MD-354 potentiates the antinociceptive effect of clonidine in the mouse tail-flick but not hot-plate assay

European Journal of Pharmacology

Volumn 495, Issue 2-3, 2004, Pages 129-136

  Wesolowska, Anna ^a   Young, Shawquia ^a   Dukat, Malgorzata ^a  

^a VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

Author keywords

2 Adrenoceptor; 5 HT3 receptor; Antinociception; In vitro and in vivo model; MD 354 (m chlorophenylguanidine)

Indexed keywords

3 CHLOROPHENYLGUANIDINE; CLONIDINE; GUANIDINE DERIVATIVE; MD 354; SEROTONIN 3 AGONIST; UNCLASSIFIED DRUG;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINOCICEPTION; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG ANTAGONISM; DRUG EFFECT; DRUG EFFICACY; DRUG MECHANISM; DRUG POTENTIATION; HOT PLATE TEST; MALE; MOUSE; NONHUMAN; PAIN; PRIORITY JOURNAL; TAIL FLICK TEST;

ANALGESICS; ANIMALS; BENZAMIDES; BICYCLO COMPOUNDS, HETEROCYCLIC; BINDING, COMPETITIVE; CLONIDINE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SYNERGISM; GUANIDINES; MICE; MICE, INBRED ICR; MORPHINE; PAIN; PAIN MEASUREMENT; RADIOLIGAND ASSAY; RECEPTOR, SEROTONIN, 5-HT1A; RECEPTORS, ADRENERGIC, ALPHA-1; RECEPTORS, ADRENERGIC, ALPHA-2; RECEPTORS, SEROTONIN;

EID: 3042836383     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2004.05.028     Document Type: Article

References (27)

1. Atwell L., Jacobson A.E. The search for less harmful analgesics. Lab. Anim. 7:1978;42-47
2. Capasso A., Loizzo A. Clonidine-induced antinociception and locomotor hypoactivity are reduced by dexamethasone in mice. J. Pharm. Pharmacol. 53:2001;351-360
3. D'Amour F.E., Smith D.L. A method for determining loss of pain sensation. J. Pharmacol. Exp. Ther. 72:1941;74-79
4. Dewey W.L., Harris L.S., Howes J.S., Nuite J.A. The effect of various neurohormonal modulations on the activity of morphine and the narcotic antagonist in tail-flick and phenylquinone test. J. Pharmacol. Exp. Ther. 175:1970;435-442
5. 3 serotonin receptor agonists: a pharmacophoric journey. Curr. Med. Chem. Cent. Nerv. Syst. Agents. 4:2004;77-94
6. 3 serotonin receptors. J. Med. Chem. 39:1996;4017-4026
7. 3 agent N-(3-chlorophenyl)guanidine (MD-354) serves as a discriminative stimulus in rats and displays partial agonist character in a shrew emesis assay. Psychopharmacology. 150:2000;200-207
8. Eddy N.B., Leimbach D. Synthetic analgesic: II. Dithienybutenyl and benzomorphans. J. Pharmacol. Exp. Ther. 107:1953;385-939
9. Fairbanks C.A., Wilcox G.L. Spinal antinociceptive synergism between morphine and clonidine persists in mice made acutely or chronically tolerant to morphine. J. Pharmacol. Exp. Ther. 288:1999;1107-1116
10. 3 receptors in nociception. King F.D., Jones B.J., Sanger G.J. 5-Hydroxytryptamine-3 receptor antagonists. 1994;241-253 CRC Press, Boca Raton, FL
11. Furst S. Transmitters involved in antinociception in the spinal cord. Brain Res. Bull. 48:1999;129-141
12. Graham B.A., Hammond D.L., Proudfit H.K. Difference in the antinociceptive effects of alpha-2 adrenergic agonists in two substrains of Sprague-Dawley rats. J. Pharmacol. Exp. Ther. 283:1997;511-519
13. Israili Z.H. Clinical pharmacology of serotonin receptor type 3 (5-HT3) antagonists. Curr. Med. Chem. Cent. Nerv. Syst. Agents. 1:2001;171-199
14. Kameyama T., Nabeshima T., Matsuno K., Sugimoto A. Comparison of α-adrenoceptor involvement in the antinociceptive action of tizanidine and clonidine in the mouse. Eur. J. Pharmacol. 125:1986;257-264
15. 2-adrenergic agonists. Anesthesiology. 93:2000;1345-1349
16. MacDonald E., Kobilka B.K., Scheinin M. Gene targeting - homing in on α2-adrenoceptor-subtype function. Trends Pharmacol. Sci. 18:1997;211-219
17. 2 Adrenoceptors in pain modulation. Which subtype should be targeted to produce analgesia? Anesthesiology. 92:2000;934-936
18. 1-opioid receptors in the fentanyl- or morphine-induced antinociception at supraspinal and spinal sites. Life Sci. 70:2002;2341-2354
19. 2c subtype mRNAs. Anesthesiology. 92:2000;968-976
20. Özdogan Ü.K., Lähdesmäki J., Scheinin M. Influence of prazosin and clonidine on morphine analgesia, tolerance and withdrawal in mice. Eur. J. Pharmacol. 460:2003;127-134
21. 2-adrenergic receptor subtype diversity: one receptor is not enough. Am. J. Physiol., Regul. Integr. Comp. Physiol. 283:2002;R287-R295
22. 3 serotonin receptor ligands meta-chlorophenylbiguanide (mCPBG) and meta-chlorophenylguanidine (mCPG). Bioorg. Med. Chem. Lett. 13:2003;1119-1123
23. 3H]RX821002-labeled rat alpha2A-adrenergic receptors in cerebral cortex to human Halpha2A-adrenergic receptor and other populations of alpha-2 adrenergic subtypes. J. Pharmacol. Exp. Ther. 270:1994;946-957
24. Spaulding T.C., Fielding S., Venafro J.J., Lal H. Antinociceptive activity of clonidine and its potentiation of morphine analgesia. Eur. J. Pharmacol. 58:1979;19-25
25. Takano Y., Yaksh T.L. Characterization of the pharmacology of intrathecally administered alpha-2 agonists and antagonists in rats. J. Pharmacol. Exp. Ther. 261:1992;764-772
26. Takano Y., Takano M., Yaksh L. The effect of intrathecally administered imiloxan and WB4101: possible role of α2-adrenoceptor subtypes in the spinal cord. Eur. J. Pharmacol. 219:1992;465-468
27. Tallarida R.J., Murray R.B. Manual of pharmacological calculations with computer programs. 1987;Springer-Verlag, New York