Aryl hydrocarbon receptor and NF-E2-related factor 2 are key regulators of human MRP4 expression

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 299, Issue 1, 2010, Pages

  Xu, Shuhua ^a   Weerachayaphorn, Jittima ^a   Cai, Shi Ying ^a   Soroka, Carol J ^a   Boyer, James L ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

ABC transporter; Cholestasis; Drug metabolism; Gene regulation; Transcription factor; Xenobiotic receptor

Indexed keywords

AROMATIC HYDROCARBON RECEPTOR; MESSENGER RNA; MULTIDRUG RESISTANCE PROTEIN 4; NUCLEAR FACTOR; OLTIPRAZ; TRANSCRIPTION FACTOR NRF2; XENOBIOTIC AGENT;

ARTICLE; BINDING AFFINITY; CELL PROTECTION; CELL STRAIN HEPG2; CHOLESTASIS; CHROMATIN IMMUNOPRECIPITATION; COMPUTER PROGRAM; GEL MOBILITY SHIFT ASSAY; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; LIVER INJURY; MUTATION; PLASMID; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; REGULATORY MECHANISM; REPORTER GENE; UPREGULATION; VECTOR CONTROL; WESTERN BLOTTING; XENOBIOTIC METABOLISM;

5' FLANKING REGION; ANIMALS; ARYL HYDROCARBON RECEPTOR NUCLEAR TRANSLOCATOR; BASE SEQUENCE; BINDING SITES; BUTYLAMINES; CHROMATIN IMMUNOPRECIPITATION; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROPHORETIC MOBILITY SHIFT ASSAY; GENES, REPORTER; HEP G2 CELLS; HEPATOCYTES; HUMANS; METHYLCHOLANTHRENE; MICE; MOLECULAR SEQUENCE DATA; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; MUTATION; NF-E2-RELATED FACTOR 2; PROMOTER REGIONS, GENETIC; PYRAZINES; RECEPTORS, ARYL HYDROCARBON; RESPONSE ELEMENTS; RNA INTERFERENCE; RNA, MESSENGER; TETRACHLORODIBENZODIOXIN; TIME FACTORS; TRANSFECTION;

EID: 77954379023     PISSN: 01931857     EISSN: 15221547     Source Type: Journal    
DOI: 10.1152/ajpgi.00522.2010     Document Type: Article

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