Differences in the antinociceptive effects of alpha-2 adrenoceptor agonists in two substrains of Sprague-Dawley rats

Journal of Pharmacology and Experimental Therapeutics

Volumn 283, Issue 2, 1997, Pages 511-519

  Graham, Brent A ^a   Hammond, Donna L ^a   Proudfit, Herbert K ^b  

^a UNIVERSITY OF CHICAGO   (United States)

^b UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 (2,6 DIETHYLANILINO) 2 IMIDAZOLINE; ALPHA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; DEXMEDETOMIDINE; RECEPTOR SUBTYPE;

ANTINOCICEPTION; ARTICLE; DRUG SELECTIVITY; NOCICEPTION; PRIORITY JOURNAL; SPINAL CORD; TAIL FLICK TEST;

ADRENERGIC ALPHA-AGONISTS; ANALGESICS, NON-NARCOTIC; ANIMALS; CLONIDINE; DOSE-RESPONSE RELATIONSHIP, DRUG; IMIDAZOLES; INJECTIONS, SPINAL; MALE; MEDETOMIDINE; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, ADRENERGIC, ALPHA-2; SPECIES SPECIFICITY; SPINAL CORD;

EID: 0030779572     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (68)

1. BENNETT, G. J. AND XIE, Y.-K.: A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man. Pain 33: 87-107, 1988.
2. CLARK, F. M. AND PROUDFIT, H. K.: The projection of locus coeruleus neurons to the spinal cord in the rat determined by anterograde tracing combined with immunocytochemistry. Brain Res. 538: 231-245, 1991a.
3. CLARK, F. M. AND PROUDFIT, H. K.: The projection of noradrenergic neurons in the A7 catecholamine cell group to the spinal cord in the rat demonstrated by anterograde tracing combined with immunocytochemistry. Brain Res. 547: 279-288, 1991b.
4. CLARK, F. M. AND PROUDFIT, H. K.: Anatomical evidence for genetic differences in the innervation of the rat spinal cord by noradrenergic locus coeruleus neurons. Brain Res. 591: 44-53, 1992.
5. D'AMOUR, F. E. AND SMITH, D. L.: A method for determining loss of pain sensation. J. Pharmacol. Exp. Ther. 72: 74-79, 1941.
6. FILOS, K. S., GOUDAS, L. C., PATRONI, O. AND POLYZOU, V.: Hemodynamic and analgesic profile after intrathecal clonidine in humans. Anesthesiology 81: 591-601, 1994.
7. FINNEY, D. J.: Statistical Method in Biological Assay, Hafner Publishing Co., New York, 1964.
8. FISHER, B., ZORNOW, M. H., YAKSH, T. L. AND PETERSON, B. M.: Antinociceptive properties of intrathecal dexmedetomidine in rats. Eur. J. Pharmacol. 192: 221-225, 1991.
9. FLEISCHER, E., HANDWERKER, H. O. AND JOUKHADAR, S.: Unmyelinated nociceptive units in two skin areas of the rat. Brain Res. 267: 81-92, 1983.
10. FRITSCHY, J. M. AND GRZANNA, R.: Demonstration of two separate descending noradrenergic pathways to the rat spinal cord: Evidence for an intragriseal trajectory of locus coeruleus axons in the superficial layers of the dorsal horn. J. Comp. Neurol. 291: 553-582, 1990.
11. GORDH, T.: Epidural clonidine for treatment of post-operative pain after thoracotomy: A double-blind placebo-controlled study. Acta Anaesthesiol. Scand. 32: 702-709, 1988.
12. GORDH, T. AND TAMSEN, A.: A study on the analgesic effect of clonidine in man. Acta Anaesthesiol. Scand. 87: suppl, 72, 1983.
13. GRAHAM, B. A., HAMMOND, D. L. AND PROUDFIT, H. K.: Spinal alpha2-noradrenergic receptors differ in substrains of Sprague-Dawley (S-D) rat. Neurosci. Abstr. 21: 651, 1995a.
14. GRAHAM, B. A., HAMMOND, D. L. AND PROUDFIT, H. K.: Differential antinociceptive effects of α-2 adrenoceptor agonists in substrains of Sprague-Dawley rats (Abstract). Anesthesiology 85: A665, 1996.
15. GRAHAM, B. A., HAMMOND, D. L. AND PROUDFIT, H. K.: Intrathecal dexmedetomidine (DEX) and ST-91 act synergistically to produce antinociception in the rat. Neurosci. Abstr. 23: 1997.
16. GRAHAM, B. A., PROUDFIT, H. K. AND HAMMOND, D. L.: Different adrenoceptor subtypes mediate the antinociceptive effects of 2 agonists in different substrains of Sprague-Dawley rats (Abstract). Anesth. Analg. 80: S155, 1995b.
17. GROSSMAN, M. L., BASBAUM, A. I. AND FIELDS, H. L.: Afferent and efferent connections in the rat tail-flick reflex (a model used to analyze pain control mechanisms). J. Comp. Neurol. 206: 9-16, 1982.
18. ORZANNA, R. AND FRITSCHY, J.-M.: Efferent projections of different subpopulations of central noradrenaline neurons. Prog. Brain Res. 88: 89-101, 1991.
19. HAMMOND, D. L.: Intrathecal administration: Methodological considerations. Prog. Brain Res. 77: 313-320, 1988.
20. HAMMOND, D. L.: Inference of pain and its modulation from simple behaviors. In Issues in Pain Measurement, ed. by C. R. Chapman and J. D. Loeser, pp. 69-91, Raven, New York, 1989.
21. HAMMOND, D. L. AND WASHINGTON, J. D.: Antagonism of L-baclofen-induced antinociception by CGP 35348 in the spinal cord of the rat. Eur. J. Pharmacol. 234: 255-262, 1993.
22. HANDWERKER, H. O., ANTON, F. AND REEH, P. W.: Discharge patterns of afferent cutaneous nerve fibers from the rat's tail during prolonged noxious mechanical stimulation. Exp. Brain Res. 65: 493-504, 1987.
23. HARGREAVES, K., DUBNER, R., BROWN, F., FLORES, C. AND JORES, J.: A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia. Pain 32: 77-88, 1988.
24. HOWE, J. R., WANG, J.-Y. AND YAKSH, T. L.: Selective antagonism of the antinociceptive effect of intrathecally applied alpha adrenergic agonists by intrathecal prazosin and intrathecal yohimbine. J. Pharmacol. Exp. Ther. 224: 552-558, 1983.
25. IDÄNPÄÄN-HEIKKLÄ, J. J., KALSO, E. A. AND SEPPÄLÄ, T.: Antinociceptive actions of dexmedetomidine and the kappa-opioid agonist U-50,488H against noxious thermal, mechanical and inflammatory stimuli. J. Pharmacol. Exp. Ther. 271: 1306-1313, 1994.
26. JASMIN, L., CARSTENS, E. AND BASBAUM, A. I.: Interneurons presynaptic to rat tail-flick motoneurons as mapped by transneural transport of pseudorabies virus: Few have long ascending collaterals. Neuroscience 76: 859-876, 1997.
27. JONES, S. L.: Descending control of nociception. In The Initial Processing of Pain and Its Descending Control: Spinal and Trigeminal Systems, ed. by A. R. Light, vol. 12, pp. 203-295, Karger, New York, 1992.
28. JONES, S. L. AND GEBHART, G. F.: Quantitative characterization of coeruleospinal inhibition of nociceptive transmission in the rat. J. Neurophysiol. 56: 1397-1410, 1986.
29. JONES, S. L. AND GEBHART, G. F.: Spinal pathways mediating tonic, coeruleospinal, and raphe-spinal descending inhibition in the rat. J. Neurophysiol. 58: 138-159, 1987.
30. KALSO, E. A., PöYGHIÄ, R. AND ROSENBERG, P. H.: Spinal antinociception by dexmedetomidine, a highly selective alpha-2-adrenergic agonist. Pharmacol. Toxicol. 68: 140-143, 1991.
31. KALSO, E. A., SULLIVAN, A. F., McQuAY, H. J., DICKENSON, A. H. AND ROQUES, B. P.: Cross-tolerance between mu opioid and alpha-2 adrenergic receptors, but not between mu and delta opioid receptors in the spinal cord of the rat. J. Pharmacol. Exp. Ther. 265: 551-558, 1993.
32. KENAKIN, T.: Pharmacologic Analysis of Drug-Receptor Interaction, Raven Press, New York, 1993.
33. KEPPEL, G.: Design and Analysis: A Researcher's Handbook, Prentice-Hall, Inc., Englewood Cliffs, New Jersey, 1973.
34. KIM, S. H. AND CHUNG, J. M.: An experimental model for peripheral neuropathy produced by segmental spinal nerve ligation in the rat. Pain 50: 335-363, 1992.
35. LEEM, J. W., WILLIS, W. D. AND CHUNG, J. M.: Cutaneous sensory receptors in the rat foot. J. Neurophysiol. 69: 1684-1699, 1993.
36. LYONS, W. E., FRITSCHY, J. M. AND GRZANNA, R.: The noradrenergic neurotoxin DSP-4 eliminates the coeruleospinal projection but spares projections of the A5 and A7 groups to the ventral horn of the rat spinal cord. J. Neurosci. 9: 1481-1489, 1989.
37. MOLANDER, C. AND GRANT, G.: Cutaneous projections from the rat hindlimb foot to the substantia gelatinosa of the spinal cord studied by transganglionic transport of WGA-HRP conjugate. J. Comp. Neurol. 237: 476-484, 1985.
38. MOLANDER, C. AND GRANT, G.: Laminar distribution and somatotopic organization of primary afferent fibers from hindlimb nerves in the dorsal horn: A study by transganglionic transport of horseradish peroxidase in the rat. Neuroscience 19: 297-312, 1986.
39. MONASKY, M. S., ZINSMEISTER, A. R., STEVENS, C. W. AND YAKSH, T. L.: Interaction of intrathecal morphine and ST-91 on antinociception in the rat: Dose-response analysis, antagonism and clearance. J. Pharmacol. Exp. Ther. 254: 383-392, 1990.
40. MURATA, K., NAKAGAWA, I., KUMETA, Y., KITAHATA, L. M. AND COLLINS, J. G.: Intrathecal clonidine suppresses noxiously evoked activity of spinal wide dynamic range neurons in cats. Anesth. Analg. 69: 185-191, 1989.
41. NECKER, R. AND HELLON, R. F.: Noxious thermal input from the rat tail: Modulation by descending inhibitory influences. Pain 4: 231-242, 1978.
42. NYGREN, L. G. AND OLSON, L.: A new major projection from locus coeruleus: The main source of noradrenergic nerve terminals in the ventral and dorsal columns of the spinal cord. Brain Res. 132: 85-93, 1976.
43. OSSIPOV, M. H., SUAREZ, L. J. AND SPAULDING, T. C.: A comparison of the antinociceptive and behavioral effects of intrathecally administered opiates, α-2-adrenergic agonists, and local anesthetics in mice and rats. Anesth. Analg. 67: 616-624, 1988.
44. PROUDFIT, H. K.: The behavioural pharmacology of the noradrenergic descending system. In Toward the Use of Noradrenergic Agonists for the Treatment of Pain, ed. by J.-M. Besson, pp. 119-136, Elsevier, Amsterdam, 1992.
45. PROUDFIT, H. K. AND CLARK, F. M.: The projections of locus coeruleus neurons to the spinal cord. Prog. Brain Res. 88: 123-141, 1991.
46. REDDY, S. V. R., MADERDRUT, J. L. AND YAKSH, T. L.: Spinal cord pharmacology of adrenergic agonist-mediated antinociception. J. Pharmacol. Exp. Ther. 213: 525-533, 1980.
47. RIVLIN, A. S. AND TATOR, C. H.: Objective clinical assessment of motor function after experimental spinal cord injury in the rat. Neurosurgery 47: 577-581, 1977.
48. ROTTO-PERCELAY, D. M., WHEELER, J. G., OSORIO, F. A., PLATT, K. B. AND LOEWY, A. D., Transneuronal labeling of spinal interneurons and sympathetic preganglionic neurons after pseudorabies virus injections in the rat medial gastrocnemius muscle. Brain Res. 574: 291-306, 1992.
49. ROUDET, C., MOUCHET, P., FEUERSTEIN, C. AND SAVASTA, M.: Normal distribution of alpha 2-adrenoceptors in the rat spinal cord and its modification after noradrenergic denervations: A quantitative autoradiographic study. J. Neurosci. Res. 39: 319-329, 1994.
50. SAEKI, S. AND YAKSH, T. L.: Suppression by spinal alpha-2 agonists of motor and autonomie responses evoked by low-and high-intensity thermal stimuli. J. Pharmacol. Exp. Ther. 260: 795-802, 1992.
51. SLUKA, K. A. AND WESTLUND, K. N.: Spinal projections of the locus coeruleus and the nucleus subcoeruleus in the Harlan and the Sasco Sprague-Dawley rat. Brain Res. 579: 67-73, 1992.
52. SOLOMON, R. E., BRODY, M. J. AND GEBHART, G. F.: Pharmacological characterization of alpha adrenoceptors involved in the antinociceptive and cardiovascular effects of intrathecally administered clonidine. J. Pharmacol. Exp. Ther. 251: 27-38, 1989.
53. 2-Adrenoceptor modulation of nociception in rat spinal cord: Location, effects and interactions with morphine. Eur. J. Pharmacol. 138: 169-177, 1987.
54. SULLIVAN, A. F., KALSO, E. A., McQUAY, H. J. AND DICKENSON, A. H.: The antinociceptive actions of dexmedetomidine on dorsal horn neuronal responses in the anaesthetized rat. Eur J Pharmacol 215: 127-133, 1992.
55. SUMMERS, R. J. AND McMARTIN, L. R.: Adrenoceptors and their second messenger systems. J. Neurochem. 60: 10-23, 1993.
56. TAKANO, Y., TAKANO, M. AND YAKSH, T. L.: The effect of intrathecally administered imiloxan and WB4101: Possible role of α2-adrenoceptor subtypes in the spinal cord. Eur. J. Pharmacol. 219: 465-168, 1992.
57. TAKANO, Y. AND YAKSH, T. L.: Relative efficacy of spinal alpha-2 agonists, dexmedetomidine, clonidine and ST-91, determined in vivo by using N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline, an irreversible antagonist. J. Pharmacol. Exp. Ther. 258: 438-446, 1991.
58. TAKANO, Y. AND YAKSH, T. L.: Characterization of the pharmacology of intrathecally administered alpha-2 agonists and antagonists in rats. J. Pharmacol. Exp. Ther. 261: 764-772, 1992.
59. TAMSEN, A. AND GORDH, T.: Epidural clonidine produces analgesia. Lancet 2: 231-232, 1984.
60. WEST, W. L., YEOMANS, D. C. AND PROUDFIT, H. K.: The function of noradrenergic neurons in mediating antinociception induced by electrical stimulation of the locus coeruleus in two different sources of Sprague-Dawley rats. Brain Res. 626: 127-135, 1993.
61. WESTLUND, K. N., BOWKER, R. M., ZIEGLER, M. G. AND COULTEB, J. D.: Descending noradrenergic projections and their spinal terminations. Prog. Brain Res. 57: 219-238, 1982.
62. WESTLUND, K. N., BOWKER, R. M., ZIEGLER, M. G. AND COULTER, J. D.: Noradrenergic projections to the spinal cord in the rat. Brain Res. 263: 15-31, 1983.
63. WOOLFE, G. AND MACDONALD, A. D.: The evaluation of the analgesic action of pethidine hydrochloride (Demerol). J. Pharmacol. Exp. Ther. 80: 300-307, 1944.
64. YAKSH, T. L. AND REDDY, S. V. R.: Studies in the primate on the analgetic effects associated with intrathecal actions of opiates, α-adrenergic agonists and baclofen. Anesthesiology 54: 451-67, 1981.
65. YAKSH, T. L. AND RUDY, T. A.: Chronic catheterization of the spinal subarachnoid space. Physiol. Behav. 17: 1031-1036, 1976.
66. YEOMANS, D. C., CLARK, F. M., PAICE, J. A. AND PROUDFIT, H. K.: Antinociception induced by electrical stimulation of spinally-projecting noradrenergic neurons in the A7 catecholamine cell group of the rat. Pain 48: 449-461, 1992.
67. YEOMANS, D. C. AND PROUDFIT, H. K.: Antinociception induced by microinjection of substance P into the A7 catecholamine cell group in the rat. Neuroscience 49: 681-691, 1992.
68. ZAR, J. H.: Biostatistical Analysis, Prentice-Hall, Inc., Englewood Cliffs, NJ, 1974.