Effect of testosterone therapy on lumbar spine and hip mineral density in elderly men

Aging Male

Volumn 11, Issue 3, 2008, Pages 140-145

  Basurto, Lourdes ^a   Zarate, Arturo ^a   Gomez, Raquel ^a   Vargas, Columba ^a   Saucedo, Renata ^a   Galván, Rosa ^a  

^a NONE

Author keywords

Bone mineral density; Estradiol; Osteoporosis; Testosterone therapy

Indexed keywords

ESTRADIOL; PLACEBO; TESTOSTERONE; TESTOSTERONE ENANTATE;

ADULT; AGED; ANDROGEN DEFICIENCY; ARTICLE; BONE DENSITY; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFECT; DRUG WITHDRAWAL; ESTRADIOL BLOOD LEVEL; FEMUR NECK; HEMATOCRIT; HIP; HORMONAL THERAPY; HUMAN; LUMBAR SPINE; MALE; PARALLEL DESIGN; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SIDE EFFECT; TESTOSTERONE BLOOD LEVEL;

AGED; BONE DENSITY; DOUBLE-BLIND METHOD; HIP; HUMANS; LUMBAR VERTEBRAE; MALE; MIDDLE AGED; OSTEOPOROSIS; TESTOSTERONE; TREATMENT OUTCOME;

EID: 52949126361     PISSN: 13685538     EISSN: 14730790     Source Type: Journal    
DOI: 10.1080/13685530802273715     Document Type: Article

References (29)

1. Kaufman M, Vermeulen A. The decline of androgen levels in elderly men and its clinical and therapeutic implications. Endocr Rev 2005;26:833-876.
2. Gennari L, Merlotti D, Martini G, Gonneli S, Franci B, Campagna S, Lucani B, Dal Canto N, Valenti R, Gennari C, Nuti R. Longitudinal association between sex hormone levels, bone loss, and bone turnover in elderly men. J Clin Endocrinol Metab 2003;88:5327-5333.
3. Rochira V, Balestrieri A, Madeo B, Zirilli L, Granata ARM, Carani C. Osteoporosis and male age-related hypogonadism: Role of sex steroids on bone (patho)physiology. Eur J Endocrinol 2006;154:175-185.
4. Vanderschueren D, Vandenput L, Boonen S, Lindberg MK, Bouillon R, Ohlsson C. Androgens and bone. Endocr Rev 2004;25:389-425.
5. Falahati-Nini A, Riggs L, Atkinson EJ, O'Fallon WM, Eastell R, Khosla S. Relative contributions of testosterone and estrogen in regulating bone resorption and formation in normal elderly men. J Clin Invest 2000;106:1553-1560.
6. Tenover JS. Effects of testosterone supplementation in the aging male. J Clin Endocrinol Metab 1992;75:1092-1098.
7. Snyder PJ, Peachey H, Berlin JA, Hannoush P, Haddad G, Dlewati A, Santanna J, Loh L, Lenrow DA, Holmes JH, Kapoor SC, Atkinson LE, Strom BL. Effects of testosterone replacement in hypogonadal men. J Clin Endocrinol Metab 2000;85:2670-2677.
8. Kenny AM, Prestwood KM, Gruman CA, Marcello KM, Raisz LG. Effect of transdermal testosterone on bone and muscle in older men with low bioavailable testosterone levels. J Gerontol A Biol Sci Med Sci 2001;56:M266-272.
9. Amory JK, Watts NB, Easley KA, Sutton PR, Anawalt BD, Matsumoto AM, Bremner WJ, Tenover JL. Exogenous testosterone or testosterone with finasteride increases bone mineral density in older men with low serum testosterone. J Clin Endocrinol Metab 2004;89:503-510.
10. Snyder PJ, H, Peachey H, Hannoush P, Berlin JA, Loh L, Holmes JH, Dlewati A, Staley J, Santanna H, Kapoor SC, Attie MF, Haddad JG, Strom BL. Effect of testosterone treatment on bone mineral density in men over 65 years of age. J Clin Endocrinol Metab 1999;84:1966-1972.
11. Saucedo R, Fonseca ME, Basurto L, Ochoa R, Sánchez M, Zárate A. Decremento en los andrógenos circulantes en el hombre durante la senescencia. Gac Med Mex 2000;136:335-339.
12. Ruiz-Argüelles GJ, Sanchez-Medal L, Loria A, Piedras J, Cordova MS. Red cell indices in normal adultsresiding at altitudes from sea level to 2670 m. Am J Hematol 1980;8:265-267.
13. Bhasin S, Cunningham GR, Hayes FJ, Matsumoto AM, Snyder PJ, Swerdloff RS, Montori VM. Testosterone therapy in adult men with androgen deficiency syndromes: An Endocrine Society clinical practice guideline. J Clin Endocrinol Metab 2006;91:1995-2010.
14. Szulc P, Munoz F, Claustrat B, Garnero P, Marchand F. Bioavailable estradiol may be an important determinant of osteoporosis in men: The MINOS study. J Clin Endocrinol Metab 2001;86:192-199.
15. Mellstrom D, Johnell O, Ljunggren O, Eriksson AL, Lorentzon M, Mallmin H, Holmberg A, Redlund-Johnell I, Orwoll E, Ohlsson C. Free testosterone is an independent predictor of BMD and prevalent fractures in elderly men: MrOS Sweden. J Bone Miner Res 2006;21:529-535.
16. Behre HM, Kliesch S, Leifke E, Link TM, Nieschlag E. Long-term effect of testosterone therapy on bone mineral density in hypogonadalmen. J Clin Endocrinol Metab 1997;82:2386-2390.
17. Benito M, Gomberg B, Wehrli FW, Weening RH, Zemel B, Wright AC, Song HK, Cucchiara C, Snyder PJ. Deterioration of trabecular architecture in hypogonadal men. J Clin Endocrinol Metab 2003;88:1497-1502.
18. Wang C, Cunningham G, Dobs A, Iranmanesh A, Matsumoto AM, Snyder PJ, Weber T, Berman N, Hull L, Swerdloff RS. Long-term testosterone gel (AndroGel) treatment maintains beneficial effects on sexual function and mood, lean and fat mass, and bone mineral density in hypogonadal men. J Clin Endocrinol Metab 2004;89:2085-2098.
19. Katznelson L, Finkelstein JS, Schoenfeld DA, Rosenthal DJ, Anderson EJ, Klinbanski A. Increase in bone density and lean body mass during testosterone administration in men with acquired hypogonadism. J Clin Endocrinol Metab 1996;81:4358-4365.
20. Duan Y, Tabensky A, DeLuca V, Seeman E. The benefit of hormone replacement therapy on bone mass is greater at the vertebral body than posterior processes or proximal femur. Bone 1997;21:447-451.
21. Emmelot-Vonk MH, Verhaar HJJ, Pour HRN, Aleman A, Lock TMT, Bosch JLH, Grobbee DE, van der Schouw IT. Effect of testosterone supplementation on functional mobility, cognition, and other parameters in older men. A randomized controlled trial. JAMA 2008;299:39-52.
22. Tracz MJ, Sideras K, Boloña ER, Haddad RM, Kennedy CC, Uraga MV, Caples SM, Edwin PJ, Montori VM. Testosterone use in men and its effects on bone health. A systematic review and meta-analysis of randomized placebo-controlled. J Clin Endocrinol Metab 2006;91:2011-2016.
23. Khosla S, Melton III LJ, Riggs BL. Estrogen and the male skeleton. J Clin Endocrinol Metab 2002;87:1443-1450.
24. Compston J. Local biosynthesis of sex steroids in bone. J Clin Endocrinol Metab 2002;87:5398-5400.
25. Meier C, Liu PY, Handelsman DJ, Seibel MJ. Endocrine regulation of bone turnover in men. Clin Endocrinol (Oxf) 2005;63:603-613.
26. Proctor DN, Melton LJ, Khosla S, Crowson CS, O'Connor MK, Riggs BL. Relative influence of physical activity, muscle mass and strength on bone density. Osteoporosis Int 2000;11:944-952.
27. Allan CA, McLachlan RI. Age-related changes in testosterone and the role of replacement therapy in older men. Clin Endocrinol (Oxf) 2004;60:653-670.
28. Kelleher S, Conway AJ, Handelsman DJ. Blood testosterone threshold for androgen deficiency symptoms. J Clin Endocrinol Metab 2004;89:3813-3817.
29. Liu PY, Swerdloff RS, Veldhuis JD. The rationale, efficacy and safety of androgen therapy in older men: Future research and current practice recommendations. J Clin Endocrinol Metab 2004;89:4789-4796.