Evaluating an hepatic enzyme induction mechanism through coarse- and fine-grained measurements of an in silico liver

Complexity

Volumn 14, Issue 6, 2009, Pages 28-34

  Ropella, Glen E P ^a   Park, Sunwoo ^b   Anthony Hunt, C ^b  

^a TEMPUS DICTUM INC   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Agent based; Complex system; Enzyme induction; Hepatic clearance; Modeling and simulation; Multi agent; Pharmacokinetics; Systems biology

Indexed keywords

EID: 68549090630     PISSN: 10762787     EISSN: 10990526     Source Type: Journal    
DOI: 10.1002/cplx.20253     Document Type: Article

References (8)

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7. Nag, D.A.; Ropella, G.E.P.; Hunt, C.A. Similarity measures and validation in automated modeling. Huntsville Simulation Conference, Huntsville, AL, 2005.
8. Yan, L.; Ropella, G.E.P.; Park, P.; Roberts, M.S.; Hunt, C.A. Modeling and simulation of hepatic drug disposition using a physiologically based, multi-agent in silicoliver. Pharm Res 2008, 25, 1023-1036.