping ^a   Ramakrishnan, Rupal ^c  

^a MERCER UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b CLINIQUES UNIVERSITAIRES SAINT LUC   (Belgium)

^c H LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE   (United States)

Author keywords

Apoptosis; Fas; Immunosuppression; ROS

Indexed keywords

1 FLUORO 2,4 DINITROBENZENE; ACETYLCYSTEINE; CASPASE; CD3 ANTIBODY; CONCANAVALIN A; FAS ANTIGEN; LIPOPOLYSACCHARIDE; MITOGENIC AGENT; MONOCLONAL ANTIBODY; PLUMBAGIN; REACTIVE OXYGEN METABOLITE; STAPHYLOCOCCUS ENTEROTOXIN B;

ANIMAL CELL; ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; ATROPHY; C57BL 6 MOUSE; CELL CULTURE; CELL PROLIFERATION; CONTROLLED STUDY; DRUG EXPOSURE; ENZYME ACTIVATION; FEMALE; HYPOTHESIS; IMMUNE RESPONSE; IMMUNOSUPPRESSIVE TREATMENT; IN VITRO STUDY; IN VIVO STUDY; LYMPHOCYTE; MOUSE; NONHUMAN; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; SPLEEN CELL; THYMUS; UPREGULATION;

ACETYLCYSTEINE; ANIMALS; ANTIGENS, CD95; APOPTOSIS; ATROPHY; CASPASES; DINITROFLUOROBENZENE; ENTEROTOXINS; ENZYME ACTIVATION; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FEMALE; IMMUNOSUPPRESSIVE AGENTS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; LYMPHOCYTES; MEMBRANE POTENTIAL, MITOCHONDRIAL; MICE; MICE, INBRED C57BL; NAPHTHOQUINONES; P38 MITOGEN-ACTIVATED PROTEIN KINASES; REACTIVE OXYGEN SPECIES; SPLEEN; THYMUS GLAND; UP-REGULATION;

MUS;

EID: 77954761256     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2010.05.013     Document Type: Article

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