Antinociceptive synergism of MD-354 and clonidine. Part II. The α2-adrenoceptor component

Basic and Clinical Pharmacology and Toxicology

Volumn 107, Issue 2, 2010, Pages 690-697

  Young, Shawquia ^a   Vainio, Minna ^b   Scheinin, Mika ^b,c   Dukat, Małgorzata ^a  

^a VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

^b UNIVERSITY OF TURKU   (Finland)

^c TURKU UNIVERSITY HOSPITAL   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

12 ETHYLSULFONYL 5,8,8A,9,10,11,12,12A,13,13A DECAHYDRO 3 METHOXY 6H ISOQUINO[2,1 G][1,6]NAPHTHYRIDINE; 2 (1 METHYL 2 ISOINDOLINYLMETHYL) 2 IMIDAZOLINE; 3 CHLOROPHENYLGUANIDINE; ALPHA 2 ADRENERGIC RECEPTOR; ALPHA 2A ADRENERGIC RECEPTOR; ALPHA 2B ADRENERGIC RECEPTOR; ALPHA 2C ADRENERGIC RECEPTOR; ANTINOCICEPTIVE AGENT; CLONIDINE; IMILOXAN; MD 354; RADIOLIGAND; SEROTONIN 3 RECEPTOR; UNCLASSIFIED DRUG; YOHIMBINE; ALPHA ADRENERGIC RECEPTOR; ALPHA ADRENERGIC RECEPTOR BLOCKING AGENT; ANALGESIC AGENT; GUANIDINE DERIVATIVE; IMIDAZOLE DERIVATIVE; ISOINDOLE DERIVATIVE; M-CHLOROPHENYLGUANIDINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTINOCICEPTION; ARTICLE; BINDING ASSAY; CONTROLLED STUDY; DOSE RESPONSE; DRUG ACTIVITY; DRUG POTENTIATION; DRUG PROTEIN BINDING; LOCOMOTION; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SEDATION; TAIL FLICK TEST; ANIMAL; ANIMAL BEHAVIOR; DRUG EFFECTS; INNERVATION; INSTITUTE FOR CANCER RESEARCH MOUSE; METABOLISM; MOTOR ACTIVITY; PAIN; PAIN MEASUREMENT; SUBCUTANEOUS DRUG ADMINISTRATION; TAIL;

ADRENERGIC ALPHA-ANTAGONISTS; ANALGESICS; ANIMALS; BEHAVIOR, ANIMAL; CLONIDINE; DRUG SYNERGISM; GUANIDINES; IMIDAZOLES; INJECTIONS, SUBCUTANEOUS; ISOINDOLES; MALE; MICE; MICE, INBRED ICR; MOTOR ACTIVITY; PAIN; PAIN MEASUREMENT; RECEPTORS, ADRENERGIC, ALPHA; TAIL; YOHIMBINE;

EID: 77954699154     PISSN: 17427835     EISSN: 17427843     Source Type: Journal    
DOI: 10.1111/j.1742-7843.2010.00563.x     Document Type: Article

References (39)

1. Tallarida RJ. Drug synergism: its detection and applications. J Pharmacol Exp Ther 2001 298 : 865 872.
2. Hao S, Takahata O, Iwasaki H. Antinociceptive interaction between spinal clonidine and lidocaine in the rat formaline test: an isobolographic analysis. Anesth Analg 2001 92 : 733 738.
3. Finkel JC, Pestieau SR, Quezado ZMN. Ketamine as an adjuvant for treatment of cancer pain in children and adolescents. J Pain 2007 8 : 515 521.
4. Knotkova H, Pappagallo M. Adjuvant analgesics. Anesthesiology Clin 2007 25 : 775 786. (Pubitemid 350180663)
5. Tryba M, Gehling M. Clonidine - a potent analgesic adjuvant. Curr Opin Anaesthesiol 2002 15 : 511 517.
6. 2-adrenoceptor subtype activated by clonidine for analgesia. Anesthesiology 2002 97 : 636 641.
7. 2-adrenoceptor subtypes in the spinal cord. Eur J Pharmacol 1992 219 : 465 468.
8. 2A-adrenoceptor deficient mice. Eur J Pharmacol 2004 485 : 193 196.
9. Dukat M, Glennon RA, Young S. MD-354: What is it good for? CNS Drug Rev 2007 13 : 1 20.
10. 3 component. Eur J Pharmacol 2005 528 : 59 64.
11. Kameyama T, Nabeshima T, Matsuno K, Sugimoto A. Comparison of α-adrenoceptor involvement in the antinociceptive action of tizanidine and clonidine in the mouse. Eur J Pharmacol 1986 125 : 257 264. (Pubitemid 16075438)
12. 3 serotonin receptors. J Med Chem 1996 39 : 4017 4026.
13. D'Amour FE, Smith DL. A method for determining loss of pain sensation. J Pharmacol Exp Ther 1941 72 : 74 9.
14. Dewey WL, Harris LS, Howes JS, Nuite JA. The effect of various neurohormonal modulations on the activity of morphine and the narcotic antagonist in tail-flick and phenylquinone test. J Pharmacol Exp Ther 1970 175 : 435 442.
15. Millan MJ, Bervoets K, Rivet J-M, Widdowson P, Renouard A, Le Marouille-Girardon S et al. Multiple alpha-2 adrenergic receptor subtypes. II. Evidence for a role of rat Ralpha-2A adrenergic receptors in the control of nociception, motor behavior and hippocampal synthesis of noradrenaline. J Pharmacol Exp Ther 1994 270 : 958 972.
16. 2- antagonist potency. J Pharm Pharmacol 1984 36 : 478 481.
17. 2A-adrenoceptor subtype mediates antinociception in mice. Eur J Pharmacol 1992 215 : 355 356.
18. Spaulding TC, Fielding S, Venafro JJ, Lal H. Antinociceptive activity of clonidine and its potentiation of morphine analgesia. Eur J Pharmacol 1979 58 : 19 25.
19. 3H]rauwolscine binding, inhibition of adenylate cyclase and RNase protection assay. Biochim Biophys Acta 1992 1134 : 169 177.
20. 2-Adrenoceptor regulation of adenylyl cyclase in CHO cells: dependence on receptor density, receptor subtype and current activity of adenylyl cyclase. Eur J Pharmacol 1997 335 : 53 63.
21. Finney D. Probit Analysis.
22. Cheng Y, Prusoff WH. Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (IC50) of an enzymatic reaction. Bichem Pharmacol 1973 22 : 3099 3108.
23. Wesolowska A, Young S, Dukat M. MD-354 potentiates the antinociceptive effect of clonidine in the mouse tail-flick but not hot-plate assay. Eur J Pharmacol 2004 495 : 129 136.
24. 35S]GTPγS binding in rat cerebral cortical membranes. Pharmacol Res 2008 57 : 435 444.
25. 3H]-MK912 is alpha-2C selective among human alpha-2A, alpha-2B and alpha-2C adrenoceptors. J Pharmacol Exp Ther 1994 271 : 1558 1565.
26. 2-adrenoceptor antagonists. Br J Pharmacol 1981 74 : 255P.
27. Graham BA, Hammond DL, Proudfit HK. Difference in the antinociceptive effects of alpha-2 adrenergic agonists in two substrains of Sprague-Dawley rats. J Pharmacol Exp Ther 1997 283 : 511 519.
28. Cleary L, Vandeputte C, Docherty JR. Investigation of postjunctional α1-and α2-adrenoceptor subtypes in vas deferens from wild-type and α2A/D-adrenoceptor knockout mice. Br J Pharmacol 2003 138 : 1069 1076.
29. 1A receptor in the rat brain. Eur J Pharmacol 1996 312 : 385 388.
30. Takano Y, Yaksh TL. Characterization of the pharmacology of intrathecally administered alpha-2 agonists and antagonists in rats. J Pharmacol Exp Ther 1992 261 : 764 772.
31. 2A/D-antagonist in the rat prefrontal cortex. Neurosci Lett 2006 402 : 253 258.
32. Uhlén S, Dambrova M, Näsman J, Schiöth HB, Gu Y, Wikberg-Matsson A et al. [3H]RS79948-197 binding to human, rat, guinea pig and pig alpha2A-, alpha2B- and alpha2C-adrenoceptors. Comparison with MK912, RX821002, rauwolscine and yohimbine. Eur J Pharmacol 1998 343 : 93 101.
33. 2-adrenoceptor knockout mice. Eur J Pharmacol 2004 497 : 301 309.
34. 3H]RX821002 as radioligands. Biochem Biophys Acta 1995 1266 : 207 214.
35. Gleason MM, Hieble JP. Ability of SK&F 104078 and SK&F 104856 to identify alpha-2 adrenoceptor subtypes in NCB20 cells and guinea pig lung. J Pharmacol Exp Ther 1991 259 : 1124 1132.
36. 2- adrenoceptors. Eur J Pharmacol 1998 355 : 275 279.
37. 2-adrenoceptor subtypes in the antinociceptive, sedative and hypothermic action of dexmedetomidine in transgenic mice. Br J Pharmacol 1997 122 : 1339 1344.
38. Lakhlani PP, McMillan LB, Guo TZ, McCool BA, Lovinger DM, Maze M et al. Substitution of a mutant alpha2a-adrenergic receptor via 'hit and run' gene targeting reveals the role of this subtype in sedative, analgesic, and anesthetic-sparing responses in vivo. Proc Natl Acad Sci USA 1997 94 : 9950 9955.
39. 2A-adrenergic receptor mice unveil unique therapeutic benefits of partial agonists. Proc Natl Acad Sci USA 2002 99 : 12471 12476.