Discovering plausible mechanistic details of hepatic drug interactions

Drug Metabolism and Disposition

Volumn 37, Issue 1, 2009, Pages 237-246

  Lam, Tai Ning ^a   Hunt, C Anthony ^a,b  

^a BioSystems Group

^b San Francisco

Author keywords

[No Author keywords available]

Indexed keywords

DIGOXIN; QUINIDINE; RIFAMPICIN;

ARTICLE; CELL VIABILITY; COMPUTER MODEL; COMPUTER PROGRAM; COMPUTER SIMULATION; DRUG LIVER LEVEL; DRUG MECHANISM; LIVER PERFUSION; NONHUMAN; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; SIMULATION; TIME SERIES ANALYSIS; WET LAB MODEL;

ANIMALS; DRUG INTERACTIONS; LIVER; RATS;

RATTUS;

EID: 58149460398     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.108.023820     Document Type: Article

References (14)

1. Bailey SM and Reinke LA (2000) Effect of low flow ischemia-reperfusion injury on liver function. Life Sci 66:1033-1044.
2. de Lannoy IA and Silverman M (1992) The MDR1 gene product, P-glycoprotein, mediates the transport of the cardiac glycoside, digoxin. Biochem Biophys Res Commun 189:551-557.
3. Fisher J and Henzinger TA (2007) Executable cell biology. Nat Biotechnol 25:1239-1249.
4. Garmire LX, Garmire DG, and Hunt CA (2007) An in silico Transwell device for the study of drug transport and drug-drug interactions. Pharm Res 24:2171-2186.
5. Hunt CA. Ropella GE, Park S, and Engelberg J (2008) The real dichotomies between computational and mathematical models. Nat Biotech 26:737-738.
6. Hunt CA, Ropella GE, Yan L, Hung DY, and Roberts MS (2006) Physiologically based synthetic models of hepatic disposition. J Pharmacokinet Phormacodyn 33:737-772.
7. Lau YY, Wu CY, Okochi H., and Benet LZ (2004) Ex situ inhibition of hepatic uptake and efflux significantly changes metabolism: hepatic enzyme-transporter interplay. J Pharmacol Exp Ther 308:1040-1045.
8. Noé B, Hagenbuch B, Stieger B, and Meier PJ (1997) Isolation of a multispecific organic anion and cardiac glycoside transporter from rat brain. Proc Natl Acad Sci U S A 94:10346-10350.
9. Rescigno A (2004) On the use of pharmacokinetic models. Phys Med Biol 49:4657-4676.
10. Sheikh-Bahnei S and Hunt CA (2006) Prediction of in vitro hepatic biliary excretion using stochastic agent-based modeling and fuzzy clustering, in Proceedings of the 37th Conference on Winter Simulation, Monterey, CA. Dec 03-06 (L.F. Perrone et al., eds) pp 1617-1624. INFORMS, Hanover, MD.
11. Straatsburg IH and Frederiks WM (1997) In situ analysis of ischaemia/reperfusion injury in rat liver studied in three different models, Int J Exp Pathol 78:149-161.
12. Tang J, Ley KF, and Hunt CA (2007) Dynamics of in silico leukocyte rolling, activation, and adhesion. BMC Syst Biol 1:14.
13. Yan L, Ropella GE, Park S, Roberts MS, and Hunt CA (2008a) Modeling and simulation of hepatic drug disposition using a physiologically based, multi-agent in silico liver. Pharm Res 25:1023-1036.
14. Yan L, Sheihk-Bahaei S, Park S, Ropella GE, and Hunt CA (2008b) Predictions of hepatic disposition properties using a mechanistically realistic, physiologically based model. Drug Metab Dispos 36:759-768.