Human dermal fibroblasts express prohormone convertases 1 and 2 and produce proopiomelanocortin-derived peptides

Journal of Investigative Dermatology

Volumn 117, Issue 2, 2001, Pages 227-235

  Schiller, Meinhard ^a   Raghunath, Michael ^b   Kubitscheck, Ulrich ^c   Scholzen, Thomas E ^a   Fisbeck, Tanja ^a   Metze, Dieter ^a   Luger, Thomas A ^a   Böhm, Markus ^a  

^a Ludwig Boltzmann Institute for Cell Biology and Immunobiology of the Skin   (Germany)

^b Dr Suwelack Skin and Health Care AG   (Germany)

^c UNIVERSITY OF MÜNSTER   (Germany)

Author keywords

Adrenocortico tropin; B endorphin; Fibroblasts; Melanocyte stimulating hormone; Prohormone convertases; Proopiomelanocortin

Indexed keywords

BETA ENDORPHIN; COLLAGEN; CORTICOTROPIN; ENZYME ANTIBODY; FURIN; INTERLEUKIN 1; PROHORMONE CONVERTASE 1; PROOPIOMELANOCORTIN; PROPROTEIN CONVERTASE 2; UNCLASSIFIED DRUG; VIMENTIN;

ARTICLE; CONTROLLED STUDY; CYTOPLASM; ENZYME ACTIVITY; ENZYME IMMUNOASSAY; ENZYME LOCALIZATION; GOLGI COMPLEX; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; IMMUNORADIOMETRIC ASSAY; NEWBORN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; RADIOIMMUNOASSAY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SKIN FIBROBLAST; WESTERN BLOTTING;

EID: 0035722168     PISSN: 0022202X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.0022-202x.2001.01412.x     Document Type: Article

References (78)

1. Mutations in the catalytic domain of prohormone convertase 2 result in decreased binding to 7B2 and loss of inhibition with 7B2 C-terminal peptide
2. Human peripheral blood-derived dendritic cells express functional melanocortin receptor MC-1R
3. PC 1 and PC2 are proprotein convertases capable of cleaving proopiomelanocortin at distinct pairs of basic residues
4. Comparative biosynthesis, covalent post-translational modifications and efficiency of prosegment cleavage of the prohormone convertases PC1 and PC2: Glycosylation, sulphation and identification of the intracellular site of prosegment cleavage of PC1 and PC2
5. 7B2 is a specific intracellular binding protein of the prohormone convertase PC2
6. Residues unique to the pro-hormone convertase PC2 modulate its autoactivation, binding to 7B2 and enzymatic activity
7. Proopiomelanocortin-derived peptides induce IL-10 production in human monocytes
8. Evidence for the differential expression of the functional a-melanocyte-stimulating hormone receptor MC-1 on human monocytes
9. Expression of μ-opiate receptor in human epidermis and keratinocytes
10. β-Endorphin stimulates cytokeratin 16 expression and downregulates μ-opiate receptor expression in human epidermis
11. Proopiomelanocortin and the immune-neuroendocrine connection
12. Identification of p90RSK as the probable CREB-Ser 133 kinase in human melanocytes
13. Detection of melanocortin-1 receptor antigenicity on human skin cells in culture and in situ
14. α-Melanocyte-stimulating hormone modulates activation of NF-κB and AP-1 and secretion of interleukin-8 in human dermal fibroblasts
15. The role of melanocortins in adipocyte function
16. Characterization of melanocortin receptor subtype expression in murine adipose tissues and in the 3T3-L1 cell line
17. Molecular basis of the α-MSH/IL-1 antagonism
18. α-Melanocyte-stimulating hormone in the modulation of host reactions
19. Ultraviolet B and melanocyte-stimulating hormone (MSH) stimulate mRNA production for α-MSH receptors and proopiomelanocortin-derived peptides in mouse melanoma cells and transformed keratinocytes
20. Production and release of proopiomelanocortin (POMC) derived peptides by human melanocytes and keratinocytes in culture: Regulation by ultraviolet B
21. Enhanced expression of melanocortin-1 receptor (MC-1R) in normal human keratinocytes during differentiation: Evidence for increased expression of POMC peptides near suprabasal layer of epidermis
22. Antimicrobial effects of α-MSH peptides
23. Increased concentration of β-endorphin in sera of patients with psoriasis and other inflammatory dermatoses
24. α-Melanocyte-stimulating hormone induces hapten-specific tolerance in mice
25. The proopiomelanocortin system
26. α-Melanocyte-stimulating hormone inhibits TNF-α stimulated intercellular adhesion molecule-1 expression in normal cutaneous human melanocytes and in melanoma cell lines
27. 4-12 is the minimal message sequence required to induce the differentiation of mouse epidermal melanocytes in serum-free primary culture
28. Two activation states of the prohormone convertase PC1 in the secretory pathway
29. Mechanisms of the antiinflammatory effects of α-MSH. Role of transcription factor NF-κB and adhesion molecule expression
30. α-Melanocyte-stimulating hormone induces collagenase/matrix metalloproteinase-1 in human dermal fibroblasts
31. Effects of the neuropeptides substance Pcalcitonin gene-related peptide and α-melanocyte-stimulating hormone on the IL-8/IL-8 receptor system in a cultured human keratinocyte cell line and dermal fibroblasts
32. β-Adrenergic receptors are involved in histamine-induced secretion of proopiomelanocortin-derived peptides and prolactin in rats
33. Effect of histamine on gene expression and release of proopiomelanocortin-derived peptides from the anterior and intermediate pituitary lobes in conscious male rats
34. Localization of single nuclear pore complexes by confocal laser scanning microscopy and analysis of their distribution
35. Effect of α- and β-melanocyte-stimulating hormones on skin color of man
36. Plasma β-endorphin and β-lipoprotein response to ultraviolet radiation
37. Colloidal gold and collidal silver metallic markers for light microscopic histochemistry
38. Production of immunosuppressing melanotropins by human keratinocytes
39. α-Melanocyte-stimulating hormone as a mediator of tolerance induction
40. The proopiomelanocortin system in cutaneous neuroimmunomodulation. An introductory overview
41. Intermediate filaments of the vimentin and prekeratin type in human epidermis
42. Electron microscopic immunocytochemical evidence for the involvement of the convertases PC1 and PC2 in the processing of proinsulin in pancreatic β-cells
43. α-Melanocyte-stimulating hormone inhibits the nuclear transcription factor NF-κB activation induced by various inflammatory agents
44. Spatiotemporal expression, distribution, and processing of POMC and POMC-derived peptides in murine skin
45. Intracellular location, temporal expression, and polysialylation of neural cell adhesion molecule in astrocytes in primary culture
46. Modulation of ICAM-1 expression by α-MSH in human melanoma cells and melanocytes
47. Mechanism of the facilitation of PC2 maturation by 7B2: Involvement in proPC2 transport and activation but not folding
48. Immunoreactivity of α-melanocyte-stimulating hormone, adrenocorticotrophic hormone and β-endorphin in cutaneous malignant melanoma and benign melanocytic naevi
49. Proneuropeptide Y processing in large dense-core vesicles: Manipulation of prohormone convertase expression in sympathetic neurons using adenoviruses
50. Proopiomelanocortin-related peptides, prohormone convertases 1 and 2 and the regulatory peptide 7B2 are present in melanosomes of human melanocytes
51. Carboxy-terminal conversion of profibrillin to fibrillin at a basic site by PACE/furin-like activity required for incorporation in the matrix
52. Prenatal alcohol exposure affects galactosyltransferase activity and glycoconjugates in the Golgi apparatus of fetal rat hepatocytes
53. UVA irradiation induces collagenase in human dermal fibroblasts in vitro and in vivo
54. Proopiomelanocortin-derived peptides are synthesized and released by human keratinocytes
55. Expression of proopiomelanocortin peptides in human dermal microvascular endothelial cells: Evidence for a regulation by ultraviolet light and interleukin- 1
56. The subtilisin/kexin family of precursor convertases. Emphasis on PC1, PC2/7B2, POMC and the novel enzyme SKI-1
57. Identification of β-endorphin, α-MSH and ACTH peptides in cultured human melanocytes, melanoma and squamous cell carcinoma cells by RP-HPLC
58. Detection of proopiomelanocortin-derived antigens in normal and pathologic human skin
59. Proopiomelanocortin corticotropin releasing hormone and corticotropin releasing hormone receptor genes are expressed in human skin
60. The expression of proopiomelanocortin (POMC) and of corticotropin releasing hormone receptor (CRH-R) genes in mouse skin
61. ACTH production in C57BL/ 6 mouse skin
62. Corticotropin releasing hormone and proopiomelanocortin involvement in the cutaneous response to stress
63. Proopiomelanocortin processing in the pituitary, central nervous system, and peripheral tissues
64. POMC-derived peptides and their biological action
65. α-MSH reduces vasculitis in the local Shwartzman reaction
66. Propiomelanocortin (POMC) gene expression by normal skin and keloid fibroblasts in culture: Modulation by cytokines
67. The role of proopiomelanocortin-derived peptides in skin fibroblast and mast cell functions
68. Does α-MSH have a role in regulating skin pigmentation in humans?
69. MSH peptides are present in mammalian skin
70. Melanoma growth-stimulatory activity/GRO decreases collagen expression by human fibroblasts. Regulation by C-X-C but not C-C cytokines
71. Survey of neuropeptide gene expression in tumor cell lines
72. Biosynthesis of the prohormone convertase mPC1 in AtT-20 cells
73. Characterisation of ACTH peptides in human skin and their activation of the melanocortin- 1 receptor
74. Proopiomelanocortin, its derived peptides, and the skin
75. UVA-induced autocrine stimulation of fibroblast-derived collagenase/MMP-1 by interrelated loops of interleukin-1 and interleukin- 6
76. An immunocytochemical approach to the study of β-endorphin production in human keratinocytes using confocal microscopy
77. Enzymatic properties of carboxyl-terminally truncated prohormone convertase 1 (PC1/SPC3) and evidence for autocatalytic conversion
78. 7B2 facilitates the maturation of proPC2 in neuroendocrine cells and is required for the expression of enzymatic activity