Essential roles of VLA-4 in the hematopoietic system

International Journal of Hematology

Volumn 91, Issue 4, 2010, Pages 569-575

  Imai, Yoichi ^a   Shimaoka, Motomu ^b   Kurokawa, Mineo ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b BOSTON CHILDREN S HOSPITAL   (United States)

Author keywords

Chemotherapy sensitivity; Hematopoiesis; Integrin; Mobilization; VLA 4

Indexed keywords

ALPHA4 INTEGRIN; NATALIZUMAB; VERY LATE ACTIVATION ANTIGEN 4;

ANTIGEN EXPRESSION; CELL INTERACTION; CELLULAR DISTRIBUTION; CONFORMATIONAL TRANSITION; GENE SEQUENCE; HEMATOLOGIC MALIGNANCY; HEMATOPOIESIS; HEMATOPOIETIC CELL; HEMATOPOIETIC STEM CELL; HEMATOPOIETIC SYSTEM; HOMEOSTASIS; HUMAN; KNOCKOUT MOUSE; LYMPHOCYTE; MULTIPLE SCLEROSIS; NONHUMAN; PROTEIN FUNCTION; REVIEW; SINGLE DRUG DOSE;

ANIMALS; HEMATOPOIESIS; HEMATOPOIETIC STEM CELL MOBILIZATION; HEMATOPOIETIC STEM CELLS; HUMANS; INTEGRIN ALPHA4BETA1; LYMPHOCYTES; MICE; MICE, MUTANT STRAINS; PROTEIN CONFORMATION; PROTEIN SUBUNITS;

EID: 77954535224     PISSN: 09255710     EISSN: None     Source Type: Journal    
DOI: 10.1007/s12185-010-0555-3     Document Type: Review

References (38)

1. Hynes RO. Integrins: bidirectional, allosteric signaling machines. Cell. 2002;110:673-687
2. Shimaoka M, Takagi J, Springer TA. Conformational regulation of integrin structure and function. Annu Rev Biophys Biomol Struct. 2002;31:485-516.
3. Humphries JD, Byron A, Humphries MJ. Integrin ligands at a glance. J Cell Sci. 2006;119:3901-3903
4. Massberg S, Schaerli P, Knezevic-Maramica I, et al. Immunosurveillance by hematopoietic progenitor cells trafficking through blood, lymph, and peripheral tissues. Cell. 2007;131:994-1008.
5. Sasaki K, Pardee AD, Qu Y, et al. IL-4 suppresses very late antigen-4 expression which is required for therapeutic Th1 T-cell trafficking into tumors. J Immunother. 2009;32:793-802.
6. Bellucci R, de Propris MS, Buccisano F, et al. Modulation of VLA-4 and L-selectin expression on normal CD34+ cells during mobilization with G-CSF. Bone Marrow Transplant. 1999; 23:1-8.
7. Potocnik AJ, Brakebusch C, Fassler R. Fetal and adult hematopoietic stem cells require β1 integrin function for colonizing fetal liver, spleen, and bone marrow. Immunity. 2000;12:653-663
8. Williams DA, Rios M, Stephens C, Patel VP. Fibronectin and VLA-4 in haematopoietic stem cell-microenvironment interactions. Nature. 1991;352:438-441
9. Miyake K, Weissman IL, Greenberger JS, Kincade PW. Evidence for a role of the integrin VLA-4 in lympho-hemopoiesis. J Exp Med. 1991;173:599-607.
10. Papayannopoulou T, Craddock C, Nakamoto B, Priestley GV, Wolf NS. The VLA4/VCAM-1 adhesion pathway defines contrasting mechanisms of lodgement of transplanted murine hemopoietic progenitors between bone marrow and spleen. Proc Natl Acad Sci USA. 1995;92:9647-9651
11. Kinashi T. Integrin regulation of lymphocyte trafficking: lessons from structural and signaling studies. Adv Immunol. 2007;93: 185-227.
12. Qian H, Georges-Labouesse E, Nystrom A, et al. Distinct roles of integrins α6 and α4 in homing of fetal liver hematopoietic stem and progenitor cells. Blood. 2007;110:2399-2407
13. Siler U, Seiffert M, Puch S, et al. Characterization and functional analysis of laminin isoforms in human bone marrow. Blood. 2000;96:4194-4203
14. Gu YC, Kortesmaa J, Tryggvason K, et al. Laminin isoformspecific promotion of adhesion and migration of human bone marrow progenitor cells. Blood. 2003;101:877-885
15. Yang JT, Rayburn H, Hynes RO. Cell adhesion events mediated by α4 integrins are essential in placental and cardiac development. Development. 1995;121:549-560
16. Arroyo AG, Yang JT, Rayburn H, Hynes RO. α4 integrins regulate the proliferation/differentiation balance of multilineage hematopoietic progenitors in vivo. Immunity. 1999;11:555-566
17. Arroyo AG, Yang JT, Rayburn H, Hynes RO. Differential requirements for α4 integrins during fetal and adult hematopoiesis. Cell. 1996;85:997-1008.
18. Scott LM, Priestley GV, Papayannopoulou T. Deletion of α4 integrins from adult hematopoietic cells reveals roles in homeostasis, regeneration, and homing. Mol Cell Biol. 2003;23: 9349-9360
19. Bungartz G, Stiller S, Bauer M, et al. Adult murine hematopoiesis can proceed without β1 and β7 integrins. Blood. 2006;108: 1857-1864
20. 4(f/f) mice are hematopoietic cell autonomous. Blood. 2007;109: 109-111
21. Grabovsky V, Feigelson S, Chen C, et al. Subsecond induction of α4 integrin clustering by immobilized chemokines stimulates leukocyte tethering and rolling on endothelial vascular cell adhesion molecule 1 unDer flow conditions. J Exp Med. 2000;192:495-505.
22. Lu C, Takagi J, Springer TA. Association of the membrane proximal regions of the α and β subunit cytoplasmic domains constrains an integrin in the inactive state. J Biol Chem. 2001;276:14642-14648
23. Hughes PE, Diaz-Gonzalez F, Leong L. et al. Breaking the integrin hinge. A defined structural constraint regulates integrin signaling. J Biol Chem. 1996;271:6571-6574
24. Tadokoro S, Shattil SJ, Eto K, et al. Talin binding to integrin β tails: a final common step in integrin activation. Science. 2003;302:103-106
25. Vinogradova O, Velyvis A, Velyviene A, et al. A structural mechanism of integrin αIIbβ3 "inside-out" activation as regulated by its cytoplasmic face. Cell. 2002;110:587-597
26. Lu CF, Springer TA. The a subunit cytoplasmic domain regulates the assembly and adhesiveness of integrin lymphocyte functionassociated antigen-1. J Immunol. 1997;159:268-278
27. Semmrich M, Smith A, Feterowski C, et al. Importance of integrin LFA-1 deactivation for the generation of immune responses. J Exp Med. 2005;201:1987-1998
28. Imai Y, Park EJ, Peer D, et al. Genetic perturbation of the putative cytoplasmic membrane-proximal salt bridge aberrantly activates α4 integrins. Blood. 2008;112:5007-5015
29. Matsunaga T, Takemoto N, Sato T, et al. Interaction between leukemic-cell VLA-4 and stromal fibronectin is a decisive factor for minimal residual disease of acute myelogenous leukemia. Nat Med. 2003;9:1158-1165
30. Noborio-Hatano K, Kikuchi J, Takatoku M, et al. Bortezomib overcomes cell-adhesion-mediated drug resistance through downregulation of VLA-4 expression in multiple myeloma. Oncogene. 2009;28:231-242
31. Gattei V, Bulian P, Del Principe MI, et al. ReleVance of CD49d protein expression as overall survival and progressive disease prognosticator in chronic lymphocytic leukemia. Blood. 2008;111:865-873
32. Becker PS, Kopecky KJ, Wilks AN, et al. Very late antigen-4 function of myeloblasts correlates with improved overall survival for patients with acute myeloid leukemia. Blood. 2009;113: 866-874
33. Chigaev A, Zwartz G, Graves SW, et al. α4β1 integrin affinity changes govern cell adhesion. J Biol Chem. 2003;278:38174-38182
34. Craddock CF, Nakamoto B, Andrews RG, Priestley GV, Papayannopoulou T. Antibodies to VLA4 integrin mobilize long-term repopulating cells and augment cytokine-induced mobilization in primates and mice. Blood. 1997;90:4779-4788
35. Bonig H, Wundes A, Chang KH, Lucas S, Papayannopoulou T. Increased numbers of circulating hematopoietic stem/progenitor cells are chronically maintained in patients treated with the CD49d blocking antibody natalizumab. Blood. 2008;111:3439-3441
36. Jetmore A, Plett PA, Tong X, et al. Homing efficiency, cell cycle kinetics, and survival of quiescent and cycling human CD34 (+) cells transplanted into conditioned NOD/SCID recipients. Blood. 2002;99:1585-1593
37. Ransohoff RM. Natalizumab and PML. Nat Neurosci. 2005;8: 1275.
38. Mahlknecht U, Schonbein C. Histone deacetylase inhibitor treatment downregulates VLA-4 adhesion in hematopoietic stem cells and acute myeloid leukemia blast cells. Haematologica. 2008;93:443-446