Very late antigen-4 function of myeloblasts correlates with improved overall survival for patients with acute myeloid leukemia

Blood

Volumn 113, Issue 4, 2009, Pages 866-874

  Becker, Pamela S ^a   Kopecky, Kenneth J ^b   Wilks, Adrianne N ^a   Chien, Sylvia ^a   Harlan, John M ^a   Willman, Cheryl L ^c   Petersdorf, Stephen H ^a   Stirewalt, Derek L ^d   Papayannopoulou, Thalia ^a   Appelbaum, Frederick R ^a,d  

^a UNIVERSITY OF WASHINGTON   (United States)

^b SOUTHWEST ONCOLOGY GROUP STATISTICAL CENTER   (United States)

^c UNIVERSITY OF NEW MEXICO   (United States)

^d Fred Hutchinson Cancer Research Center   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTHRACYCLINE; CYTARABINE; VASCULAR CELL ADHESION MOLECULE 1; VERY LATE ACTIVATION ANTIGEN 4; ANTINEOPLASTIC AGENT; CYTOKINE; FIBRONECTIN; PEPTIDE FRAGMENT; RECOMBINANT PROTEIN;

ACUTE GRANULOCYTIC LEUKEMIA; ADULT; AGED; ANTIGEN EXPRESSION; ARTICLE; BLAST CELL CRISIS; BONE MARROW BIOPSY; CANCER CHEMOTHERAPY; CANCER PATIENT; CANCER SURVIVAL; CELL ADHESION; CELL MIGRATION; CHEMOSENSITIVITY; CONFIDENCE INTERVAL; CONTROLLED STUDY; DISEASE FREE SURVIVAL; FEMALE; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IN VITRO STUDY; LEUKEMIA RELAPSE; LEUKEMIA REMISSION; LIGAND BINDING; MAJOR CLINICAL STUDY; MALE; MYELOBLAST; OVERALL SURVIVAL; PRIORITY JOURNAL; PROGNOSIS; PROTEIN BINDING; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SURVIVAL TIME; TREATMENT OUTCOME; TREATMENT RESPONSE; ADOLESCENT; DRUG EFFECT; GENE EXPRESSION REGULATION; GENETICS; GRANULOCYTE PRECURSOR; METABOLISM; MIDDLE AGED; PATHOLOGY; SURVIVAL RATE; TUMOR CELL LINE;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; ANTINEOPLASTIC AGENTS; CELL ADHESION; CELL LINE, TUMOR; CYTOKINES; FEMALE; FIBRONECTINS; GENE EXPRESSION REGULATION, NEOPLASTIC; GRANULOCYTE PRECURSOR CELLS; HUMANS; INTEGRIN ALPHA4BETA1; LEUKEMIA, MYELOID, ACUTE; MALE; MIDDLE AGED; PEPTIDE FRAGMENTS; PROTEIN BINDING; RECOMBINANT PROTEINS; SURVIVAL RATE; TREATMENT OUTCOME; VASCULAR CELL ADHESION MOLECULE-1;

EID: 59649089647     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2007-12-124818     Document Type: Article

References (35)

1. Bullinger L, Valk PJ. Gene expression profiling in acute myeloid leukemia. J Clin Oncol. 2005;23: 6296-6305.
2. Peled A, Petit I, Kollet O, et al. Dependence of human stem cell engraftment and repopulation of NOD/SCID mice on CXCR4. Science. 1999;283: 845-848.
3. Stucki A, Rivier AS, Gikic M, Monai N, Schapira M, Spertini O. Endothelial cell activation by myeloblasts: molecular mechanisms of leukostasis and leukemic cell dissemination. Blood. 2001;97: 2121-2129.
4. Burger JA, Spoo A, Dwenger A, Burger M, Behringer D. CXCR4 chemokine receptors (CD184) and alpha4beta1 integrins mediate spontaneous migration of human CD34-progenitors and acute myeloid leukaemia cells beneath marrow stromal cells (pseudoemperipolesis). Br J Haematol. 2003;122:579-589.
5. Andreeff M, Konoplev S, Wang R-Y, et al. Massive mobilization of AML cells into circulation by disruption of leukemia/stroma cell interactions using CXCR4 antagonist AMD3100: first evidence in patients and potential for abolishing bone marrow microenvironment-mediated resistance [abstract]. Blood. 2006;108:568.
6. Jin L, Hope KJ, Zhai Q, Smadja-Joffe F, Dick JE. Targeting of CD44 eradicates human acute myeloid leukemic stem cells. Nat Med. 2006;12: 1167-1174.
7. Garrido SM, Appelbaum FR, Willman CL, Banker DE. Acute myeloid leukemia cells are protected from spontaneous and drug-induced apoptosis by direct contact with a human bone marrow stromal cell line (HS-5). Exp Hematol. 2001;29:448-457.
8. Hazlehurst LA, Valkov N, Wisner L, et al. Reduction in drug-induced DNA double-strand breaks associated with beta1 integrin-mediated adhesion correlates with drug resistance in U937 cells. Blood. 2001;98:1897-1903.
9. Matsunaga T, Takemoto N, Sato T, et al. Interaction between leukemic-cell VLA-4 and stromal fibronectin is a decisive factor for minimal residual disease of acute myelogenous leukemia. Nat Med. 2003;9:1158-1165.
10. De Toni F, Racaud-Sultan C, Chicanne G, et al. A crosstalk between the Wnt and the adhesion-dependent signaling pathways governs the chemosensitivity of acute myeloid leukemia. Oncogene. 2006;25:3113-3122.
11. Weick JK, Kopecky KJ, Appelbaum FR, et al. A randomized investigation of high-dose versus standard dose cytosine arabinoside with daunorubicin in patients with previously untreated acute myeloid leukemia. Blood. 1996;88:2841-2851.
12. Godwin J, Kopecky KJ, Head DR, et al. A double blind placebo controlled trial of granulocyte colony-stimulating factor in elderly patients with previously untreated acute myeloid leukemia: a Southwest Oncology Group study (9031). Blood. 1998;91:3607-3615.
13. List AF, Kopecky KJ, Willman CL, et al. Benefit of cyclosporine modulation of drug resistance in patients with poor-risk acute myeloid leukemia: a Southwest Oncology Group study. Blood. 2001; 98:3212-3220.
14. Anderson JE, Kopecky KJ, Willman CL, et al. Outcome after induction chemotherapy for older patients with acute myeloid leukemia is not improved with mitoxantrone and etoposide compared to cytarabine and daunorubicin: a Southwest Oncology Group study. Blood. 2002;100: 3869-3876.
15. Petersdorf SH, Rankin C, Head DR, et al. Phase II evaluation of an intensified induction therapy with standard daunomycin and cytarabine followed by high dose cytarabine for adults with previously untreated acute myeloid leukemia: a Southwest Oncology Group study (SWOG-9500). Am J Hematol. 2007;82:1056-1062.
16. Stelzer GT, Shults KE, Loken MR. CD45 gating for routine flow cytometric analysis of human bone marrow specimens. Ann N Y Acad Sci. 1993;20:265-280.
17. Borowitz MJ, Guenther KL, Shults KE, Stelzer GT. Immunophenotyping of acute leukemia by flow cytometric analysis: use of CD45 and right-angle light scatter to gate on leukemic blasts in three-color analysis. Am J Clin Pathol. 1993;100:534-540.
18. Chigaev A, Zwartz G, Graves SW, et al. -4-1 integrin affinity changes govern cell adhesion. J Biol Chem. 2003;278:38174-38182.
19. Kovach NL, Carlos TM, Yee E, Harlan JM. A monoclonal antibody to -1 integrin (CD29) stimulates VLA dependent adherence of leukocytes to human umbilical vein endothelial cells and matrix components. J Cell Biol. 1992;116:499-509.
20. Leith CP, Kopecky KJ, Godwin J, et al. Acute myeloid leukemia in the elderly: assessment of multidrug resistance (MDR1) and cytogenetics distinguishes biologic subgroups with remarkably distinct responses to standard chemotherapy. A Southwest Oncology Group Study. Blood. 1997; 89:3323-3329.
21. Stirewalt DL, Kopecky KJ, Meshinchi S, et al. Size of FLT3 internal tandem duplication has prognostic significance in patients with acute myeloid leukemia. Blood. 2006;107:3724-3726.
22. Kaplan EL, Meier P. Nonparametric estimation from incomplete observations. J Am Stat Assoc. 1958;53:457-481.
23. Gattei V, Bulian P, Del Principe MI, et al. Relevance of CD49d protein expression as overall survival and progressive disease prognosticator in chronic lymphocytic leukemia. Blood. 2008; 111:865-873.
24. Quaranta MT, Spinello I, Testa U, et al. PLZF-mediated control on VLA-4 expression in normal and leukemic myeloid cells. Oncogene. 2006;25:399-408.
25. Zeng Z, Samudio IJ, Munsell M, et al. Inhibition of CXCR4 with the novel RCP168 peptide overcomes stroma-mediated chemoresistance in chronic and acute leukemias. Mol Cancer Ther. 2006;5:3113-3121.
26. Becker PS, Nilsson SK, Li Z, et al. Adhesion receptor expression by hematopoietic cell lines and murine progenitors: modulation by cytokines and cell cycle status. Exp Hematol. 1999;27:533-541.
27. Delforge M, Raets V, Van Duppen V, Vandenberghe P, Boogaerts M. Myelodysplasias: CD34-marrow progenitors from MDS patients with high levels of intramedullary apoptosis have reduced expression of -4-1and -5-1 integrins. Leukemia. 2005;19:57-63.
28. Appelbaum FR, Gundacker H, Head DR, et al. Age and acute myeloid leukemia. Blood. 2006; 107:3481-3485.
29. Rose DM, Grabovsky V, Alon R, Ginsberg MH. The affinity of integrin -4-1 governs lymphocyte migration. J Immunol. 2001;167:2824-2830.
30. Sudhoff T, Wehmeier A, Kliche KO, et al. Levels of circulating endothelial adhesion molecules (sEselectin and sVCAM-1) in adult patients with acute leukemia. Leukemia. 1996;10:682-686.
31. Zheng R, Small D. Mutant FLT3 signaling contributes to a block in myeloid differentiation. Leuk Lymphoma. 2005;46:1679-1687.
32. Solanilla A, Grosset C, Duchez P, et al. Flt3-ligand induces adhesion of haematopoietic progenitor cells via a very late antigen (VLA)-4- and VLA-5-dependent mechanism. Br J Haematol. 2003;120:782-786.
33. Rombouts EJC, Pavic B, Lowenberg B, Ploemacher RE. Relation between CXCR-4 expression, Flt3 mutations, and unfavorable prognosis of adult acute myeloid leukemia Blood. 2004;104:550-557.
34. Konoplev S, Rassidakis GZ, Estey E, et al. Overexpression of CXCR4 predicts adverse overall and event-free survival in patients with unmutated FLT3 acute myeloid leukemia with normal karyotype. Cancer. 2007;109:1152-1156.
35. Spoo AC, Lü bbert M, Wierda WG, Burger JA. CXCR4 is a prognostic marker in acute myelogenous leukemia. Blood. 2007;109:786-791.