Disorderly conduct in γδ versus αβ T cell lineage commitment

Seminars in Immunology

Volumn 22, Issue 4, 2010, Pages 222-227

  Narayan, Kavitha ^a   Kang, Joonsoo ^a  

^a UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

Author keywords

T cells; T cell development; T cell lineage commitment; T cell receptor; WNT signaling

Indexed keywords

T LYMPHOCYTE RECEPTOR; WNT PROTEIN; LYMPHOCYTE ANTIGEN RECEPTOR;

ALPHA BETA T LYMPHOCYTE; CELL LINEAGE; CELL MATURATION; GAMMA DELTA T LYMPHOCYTE; GENE EXPRESSION; HUMAN; NATURAL KILLER T CELL; NONHUMAN; REVIEW; SIGNAL TRANSDUCTION; STOCHASTIC MODEL; T LYMPHOCYTE SUBPOPULATION; ANIMAL; CYTOLOGY; IMMUNOLOGY; METABOLISM; T LYMPHOCYTE;

ANIMALS; CELL LINEAGE; HUMANS; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA; RECEPTORS, ANTIGEN, T-CELL, GAMMA-DELTA; SIGNAL TRANSDUCTION; T-LYMPHOCYTES;

EID: 77954656376     PISSN: 10445323     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.smim.2010.04.003     Document Type: Review

References (67)

1. + Pro-T thymocytes. Proc Natl Acad Sci USA 1998, 95:12522-12527.
2. Livák F., Tourigny M., Schatz D.G., Petrie H.T. Characterization of TCR gene rearrangements during adult murine T cell development. J Immunol 1999, 162:2575-2580.
3. Hayes S.M., Li L., Love P.E. TCR signal strength influences alphabeta/gammadelta lineage fate. Immunity 2005, 22:583-593.
4. Haks M.C., Lefebvre J.M., Lauritsen J.P., Carleton M., Rhodes M., Miyazaki T., et al. Attenuation of gammadeltaTCR signaling efficiently diverts thymocytes to the alphabeta lineage. Immunity 2005, 22:595-606.
5. + T cells from a common precursor. Sem Immunol 1997, 9:171-179.
6. Livak F., Wilson A., MacDonald H.R., Schatz D.G. αβ Lineage-committed thymocytes can be rescued by the γδ T cell receptor (TCR) in the absence of TCR β chain. Eur J Immunol 1997, 27:2948-2958.
7. Kang J., Volkmann A., Raulet D.H. Evidence that gammadelta versus alphabeta T cell fate determination is initiated independently of T cell receptor signaling. J Exp Med 2001, 193:689-698.
8. Ishida I., Verbeek S., Bonneville M., Itohara S., Berns A., Tonegawa S. T-cell receptor γδ and γ transgenic mice suggest a role of a γ gene silencer in the generation of αβ T cells. Proc Natl Acad Sci USA 1990, 87:3067-3071.
9. Turka L.A., Schatz D.G., Oettinger M.A., Chun J.J., Gorka C., Lee K., et al. Thymocyte expression of RAG-1 and RAG-2: termination by T cell receptor cross-linking. Science 1991, 253:778-781.
10. Wilson A., Held W., MacDonald H.R. Two waves of recombinase gene expression in developing thymocytes. J Exp Med 1994, 179:1355-1360.
11. Aifantis I., Pivniouk V.I., Gartner F., Feinberg J., Swat W., Alt F.W., et al. Allelic exclusion of the T cell receptor beta locus requires the SH2 domain-containing leukocyte protein (SLP)-76 adaptor protein. J Exp Med 1999, 190:1093-1102.
12. Hayes S.M., Love P.E. Distinct structure and signaling potential of the gamma delta TCR complex. Immunity 2002, 16:827-838.
13. + T cells. J Immunol 2002, 168:3825-3832.
14. Singer A., Adoro S., Park J.H. Lineage fate and intense debate: myths, models and mechanisms of CD4- versus CD8-lineage choice. Nat Rev Immunol 2008, 8:788-801.
15. Schweighoffer E., Fowlkes B.J. Positive selection is not requried for thymic maturation of transgenic γδ T cells. J Exp Med 1996, 183:2033-2041.
16. Jensen K.D., Su X., Shin S., Li L., Youssef S., Yamasaki S., et al. Thymic selection determines gammadelta T cell effector fate: antigen-naive cells make interleukin-17 and antigen-experienced cells make interferon gamma. Immunity 2008, 29:90-100.
17. Kreslavsky T., Garbe A.I., Krueger A., von Boehmer H. T cell receptor-instructed alphabeta versus gammadelta lineage commitment revealed by single-cell analysis. J Exp Med 2008, 205:1173-1186.
18. Bruno L., Fehling H.J., von Boehmer H. The ab T cell receptor can replace the gd receptor in the development of gd lineage cells. Immunity 1996, 5:343-352.
19. Terrence K., Pavlovich C.P., Matechak E.O., Fowlkes B.J. Premature expression of T Cell receptor (TCR)alphabeta suppresses TCRgammadelta gene rearrangement but permits development of gammadelta lineage T cells. J Exp Med 2000, 192:537-548.
20. Porritt H.E., Gordon K., Petrie H.T. Kinetics of steady-state differentiation and mapping of intrathymic-signaling environments by stem cell transplantation in nonirradiated mice. J Exp Med 2003, 198:957-962.
21. + thymocytes by T cell receptor-induced apoptosis requires a costimulatory signal that can be provided by CD28. J Exp Med 1994, 179:709-713.
22. Passoni L., Hoffman E.S., Kim S., Crompton T., Pao W., Dong M.Q., et al. Intrathymic δ selection events in γδ cell development. Immunity 1997, 7:83-95.
23. Kang J., Coles M., Cado D., Raulet D.H. The developmental fate of T cells is critically influenced by TCRgammadelta expression. Immunity 1998, 8:427-438.
24. Wilson A., MacDonald H.R. A limited role for beta-selection during gamma delta T cell development. J Immunol 1998, 161:5851-5854.
25. Adams E.J., Strop P., Shin S., Chien Y.H., Garcia K.C. An autonomous CDR3delta is sufficient for recognition of the nonclassical MHC class I molecules T10 and T22 by gammadelta T cells. Nat Immunol 2008, 9:777-784.
26. Baldwin T.A., Sandau M.M., Jameson S.C., Hogquist K.A. The timing of TCR alpha expression critically influences T cell development and selection. J Exp Med 2005, 202:111-121.
27. O'Brien R.L., Roark C.L., Jin N., Aydintug M.K., French J.D., Chain J.L., et al. gammadelta T-cell receptors: functional correlations. Immunol Rev 2007, 215:77-88.
28. Ribot J.C., deBarros A., Pang D.J., Neves J.F., Peperzak V., Roberts S.J., et al. CD27 is a thymic determinant of the balance between interferon-gamma- and interleukin 17-producing gammadelta T cell subsets. Nat Immunol 2009, 10:427-436.
29. Pennington D.J., Silva-Santos B., Shires J., Theodoridis E., Pollitt C., Wise E.L., et al. The inter-relatedness and interdependence of mouse T cell receptor gammadelta+ and alphabeta+ cells. Nat Immunol 2003, 4:991-998.
30. Savage A.K., Constantinides M.G., Han J., Picard D., Martin E., Li B., et al. The transcription factor PLZF directs the effector program of the NKT cell lineage. Immunity 2008, 29:391-403.
31. Kovalovsky D., Uche O.U., Eladad S., Hobbs R.M., Yi W., Alonzo E., et al. The BTB-zinc finger transcriptional regulator PLZF controls the development of invariant natural killer T cell effector functions. Nat Immunol 2008, 9:1055-1064.
32. Kreslavsky T., Savage A.K., Hobbs R., Gounari F., Bronson R., Pereira P., et al. TCR-inducible PLZF transcription factor required for innate phenotype of a subset of gammadelta T cells with restricted TCR diversity. Proc Natl Acad Sci USA 2009, 106:12453-12458.
33. Alonzo E.S., Gottschalk R.A., Das J., Egawa T., Hobbs R.M., Pandolfi P.P., et al. Development of promyelocytic zinc finger and ThPOK-expressing innate gammadelta T cells is controlled by strength of TCR signaling and Id3. J Immunol 2010, 184:1268-1279.
34. Azuara V., Levraud J.P., Lembezat M.P., Pereira P. A novel subset of adult gamma delta thymocytes that secretes a distinct pattern of cytokines and expresses a very restricted T cell receptor repertoire. Eur J Immunol 1997, 27:544-553.
35. Pereira P., Hermitte V., Lembezat M.P., Boucontet L., Azuara V., Grigoriadou K. Developmentally regulated and lineage-specific rearrangement of T cell receptor Valpha/delta gene segments. Eur J Immunol 2000, 30:1988-1997.
36. Lees R.K., Ferrero I., MacDonald H.R. Tissue-specific segregation of TCRgamma delta+ NKT cells according to phenotype TCR repertoire and activation status: parallels with TCR alphabeta+ NKT cells. Eur J Immunol 2001, 31:2901-2909.
37. Felices M., Yin C.C., Kosaka Y., Kang J., Berg L.J. Tec kinase Itk in gammadeltaT cells is pivotal for controlling IgE production in vivo. Proc Natl Acad Sci USA 2009, 106:8308-8313.
38. + gammadelta T cells in the absence of Itk results in elevated IgE production. Blood 2009, 114:564-571.
39. Nunez-Cruz S., Aguado E., Richelme S., Chetaille B., Mura A.M., Richelme M., et al. LAT regulates gammadelta T cell homeostasis and differentiation. Nat Immunol 2003, 4:999-1008.
40. + TCR-gamma/delta+ T cell development in CD3 zeta-deficient mice. J Exp Med 1995, 182:891-895.
41. Lauritsen J.P., Wong G.W., Lee S.Y., Lefebvre J.M., Ciofani M., Rhodes M., et al. Marked induction of the helix-loop-helix protein Id3 promotes the gammadelta T cell fate and renders their functional maturation Notch independent. Immunity 2009, 31:565-575.
42. Verykokakis M., Boos M.D., Bendelac A., Adams E.J., Pereira P., Kee B.L. Inhibitor of DNA binding 3 limits development of murine slam-associated adaptor protein-dependent " innate" gammadelta T cells. PloS One 2010, 5:e9303.
43. Ueda-Hayakawa I., Mahlios J., Zhuang Y. Id3 restricts the developmental potential of gamma delta lineage during thymopoiesis. J Immunol 2009, 182:5306-5316.
44. Prince A.L., Yin C.C., Enos M.E., Felices M., Berg L.J. The Tec kinases Itk and Rlk regulate conventional versus innate T-cell development. Immunol Rev 2009, 228:115-131.
45. Jordan M.S., Smith J.E., Burns J.C., Austin J.E., Nichols K.E., Aschenbrenner A.C., et al. Complementation in trans of altered thymocyte development in mice expressing mutant forms of the adaptor molecule SLP76. Immunity 2008, 28:359-369.
46. Rivera R.R., Johns C.P., Quan J., Johnson R.S., Murre C. Thymocyte selection is regulated by the helix-loop-helix inhibitor protein, Id3. Immunity 2000, 12:17-26.
47. Pasquier B., Yin L., Fondaneche M.C., Relouzat F., Bloch-Queyrat C., Lambert N., et al. Defective NKT cell development in mice and humans lacking the adapter SAP, the X-linked lymphoproliferative syndrome gene product. J Exp Med 2005, 201:695-701.
48. Chung B., Aoukaty A., Dutz J., Terhorst C., Tan R. Signaling lymphocytic activation molecule-associated protein controls NKT cell functions. J Immunol 2005, 174:3153-3157.
49. Nichols K.E., Hom J., Gong S.Y., Ganguly A., Ma C.S., Cannons J.L., et al. Regulation of NKT cell development by SAP, the protein defective in XLP. Nat Med 2005, 11:340-345.
50. Horai R., Mueller K.L., Handon R.A., Cannons J.L., Anderson S.M., Kirby M.R., et al. Requirements for selection of conventional and innate T lymphocyte lineages. Immunity 2007, 27:775-785.
51. Schwartzberg P.L., Mueller K.L., Qi H., Cannons J.L. SLAM receptors and SAP influence lymphocyte interactions, development and function. Nat Rev 2009, 9:39-46.
52. Gounari F., Aifantis I., Martin C., Fehling H.J., Hoeflinger S., Leder P., et al. Tracing lymphopoiesis with the aid of a pTalpha-controlled reporter gene. Nat Immunol 2002, 3:489-496.
53. Melichar H.J., Narayan K., Der S.D., Hiraoka Y., Gardiol N., Jeannet G., et al. Regulation of gammadelta versus alphabeta T lymphocyte differentiation by the transcription factor SOX13. Science 2007, 315:230-233.
54. Jeannet G., Scheller M., Scarpellino L., Duboux S., Gardiol N., Back J., et al. Long-term, multilineage hematopoiesis occurs in the combined absence of beta-catenin and gamma-catenin. Blood 2008, 111:142-149.
55. Ciofani M., Knowles G.C., Wiest D.L., von Boehmer H., Zuniga-Pflucker J.C. Stage-specific and differential notch dependency at the alphabeta and gammadelta T lineage bifurcation. Immunity 2006, 25:105-116.
56. Kang J., DiBenedetto B., Narayan K., Zhao H., Der S.D., Chambers C.A. STAT5 is required for thymopoiesis in a development stage-specific manner. J Immunol 2004, 173:2307-2314.
57. Wang J.H., Nichogiannopoulou A., Wu L., Sun L., Sharpe A.H., Bigby M., et al. Selective defects in the development of the fetal and adult lymphoid system in mice with an Ikaros null mutation. Immunity 1996, 5:537-549.
58. Gerber D., Boucontet L., Pereira P. Early expression of a functional TCRbeta chain inhibits TCRgamma gene rearrangements without altering the frequency of TCRgammadelta lineage cells. J Immunol 2004, 173:2516-2523.
59. Krotkova A., Smith E., Nerz G., Falk I., Eichmann K. Delayed and restricted expression limits putative instructional opportunities of Vgamma1.1/Vgamma2 gammadelta TCR in alphabeta/gammadelta lineage choice in the thymus. J Immunol 2004, 173:25-32.
60. Maki K., Sunaga S., Ikuta K. The V-J recombination of T cell receptor-gamma genes is blocked in interleukin-7 receptor-deficient mice. J Exp Med 1996, 184:2423-2427.
61. Kang J., Coles M., Raulet D.H. Defective development of γδ T cells in interleukin 7 receptor-deficient mice is due to impaired expression of T cell receptor γ genes. J Exp Med 1999, 190:973-982.
62. Perumal N.B., Kenniston T.W., Tweardy D.J., Dyer K.F., Hoffman R., Peschon J., et al. TCR-gamma genes are rearranged but not transcribed in IL-7R alpha-deficient mice. J Immunol 1997, 158:5744-5750.
63. Verbeek S., Izon D., Hofhuis F., Robanus-Maandag E., te Riele H., van de Wetering M., et al. An HMG-box-containing T-cell factor required for thymocyte differentiation. Nature 1995, 374:70-74.
64. Okamura R.M., Sigvardsson M., Galceran J., Verbeek S., Clevers H., Grosschedl R. Redundant regulation of T cell differentiation and TCRalpha gene expression by the transcription factors LEF-1 and TCF-1. Immunity 1998, 8:11-20.
65. Aliahmad P., Kaye J. Development of all CD4 T lineages requires nuclear factor TOX. J Exp Med 2008, 205:245-256.
66. Koch U., Wilson A., Cobas M., Kemler R., Macdonald H.R., Radtke F. Simultaneous loss of beta- and gamma-catenin does not perturb hematopoiesis or lymphopoiesis. Blood 2008, 111:160-164.
67. Lustig B., Jerchow B., Sachs M., Weiler S., Pietsch T., Karsten U., et al. Negative feedback loop of Wnt signaling through upregulation of conductin/axin2 in colorectal and liver tumors. Mol Cell Biol 2002, 22:1184-1193.