FOXO4 induces human plasminogen activator inhibitor-1 gene expression via an indirect mechanism by modulating hif-1α and creb levels

Antioxidants and Redox Signaling

Volumn 13, Issue 4, 2010, Pages 413-424

  Dimova, Elitsa Y ^a,b   Samoylenko, Anatoly ^c   Kietzmann, Thomas ^a,b  

^a Rheinland Pfälzische Technische Universität Kaiserslautern Landau   (Germany)

^b UNIVERSITY OF OULU   (Finland)

^c PALLADIN INSTITUTE OF BIOCHEMISTRY   (Ukraine)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; HYDROGEN PEROXIDE; HYPOXIA INDUCIBLE FACTOR 1ALPHA; MESSENGER RNA; PLASMINOGEN ACTIVATOR INHIBITOR 1; TRANSCRIPTION FACTOR FOXO; TRANSCRIPTION FACTOR FOXO4; UNCLASSIFIED DRUG;

ARTICLE; CELL HYPOXIA; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; DOWN REGULATION; GENE EXPRESSION REGULATION; GENE OVEREXPRESSION; GENE SILENCING; HUMAN; HUMAN CELL; NORTHERN BLOTTING; OXIDATIVE STRESS; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INDUCTION; TRANSIENT TRANSFECTION; WESTERN BLOTTING;

BINDING SITES; BIOLOGICAL TRANSPORT; BLOTTING, NORTHERN; BLOTTING, WESTERN; CELLS, CULTURED; CHROMATIN IMMUNOPRECIPITATION; CREB-BINDING PROTEIN; HEP G2 CELLS; HUMANS; HYDROGEN PEROXIDE; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; OXIDATIVE STRESS; PLASMINOGEN ACTIVATOR INHIBITOR 1; PROMOTER REGIONS, GENETIC; PROTEIN BINDING; RNA, SMALL INTERFERING; TRANSCRIPTION FACTORS;

EID: 77954482870     PISSN: 15230864     EISSN: None     Source Type: Journal    
DOI: 10.1089/ars.2009.2999     Document Type: Article

References (45)

1. Andreasen PA. PAI-1: a potential therapeutic target in cancer. Curr Drug Targets 8: 1030-1041, 2007.
2. Andreasen PA, Egelund R, and Petersen HH. The plasmin-ogen activation system in tumor growth, invasion, and metastasis. Cell Mol Life Sci 57: 25-40, 2000.
3. Barthel A, Schmoll D, and Unterman TG. FoxO proteins in insulin action and metabolism. Trends Endocrinol Metab 16: 183-189, 2005.
4. Beitner JD and Millhorn DE. Hypoxia induces phosphory-lation of the cyclic AMP response element-binding protein by a novel signaling mechanism. J Biol Chem 273: 19834-19839, 1998.
5. BelAiba RS, Djordjevic T, Bonello S, Flugel D, Hess J, Kietzmann T, and Gorlach A. Redox-sensitive regulation of the HIF pathway under non-hypoxic conditions in pulmonary artery smooth muscle cells. Biol Chem 385: 249-257, 2004. (Pubitemid 38679070)
6. Bonello S, Zahringer C, BelAiba RS, Djordjevic T, Hess J, Michiels C, Kietzmann T, and Gorlach A. Reactive oxygen species activate the HIF-1alpha promoter via a functional NFkappaB site. Arterioscler Thromb Vasc Biol 27: 755-761, 2007.
7. 2 sensing. J Biol Chem 275: 25130-25138, 2000.
8. Cheng JC, Kinjo K, Judelson DR, Chang J, Wu WS, Schmid I, Shankar DB, Kasahara N, Stripecke R, Bhatia R, Landaw EM, and Sakamoto KM. CREB is a critical regulator of normal he-matopoiesis and leukemogenesis. Blood 111: 1182-1192, 2008.
9. Dansen TB, Smits LM, van Triest MH, de Keizer PL, van Leenen D, Koerkamp MG, Szypowska A, Meppelink A, Brenkman AB, Yodoi J, Holstege FC, and Burgering BM. Redox-sensitive cysteines bridge p300=CBP-mediated acet-ylation and FoxO4 activity. Nat Chem Biol 5: 664-672, 2009.
10. Dellas C and Loskutoff DJ. Historical analysis of PAI-1 from its discovery to its potential role in cell motility and disease. Thromb Haemost 93: 631-640, 2005.
11. Dimova EY, Jakubowska MM, and Kietzmann T. CREB binding to the hypoxia-inducible factor-1 responsive elements in the plasminogen activator inhibitor-1 promoter mediates the glucagon effect. Thromb Haemost 98: 296-303, 2007.
12. Dimova EY and Kietzmann T. The MAPK pathway and HIF-1 are involved in the induction of the human PAI-1 gene expression by insulin in the human hepatoma cell line HepG2. Ann N Y Acad Sci 1090: 355-367, 2006.
13. Dimova EY and Kietzmann T. Metabolic, hormonal and environmental regulation of plasminogen activator inhibi-tor-1 (PAI-1) expression: lessons from the liver. Thromb Haemost 100: 992-1006, 2008.
14. Dimova EY, Moller U, Herzig S, Fink T, Zachar V, Ebbesen P, and Kietzmann T. Transcriptional regulation of plasmin-ogen activator inhibitor-1 expression by insulin-like growth factor-1 via MAP kinases and hypoxia-inducible factor-1 in HepG2 cells. Thromb Haemost 93: 1176-1184, 2005.
15. Emerling BM, Weinberg F, Liu JL, Mak TW, and Chandel NS. PTEN regulates p300-dependent hypoxia-inducible factor 1 transcriptional activity through Forkhead transcription factor 3a (FOXO3a). Proc Natl Acad Sci USA 105: 2622-2627, 2008.
16. Essers MA, Vries-Smits LM, Barker N, Polderman PE, Bur-gering BM, and Korswagen HC. Functional interaction between beta-catenin and FOXO in oxidative stress signaling. Science 308: 1181-1184, 2005.
17. Essers MA, Weijzen S, Vries-Smits AM, Saarloos I, de Ruiter ND, Bos JL, and Burgering BM. FOXO transcription factor activation by oxidative stress mediated by the small GTPase Ral and JNK. EMBO J 23: 4802-4812, 2004.
18. Fink T, Kazlauskas A, Poellinger L, Ebbesen P, and Zachar V. Identification of a tightly regulated hypoxia-response element in the promoter of human plasminogen activator inhibitor-1. Blood 99: 2077-2083, 2002.
19. Fujita H, Kang M, Eren M, Gleaves LA, Vaughan DE, and Kume T. Foxc2 is a common mediator of insulin and transforming growth factor beta signaling to regulate plasmino-gen activator inhibitor type I gene expression. Circ Res 98: 626-634, 2006.
20. Ghosh AK, Lacson R, Liu P, Cichy SB, Danilkovich A, Guo S, and Unterman TG. A nucleoprotein complex containing CCAAT=enhancer-binding protein beta interacts with an insulin response sequence in the insulin-like growth factor-binding protein-1 gene and contributes to insulin-regulated gene expression. J Biol Chem 276: 8507-8515, 2001.
21. Harbeck N, Kates RE, Gauger K, Willems A, Kiechle M, Magdolen V, and Schmitt M. Urokinase-type plasminogen activator (uPA) and its inhibitor PAI-I: novel tumor-derived factors with a high prognostic and predictive impact in breast cancer. Thromb Haemost 91: 450-456, 2004. (Pubitemid 38396866)
22. Huang H, Regan KM, Wang F, Wang D, Smith DI, van Deursen JM, and Tindall DJ. Skp2 inhibits FOXO1 in tumor suppression through ubiquitin-mediated degradation. Proc Natl Acad Sci USA 102: 1649-1654, 2005.
23. Huang H and Tindall DJ. Dynamic FoxO transcription factors. J Cell Sci 120: 2479-2487, 2007.
24. Huang LE, Arany Z, Livingston DM, and Bunn HF. Activation of hypoxia-inducible transcription factor depends primarily upon redox-sensitive stabilization of its alpha subunit. J Biol Chem 271: 32253-32259, 1996.
25. Jag UR, Zavadil J, and Stanley FM. Insulin acts through FOXO3a to activate transcription of plasminogen activator inhibitor type 1. Mol Endocrinol 23: 1587-1602, 2009.
26. Juhan VI, Roul C, Alessi MC, Ardissone JP, Heim M, and Vague P. Increased plasminogen activator inhibitor activity in non insulin dependent diabetic patients\relationship with plasma insulin. Thromb Haemost 61: 370-373, 1989.
27. Kietzmann T, Cornesse Y, Brechtel K, Modaressi S, and Jungermann K. Perivenous expression of the mRNA of the three hypoxia-inducible factor alpha-subunits, HIF1alpha, HIF2alpha and HIF3alpha, in rat liver. Biochem J 354: 531-537, 2001.
28. Kietzmann T and Gorlach A. Reactive oxygen species in the control of hypoxia-inducible factor-mediated gene expression. Semin Cell Dev Biol 16: 474-486, 2005.
29. Kietzmann T, Roth U, and Jungermann K. Induction of the plasminogen activator inhibitor-1 gene expression by mild hypoxia via a hypoxia response element binding the hypoxia inducible factor-1 in rat hepatocytes. Blood 94: 4177-4185, 1999.
30. Klein A, Flugel D, and Kietzmann T. Transcriptional regulation of serine=threonine kinase-15 (STK15) expression by hypoxia and HIF-1. Mol Biol Cell 19: 3667-3675, 2008.
31. Klimova T and Chandel NS. Mitochondrial complex III regulates hypoxic activation of HIF. Cell Death Differ 15: 660-666, 2008.
32. Kops GJ, Dansen TB, Polderman PE, Saarloos I, Wirtz KW, Coffer PJ, Huang TT, Bos JL, Medema RH, and Burgering BM. Forkhead transcription factor FOXO3a protects quiescent cells from oxidative stress. Nature 419: 316-321, 2002.
33. Kuiperij HB, van der HA, Raaijmakers J, Weijzen S, Medema RH, Bos JL, Burgering BM, and Zwartkruis FJ. Activation of FoxO transcription factors contributes to the anti-proliferative effect of cAMP. Oncogene 24: 2087-2095, 2005.
34. Paik JH, Kollipara R, Chu G, Ji H, Xiao Y, Ding Z, Miao L, Tothova Z, Horner JW, Carrasco DR, Jiang S, Gilliland DG, Chin L, Wong WH, Castrillon DH, and DePinho RA. FoxOs are lineage-restricted redundant tumor suppressors and regulate endothelial cell homeostasis. Cell 128: 309-323, 2007.
35. Pflueger A, Abramowitz D, and Calvin AD. Role of oxida-tive stress in contrast-induced acute kidney injury in diabetes mellitus. Med Sci Monit 15: RA125-RA136, 2009.
36. Schleef RR, Higgins DL, Pillemer E, and Levitt LJ. Bleeding diathesis due to decreased functional activity of type 1 plas-minogen activator inhibitor. J Clin Invest 83: 1747-1752, 1989.
37. Schneider DJ, Nordt TK, and Sobel BE. Attenuated fibrino-lysis and accelerated atherogenesis in type II diabetic patients. Diabetes 42: 1-7, 1993.
38. Stork PJ and Schmitt JM. Crosstalk between cAMP and MAP kinase signaling in the regulation of cell proliferation. Trends Cell Biol 12: 258-266, 2002.
39. Tang TT and Lasky LA. The forkhead transcription factor FOXO4 induces the down-regulation of hypoxia-inducible factor 1 alpha by a von Hippel-Lindau protein-independent mechanism. J Biol Chem 278: 30125-30135, 2003.
40. Tothova Z, Kollipara R, Huntly BJ, Lee BH, Castrillon DH, Cullen DE, McDowell EP, Lazo-KallanianS,Williams IR, Sears C, Armstrong SA, Passegue E, DePinho RA, and Gilliland DG. FoxOs are critical mediators of hematopoietic stem cell resistance to physiologic oxidative stress. Cell 128: 325-339, 2007.
41. van der HA and Burgering BM. Stressing the role of FoxO proteins in lifespan and disease. Nat Rev Mol Cell Biol 8: 440-450, 2007.
42. van der Horst A, Vries-Smits AM, Brenkman AB, van Triest MH, van den BN, Colland F, Maurice MM, and Burgering BM. FOXO4 transcriptional activity is regulated by monoubiqui-tination and USP7=HAUSP. Nat Cell Biol 8: 1064-1073, 2006.
43. Vulin AI and Stanley FM. A Forkhead=winged helix-related transcription factor mediates insulin-increased plasminogen activator inhibitor-1 gene transcription. J Biol Chem 277: 20169-20176, 2002.
44. Wiesener MS, Turley H, Allen WE, Willam C, Eckardt KU, Talks KL, Wood SM, Gatter KC, Harris AL, Pugh CW, Ratcliffe PJ, and Maxwell PH. Induction of endothelial PAS domain protein-1 by hypoxia: characterization and comparison with hypoxia-inducible factor-1alpha. Blood 92: 2260-2268, 1998.
45. Wiznerowicz M and Trono D. Conditional suppression of cellular genes: lentivirus vector-mediated drug-inducible RNA interference. J Virol 77: 8957-8961, 2003.