Toll-like receptor engagement enhances the immunosuppressive properties of human bone marrow-derived mesenchymal stem cells by inducing indoleamine-2,3-dioxygenase-1 via Interferon-b and protein kinase R

Stem Cells

Volumn 27, Issue 4, 2009, Pages 909-919

  Opitz, Christiane A ^a,b   Litzenburger, Ulrike M ^a   Lutz, Christian ^c   Lanz, Tobias V ^b   Tritschler, Isabel ^b   Köppel, Alexandra ^d   Tolosa, Eva ^b,e   Hoberg, Maik ^f   Anderl, Jan ^c   Aicher, Wilhelm K ^g   Weller, Michael ^b,h   Wick, Wolfgang ^a,b   Platten, Michael ^a,b  

^a UNIVERSITY HOSPITAL HEIDELBERG   (Germany)

^b UNIVERSITY OF TÜBINGEN   (Germany)

^c Wilex Biotechnology GmbH   (Germany)

^d UNIVERSITY OF HEIDELBERG   (Germany)

^e UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

^f TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^g UNIVERSITY OF TÜBINGEN   (Germany)

^h UNIVERSITY HOSPITAL ZURICH   (Switzerland)

Author keywords

Immunosuppression; Indoleamine 2,3 dioxygenase; Mesenchymal stem cells; Toll like receptor

Indexed keywords

BETA INTERFERON; GAMMA INTERFERON; INDOLEAMINE 2,3 DIOXYGENASE; INDOLEAMINE 2,3 DIOXYGENASE 1; INDOLEAMINE 2,3 DIOXYGENASE 2; KYNURENINE; PROTEIN KINASE R; TOLL LIKE RECEPTOR 3; TOLL LIKE RECEPTOR 4; TRYPTOPHAN; TRYPTOPHAN 2,3 DIOXYGENASE; UNCLASSIFIED DRUG;

ARTICLE; CELL FUNCTION; CONTROLLED STUDY; HUMAN; HUMAN CELL; IMMUNE RESPONSE; IMMUNOSUPPRESSIVE TREATMENT; MESENCHYMAL STEM CELL TRANSPLANTATION; PHENOTYPE; PROTEIN DEGRADATION; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION;

EID: 65649089411     PISSN: 10665099     EISSN: None     Source Type: Journal    
DOI: 10.1002/stem.7     Document Type: Article

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