Modeling and simulation of hepatic drug disposition using a physiologically based, multi-agent in silico liver

Pharmaceutical Research

Volumn 25, Issue 5, 2008, Pages 1023-1036

  Yan, Li ^a   Ropella, Glen E P ^b   Park, Sunwoo ^b   Roberts, Michael S ^c   Hunt, C Anthony ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF QUEENSLAND   (Australia)

Author keywords

Agent based; Complex systems; Discrete event; Liver; Mechanistic; Modeling; Physiologically based; Predict; Simulation

Indexed keywords

ATENOLOL; DILTIAZEM; LABETALOL; PHENAZONE; SUCROSE;

ARTICLE; COMPUTER MODEL; COMPUTER SIMULATION; DRUG DISPOSITION; LIVER CELL; LIVER METABOLISM; LIVER SINUSOID; MONTE CARLO METHOD; PARAMETER; PHYSICAL CHEMISTRY; PREDICTION; PRIORITY JOURNAL; VALIDATION PROCESS;

CATIONS; CHEMISTRY, PHYSICAL; COMPUTER SIMULATION; COMPUTERS; DRUG INTERACTIONS; LIVER; LIVER CIRCULATION; MODELS, STATISTICAL; PHARMACEUTICAL PREPARATIONS; PHARMACOKINETICS; PORTAL VEIN; SOFTWARE; SUCROSE;

EID: 42049114288     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-007-9494-y     Document Type: Article

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