Age-related changes in pro-opiomelanocortin (POMC) and related receptors in human epidermis

International Journal of Cosmetic Science

Volumn 32, Issue 4, 2010, Pages 266-275

  Pain, S ^a   Dezutter, C ^a   Reymermier, C ^a   Vogelgesang, B ^a   Delay, E ^a   Andre V ^a  

^a Beauty Care Solutions   (France)

Author keywords

MC 1R; MC 2R; MOR 1; pro opiomelanocortin; skin ageing

Indexed keywords

ALPHA INTERMEDIN; MELANOCORTIN 1 RECEPTOR; MELANOCORTIN 2 RECEPTOR; MELANOCORTIN RECEPTOR; MESSENGER RNA; MU OPIATE RECEPTOR; PROOPIOMELANOCORTIN;

ADOLESCENT; ADULT; AGED; ARTICLE; BIOMECHANICS; CELL DIFFERENTIATION; CONTROLLED STUDY; CUTANEOUS PARAMETERS; EPIDERMIS; FEMALE; GENE EXPRESSION; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; KERATINOCYTE; NUCLEOTIDE SEQUENCE; QUANTITATIVE ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA EXTRACTION; SKIN BIOPSY; THICKNESS; ULTRAVIOLET RADIATION; WESTERN BLOTTING;

ADOLESCENT; ADRENOCORTICOTROPIC HORMONE; ADULT; AGED; AGING; ALPHA-MSH; BETA-ENDORPHIN; BIOPSY; EPIDERMIS; FEMALE; HUMANS; KERATINOCYTES; MIDDLE AGED; PRO-OPIOMELANOCORTIN; RECEPTOR, MELANOCORTIN, TYPE 1; RECEPTOR, MELANOCORTIN, TYPE 2; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA; YOUNG ADULT;

EID: 77954351107     PISSN: 01425463     EISSN: 14682494     Source Type: Journal    
DOI: 10.1111/j.1468-2494.2009.00569.x     Document Type: Article

References (41)

1. Mains, R.E. Eipper, B.A. Synthesis and secretion of corticotropins, melanotropins, and endorphins by rat intermediate pituitary cells. J. Biol. Chem. 254, 7885 7894 (1979).
2. Wintzen, M. Gilchrest, B.A. Proopiomelanocortin, its derived peptides, and the skin. J. Invest. Dermatol. 106, 3 10 (1996).
3. Seidah, N.G. Chrétien, M. Proprotein and prohormone convertases: a family of subtilases generating diverse bioactive polypeptides. Brain Res. 848, 45 62 (1999).
4. Gantz, I. Fong, T.M. The melanocortin system. Am. J. Physiol. Endocrinol. Metab. 284, E468 E474 (2003).
5. Slominski, A. Identifiaction of beta-endorphin, alpha-MSH and ACTH peptides in cultured human melanocytes, melanoma and squamous cell carcinoma cells by RP-HPLC. Exp. Dermatol. 7, 213 216 (1998)
6. Thody, A.J., Ridley, K., Penny, R.J., Chalmers, R., Fisher, C. Shuster, S. MSH peptides are present in mammalian skin. Peptides 4, 813 816 (1983).
7. Slominski, A., Wortsman, J., Mazurkiewicz, J.E. et al. Detection of proopiomelanocortin-derived antigens in normal and pathologic human skin. J. Lab. Clin. Med. 122, 658 666 (1993).
8. Schauer, E., Trautinger, F., Köck, A. et al. Proopiomelanocortin- derived peptides are synthesized and released by human keratinocytes. J. Clin. Invest. 93, 2258 2262 (1994).
9. Rousseau, K., Kauser, S., Pritchard, L.E. et al. Proopiomelanocortin (POMC), the ACTH/melanocortin precursor, is secreted by human epidermal keratinocytes and melanocytes and stimulates melanogenesis. FASEB J., 21, 1844 1856 (2007).
10. Slominski, A., Szczesniewski, A. Wortsman, J. Liquid chromatography-mass spectrometry detection of corticotropin-releasing hormone and proopiomelanocortin-derived peptides in human skin. J. Clin. Endocrinol. Metab. 85, 3582 3588 (2000).
11. Schiller, M., Raghunath, M., Kubitscheck, U. et al. Human dermal fibroblasts express prohormone convertases 1 and 2 and produce proopiomelanocortin-derived peptides. J. Invest. Dermatol. 117, 227 235 (2001).
12. Wintzen, M., Yaar, M., Burbach, J.P. Gilchrest, B.A. Proopiomelanocortin, gene product regulation in keratinocytes. J. Invest. Dermatol. 106, 673 678 (1996).
13. Bigliardi-Qi, M., Sumanovski, L.T., Buchner, S., Rufli, T. Bigliardi, P.L. Mu-opioid receptor and beta-endorphin expression in nerve endings and keratinocytes in human skin. Dermatology 209, 183 189 (2004).
14. Böhm, M., Metze, D., Schulte, U., Becher, E., Luger, T.A. Brzoska, T. Detection of melanocortin-1 receptor antigenicity on human skin cells in culture and in situ. Exp. Dermatol. 8, 453 456 (1999).
15. Slominski, A., Ermak, G. Mihm, M. ACTH receptor, CYP11A1, CYP17 and CYP21A2 genes are expressed in skin. J. Clin. Endocrinol. Metab. 81, 2746 2749 (1996).
16. Bigliardi, P.L., Bigliardi-Qi, M., Buechner, S. Rufli, T. Expression of μ-opioid receptor in human epidermis and keratinocytes. J. Invest. Dermatol. 111, 297 301 (1998).
17. Bigliardi-Qi, M., Bigliardi, P.L., Buchner, S. Rufli, T. Characterization of mu-opioid receptor in human epidermis and keratinocytes. Ann. N Y Acad. Sci. 885, 368 371 (1999).
18. Chhajlani, V. Wikberg, J.E. Molecular cloning and expression of the human melanocyte stimulating hormone receptor cDNA. FEBS Lett. 309, 417 420 (1992).
19. Mountjoy, K.G., Robbins, L.S., Mortrud, M.T. Cone, R.D. The cloning of a family of genes that encode the melanocortin receptors. Science 257, 1248 1251 (1992).
20. Tsatmali, M., Yukitake, J. Thody, A.J. ACTH1-17 is a more potent agonist at the human MC1 receptor than alpha-MSH. Cell. Mol. Biol. 45, 1029 1034 (1999).
21. Chakraborty, A.K., Funasaka, Y., Slominski, A. et al. Production and release of proopiomelanocortin (POMC) derived peptides by human melanocytes and keratinocytes in culture: regulation by ultraviolet. B. Biochim. Biophys. Acta. 1313, 130 138 (1996).
22. Moustafa, M., Szabo, M., Ghanem, G.E., Kemp, E.H., MacNeil, S. Haycock, J.W. Inhibition of tumor necrosis factor-alpha stimulated NFkappaB/p65 in human keratinocytes by alpha-melanocyte stimulating hormone and adrenocorticotropic hormone peptides. J. Invest. Dermatol. 119, 1244 1253 (2002).
23. Luger, T.A., Scholzen, T., Brzoska, T., Becher, E., Slominski, A. Paus, R. Cutaneous immunomodulation and coordination of skin stress responses by alpha-melanocyte-stimulating hormone, Ann. N Y Acad. Sci. 840, 381 394 (1998).
24. Slominski, A., Wortsman, J., Luger, T., Paus, R. Solomon, S. Corticotropin releasing hormone and propopiomelanocortin: involvement in the cutaneous response to stress. Physiol. Rev. 80, 979 1020 (2000).
25. Thiboutot, D., Sivarajah, A., Gilliland, K., Cong, Z. Clawson, G. The melanocortin 5 receptor is expressed in human sebaceous glands and rat preputial cells. J. Invest. Dermatol. 115, 614 619 (2000).
26. Hatta, N., Dixon, C., Ray, A.J. et al. Expression, candidate gene, and population studies of the melanocortin 5 receptor. J. Invest. Dermatol. 116, 564 570 (2001).
27. Böhm, M., Schiller, M., Ständer, S. et al. Evidence for expression of melanocortin-1 receptor in human sebocytes in vitro and in situ. J. Invest. Dermatol. 118, 533 539 (2002).
28. Hunt, G., Todd, C., Kyne, S. Thody, A.J. ACTH stimulates melanogenesis in cultured human melanocytes. J. Endocrinol. 140, R1 R3 (1994).
29. Kauser, S., Schallreuter, K.U., Thody, A.J., Gummer, C. Tobin, D.J. Regulation of human epidermal melanocyte biology by beta-endorphin. J. Invest. Dermatol. 120, 1073 1080 (2003).
30. Kauser, S., Thody, A.J., Schallreuter, K.U., Gummer, C.L. Tobin, D.J. β-endorphin as a regulator of human hair follicle melanocyte biology. J. Invest. Dermatol. 123, 184 195 (2004).
31. Slominski, A., Wortsman, J., Plonka, P.M., Schallreuter, K.U., Paus, R. Tobin, D. Hair Follicle Pigmentation. J. Invest. Dermatol. 124, 13 21 (2005).
32. Luger, T.A., Brzoska, T., Böhm, M., Schiller, M., Fisbeck, T. Scholzen, T. The effect of the ultraviolet light of the production and processing of the proopiomelanocortin in the skin. In : Mechanisms of Suntanning (Ortonne, J.P. Ballotti, R., eds), pp 135 142. Martin Dunitz Ltd
33. Brzoska, T., Scholzen, T., Becher, E. Luger, T.A. Effect of UV light on the production of proopiomelanocortin-derived peptides and melanocortins receptors in the skin. In : Skin Cancer and UV Radiation (Altmeyer, P., Hoffmann, K. Stücker, M., eds), pp 227 237. Springer-Verlag
34. Chakraborty, A., Slominski, A., Ermak, G., Hwang, J. Pawelek, J. Ultraviolet B and melanocyte-stimulating hormone (MSH) stimulate mRNA production for α-MSH receptors and proopiomelanocortin-derived peptides in mouse melanoma cells and transformed keratinocytes. J. Invest. Dermatol. 105, 655 659 (1995).
35. Schiller, M., Brzoska, T., Böhm, M., Metze, D., Scholzen, T.E., Rougier, A. Luger, T.A. Solar-simulated ultraviolet radiation-induced upregulation of the melanocortin-1 receptor, proopiomelanocortin, and alpha-melanocyte-stimulating hormone in human epidermis in vivo. J. Invest. Dermatol. 122, 468 476 (2004).
36. Chakraborty, A.K., Funasaka, Y., Pawelek, J.M., Nagahama, M., Ito, A. Ichihashi, M. Enhanced expression of melanocortin-1 receptor (MC1-R) in normal human keratinocytes during differentiation: evidence for increased expression of POMC peptides near suprabasal layer of epidermis. J. Invest. Dermatol. 112, 853 860 (1999).
37. Bigliardi-Qi, M., Bigliardi, P.L., Eberle, A.N., Buchner, S. Rufli, T. Beta-endorphin stimulates cytokeratin 16 expression and downregulates mu-opioid receptor expression in human epidermis. J. Invest. Dermatol. 114, 527 532 (2000).
38. Cone, R.D., Lu, D. Koppula, S. The melanocortin receptors: Agonists, antagonists, and the hormonal control of pigmentation. Recent Prog. Horm. Res. 51, 287 317 (1996).
39. Weinstein, D.D., Spector, S., Nanney, L.B. King, L.E., Jr. Endogenous opioid alkaloids and human skin. J. Invest. Dermatol. 119, 709 710 (2002).
40. Bigliardi, P.L., Sumanovski, L.T., Buchner, S., Rufli, T. Bigliardi-Qi, M. Different expression of μ-opioid receptor in chronic and acute wounds and the effect of beta-endorphin on transforming growth factor beta type II receptor and cytokeratin 16 expression. J. Invest. Dermatol. 120, 145 152 (2003).
41. Akhan, S.E., Gürel, T., Has, R., Iyibozkurt, A.C. Turfanda, A. Effects of long term oral hormone replacement therapy on plasma nitric oxide and beta-endorphin levels in postmenopausal women. Gynecol. Obstet. Invest. 54, 196 200 (2002).