AA2500 testosterone gel normalizes androgen levels in aging males with improvements in body composition and sexual function

Journal of Clinical Endocrinology and Metabolism

Volumn 88, Issue 6, 2003, Pages 2673-2681

  Steidle, Christopher ^a,e   Schwartz, S ^b   Jacoby, K ^c   Sebree, T ^d   Smith, T ^d   Bachand, R ^d  

^a Northeast Indiana Urology   (United States)

^b Diabet/Glandular Dis Res Assoc   (United States)

^c Integrity Medical Research   (United States)

^d Auxilium Pharmaceuticals Inc   (United States)

^e NorthEast Indiana Research LLC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANDROGEN; TESTOSTERONE;

ADULT; AGED; AGING; ARTICLE; BLISTER; BLOOD DISEASE; BODY COMPOSITION; BODY FAT; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CORONARY ARTERY DISEASE; DEPRESSION; DOSE RESPONSE; DOUBLE BLIND PROCEDURE; DRUG ERUPTION; DRUG FORMULATION; DRUG TOLERABILITY; ERECTILE DYSFUNCTION; ERYTHEMA; GYNECOMASTIA; HEADACHE; HORMONE ACTION; HORMONE BLOOD LEVEL; HOT FLUSH; HUMAN; HYPERTENSION; HYPOGONADISM; INSOMNIA; LACRIMATION; LEAN BODY WEIGHT; MAJOR CLINICAL STUDY; MALE; MENTAL INSTABILITY; MOOD; MOTIVATION; PENIS ERECTION; PNEUMONIA; PRIORITY JOURNAL; PRURITUS; RANDOMIZED CONTROLLED TRIAL; SEXUAL FUNCTION; SIDE EFFECT; SKIN EDEMA; SKIN IRRITATION; SMELLING DISORDER; SUICIDAL BEHAVIOR; TASTE DISORDER; TESTOSTERONE BLOOD LEVEL; TREATMENT OUTCOME; URINARY TRACT INFECTION; VERTIGO;

EID: 0012619789     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jc.2002-021058     Document Type: Article

References (11)

1. Wang C, Swerdloff RS, Iranmanesh A, Dobs A, Snyder PJ, Cunningham G, Matsumoto M, Weber T, Berman N, Testosterone Gel Study Group 2000 Transdermal testosterone gel improves sexual function, mood, muscle strength, and body composition parameters in hypogonadal men. J Clin Endocrinol Metab 85:2839-2853
2. Arver S, Dobs AS, Meikle AW, Caramelli KE, Rajaram L, Sanders SW, Mazer NA 1997 Long-term efficacy, and safety of a permeation-enhanced testosterone transdermal system in hypogonadal men. Clin Endocrinol (Oxf) 47:727-737
3. Behre HM, von Eckardstein S, Kliesch S, Nieschlag E 1999 Long-term substitution therapy of hypogonadal men with transscrotal testosterone over 7-10 years. Clin Endocinol (Oxf) 50:629-635
4. Snyder PJ, Peachey H, Hannoush P, Berlin JA, Loh L, Holmes JH, Dlewati A, Staley J, Santanna J, Kapoor SC, Attie MF, Haddad Jr JG, Strom BL 1999 Effect of testosterone treatment on bone mineral density in men over 65 years of age. J Clin Endocrinol Metab 84:1966-1972
5. Snyder PJ, Peachey H, Hannoush P, Berlin JA, Loh L, Lenrow DA, Holmes JH, Dlewati A, Santanna J, Rosen CJ, Strom BL 1999 Effect of testosterone treatment on body composition and muscle strength in men over 65 years of age. J Clin Endocrinol Metab 84:2647-2653
6. Jordan Jr WP, Atkinson LE, Lai C 1998 Comparison of the skin irritation potential of two testosterone transdermal systems: an investigational system and a marketed product. Clin Ther 20:80-87
7. Jordan Jr WP 1997 Allergy and topical irritation associated with transdermal testosterone administration: a comparison of scrotal and nonscrotal transdermal systems. Am J Contact Dermatitis 8:108-113
8. Marbury T, Hamill E, Bachand R, Sebree T, Smith T 2003 Evaluation of the pharmacokinetic profiles of the new testosterone topical gel formulation, Testim compared to AndroGel. Biopharm Drug Dispos 24:115-120
9. Dobs AS, Meikle AW, Arver S, Sanders SW, Caramelli KE, Mazer NA 1999 Pharmacokinetics, efficacy, and safety of a permeation-enhanced testosterone transdermal system in comparison with biweekly injections of testosterone enanthate for the treatment of hypogonadal men. J Clin Endocrinol Metab 84:3469-3478
10. Gann PH, Hennekens CH, Ma J, Longcope C, Stampfer MJ 1996 Prospective study of sex hormone levels and risk of prostate cancer. J Natl Cancer Inst 88:1118-1126
11. Mohr BA, Feldman HA, Kalish LA, Longcope C, McKinlay JB 2001 Are serum hormones associated with the risk of prostate cancer? Prospective results from the Massachusetts Male Aging Study. Urology 57:930-935