Proopiomelanocortin, Its Derived Peptides, and the Skin

Journal of Investigative Dermatology

Volumn 106, Issue 1, 1996, Pages 3-10

  Wintzen, Marjolein ^a   Gilchrest, Barbara A ^b  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^b BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Epidermis; Immunomodulation; Melanogenesis; POMC gene expression

Indexed keywords

ALPHA INTERMEDIN; BETA ENDORPHIN; BETA INTERMEDIN; CORTICOTROPIN; PROOPIOMELANOCORTIN;

ANIMAL; ANIMAL CELL; ANIMAL TISSUE; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOMODULATION; MELANOGENESIS; NONHUMAN; PRIORITY JOURNAL; REVIEW; SKIN;

GENE EXPRESSION; GENE EXPRESSION REGULATION; HUMANS; PEPTIDES; PRO-OPIOMELANOCORTIN; PROTEIN PROCESSING, POST-TRANSLATIONAL; SKIN; SKIN DISEASES; SKIN PHYSIOLOGY; TERMINOLOGY;

EID: 0030071776     PISSN: 0022202X     EISSN: None     Source Type: Journal    
DOI: 10.1111/1523-1747.ep12326950     Document Type: Review

References (155)

1. Bennet AM: The results of extirpation of the anterior lobe of the hypophysis and of the thyroid of rana pipiens larvae. Science 44:755-758, 1916
2. Atwell WJ: On the nature of the pigmentation hanges following pypophysectomy. Science 49:48-50, 1919
3. Smith PE: Hypophysectomy and a replacement therapy in the rat. Am J Anat 45:205-273, 1930
4. Lerner AB, Lee TH: Isolation of homogeneous melanocyte stimulating hormone from hog pituitary gland. J Am Chem Soc 77:1066-1067, 1955
5. Lohmar P, Li CH: Biological properties of ovine β-lipotropic hormone. Endocrinology 82:898-904, 1968
6. Li CH, Chung D: Isolation and structure of an untrikontapeptide with opiate activity from camel pituitary glands. Proc Natl Acad Sci USA 73:1145-1148, 1976
7. Mains RE, Eipper BA, Ling N: Common precursor to corticotropins and endorphins. Proc Natl Acad Sci USA 74:3014-3018, 1977
8. Axelrod J, Reisine T: Stress hormones: their interaction and regulation. Science 224:452-459, 1984
9. Lerner AB, McGuire JS: Melanocyte-stimulating hormone and adrenocortictrophic hormone: their relation to pigmentation. N Engl J Med 270:539-546, 1964
10. Lerner AB, McGuire JS: Effect of alpha- and beta-melanocyte stimulating hormones on the skin colour of man. Nature 189:176-179, 1961
11. Levins PC, Carr DB, Fisher JE, Momtaz K, Parrish JA: Plasma β-endorphin and β-lipotropin response to ultraviolet radiation. Lancet 2:166, 1983
12. Hargreaves KM, Dionne KA, Mueller GP: Plasma beta-endorphin like immunoreactivity, pain and anxiety following administration of placebo in oral surgery patients. J Dent Res 62:1170-1173, 1983
13. Schally AV, Lipscomb HS, Long HJ, Dear WE, Guillemin R: Chromatography and hormonal activities of dog hypothalamus. Endocrinology 70:478-480, 1962
14. Guillemin R, Schally AV, Lipscomb HS, Andersen RN, Long JM: On the presence in hog hypothalamus of β-corticotropin releasing factor, α- and β-melanocyte stimulating hormones, adrenocorticotropin, lysine-vasopressin and oxytocin. Endocrinology 70:471-477, 1962
15. Höllt V, Müller OA, Gramsch C, Kleber G, Pasi A, Herz A: β-Lipotropin (β1 PH), β-endorphin (βE), ACTH and α-MSH in human plasma, pituitary and brain. Acta Endocr 91 (suppl 225):69, 1979
16. Hiller JM, Pearson J, Simon EJ: Distribution of stereospecific binding of the potent narcotic analgesic etorphine in the human brain: predominance in the limbic system. Res Commun Chem Pathol Pharmacol 6:1052-1062, 1973
17. Kastin AJ, Miller LH, Nockton R, Sandman CA, Schally AV, Stratton LO: Behavioural aspects of melanocyte stimulating hormone (MSH). Prog Brain Res 39:461-470, 1973
18. De Wied D: Peptides and behaviour. Life Sci 20:195-204, 1977
19. Akil H, Richardson DE, Hughes J, Barchas JD: Elevation of enkephalin levels in the ventricular CSF of pain patients upon analgetic focal stimulation. Science 201:463-465, 1978
20. Richardson DE: Brain stimulation for pain control. IEEE Trans Biomed Eng BME-23:304-306, 1976
21. Terenius L: Endogenous peptides and analgesia. Annu Rev Pharmacol Toxicol 18:189-204, 1978
22. Simon EJ, Hiller JM: Opioid peptides and opioid receptors. In: Siegel G, Agranoff B, Albers R, Molinoff P (eds.). Basic Neurochemistry. Raven Press, New York, 1989, pp 271-285
23. Bruni JF, Watkins WB, Yen SSC: β-Endorphin in the human pancreas. J Clin Endocrinol Metab 49:649-651, 1979
24. Larsson LI: Radioimmunochemical characterization of ACTH-like peptides in the antropyloric mucosa. Life Sci 25:1565-1570, 1979
25. Tanaka I, Yoshikatsu N, Kazuwa N, Oki S, Masaki N, Ohtsuki H, Imamura H: Presence of immunoreactive γ-melanocyte stimulating hormone, adrenocortricotropin, and β-endorphin in human gastric antral mucosa. J Clin Endocrinol Metab 54:392-396, 1982
26. Genazzani AR, Facchenetti F, Parrini D: β-Lipotropin and β-endorphin plasma levels during pregnancy. Clin Endocrinol 14:408-418, 1981
27. Sharp B, Pekary AE: β-Endorphin (61-91) and other β-endorphin immunoreactive peptides in human semen. J Clin Endocrinol Metab 52:586-588, 1981
28. Blalock JE, Smith EM: A complete regulatory loop between the immune and neuroendocrine systems. Fed Proc 44:108-111, 1985
29. Harbour-McMenamin D, Smith EM, Blalock JE: Bacterial lipopolysaccharide induction of leukocyte-derived corticotropin and endorphins. Infect Immunol 48:813-817, 1985
30. Kavelaars A, Ballieux RE, Heijuen CJ: The role of IL-1 in the corticotropin releasing factor and arginine-vasopressin-induced secretion of immunoreactive β-endorphin by human peripheral blood mononuclear cells. J Immunol 142: 2338-2342, 1989
31. Smith EM, Blalock JE: Human lymphocyte production of corticotropin and endorphin-like substances: association with leukocyte interferon. Proc Natl Acad Sci USA 78:7530-7534, 1981
32. Smith EM, Morril AC, Meyer IWJ, Blalock JE: Corticotropin releasing factor induction of leukocyte derived immunoreactive ACTH and endorphins. Nature 321:881-882, 1986
33. Alvarez-Mon A, Kehrl JH, Fauci AS: A potential role for adrenocorticotropin in regulating human B lymphocyte functions. J Immunol 135:3823-3826, 1985
34. Apte RN, Durum SK, Oppenheim JJ: Opioids modulate interleukin-1 production and secretion by bone-marrow macrophages. Immunol Lett 24:141-148, 1990
35. Carr DJJ, Klimpel GR: Enhancement of the generation of cytotoxic T cells by endogenous opiates. J Neuroimmunol 12:75-87, 1986
36. Daynes RA, Robertson BA, Cho BH, Burnham DK, Newton R: α-Melanocyte-stimulating hormone exhibits target cell selectivity in its capacity to affect interteukin 1-inducible responses in vivo and in vitro. J Immunol 139(1):103-109, 1987
37. Heijnen CJ, Ballieux RE: Influence of opioid peptides on the immune system. Inst Adv Health Sci 3:114-117, 1986
38. Johnson HM, Smith EM, Torres BA, Blaloch JE: Neuroendocrine hormone regulation of in vitro antibody production. Proc Natl Acad Sci USA 79:4171-4174, 1982
39. Kay N, Allen J, Morley JE: Endorphins stimulate normal peripheral blood lymphocyte natural killer activity. Life Sci 35:53-59, 1984
40. Mason MJ, Van Epps D: Modulation of IL-1, tumor necrosis factor, and C5A-mediated murine neutrophil migration by α-melanocyte stimulating hormone. J Immunol 142:1646-1651, 1989
41. Slominski A, Paus R, Mazurkiewicz J: Proopiomelanocortin expression in the skin during induced hair growth in mice. Experientia 48:50-54, 1992
42. Farooqui JZ, Medrano EE, Abdel-Malek Z, Nordlund J: The expression of proopiomelanocortin and various POMC-derived peptides in mouse and human skin. Ann NY Acad Sci 680:508-510, 1993
43. Luger TA, Schauer E, Trautinger F, Krutmann J, Ansel J, Schwarz A, Schwarz T: Production of immunosuppressing melanotropins by human keratinocytes. Ann NY Acad Sci 680:567-570, 1993
44. Schauer E, Trautinger F, Köck A, Schwarz A, Bhardwaj R, Simon M, Ansel JC, Schwarz T, Luger TA: Proopiomelanocortin-derived peptides are synthesized and released by human keratinocytes. J Clin Invest 93:2258-2262, 1994
45. Li CH: Proposed system of terminology for preparations of adrenocorticotropic hormone. Science 129:969-970, 1959
46. Lerner AB, Shizume K, Bunding I: The mechanism of endocrine control of melanin pigmentation. J Endocrinol Metab 14:1463-1490, 1954
47. Lee TH, Lerner AB: Isolation of melanocyte stimulating hormone from hog pituitary gland. J Biol Chem 221:943-959, 1956
48. Li CH, Barnafi L, Chrétien M, Chung D: Isolation and amino acid sequence of βLPH from sheep pituitary glands. Nature 208:1093-1094, 1965
49. Bloom F, Battenberg ELH, Shibasaki T, Benoit R, Ling N, Guillemin R: Localization of γ-melanocyte stimulating hormone (γMSH) immunoreactivity in rat brain and pituitary. Regul Pept 1:205-222, 1980
50. Jeffcoate WJ, Rees LH, Lowry PJ, Hope J, Besser GM: β-Lipotrophin in human plasma and cerebrospinal fluid: radioimmunoassay evidence for γ-lipotrophin and β-endorphin. J Endocrinol 77:278-288, 1978
51. Austen BM, Smyth DG, Snell CR: γ-Endorphin, α-endorphin and Metenkephalin are formed extracellularly from lipotropin C fragment. Nature 269:619-621, 1977
52. Scott AP, Lowry PJ, Ratcliffe LG, Rees LH, Landon J: Corticotrophin-like peptides in the rat pituitary. J Endocrinol 61:355-367, 1974
53. 2+ regulates hormone secretion and proopiomelanocortin gene expression in melanotrope cells via the calmodulin and protein kinase C pathways. J Neurochem 52(4):1279-1283, 1989
54. Fenger M: Proopiomelanocortin: α-amidated and related peptides. Scan J Clin Lab Invest 50:229-245, 1990
55. Cochet M, Chang ACY, Cohen SN: Characterization of the structural gene and putative 5′-regulatory sequences for human proopiomelanocortin. Nature 297:335-339, 1982
56. Drouin J, Chamberland M, Charron J, Jeannotte L, Nemer M: Structure of the rat proopiomelanocortin (POMC) gene. FEBS Lett 193:54-58, 1985
57. Nakanishi S, Inoue A, Kita T, Nakamura M, Chang ACY, Cohen SN, Numa S: Nucleotide sequence of cloned cDNA for bovine corticotropin-β-lipotropin precursor. Nature 278:423-427, 1979
58. Walter P, Gilmore R, Blobel G: Protein translocation across the endoplasmatic reticulum. Cell 38:5-8, 1984
59. Drouin J, Goodman HM: Most of the coding region of rat ACTH/β-LPH precursor gene lacks intervening sequences. Nature 288:610-613, 1980
60. Höllt V: Precursors of opioid peptides and their gene regulation. Clin Neuropharmacol 15(suppl 1):50A-51A, 1992
61. Smith AI, Funder JW: Proopiomelanocortin processing in the pituitary, central nervous system, and peripheral tissues. Endocr Rev 9(1):159-178, 1988
62. Civelli O, Birnberg N, Herbert E: Detection and quantitation of proopiomelanocortin mRNA in pituitary and brain tissues from different species. J Biol Chem 257:6783-6787, 1982
63. Krieger DT, Liotta AS: Pituitary hormones in brain: where, how and why? Science 205:366-370, 1979
64. Pintar JE, Schachter BS, Herman AB, Durgerian S, Krieger DT: Characterization and localization of proopiomelanocortin messenger RNA in the adult rat testes. Science 225:632-634, 1984
65. De Bold CR, Nicholson WE, Orth DN: Immunoreactive proopiomelanocortin (POMC) peptides and POMC-like messenger ribonucleic acid are present in many rat nonpituitary tissues. Endocrinology 122:2648-2657, 1988
66. Blalock JE: A molecular basis for bidirectional communication between the immune and neuroendocrine systems. Physiol Rev 69(1):1-32, 1989
67. Heijnen CJ, Kavelaars A, Ballieux RE: β-Endorphin: cytokine and neuropeptide. Immunol Rev 119:41-63, 1991
68. Jeannotte L, Burbach JPH, Drouin J: Unusual proopiomelanocortin ribonucleic acids in extrapituitary tissues: intronless transcripts in testes and long poly(A) tails in hypothalamus. Mol Endocrinol 1:749-757, 1987
69. Clark AJL, Lavender PM, Coates P, Johnson MR, Rees LH: In vitro and in vivo analysis of the processing and fate of the peptide products of the short proopiomelanocortin mRNA. Mol Endocrinol 4:1737-1743, 1990
70. Vale W, Rivier C: Substances modulating the secretion of ACTH by cultured anterior pituitary cells. Fed Proc 36:2094-2099, 1976
71. Young SL, Searles RP, Kaynard AH, Melner MH: Specific inhibition of protein kinase A in granulosa cells abolishes gonadotropin regulation of the proopiomelanocortin promoter. J Biol Chem 266(24):15839-15844, 1991
72. Vale W, Spiess J, Rivier C, Rivier J: Characterization of a 41-residu ovine hypothalamic peptide that stimulates secretion of corticotropin and β-endorphin. Science 213:1394-1397, 1981
73. Brown SL, Smith LR, Blalock JE: Interleukin 1 and interleukin 2 enhance proopiomelanocortin gene expression in pituitary cells. J Immunol 139:3181-3183, 1987
74. Shiomi H, Watson SJ, Kelsey JE, Akil H: Pretranslational and posttranslational mechanisms for regulating β-endorphin-adrenocorticotropin of the anterior pituitary lobe. Endocrinology 119(4):1793-1799, 1986
75. Guillemin R, Vargo T, Rossier J, Minick S, Ling N, Rivier C, Vale W, Bloom F: β-Endorphin and adrenocorticotropin are secreted concomitantly by the pituitary gland. Science 197:1367-1369, 1977
76. Autelitano DJ, Lundblad JR, Blum M, Roberts JL: Hormonal regulation of POMC gene expression. Annu Rev Physiol 51:715-726, 1989
77. Loeffler JP, Demeneix BA, Kley NA, Höllt V: Dopamine inhibition of proopiomelanocortin gene expression in the intermediate lobe of the pituitary. Neuroendocrinology 47:95-101, 1988
78. Harbour-McMenamin DV, Smith EM, Blalock JE: Endotoxin induction of leukocyte-derived proopiomelanocortin related peptides. Infect Immun 48:813-819, 1984
79. Kavelaars A, Ballieux RE, Heijnen CJ: Two different signalling pathways for the induction of immunoreactive β-endorphin secretion by peripheral blood mononuclear cells. Endocrinology 128:765-770, 1991
80. Burbach JPH, Wiegant VM: Isolation and characterization of α-endorphin and γ-endorphin from single human pituitary glands. FEBS Lett 166:267-272, 1984
81. Eipper BA, Mains RE: Structure and biosynthesis of pro-adrenocorticotropin/ endorphin and related peptides. Endocr Rev 1(1):1-27, 1980
82. Sabol SL: Storage and secretion of β-endorphin and related peptides by mouse pituitary tumor cells: regulation by glucocorticoids. Arch Biochem Biophys 203(1):37-48, 1980
83. Birch NP, Bennett HPJ, Estivariz FE, Loh YP: Effect of calcium ions on the processing of proopiomelanocortin by bovine intermediate lobe proopiomelanocortin-converting enzyme. Eur J Biochem 201:85-89, 1991
84. Bateman A, Singh A, Kral T, Solomon S: The immune-hypothalamic-pituitary-adrenal axis. Endocr Rev 10(1):92-112, 1989
85. Morley JE, Kay NE, Solomon GF, Plotnikoff NP: Neuropeptides: conductors of the immune orchestra. Life Sci 41:527-544, 1987
86. Smith EM, Hughes TK Jr, Hashemi F, Stefano GB: Immunosuppressive effects of corticotropin and melanotropin and their possible significance in human immunodeficiency virus infection. Proc Natl Acad Sci USA 89:782-786, 1992
87. Slominski A: POMC gene expression in mouse and hamster melanoma cells. FEBS Lett 291(2):165-168, 1991
88. Johansson O, Liu PY: γ-Melanocyte stimulating hormone (γ-MSH)-like immunoreactivity is present in certain normal human keratinocytes. Exp Dermatol 2:204-208, 1993
89. Thody AJ, Ridley K, Penny RJ, Chalmers R, Fisher C, Shuster S: MSH peptides present in mammilian skin. Peptides 4:813-816, 1983
90. Simic-Krstic J, Sevaljevic L: Adrenocorticotropin binding activity of B16/C3 melanoma cells. Exp Cell Biol 56:138-142, 1988
91. DeLuca M, Siegrist W, Bondanza S, Mathor M, Cancedda R, Eberle AN: α-Melanocyte stimulating hormone (γMSH) stimulates normal human melanocyte growth by binding to high-affinity receptors. J Cell Sci 105:1079-1084, 1993
92. Donatien PD, Hunt G, Pieron C, Lunec J, Taïeb A, Thody AJ: The expression of functional MSH receptors on cultured human melanocytes. Arch Dermatol Res 284:424-426, 1992
93. Mountjoy KG, Robbins LS, Mortrud MT, Cone RD: The cloning of a family of genes that encode the melanocortin receptors. Science 257:1248-1251, 1992
94. Birchall N, Orlow SJ, Kupper T, Pawelek J: Interactions between ultraviolet light and interleukin-1 on MSH binding in both mouse melanoma and human squamous carcinoma cells. Biochem Biophys Res Commun 175:839-845, 1991
95. Charkraborty AK, Pawelek JM: Up-regulation of MSH receptors by MSH Cloudman melanoma cells. Biochem Biophys Res Commun 188:1325-1331, 1992
96. Bolognia J, Murray M, Pawelek J: UVB-induced melanogenesis may be mediated through the MSH-receptor system. J Invest Dermatol 92:651-656, 1989
97. Slominski A, Pawelek J: MSH binding in Bomirski amelanotic hamster melanoma cells is stimulated by L-tyrosine. Biosci Rep 7:949-954, 1987
98. McLane J, Osber M, Pawelek JM: Phosphorylated isomers of L-dopa stimulate MSH binding capacity and responsiveness to MSH in cultured melanoma cells. Biochem Res Commun 2:719-725, 1987
99. Chakraborty A, Pawelek J: MSH receoptors in immortalized human keratinocytes: a potential mechanism for coordinate regulation of the epidermalmelanin unit. J Cell Physiol 2:344-350, 1993
100. Howard AD, de la Baume S, Gioannini TL, Hiller JM, Simon EJ: Covalent labeling of opioid receptors with radioiodinated human β-endorphin. J Biol Chem 260:10833-10839, 1985
101. Hazum E, Chang KJ, Cuatrecasas P: Specific nonopiate receptors for β-endorphin. Science 205:1033-1035, 1979
102. McCormack AM, Carter RJ, Thody AJ, Shuster S: Des-acetyl MSH and γ-MSH act as partial agonists to α-MSH on the Anolis melanophore. Peptides 3:13-16, 1982
103. Negishi S, Kawazoe I, Kawauchi H: A sensitive bioassay for melanotropic hormones using isolated Medaka melanophores. Gen Comp Endocrinol 70:127-132, 1988
104. Slominski A, Costantino R, Wortsman J, Paus R, Ling N: Melanotropic activity of gamma MSH peptides in melanoma cells. Life Sci 50:1103-1108, 1992
105. Eberle AN: Secretion, distribution and inactivation of MSH. In: Eberle AN (ed.). The Melanotropins. Karger, Basel, 1988, pp 173-289
106. Bloomfield GA, Scott AP, Lowry PJ, Gilkes JJH, Rees LH: A reappraisal of human β-MSH. Nature 252:492-493, 1974
107. Hunt G, Todd C, Kyne S, Thody AJ: ACTH stimulates melanogenesis in cultured human melanocytes. J Endocrinol 140:R1-R3, 1994
108. 7α-MSH affect morphology, tyrosinase activity and melanogenesis in cultured human melanocytes. J Cell Sci 107:205-211, 1994
109. Levine N, Sheftel SN, Eytan T, Dorr RT, Hadley ME, Weinrach JC, Ertl GA, Toth K, McGee DC, Hruby VJ: Induction of skin tanning by subcutaneous administration of a potent synthetic melanotropin. J Am Med Assoc 226:2730-2736, 1991
110. 3, α-melanocyte stimulating hormone, and beta-estradiol. J Invest Dermatol 91:593-598, 1988
111. Wilson JD: Endocrine diseases. In: Petersdorf RG, Adams RD, Braunwald E, Isselbacher KJ, Martin JB, Wilson JD (eds.). Harrison's Principles of Internal medicine. McGraw-Hill, New York, 1983, pp 580-750
112. Quevedo WC Jr, Fitzpatrick TB, Szabo G, Jimbow K: Biology of melanocytes. In: Fitzpatrick TB, Eisen AZ, Wolff K, Freeberg I, Austen K (eds.). Dermatology in General Medicine. McGraw-Hill, New York, 1987
113. Schwyzer R, Eberle A: On the molecular mechanisms of the α-MSH receptor interactions. In: van Wimersma Greidanus TB (ed.). Karger, Basel, 1977, pp 18-25
114. Rustom KA, Gerard J, Pierard GE: Extrapituitary neuroendocrine melanoderma. Dermatologica 173:157-162, 1986
115. Lunec J, Pieron C, Thody AJ: MSH expression and the relationship to melanogenesis and metastatic activity in B16 melanoma. Melanoma Res 1:5-12, 1992
116. Slominski A, Moellmann G, Kuklinska E: MSH inhibits growth in a line of amelanotic hamster melanoma cells and induces increases in cyclic AMP levels and tyrosinase activity without inducing melanogenesis. J Cell Sci 92:551-559, 1989
117. Slominski A, Paus R, Wortsman J: Can some melanotropins modulate keratinocyte proliferation? J Invest Dermatol 97:747, 1991
118. Thody AJ, Shuster S: Sebotropic activity of β-lipotrophin. J Endocrinol 50:533-534, 1971
119. Thody AJ, Shuster S: Control of sebaceous gland function in the rat by α-melanocyte stimulating hormone. J Endocrinol 64:503-510, 1975
120. Gilman SC, Schwartz JM, Milner RJ, Bloom FE, Feldman JD: β-Endorphin enhances lymphocyte proliferative responses. Proc Natl Acad Sci USA 79:4226-4230, 1982
121. McCain HW, Lamster IB, Bozzone JM, Grbic JT: β-Endorphin modulates human immune activity via non-opiate receptor mechanisms. Life Sci 31:1619-1624, 1982
122. Johnson HM, Torres BA, Smith EM, Dion LD, Blalock JE: Regulation of lymphokine (interferon-γ) production by corticotropin. J Immunol 132:246-250, 1984
123. Mandler RM, Biddison WE, Mandler R, Serrate SA: β-Endorphin augments the cytolytic activity and interferon production of natural killer cells. J Immunol 136:934-939, 1986
124. Miller GC, Murgo AJ, Plotnikoff NP: Enkephalins enhancement of active T-cell rosettes from normal volunteers. Clin Immunol Immunopathol 31:132-137, 1984
125. Genedani S, Bernardi M, Baldini MG, Bertolini G: ACTH(1-24) stimulates the migration of monocytes in vitro. Peptides 11:1305-1307, 1990
126. Ruff MR, Wahl SM, Mergenhagen S, Pert CB: Opiate receptor-mediated chemotaxis of human monocytes. Neuropeptides 5:363-366, 1985
127. Koff WC, Dunegan MA: Modulation of macrophage-mediated tumoricidal activity by neuropeptides and neurohormones. J Immunol 135:350-354, 1985
128. Bernstein JE: Neuropeptides and the skin. In: Goldsmith LA (ed.). Biochemistry and Physiology of the Skin. Oxford University Press, New York, 1983, pp 816-835
129. Ansel J, Perry P, Brown J, Damm D, Phon T, Hart C, Luger T, Hefeneider S: Cytokine modulation of kertinocyte cytokines. J Invest Dermatol 94 (6 suppl): 101S-107S, 1990
130. Georgala S, Schulpis KH, Papaconstantinou ED, Stratigos J: Raised β-endorphin serum levels in children with atopic dermatitis and pruritus. J Dermatol Sci 8:125-128, 1994
131. Pincelli C, Fantini I, Romualdi P, Sevignani C, Lesa G, Benassi L, Giannetti A: Substance P is diminished and vasoactive intestinal peptide is augmented in psoriatic lesions and these peptides exert disparate effects on proliferation of cultured human keratinocytes. J Invest Dermatol 98:421-427, 1992
132. Leung DV, Schneeberger EE, Gerha RS: The presence of IgE on macrophages and dendritic cells infiltrating into the skin lesions of atopic dermatitis. Clin Immunol Immunopathol 42:328-337, 1987
133. Carr DB, Bullen BA, Skrinar GS, Arnold MA, Rosenblatt M, Beitins IZ, Martin JB, McArthur JW: Physical conditioning facilitates the exercise-induced secretion of beta-endorphin and beta-lipotropin in women. N Engl J Med 305:560-563, 1981
134. Fraioli F, Moretti C, Paolucci D, Alicicco E, Crescenzi F, Fortunio G: Physical exercise stimulates marked concomitant increase of β-endorphin and adrenocorticotropic hormone (ACTH) in peripheral blood in man. Experientia 36:987-989, 1980
135. Hartwig AC: Peripheral beta-endorphin and pain modulation. Anesth Prog 38:75-78, 1991
136. Stein C, Hassan AHS, Przewkochi R, Gramsch C, Peter K, Herz A: Opioids from immunocytes interact with receptors on sensory nerves to inhibit nociception in inflammation. Proc Natl Acad Sci USA 87:5935-5939, 1990
137. Kupper TA, Lee F, Birchall N, Clark S, Dower S: Interleukin 1 binds to specific receptors on human keratinocytes and induces granulocyte macrophage colony-stimulating factor mRNA and protein. J Clin Invest 82:1787-1792, 1988
138. Belon PE: UVA exposure and pituitary secretion. Variations of human lipotropin concentrations (βLPH) after UVA exposure. Photochem Photobiol 42(3): 327-329, 1985
139. Yasuda N, Greer MA: Demonstration of corticotropin-releasing activity in rat and human peripheral blood. Acta Endocrinol 84:1-10, 1977
140. Rivier CL, Plotsky PM: Mediation by Corticotropin Releasing Factor (CRF) of adenohypophysal hormone secretion. Annu Rev Physiol 48:475, 1086
141. Keller-Wood ME, Dallman MF: Corticosteroid inhibition of ACTH secretion. Endocr Rev 5:1-24, 1984
142. Evans CJ, Erdelyi E, Weber E, Barchas JD: Identification of proopiomelanocortin derived peptides in the human adrenal medulla. Science 221:957-960, 1983
143. Gibbs DM, Vale W: Presence of corticotropin releasing factor-like immunoreactivity in hypophysal portal blood. Endocrinology 111:1418-1420, 1982
144. Bernton EW, Beach JE, Holaday JW, Smallridge RC, Fein HG: Release of multiple hormones by a direct action of interleukin-1 on pituitary cells. Science 238:519-521, 1987
145. Shuster S, Carter RJ, Thody AJ, Smith AG, Fisher C, Cook J: MSH peptides in the adult human brain and pituitary. IRCS Med Sci 6:330, 1978
146. Liotta A, Osathanondh R, Ryan KJ, Krieger DT: Presence of corticotropin in human placenta: demonstration of in vitro synthesis. Endocrinology 101:1552-1558, 1977
147. Osamura RY, Komatsu N, Watanabe K, Nakai Y, Tanaka I, Imamura H: Immunohistochemical and immunocytochemical localization of γ-melanocyte stimulating hormone (γ-MSH)-like immunoreactivity in human and rat hypothalamus. Peptides 3:781-787, 1982
148. Johansson O, Ljungberg A, Han S-W, Vaalasti A: Evidence for γ-melanocyte stimulating hormone containing nerves and neutrophilic granulocytes in the human skin by indirect immunofluorescence. J Invest Dermatol 96:852-856, 1991
149. Fuerle GE, Weber U, Helmstaedter V: β-Lipotropin-like material in human pancreas and pyloric antral mucosa. Life Sci 27:467-473, 1980
150. Vale W, Rivier C, Lang L, Minick S, Guillemin R: Effects of purified hypothalamic corticotropin releasing factor and other substances on the secretion of adrenocorticotropin and β-endorphin like immunoreactivities in vitro. Endocrinology 103:1910-1915, 1978
151. Kavelaars A, Ballieux RE, Heijnen CJ: In vitro β-adrenergic stimulation of lymphocytes induces the release of immunoreactive β-endorphin. Endocrinology 126:3028-3032, 1990
152. Brummit CF, Sharp B, Gekker G, Keane WF, Peterson WK: β-Endorphin inhibits interleukin-1β release by peripheral blood mononuclear cells. Monokines and Other Nonlymphocytic Cytokines :125-130, 1988
153. Loh HH, Tseng LF, Wei E, Li CH: β-Endorphin is a potent analgesic agent. Proc Natl Acad Sci USA 73:2895-2898, 1976
154. Sharp BM, Keane WF, Suh HJ, Gekker G, Tsukayama D, Peterson PK: Opioid peptides rapidly stimulate superoxide production by human polymorphonuclear leukocytes and macrophages. Endocrinology 117:793-795, 1985
155. Pawelek JM, Chakrabory AK, Osber MP, Orlow SJ, Min KK, Rosenzweig KE, Blolgnia JL: Molecular cascades in UV-induced melanogenesis: A central role for melanotrpins? Pigment Cell Res 5:348-356, 1992