Skin inflammation during contact hypersensitivity is mediated by early recruitment of CD8+ T cytotoxic 1 cells inducing keratinocyte apoptosis

Journal of Immunology

Volumn 168, Issue 6, 2002, Pages 3079-3087

  Akiba, Hitoshi ^a   Kehren, Jeanne ^a   Ducluzeau, Marie Thérèse ^a   Krasteva, Maya ^a   Horand, Françoise ^a   Kaiserlian, Dominique ^a   Kaneko, Fumio ^a   Nicolas, Jean François ^a  

^a FUKUSHIMA MEDICAL UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

1 FLUORO 2,4 DINITROBENZENE; CD4 ANTIGEN; CD8 ANTIGEN; GAMMA INTERFERON; HAPTEN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CONTACT ALLERGY; CONTROLLED STUDY; CORNEA CELL; CYTOTOXICITY; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; IMMUNOPATHOLOGY; MEDIATOR RELEASE; MOUSE; NONHUMAN; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SKIN INFLAMMATION; T LYMPHOCYTE SUBPOPULATION; TH2 CELL;

EID: 0037087322     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.168.6.3079     Document Type: Article

References (60)

1. Hapten-peptide-T cell receptor interactions: Molecular basis for the recognition of haptens by T lymphocytes
2. + T cells
3. + T cells, respectively, mediate and regulate contact sensitivity to dinitrofluorobenzene
4. Contact dermatitis. I. Pathophysiology of contact sensitivity
5. Effector and regulatory T cells in allergic contact dermatitis
6. + type 1 cytotoxic T cells both play a crucial role in the full development of contact hypersensitivity
7. Immunoregulatory mechanisms involved in elicitation of allergic contact hypersensitivity
8. Insights into molecular mechanisms of contact hypersensitivity gained from gene knockout studies
9. + T cell-mediated contact hypersensitivity
10. + T cells are the dominant effector cells in trinitrophenyl-specific contact hypersensitivity
11. + T cells
12. + effector T cells in vivo
13. + T cells
14. + T cells during the development of contact hypersensitivity responses
15. + T lymphocytes with remarkable regulatory functions on dendritic cells and nickel-specific Th1 immune responses
16. Dual role of dendritic cells in the induction and down-regulation of antigen-specific cutaneous inflammation
17. - dendritic cells induce hapten-specific immune responses in vitro and in vivo
18. + T cells
19. An early component of delayed-type hypersensitivity mediated by T cells and mast cells
20. Required early complement activation in contact sensitivity with generation of local C5-dependent chemotactic activity, and late T cell interferon γ: A possible initiating role of B cells
21. Early local generation of C5a initiates the elicitation of contact sensitivity by leading to early T cell recruitment
22. The immunologic properties of epidermal Langerhans cells as a part of the dendritic cell system
23. Removal of the majority of epidermal Langerhans cells by topical or systemic steroid application enhances the effector phase of murine contact hypersensitivity
24. Keratinocytes as initiators of inflammation
25. The role of antigen-presenting cells in the regulation of delayed-type hypersensitivity. II. Epidermal Langerhans' cells and peritoneal exudate macrophages
26. Unexpected lack of reactivity of allogeneic anti-Ia monoclonal antibodies with MHC class II molecules expressed by mouse intestinal epithelial cells
27. Optimization of the mouse ear swelling test for in vivo and in vitro studies of weak contact sensitizers
28. Differential cytokine expression in maternal blood and placenta during murine gestation
29. Evidence that cutaneous antigen-presenting cells migrate to regional lymph nodes during contact sensitization
30. + T cells during the elicitation of contact hypersensitivity
31. + T cells
32. Interferon-γ production in skin during contact hypersensitivity: No contribution from keratinocytes
33. Nickel chloride and cobalt chloride, two common contact sensitizers, directly induce expression of intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), and endothelial leukocyte adhesion molecule (ELAM-1) by endothelial cells
34. Multiple signaling pathways regulate NF-κB-dependent transcription of the monocyte chemoattractant protein-1 gene in primary endothelial cells
35. Early time course of recruitment of immune surveillance in human skin after chemical provocation
36. Vascular endothelial cell expression of ICAM-1 and VCAM-1 at the onset of eliciting contact hypersensitivity in mice: Evidence for a dominant role of TNF-α
37. Delayed-type hypersensitivity in mast cell-deficient mice: Dependence on platelets for expression of contact sensitivity
38. T cell-dependent mast cell degranulation and release of serotonin in murine delayed-type hypersensitivity
39. Human platelets can initiate T cell-dependent contact sensitivity through local serotonin release mediated by IgE antibodies
40. Tumor necrosis factor is a critical mediator in hapten induced irritant and contact hypersensitivity reactions
41. The effect of locally injected vasoactive amines on the elicitation of delayed-type hypersensitivity
42. Lymphocyte traffic control by chemokines
43. Inhibition of T cell recruitment and cutaneous delayed-type hypersensitivity-induced inflammation with antibodies to monocyte chemoattractant protein-1
44. Analysis of contact hypersensitivity response in human monocyte chemoattractant protein (MCP)-1 transgenic mice
45. Keratinocyte-derived monocyte chemoattractant protein I (MCP-1): Analysis in a transgenic model demonstrates MCP-1 can recruit dendritic and Langerhans cells to skin
46. Chemokine expression in trinitrochlorobenzene-mediated contact hypersensitivity
47. Beta chemokines costimulate lymphocyte cytolysis, proliferation, and lymphokine production
48. + T cell development for contact hypersensitivity responses and circumvents anti-CD154 antibody-mediated inhibition
49. P-selectin glycoprotein ligand-1 (PSGL-1) on T helper 1 but not on T helper 2 cells binds to P-selectin and supports migration into inflamed skin
50. P- and E-selectin mediate recruitment of T-helper-1 but not T-helper-2 cells into inflammed tissues
51. + T cells
52. Pivotal role of TARC, a CC chemokine, in bacteria-induced fulminant hepatic failure in mice
53. Modulation of airway inflammation by passive transfer of allergen-specific Th1 and Th2 cells in a mouse model of asthma
54. Switch in chemokine receptor expression upon TCR stimulation reveals novel homing potential for recently activated T cells
55. Differential and sequential expression of multiple chemokines during elicitation of allergic contact hypersensitivity
56. Localization of Th-cell subsets in inflammation: Differential thresholds for extravasation of Th1 and Th2 cells
57. + T lymphocytes with regulatory activity
58. The chemokine receptor CCR8 is preferentially expressed in Th2 but not Th1 cells
59. Chemokine-induced cutaneous inflammatory cell infiltration in a model of Hu-PBMC-SCID mice grafted with human skin
60. Reversal of established delayed type hypersensitivity reactions following therapy with IL-4 or antigen-specific Th2 cells